Integrated hepatitis e virus monitoring in central Argentina : a six-year analysis of clinical surveillance and wastewater-based epidemiology
- Autores
- Fantilli, Anabella Clara; Masachessi, Gisela; Di Cola, Guadalupe; Castro, Gonzalo; Sicilia, Paola; Marinzalda, María de los Angeles; Cachi, Ariana Mariela; Moreno, Claudia; Borda, Mariel; Ibarra, Gustavo; Rojas, Ricardo Manuel; Parreño, Gladys Viviana; Barbás, María Gabriela; Nates, Silvia Viviana; Pisano, María Belén; Ré, Viviana Elizabeth
- Año de publicación
- 2024
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Wastewater-based epidemiology (WBE) has gained prominence worldwide as a powerful tool in public health. This study aimed to monitor the circulation of Hepatitis E Virus (HEV) from wastewater samples collected during a six-year period and compare these results with clinical surveillance in the central region of Argentina. From 2017 to 2022, 1008 raw wastewater samples were analyzed, including four wastewater treatment plants from four cities (n=319), and 7 local neighborhood collector sewers in Córdoba city (n=689). Serum and/or stool samples from patients suspected of HEV infection were also analyzed (n=48). HEV molecular detection and viral load quantification were performed by real time RT-qPCR, and genetic characterization by two RT-Nested PCRs (targeting partial ORF-1 and ORF-2 genomic regions), sequencing and phylogenetic analysis. Fifty-three (5.3%) wastewater samples were RNA-HEV positive by real time RT-qPCR, with variations according to the location and year (0.0% - 21.6%). Out of these, ORF-2 genomic region was amplified in 20 samples (37.7%) and ORF-1 partial region in 12 (22.6%), and eighteen sequences were obtained. Throughout the study period, two (4.2%) HEV confirmed infections were reported, and one sequence was obtained. Phylogenetic analyses for both genomic regions showed that all the isolates were genotype HEV-3 clade abchijklm. Our study detected HEV in wastewater over a six-year period, despite a low number of clinical cases, emphasizing WBE as a valuable tool that complements clinical surveillance, by detecting pathogens' presence; identifying their transmission, circulation dynamics and excretion hotspots; and revealing changes in their genomic diversity.
Instituto de Virología
Fil: Fantilli, Anabella Clara. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología “Dr. J. M. Vanella”; Argentina
Fil: Fantilli, Anabella Clara. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Masachessi, Gisela. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología “Dr. J. M. Vanella”; Argentina
Fil: Masachessi, Gisela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Di Cola, Guadalupe. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología “Dr. J. M. Vanella”; Argentina
Fil: Di Cola, Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Castro, Gonzalo. Ministerio de Salud de la Provincia de Córdoba. Departamento Laboratorio Central; Argentina
Fil: Sicilia, Paola. Ministerio de Salud de la Provincia de Córdoba. Departamento Laboratorio Central; Argentina
Fil: Marinzalda, María de los Angeles. Universidad de la Defensa Nacional. Facultad de la Fuerza Aérea. Instituto Nacional de Medicina Aeronáutica y Espacial; Argentina
Fil: Marinzalda, María de los Angeles. Planta Municipal de tratamiento de efluente cloacales Bajo Grande. Laboratorio de análisis fisicoquímicos, bacteriológicos EDAR Bajo Grande; Argentina
Fil: Cachi, Ariana Mariela. Universidad de la Defensa Nacional. Facultad de la Fuerza Aérea. Instituto Nacional de Medicina Aeronáutica y Espacial; Argentina
Fil: Cachi, Ariana Mariela. Planta Municipal de tratamiento de efluente cloacales Bajo Grande. Laboratorio de análisis fisicoquímicos, bacteriológicos EDAR Bajo Grande; Argentina
Fil: Moreno, Claudia. Ministerio de Salud de la Provincia de Córdoba. Departamento Laboratorio Central; Argentina
Fil: Borda, Mariel. Ministerio de Salud de la Provincia de Córdoba. Departamento Laboratorio Central; Argentina
Fil: Ibarra, Gustavo. Planta Municipal de tratamiento de efluente cloacales Bajo Grande. Laboratorio de análisis fisicoquímicos, bacteriológicos EDAR Bajo Grande; Argentina
Fil: Rojas, Ricardo Manuel. Cooperativa Integral Regional de Provisión de Servicios Públicos, Vivienda y Consumo Limitada (COOPI); Argentina
Fil: Parreño, Gladys Viviana. Consejo Nacional de Investigaciones Cientificas y Tecnicas; Argentina
