Human brucellosis and adverse pregnancy outcomes

Autores
Arenas-Gamboa, Angela M.; Rossetti, Carlos Alberto; Chaki, Sankar P.; Garcia-Gonzalez, Daniel G.; Adams, Leslie G.; Ficht, Thomas A.
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Purpose of Review Brucellosis is a neglected, zoonotic disease of nearly worldwide distribution. Despite brucellosis being recognized as a reproductive disease in animals, it has been historically known as a flu-like illness in humans with little or no significant role in maternal or newborn health. This review focuses on what is currently known relative to the epidemiology of brucellosis in human pregnancy as well as new insights of placental immunology. Recent Findings New evidence suggests that maternal infection poses a significant risk factor for adverse pregnancy outcomes including increased risk for miscarriage during the first and second trimester of gestation, preterm delivery, and vertical transmission to the fetus. Adverse pregnancy outcomes were not associated with any specific clinical sign. However, prompt diagnosis and treatment significantly decreased the risk of miscarriage or any other adverse effect. Summary Brucellosis during pregnancy should be considered a significant risk factor for adverse pregnancy outcomes in humans. The identification of the mechanism behind bacterial tropism should prove powerful for the development of new countermeasures to prevent these detrimental effects. Increased awareness concerning brucellosis in pregnant women, its transmission, and prevention measures should be considered as a pressing need.
Instituto de Patobiología
Fil: Arenas-Gamboa, Angela M. Texas A&M University. College of Veterinary Medicine & Biomedical Sciences. Department of Veterinary Pathobiology; Estados Unidos
Fil: Rossetti, Carlos Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
Fil: Chaki, Sankar P. Texas A&M University. College of Veterinary Medicine & Biomedical Sciences. Department of Veterinary Pathobiology; Estados Unidos
Fil: Garcia-Gonzalez, Daniel G. Texas A&M University. College of Veterinary Medicine & Biomedical Sciences. Department of Veterinary Pathobiology; Estados Unidos
Fil: Adams, Leslie G. Texas A&M University. College of Veterinary Medicine & Biomedical Sciences. Department of Veterinary Pathobiology; Estados Unidos
Fil: Ficht, Thomas A. Texas A&M University. College of Veterinary Medicine & Biomedical Sciences. Department of Veterinary Pathobiology; Estados Unidos
Fuente
Current tropical medicine reports 3 (4) : 164–172. (December 2016)
Materia
Human Diseases
Abortion
Zoonoses
Pregnancy
Enfermedades Humanas
Brucellosis
Aborto
Zoonosis
Placenta
Gestación
Nivel de accesibilidad
acceso restringido
Condiciones de uso
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
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spelling Human brucellosis and adverse pregnancy outcomesArenas-Gamboa, Angela M.Rossetti, Carlos AlbertoChaki, Sankar P.Garcia-Gonzalez, Daniel G.Adams, Leslie G.Ficht, Thomas A.Human DiseasesAbortionZoonosesPregnancyEnfermedades HumanasBrucellosisAbortoZoonosisPlacentaGestaciónPurpose of Review Brucellosis is a neglected, zoonotic disease of nearly worldwide distribution. Despite brucellosis being recognized as a reproductive disease in animals, it has been historically known as a flu-like illness in humans with little or no significant role in maternal or newborn health. This review focuses on what is currently known relative to the epidemiology of brucellosis in human pregnancy as well as new insights of placental immunology. Recent Findings New evidence suggests that maternal infection poses a significant risk factor for adverse pregnancy outcomes including increased risk for miscarriage during the first and second trimester of gestation, preterm delivery, and vertical transmission to the fetus. Adverse pregnancy outcomes were not associated with any specific clinical sign. However, prompt diagnosis and treatment significantly decreased the risk of miscarriage or any other adverse effect. Summary Brucellosis during pregnancy should be considered a significant risk factor for adverse pregnancy outcomes in humans. The identification of the mechanism behind bacterial tropism should prove powerful for the development of new countermeasures to prevent these detrimental effects. Increased awareness concerning brucellosis in pregnant women, its transmission, and prevention measures should be considered as a pressing need.Instituto de PatobiologíaFil: Arenas-Gamboa, Angela M. Texas A&M University. College of Veterinary Medicine & Biomedical Sciences. Department of Veterinary Pathobiology; Estados UnidosFil: Rossetti, Carlos Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; ArgentinaFil: Chaki, Sankar P. Texas A&M University. College of Veterinary Medicine & Biomedical Sciences. Department of Veterinary Pathobiology; Estados UnidosFil: Garcia-Gonzalez, Daniel G. Texas A&M University. College of Veterinary Medicine & Biomedical Sciences. Department of Veterinary Pathobiology; Estados UnidosFil: Adams, Leslie G. Texas A&M University. College of Veterinary Medicine & Biomedical Sciences. Department of Veterinary Pathobiology; Estados UnidosFil: Ficht, Thomas A. Texas A&M University. College of Veterinary Medicine & Biomedical Sciences. Department of Veterinary Pathobiology; Estados UnidosSpringer2019-02-26T17:08:39Z2019-02-26T17:08:39Z2016-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/4498https://link.springer.com/article/10.1007/s40475-016-0092-0#citeas2196-3045 (Online)https://doi.org/10.1007/s40475-016-0092-0Current tropical medicine reports 3 (4) : 164–172. (December 2016)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccess2025-09-29T13:44:34Zoai:localhost:20.500.12123/4498instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-29 13:44:35.177INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Human brucellosis and adverse pregnancy outcomes
title Human brucellosis and adverse pregnancy outcomes
spellingShingle Human brucellosis and adverse pregnancy outcomes
Arenas-Gamboa, Angela M.
