Evidence of Hepatitis A virus circulation in central Argentina: Seroprevalence and environmental surveillance

Autores
Yanez, Laura Anahi; Lucero, Noelia S.; Barril, Patricia Angelica; Diaz, Maria del Pilar; Tenaglia, Maria Magdalena; Spinsanti, Lorena Ivana; Nates, Silvia Viviana; Isa, Maria Beatriz; Ré, Viviana Elizabeth
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Hepatitis A virus (HAV) has shown intermediate endemicity in Argentina, but notification of clinical cases has decreased since the introduction of the vaccine in 2005. Objectives: In order to get insight into the local circulation of this virus after four years of the official introduction of the vaccine, the aims of this study were to provide information on HAV immune status of the adult population of Córdoba city and to conduct environmental surveillance of HAV in sewage and river samples in the same region. Study design: The prevalence of anti-HAV was determined by EIA in 416 samples of people (without prior vaccination) from Córdoba city (2009-2010). Spline regression models were estimated under generalized additive models. Environmental surveillance was conducted in river and sewage samples collected in the same period. Viral detection was performed by RT-Nested PCR of the 5'UTR. Results: In Córdoba, the global prevalence of anti-HAV was 73.5%. It increased with age (p<. 0.0001) and it was associated with the low-income population (OR: 1.14; 95% CI 1.05-1.25). This prevalence decreased in younger age groups, especially in the high-income population. Environmental monitoring revealed the presence of HAV (IA) in 20.8% and 16.1% of wastewater and river samples, respectively. Conclusions: As a consequence of a decrease in HAV circulation due to improvements in immunization, socio-economic and hygienic conditions, young adults are becoming increasingly susceptible to HAV infections. Environmental monitoring demonstrated that HAV circulates in the local population; therefore, health care systems should consider the implementation of preventive measures for susceptible adults in order to reduce the risk of HAV infection.
Fil: Yanez, Laura Anahi. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina
Fil: Lucero, Noelia S.. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina
Fil: Barril, Patricia Angelica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina
Fil: Diaz, Maria del Pilar. Universidad Nacional de Córdoba. Facultad de Medicina. Escuela de Nutrición; Argentina
Fil: Tenaglia, Maria Magdalena. Universidad Católica de Córdoba. Facultad de Medicina. Clínica Universitaria Reina Fabiola; Argentina
Fil: Spinsanti, Lorena Ivana. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina
Fil: Nates, Silvia Viviana. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina
Fil: Isa, Maria Beatriz. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina. Universidad Católica de Córdoba. Facultad de Medicina. Clínica Universitaria Reina Fabiola; Argentina
Fil: Ré, Viviana Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina
Materia
ARGENTINA
ENVIRONMENTAL SURVEILLANCE
HEPATITIS A VIRUS
SEROPREVALENCE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/180450
Acceder
id CONICETDig_fd535dcda9ee41fb3cf9282b1eba6fc2
oai_identifier_str oai:ri.conicet.gov.ar:11336/180450
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Evidence of Hepatitis A virus circulation in central Argentina: Seroprevalence and environmental surveillanceYanez, Laura AnahiLucero, Noelia S.Barril, Patricia AngelicaDiaz, Maria del PilarTenaglia, Maria MagdalenaSpinsanti, Lorena IvanaNates, Silvia VivianaIsa, Maria BeatrizRé, Viviana ElizabethARGENTINAENVIRONMENTAL SURVEILLANCEHEPATITIS A VIRUSSEROPREVALENCEhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background: Hepatitis A virus (HAV) has shown intermediate endemicity in Argentina, but notification of clinical cases has decreased since the introduction of the vaccine in 2005. Objectives: In order to get insight into the local circulation of this virus after four years of the official introduction of the vaccine, the aims of this study were to provide information on HAV immune status of the adult population of Córdoba city and to conduct environmental surveillance of HAV in sewage and river samples in the same region. Study design: The prevalence of anti-HAV was determined by EIA in 416 samples of people (without prior vaccination) from Córdoba city (2009-2010). Spline regression models were estimated under generalized additive models. Environmental surveillance was conducted in river and sewage samples collected in the same period. Viral detection was performed by RT-Nested PCR of the 5'UTR. Results: In Córdoba, the global prevalence of anti-HAV was 73.5%. It increased with age (p<. 