Fil: Parreño, Gladys Viviana. Instituto Nacional de Tecnología Agropecuaria (INTA). INCUINTA. Instituto de Virologia e Innovaciones Tecnologicas (IVIT); Argentina
Fil: Barbás, María Gabriela. Ministerio de Salud de la Provincia de Córdoba. Departamento Laboratorio Central; Argentina
Fil: Nates, Silvia Viviana. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología “Dr. J. M. Vanella”; Argentina
Fil: Pisano, María Belén. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología “Dr. J. M. Vanella”; Argentina
Fil: Pisano, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ré, Viviana Elizabeth. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología “Dr. J. M. Vanella”; Argentina
Fil: Ré, Viviana Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina - Fuente
- Water Research 261 : 122004 (Septiembre 2024)
- Materia
-
Hepatitis
Wastewater
Epidemiology
Surveillance Systems
Agua Residual
Epidemiología
Sistemas de Vigilancia
Argentina
Hepatitis E Virus
Virus Hepatitis E - Nivel de accesibilidad
- acceso restringido
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
.jpg)
- Institución
- Instituto Nacional de Tecnología Agropecuaria
- OAI Identificador
- oai:localhost:20.500.12123/18503
Ver los metadatos del registro completo
| id |
INTADig_d5adbbef03264ef71dfa44d12c677395 |
|---|---|
| oai_identifier_str |
oai:localhost:20.500.12123/18503 |
| network_acronym_str |
INTADig |
| repository_id_str |
l |
| network_name_str |
INTA Digital (INTA) |
| spelling |
Integrated hepatitis e virus monitoring in central Argentina : a six-year analysis of clinical surveillance and wastewater-based epidemiologyFantilli, Anabella ClaraMasachessi, GiselaDi Cola, GuadalupeCastro, GonzaloSicilia, PaolaMarinzalda, María de los AngelesCachi, Ariana MarielaMoreno, ClaudiaBorda, MarielIbarra, GustavoRojas, Ricardo ManuelParreño, Gladys VivianaBarbás, María GabrielaNates, Silvia VivianaPisano, María BelénRé, Viviana ElizabethHepatitisWastewaterEpidemiologySurveillance SystemsAgua ResidualEpidemiologíaSistemas de VigilanciaArgentinaHepatitis E VirusVirus Hepatitis EWastewater-based epidemiology (WBE) has gained prominence worldwide as a powerful tool in public health. This study aimed to monitor the circulation of Hepatitis E Virus (HEV) from wastewater samples collected during a six-year period and compare these results with clinical surveillance in the central region of Argentina. From 2017 to 2022, 1008 raw wastewater samples were analyzed, including four wastewater treatment plants from four cities (n=319), and 7 local neighborhood collector sewers in Córdoba city (n=689). Serum and/or stool samples from patients suspected of HEV infection were also analyzed (n=48). HEV molecular detection and viral load quantification were performed by real time RT-qPCR, and genetic characterization by two RT-Nested PCRs (targeting partial ORF-1 and ORF-2 genomic regions), sequencing and phylogenetic analysis. Fifty-three (5.3%) wastewater samples were RNA-HEV positive by real time RT-qPCR, with variations according to the location and year (0.0% - 21.6%). Out of these, ORF-2 genomic region was amplified in 20 samples (37.7%) and ORF-1 partial region in 12 (22.6%), and eighteen sequences were obtained. Throughout the study period, two (4.2%) HEV confirmed infections were reported, and one sequence was obtained. Phylogenetic analyses for both genomic regions showed that all the isolates were genotype HEV-3 clade abchijklm. Our study detected HEV in wastewater over a six-year period, despite a low number of clinical cases, emphasizing WBE as a valuable tool that complements clinical surveillance, by detecting pathogens' presence; identifying their transmission, circulation dynamics and excretion hotspots; and revealing changes in their genomic diversity.Instituto de VirologíaFil: Fantilli, Anabella Clara. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología “Dr. J. M. Vanella”; ArgentinaFil: Fantilli, Anabella Clara. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Masachessi, Gisela. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología “Dr. J. M. Vanella”; ArgentinaFil: Masachessi, Gisela. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Di Cola, Guadalupe. