Development of a Bioproduct for Medicinal Use with Extracts of Zuccagnia-type Propolis

Autores
Salas, Ana Lilia; Zampini, Iris Catiana; Maldonado, Luis Maria; Isla, María Inés
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Propolis with a botanic origin in Zuccagnia punctata Cav. (Fabaceae), a plant species widely distributed in the Argentinean Monte region, was used to produce a standardized propolis extract by biological activity and chemical composition. In this paper the effect on microorganisms isolated from otitis was determined. The extract was active against different Staphylococcus strains with MIC and MBC values (75 and 150 μg DE/mL, 200 and 600 μg DE/mL, respectively) and with MIC values of 800 μg DE/mL against Proteus mirabilis. A pharmaceutical product, ear drops containing this extract as bioactive was developed. Stability of ear drops was evaluated for 6 months, and their biological activity, physical and phytochemical properties were preserved. Ear drops showed inhibitory activity on pro-inflammatory enzymes such as lipoxygenase (IC50 values 90 and 100 μg DE/mL), free radical-scavenging effect (SC50 values 23 and 30 μg DE/mL), antihelmintic (LC50 values 70 and 71 μg DE/mL), anti-candida (400 μg DE/mL) and antibacterial activity against Gram-positive bacteria (200 μg DE/mL) at zero time and during six month-storage, respectively. The content of two chalcones, chemical markers of Zuccagnia -type propolis was quantified and its level was maintained while stored at room temperature. Its toxicity was also assayed. Our results are interesting since the extract and ear drops of Zuccagnia -type propolis developed could be promising for use in alternative medicine or phytomedicine as antibacterial, anti-candida, antihelmintic, anti-inflammatory and antioxidant.
EEA Famaillá
Fil: Salas, Ana Lilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Bioprospección y Fisiología Vegetal; Argentina
Fil: Salas, Ana Lilia. Universidad Nacional de Tucumán. Instituto de Bioprospección y Fisiología Vegetal; Argentina
Fil: Zampini, Iris Catiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Bioprospección y Fisiología Vegetal; Argentina
Fil: Zampini, Iris Catiana. Universidad Nacional de Tucumán. Instituto de Bioprospección y Fisiología Vegetal; Argentina
Fil: Zampini, Iris Catiana. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina
Fil: Maldonado, Luis Maria. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Famaillá; Argentina
Fil: Isla, María Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Bioprospección y Fisiología Vegetal; Argentina
Fil: Isla, María Inés. Universidad Nacional de Tucumán. Instituto de Bioprospección y Fisiología Vegetal; Argentina
Fil: Isla, María Inés. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina
Fuente
Natural Product Communications 13 (2) : 167-170 (February 2018)
Materia
Propóleos
Calcona
Propiedades Medicinales
Fabaceae
Extractos Vegetales
Propolis
Chalcones
Medicinal Properties
Plant Extracts
Zuccagnia
Zuccagnia punctata
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
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oai_identifier_str oai:localhost:20.500.12123/12342
network_acronym_str INTADig
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network_name_str INTA Digital (INTA)
spelling Development of a Bioproduct for Medicinal Use with Extracts of Zuccagnia-type PropolisSalas, Ana LiliaZampini, Iris CatianaMaldonado, Luis MariaIsla, María InésPropóleosCalconaPropiedades MedicinalesFabaceaeExtractos VegetalesPropolisChalconesMedicinal PropertiesPlant ExtractsZuccagniaZuccagnia punctataPropolis with a botanic origin in Zuccagnia punctata Cav. (Fabaceae), a plant species widely distributed in the Argentinean Monte region, was used to produce a standardized propolis extract by biological activity and chemical composition. In this paper the effect on microorganisms isolated from otitis was determined. The extract was active against different Staphylococcus strains with MIC and MBC values (75 and 150 μg DE/mL, 200 and 600 μg DE/mL, respectively) and