0.0001) and it was associated with the low-income population (OR: 1.14; 95% CI 1.05-1.25). This prevalence decreased in younger age groups, especially in the high-income population. Environmental monitoring revealed the presence of HAV (IA) in 20.8% and 16.1% of wastewater and river samples, respectively. Conclusions: As a consequence of a decrease in HAV circulation due to improvements in immunization, socio-economic and hygienic conditions, young adults are becoming increasingly susceptible to HAV infections. Environmental monitoring demonstrated that HAV circulates in the local population; therefore, health care systems should consider the implementation of preventive measures for susceptible adults in order to reduce the risk of HAV infection.Fil: Yanez, Laura Anahi. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; ArgentinaFil: Lucero, Noelia S.. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; ArgentinaFil: Barril, Patricia Angelica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; ArgentinaFil: Diaz, Maria del Pilar. Universidad Nacional de Córdoba. Facultad de Medicina. Escuela de Nutrición; ArgentinaFil: Tenaglia, Maria Magdalena. Universidad Católica de Córdoba. Facultad de Medicina. Clínica Universitaria Reina Fabiola; ArgentinaFil: Spinsanti, Lorena Ivana. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; ArgentinaFil: Nates, Silvia Viviana. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; ArgentinaFil: Isa, Maria Beatriz. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina. Universidad Católica de Córdoba. Facultad de Medicina. Clínica Universitaria Reina Fabiola; ArgentinaFil: Ré, Viviana Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; ArgentinaElsevier Science2014-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/180450Yanez, Laura Anahi; Lucero, Noelia S.; Barril, Patricia Angelica; Diaz, Maria del Pilar; Tenaglia, Maria Magdalena; et al.; Evidence of Hepatitis A virus circulation in central Argentina: Seroprevalence and environmental surveillance; Elsevier Science; Journal of Clinical Virology; 59; 1; 1-2014; 38-431386-6532CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1386653213004836info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jcv.2013.11.005info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:55:50Zoai:ri.conicet.gov.ar:11336/180450instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:55:50.517CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Evidence of Hepatitis A virus circulation in central Argentina: Seroprevalence and environmental surveillance
title Evidence of Hepatitis A virus circulation in central Argentina: Seroprevalence and environmental surveillance
spellingShingle Evidence of Hepatitis A virus circulation in central Argentina: Seroprevalence and environmental surveillance
Yanez, Laura Anahi
ARGENTINA
ENVIRONMENTAL SURVEILLANCE
HEPATITIS A VIRUS
SEROPREVALENCE
title_short Evidence of Hepatitis A virus circulation in central Argentina: Seroprevalence and environmental surveillance
title_full Evidence of Hepatitis A virus circulation in central Argentina: Seroprevalence and environmental surveillance
title_fullStr Evidence of Hepatitis A virus circulation in central Argentina: Seroprevalence and environmental surveillance
title_full_unstemmed Evidence of Hepatitis A virus circulation in central Argentina: Seroprevalence and environmental surveillance
title_sort Evidence of Hepatitis A virus circulation in central Argentina: Seroprevalence and environmental surveillance
dc.creator.none.fl_str_mv Yanez, Laura Anahi
Lucero, Noelia S.
Barril, Patricia Angelica
Diaz, Maria del Pilar
Tenaglia, Maria Magdalena
Spinsanti, Lorena Ivana
Nates, Silvia Viviana
Isa, Maria Beatriz
Ré, Viviana Elizabeth
author Yanez, Laura Anahi
author_facet Yanez, Laura Anahi
Lucero, Noelia S.
Barril, Patricia Angelica
Diaz, Maria del Pilar
Tenaglia, Maria Magdalena
Spinsanti, Lorena Ivana
Nates, Silvia Viviana
Isa, Maria Beatriz
Ré, Viviana Elizabeth
author_role author
author2 Lucero, Noelia S.