Human Diseases
Abortion
Zoonoses
Pregnancy
Enfermedades Humanas
Brucellosis
Aborto
Zoonosis
Placenta
Gestación
title_short Human brucellosis and adverse pregnancy outcomes
title_full Human brucellosis and adverse pregnancy outcomes
title_fullStr Human brucellosis and adverse pregnancy outcomes
title_full_unstemmed Human brucellosis and adverse pregnancy outcomes
title_sort Human brucellosis and adverse pregnancy outcomes
dc.creator.none.fl_str_mv Arenas-Gamboa, Angela M.
Rossetti, Carlos Alberto
Chaki, Sankar P.
Garcia-Gonzalez, Daniel G.
Adams, Leslie G.
Ficht, Thomas A.
author Arenas-Gamboa, Angela M.
author_facet Arenas-Gamboa, Angela M.
Rossetti, Carlos Alberto
Chaki, Sankar P.
Garcia-Gonzalez, Daniel G.
Adams, Leslie G.
Ficht, Thomas A.
author_role author
author2 Rossetti, Carlos Alberto
Chaki, Sankar P.
Garcia-Gonzalez, Daniel G.
Adams, Leslie G.
Ficht, Thomas A.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Human Diseases
Abortion
Zoonoses
Pregnancy
Enfermedades Humanas
Brucellosis
Aborto
Zoonosis
Placenta
Gestación
topic Human Diseases
Abortion
Zoonoses
Pregnancy
Enfermedades Humanas
Brucellosis
Aborto
Zoonosis
Placenta
Gestación
dc.description.none.fl_txt_mv Purpose of Review Brucellosis is a neglected, zoonotic disease of nearly worldwide distribution. Despite brucellosis being recognized as a reproductive disease in animals, it has been historically known as a flu-like illness in humans with little or no significant role in maternal or newborn health. This review focuses on what is currently known relative to the epidemiology of brucellosis in human pregnancy as well as new insights of placental immunology. Recent Findings New evidence suggests that maternal infection poses a significant risk factor for adverse pregnancy outcomes including increased risk for miscarriage during the first and second trimester of gestation, preterm delivery, and vertical transmission to the fetus. Adverse pregnancy outcomes were not associated with any specific clinical sign. However, prompt diagnosis and treatment significantly decreased the risk of miscarriage or any other adverse effect. Summary Brucellosis during pregnancy should be considered a significant risk factor for adverse pregnancy outcomes in humans. The identification of the mechanism behind bacterial tropism should prove powerful for the development of new countermeasures to prevent these detrimental effects. Increased awareness concerning brucellosis in pregnant women, its transmission, and prevention measures should be considered as a pressing need.
Instituto de Patobiología
Fil: Arenas-Gamboa, Angela M. Texas A&M University. College of Veterinary Medicine & Biomedical Sciences. Department of Veterinary Pathobiology; Estados Unidos
Fil: Rossetti, Carlos Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
Fil: Chaki, Sankar P. Texas A&M University. College of Veterinary Medicine & Biomedical Sciences. Department of Veterinary Pathobiology; Estados Unidos
Fil: Garcia-Gonzalez, Daniel G. Texas A&M University. College of Veterinary Medicine & Biomedical Sciences. Department of Veterinary Pathobiology; Estados Unidos
Fil: Adams, Leslie G. Texas A&M University. College of Veterinary Medicine & Biomedical Sciences. Department of Veterinary Pathobiology; Estados Unidos
Fil: Ficht, Thomas A. Texas A&M University. College of Veterinary Medicine & Biomedical Sciences. Department of Veterinary Pathobiology; Estados Unidos
description Purpose of Review Brucellosis is a neglected, zoonotic disease of nearly worldwide distribution. Despite brucellosis being recognized as a reproductive disease in animals, it has been historically known as a flu-like illness in humans with little or no significant role in maternal or newborn health. This review focuses on what is currently known relative to the epidemiology of brucellosis in human pregnancy as well as new insights of placental immunology. Recent Findings New evidence suggests that maternal infection poses a significant risk factor for adverse pregnancy outcomes including increased risk for miscarriage during the first and second trimester of gestation, preterm delivery, and vertical transmission to the fetus. Adverse pregnancy outcomes were not associated with any specific clinical sign. However, prompt diagnosis and treatment significantly decreased the risk of miscarriage or any other adverse effect. Summary Brucellosis during pregnancy should be considered a significant risk factor for adverse pregnancy outcomes in humans. The identification of the mechanism behind bacterial tropism should prove powerful for the development of new countermeasures to prevent these detrimental effects. Increased awareness concerning brucellosis in pregnant women, its transmission, and prevention measures should be considered as a pressing need.
publishDate 2016
dc.date.none.fl_str_mv 2016-12
2019-02-26T17:08:39Z
2019-02-26T17:08:39Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/4498
https://link.springer.com/article/10.1007/s40475-016-0092-0#citeas
2196-3045 (Online)
https://doi.org/10.1007/s40475-016-0092-0
url http://hdl.handle.net/20.500.12123/4498
https://link.springer.com/article/10.1007/s40475-016-0092-0#citeas
https://doi.org/10.1007/s40475-016-0092-0
identifier_str_mv 2196-3045 (Online)
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/restrictedAccess
eu_rights_str_mv restrictedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv Current tropical medicine reports 3 (4) : 164–172. (December 2016)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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