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología “Dr. J. M. Vanella”; ArgentinaFil: Di Cola, Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Castro, Gonzalo. Ministerio de Salud de la Provincia de Córdoba. Departamento Laboratorio Central; ArgentinaFil: Sicilia, Paola. Ministerio de Salud de la Provincia de Córdoba. Departamento Laboratorio Central; ArgentinaFil: Marinzalda, María de los Angeles. Universidad de la Defensa Nacional. Facultad de la Fuerza Aérea. Instituto Nacional de Medicina Aeronáutica y Espacial; ArgentinaFil: Marinzalda, María de los Angeles. Planta Municipal de tratamiento de efluente cloacales Bajo Grande. Laboratorio de análisis fisicoquímicos, bacteriológicos EDAR Bajo Grande; ArgentinaFil: Cachi, Ariana Mariela. Universidad de la Defensa Nacional. Facultad de la Fuerza Aérea. Instituto Nacional de Medicina Aeronáutica y Espacial; ArgentinaFil: Cachi, Ariana Mariela. Planta Municipal de tratamiento de efluente cloacales Bajo Grande. Laboratorio de análisis fisicoquímicos, bacteriológicos EDAR Bajo Grande; ArgentinaFil: Moreno, Claudia. Ministerio de Salud de la Provincia de Córdoba. Departamento Laboratorio Central; ArgentinaFil: Borda, Mariel. Ministerio de Salud de la Provincia de Córdoba. Departamento Laboratorio Central; ArgentinaFil: Ibarra, Gustavo. Planta Municipal de tratamiento de efluente cloacales Bajo Grande. Laboratorio de análisis fisicoquímicos, bacteriológicos EDAR Bajo Grande; ArgentinaFil: Rojas, Ricardo Manuel. Cooperativa Integral Regional de Provisión de Servicios Públicos, Vivienda y Consumo Limitada (COOPI); ArgentinaFil: Parreño, Gladys Viviana. Consejo Nacional de Investigaciones Cientificas y Tecnicas; ArgentinaFil: Parreño, Gladys Viviana. Instituto Nacional de Tecnología Agropecuaria (INTA). INCUINTA. Instituto de Virologia e Innovaciones Tecnologicas (IVIT); ArgentinaFil: Barbás, María Gabriela. Ministerio de Salud de la Provincia de Córdoba. Departamento Laboratorio Central; ArgentinaFil: Nates, Silvia Viviana. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología “Dr. J. M. Vanella”; ArgentinaFil: Pisano, María Belén. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología “Dr. J. M. Vanella”; ArgentinaFil: Pisano, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ré, Viviana Elizabeth. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología “Dr. J. M. Vanella”; ArgentinaFil: Ré, Viviana Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier2024-07-15T10:22:45Z2024-07-15T10:22:45Z2024-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/18503https://www.sciencedirect.com/science/article/abs/pii/S00431354240090471879-2448https://doi.org/10.1016/j.watres.2024.122004Water Research 261 : 122004 (Septiembre 2024)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-04T09:50:30Zoai:localhost:20.500.12123/18503instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-04 09:50:30.774INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse |
| dc.title.none.fl_str_mv |
Integrated hepatitis e virus monitoring in central Argentina : a six-year analysis of clinical surveillance and wastewater-based epidemiology |
| title |
Integrated hepatitis e virus monitoring in central Argentina : a six-year analysis of clinical surveillance and wastewater-based epidemiology |
| spellingShingle |
Integrated hepatitis e virus monitoring in central Argentina : a six-year analysis of clinical surveillance and wastewater-based epidemiology Fantilli, Anabella Clara Hepatitis Wastewater Epidemiology Surveillance Systems Agua Residual Epidemiología Sistemas de Vigilancia Argentina Hepatitis E Virus Virus Hepatitis E |
| title_short |
Integrated hepatitis e virus monitoring in central Argentina : a six-year analysis of clinical surveillance and wastewater-based epidemiology |
| title_full |
Integrated hepatitis e virus monitoring in central Argentina : a six-year analysis of clinical surveillance and wastewater-based epidemiology |
| title_fullStr |
Integrated hepatitis e virus monitoring in central Argentina : a six-year analysis of clinical surveillance and wastewater-based epidemiology |
| title_full_unstemmed |
Integrated hepatitis e virus monitoring in central Argentina : a six-year analysis of clinical surveillance and wastewater-based epidemiology |
| title_sort |
Integrated hepatitis e virus monitoring in central Argentina : a six-year analysis of clinical surveillance and wastewater-based epidemiology |
| dc.creator.none.fl_str_mv |
Fantilli, Anabella Clara Masachessi, Gisela Di Cola, Guadalupe Castro, Gonzalo Sicilia, Paola Marinzalda, María de los Angeles Cachi, Ariana Mariela Moreno, Claudia Borda, Mariel Ibarra, Gustavo Rojas, Ricardo Manuel Parreño, Gladys Viviana Barbás, María Gabriela Nates, Silvia Viviana Pisano, María Belén Ré, Viviana Elizabeth |