Barril, Patricia Angelica
Diaz, Maria del Pilar
Tenaglia, Maria Magdalena
Spinsanti, Lorena Ivana
Nates, Silvia Viviana
Isa, Maria Beatriz
Ré, Viviana Elizabeth
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ARGENTINA
ENVIRONMENTAL SURVEILLANCE
HEPATITIS A VIRUS
SEROPREVALENCE
topic ARGENTINA
ENVIRONMENTAL SURVEILLANCE
HEPATITIS A VIRUS
SEROPREVALENCE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: Hepatitis A virus (HAV) has shown intermediate endemicity in Argentina, but notification of clinical cases has decreased since the introduction of the vaccine in 2005. Objectives: In order to get insight into the local circulation of this virus after four years of the official introduction of the vaccine, the aims of this study were to provide information on HAV immune status of the adult population of Córdoba city and to conduct environmental surveillance of HAV in sewage and river samples in the same region. Study design: The prevalence of anti-HAV was determined by EIA in 416 samples of people (without prior vaccination) from Córdoba city (2009-2010). Spline regression models were estimated under generalized additive models. Environmental surveillance was conducted in river and sewage samples collected in the same period. Viral detection was performed by RT-Nested PCR of the 5'UTR. Results: In Córdoba, the global prevalence of anti-HAV was 73.5%. It increased with age (p<. 0.0001) and it was associated with the low-income population (OR: 1.14; 95% CI 1.05-1.25). This prevalence decreased in younger age groups, especially in the high-income population. Environmental monitoring revealed the presence of HAV (IA) in 20.8% and 16.1% of wastewater and river samples, respectively. Conclusions: As a consequence of a decrease in HAV circulation due to improvements in immunization, socio-economic and hygienic conditions, young adults are becoming increasingly susceptible to HAV infections. Environmental monitoring demonstrated that HAV circulates in the local population; therefore, health care systems should consider the implementation of preventive measures for susceptible adults in order to reduce the risk of HAV infection.
Fil: Yanez, Laura Anahi. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina
Fil: Lucero, Noelia S.. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina
Fil: Barril, Patricia Angelica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina
Fil: Diaz, Maria del Pilar. Universidad Nacional de Córdoba. Facultad de Medicina. Escuela de Nutrición; Argentina
Fil: Tenaglia, Maria Magdalena. Universidad Católica de Córdoba. Facultad de Medicina. Clínica Universitaria Reina Fabiola; Argentina
Fil: Spinsanti, Lorena Ivana. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina
Fil: Nates, Silvia Viviana. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina
Fil: Isa, Maria Beatriz. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina. Universidad Católica de Córdoba. Facultad de Medicina. Clínica Universitaria Reina Fabiola; Argentina
Fil: Ré, Viviana Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina
description Background: Hepatitis A virus (HAV) has shown intermediate endemicity in Argentina, but notification of clinical cases has decreased since the introduction of the vaccine in 2005. Objectives: In order to get insight into the local circulation of this virus after four years of the official introduction of the vaccine, the aims of this study were to provide information on HAV immune status of the adult population of Córdoba city and to conduct environmental surveillance of HAV in sewage and river samples in the same region. Study design: The prevalence of anti-HAV was determined by EIA in 416 samples of people (without prior vaccination) from Córdoba city (2009-2010). Spline regression models were estimated under generalized additive models. Environmental surveillance was conducted in river and sewage samples collected in the same period. Viral detection was performed by RT-Nested PCR of the 5'UTR. Results: In Córdoba, the global prevalence of anti-HAV was 73.5%. It increased with age (p<. 0.0001) and it was associated with the low-income population (OR: 1.14; 95% CI 1.05-1.25). This prevalence decreased in younger age groups, especially in the high-income population. Environmental monitoring revealed the presence of HAV (IA) in 20.8% and 16.1% of wastewater and river samples, respectively. Conclusions: As a consequence of a decrease in HAV circulation due to improvements in immunization, socio-economic and hygienic conditions, young adults are becoming increasingly susceptible to HAV infections. Environmental monitoring demonstrated that HAV circulates in the local population; therefore, health care systems should consider the implementation of preventive measures for susceptible adults in order to reduce the risk of HAV infection.
publishDate 2014
dc.date.none.fl_str_mv 2014-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/180450
Yanez, Laura Anahi; Lucero, Noelia S.; Barril, Patricia Angelica; Diaz, Maria del Pilar; Tenaglia, Maria Magdalena; et al.; Evidence of Hepatitis A virus circulation in central Argentina: Seroprevalence and environmental surveillance; Elsevier Science; Journal of Clinical Virology; 59; 1; 1-2014; 38-43
1386-6532
CONICET Digital
CONICET
url http://hdl.handle.net/11336/180450
identifier_str_mv Yanez, Laura Anahi; Lucero, Noelia S.; Barril, Patricia Angelica; Diaz, Maria del Pilar; Tenaglia, Maria Magdalena; et al.; Evidence of Hepatitis A virus circulation in central Argentina: Seroprevalence and environmental surveillance; Elsevier Science; Journal of Clinical Virology; 59; 1; 1-2014; 38-43
1386-6532
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1386653213004836
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jcv.2013.11.005
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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