| author |
Fantilli, Anabella Clara |
| author_facet |
Fantilli, Anabella Clara Masachessi, Gisela Di Cola, Guadalupe Castro, Gonzalo Sicilia, Paola Marinzalda, María de los Angeles Cachi, Ariana Mariela Moreno, Claudia Borda, Mariel Ibarra, Gustavo Rojas, Ricardo Manuel Parreño, Gladys Viviana Barbás, María Gabriela Nates, Silvia Viviana Pisano, María Belén Ré, Viviana Elizabeth |
| author_role |
author |
| author2 |
Masachessi, Gisela Di Cola, Guadalupe Castro, Gonzalo Sicilia, Paola Marinzalda, María de los Angeles Cachi, Ariana Mariela Moreno, Claudia Borda, Mariel Ibarra, Gustavo Rojas, Ricardo Manuel Parreño, Gladys Viviana Barbás, María Gabriela Nates, Silvia Viviana Pisano, María Belén Ré, Viviana Elizabeth |
| author2_role |
author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Hepatitis Wastewater Epidemiology Surveillance Systems Agua Residual Epidemiología Sistemas de Vigilancia Argentina Hepatitis E Virus Virus Hepatitis E |
| topic |
Hepatitis Wastewater Epidemiology Surveillance Systems Agua Residual Epidemiología Sistemas de Vigilancia Argentina Hepatitis E Virus Virus Hepatitis E |
| dc.description.none.fl_txt_mv |
Wastewater-based epidemiology (WBE) has gained prominence worldwide as a powerful tool in public health. This study aimed to monitor the circulation of Hepatitis E Virus (HEV) from wastewater samples collected during a six-year period and compare these results with clinical surveillance in the central region of Argentina. From 2017 to 2022, 1008 raw wastewater samples were analyzed, including four wastewater treatment plants from four cities (n=319), and 7 local neighborhood collector sewers in Córdoba city (n=689). Serum and/or stool samples from patients suspected of HEV infection were also analyzed (n=48). HEV molecular detection and viral load quantification were performed by real time RT-qPCR, and genetic characterization by two RT-Nested PCRs (targeting partial ORF-1 and ORF-2 genomic regions), sequencing and phylogenetic analysis. Fifty-three (5.3%) wastewater samples were RNA-HEV positive by real time RT-qPCR, with variations according to the location and year (0.0% - 21.6%). Out of these, ORF-2 genomic region was amplified in 20 samples (37.7%) and ORF-1 partial region in 12 (22.6%), and eighteen sequences were obtained. Throughout the study period, two (4.2%) HEV confirmed infections were reported, and one sequence was obtained. Phylogenetic analyses for both genomic regions showed that all the isolates were genotype HEV-3 clade abchijklm. Our study detected HEV in wastewater over a six-year period, despite a low number of clinical cases, emphasizing WBE as a valuable tool that complements clinical surveillance, by detecting pathogens' presence; identifying their transmission, circulation dynamics and excretion hotspots; and revealing changes in their genomic diversity. Instituto de Virología Fil: Fantilli, Anabella Clara. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología “Dr. J. M. Vanella”; Argentina Fil: Fantilli, Anabella Clara. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Masachessi, Gisela. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología “Dr. J. M. Vanella”; Argentina Fil: Masachessi, Gisela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Di Cola, Guadalupe. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología “Dr. J. M. Vanella”; Argentina Fil: Di Cola, Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Castro, Gonzalo. Ministerio de Salud de la Provincia de Córdoba. Departamento Laboratorio Central; Argentina Fil: Sicilia, Paola. Ministerio de Salud de la Provincia de Córdoba. Departamento Laboratorio Central; Argentina Fil: Marinzalda, María de los Angeles. Universidad de la Defensa Nacional. Facultad de la Fuerza Aérea. Instituto Nacional de Medicina Aeronáutica y Espacial; Argentina Fil: Marinzalda, María de los Angeles. Planta Municipal de tratamiento de efluente cloacales Bajo Grande. Laboratorio de análisis fisicoquímicos, bacteriológicos EDAR Bajo Grande; Argentina Fil: Cachi, Ariana Mariela. Universidad de la Defensa Nacional. Facultad de la Fuerza Aérea. Instituto Nacional de Medicina Aeronáutica y Espacial; Argentina Fil: Cachi, Ariana Mariela. Planta Municipal de tratamiento de efluente cloacales Bajo Grande. Laboratorio de análisis fisicoquímicos, bacteriológicos EDAR Bajo Grande; Argentina Fil: Moreno, Claudia. Ministerio de Salud de la Provincia de Córdoba. Departamento Laboratorio Central; Argentina Fil: Borda, Mariel. Ministerio de Salud de la Provincia de Córdoba. Departamento Laboratorio Central; Argentina Fil: Ibarra, Gustavo. Planta Municipal de tratamiento de efluente cloacales Bajo Grande. Laboratorio de análisis fisicoquímicos, bacteriológicos EDAR Bajo Grande; Argentina Fil: Rojas, Ricardo Manuel. Cooperativa Integral Regional de Provisión de Servicios Públicos, Vivienda y Consumo Limitada (COOPI); Argentina Fil: Parreño, Gladys Viviana. Consejo Nacional de Investigaciones Cientificas y Tecnicas; Argentina Fil: Parreño, Gladys Viviana. Instituto Nacional de Tecnología Agropecuaria (INTA). INCUINTA. Instituto de Virologia e Innovaciones Tecnologicas (IVIT); Argentina Fil: Barbás, María Gabriela. Ministerio de Salud de la Provincia de Córdoba. Departamento Laboratorio Central; Argentina Fil: Nates, Silvia Viviana. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología “Dr. J. M. Vanella”; Argentina Fil: Pisano, María Belén. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología “Dr. J. M. Vanella”; Argentina Fil: Pisano, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Ré, Viviana Elizabeth. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología “Dr. J. M. Vanella”; Argentina Fil: Ré, Viviana Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
| description |
Wastewater-based epidemiology (WBE) has gained prominence worldwide as a powerful tool in public health. This study aimed to monitor the circulation of Hepatitis E Virus (HEV) from wastewater samples collected during a six-year period and compare these results with clinical surveillance in the central region of Argentina. From 2017 to 2022, 1008 raw wastewater samples were analyzed, including four wastewater treatment plants from four cities (n=319), and 7 local neighborhood collector sewers in Córdoba city (n=689). Serum and/or stool samples from patients suspected of HEV infection were also analyzed (n=48). HEV molecular detection and viral load quantification were performed by real time RT-qPCR, and genetic characterization by two RT-Nested PCRs (targeting partial ORF-1 and ORF-2 genomic regions), sequencing and phylogenetic analysis. Fifty-three (5.3%) wastewater samples were RNA-HEV positive by real time RT-qPCR, with variations according to the location and year (0.0% - 21.6%). Out of these, ORF-2 genomic region was amplified in 20 samples (37.7%) and ORF-1 partial region in 12 (22.6%), and eighteen sequences were obtained. Throughout the study period, two (4.2%) HEV confirmed infections were reported, and one sequence was obtained. Phylogenetic analyses for both genomic regions showed that all the isolates were genotype HEV-3 clade abchijklm. Our study detected HEV in wastewater over a six-year period, despite a low number of clinical cases, emphasizing WBE as a valuable tool that complements clinical surveillance, by detecting pathogens' presence; identifying their transmission, circulation dynamics and excretion hotspots; and revealing changes in their genomic diversity. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024-07-15T10:22:45Z 2024-07-15T10:22:45Z 2024-09 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/20.500.12123/18503 https://www.sciencedirect.com/science/article/abs/pii/S0043135424009047 1879-2448 https://doi.org/10.1016/j.watres.2024.122004 |
| url |
http://hdl.handle.net/20.500.12123/18503 https://www.sciencedirect.com/science/article/abs/pii/S0043135424009047 https://doi.org/10.1016/j.watres.2024.122004 |
| identifier_str_mv |
1879-2448 |
| dc.language.none.fl_str_mv |
eng |
| language |
eng |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/restrictedAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
| eu_rights_str_mv |
restrictedAccess |
| rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier |
| publisher.none.fl_str_mv |
Elsevier |
| dc.source.none.fl_str_mv |
Water Research 261 : 122004 (Septiembre 2024) reponame:INTA Digital (INTA) instname:Instituto Nacional de Tecnología Agropecuaria |
| reponame_str |
INTA Digital (INTA) |
| collection |
INTA Digital (INTA) |
| instname_str |
Instituto Nacional de Tecnología Agropecuaria |
| repository.name.fl_str_mv |
INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria |
| repository.mail.fl_str_mv |
tripaldi.nicolas@inta.gob.ar |
| _version_ |
1842341424594419712 |
| score |
12.623145 |