with MIC values of 800 μg DE/mL against Proteus mirabilis. A pharmaceutical product, ear drops containing this extract as bioactive was developed. Stability of ear drops was evaluated for 6 months, and their biological activity, physical and phytochemical properties were preserved. Ear drops showed inhibitory activity on pro-inflammatory enzymes such as lipoxygenase (IC50 values 90 and 100 μg DE/mL), free radical-scavenging effect (SC50 values 23 and 30 μg DE/mL), antihelmintic (LC50 values 70 and 71 μg DE/mL), anti-candida (400 μg DE/mL) and antibacterial activity against Gram-positive bacteria (200 μg DE/mL) at zero time and during six month-storage, respectively. The content of two chalcones, chemical markers of Zuccagnia -type propolis was quantified and its level was maintained while stored at room temperature. Its toxicity was also assayed. Our results are interesting since the extract and ear drops of Zuccagnia -type propolis developed could be promising for use in alternative medicine or phytomedicine as antibacterial, anti-candida, antihelmintic, anti-inflammatory and antioxidant.EEA FamailláFil: Salas, Ana Lilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Bioprospección y Fisiología Vegetal; ArgentinaFil: Salas, Ana Lilia. Universidad Nacional de Tucumán. Instituto de Bioprospección y Fisiología Vegetal; ArgentinaFil: Zampini, Iris Catiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Bioprospección y Fisiología Vegetal; ArgentinaFil: Zampini, Iris Catiana. Universidad Nacional de Tucumán. Instituto de Bioprospección y Fisiología Vegetal; ArgentinaFil: Zampini, Iris Catiana. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; ArgentinaFil: Maldonado, Luis Maria. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Famaillá; ArgentinaFil: Isla, María Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Bioprospección y Fisiología Vegetal; ArgentinaFil: Isla, María Inés. Universidad Nacional de Tucumán. Instituto de Bioprospección y Fisiología Vegetal; ArgentinaFil: Isla, María Inés. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; ArgentinaSage Publishing2022-07-18T13:39:43Z2022-07-18T13:39:43Z2018-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/12342https://journals.sagepub.com/doi/abs/10.1177/1934578X18013002141934-578X1555-9475https://doi.org/10.1177/1934578X1801300214Natural Product Communications 13 (2) : 167-170 (February 2018)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-11T10:24:13Zoai:localhost:20.500.12123/12342instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-11 10:24:14.399INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Development of a Bioproduct for Medicinal Use with Extracts of Zuccagnia-type Propolis
title Development of a Bioproduct for Medicinal Use with Extracts of Zuccagnia-type Propolis
spellingShingle Development of a Bioproduct for Medicinal Use with Extracts of Zuccagnia-type Propolis
Salas, Ana Lilia
Propóleos
Calcona
Propiedades Medicinales
Fabaceae
Extractos Vegetales
Propolis
Chalcones
Medicinal Properties
Plant Extracts
Zuccagnia
Zuccagnia punctata
title_short Development of a Bioproduct for Medicinal Use with Extracts of Zuccagnia-type Propolis
title_full Development of a Bioproduct for Medicinal Use with Extracts of Zuccagnia-type Propolis
title_fullStr Development of a Bioproduct for Medicinal Use with Extracts of Zuccagnia-type Propolis
title_full_unstemmed Development of a Bioproduct for Medicinal Use with Extracts of Zuccagnia-type Propolis
title_sort Development of a Bioproduct for Medicinal Use with Extracts of Zuccagnia-type Propolis
dc.creator.none.fl_str_mv Salas, Ana Lilia
Zampini, Iris Catiana
Maldonado, Luis Maria
Isla, María Inés
author Salas, Ana Lilia
author_facet Salas, Ana Lilia
Zampini, Iris Catiana
Maldonado, Luis Maria
Isla, María Inés
author_role author
author2 Zampini, Iris Catiana
Maldonado, Luis Maria
Isla, María Inés
author2_role author
author
author
dc.subject.none.fl_str_mv Propóleos
Calcona
Propiedades Medicinales
Fabaceae
Extractos Vegetales
Propolis
Chalcones
Medicinal Properties
Plant Extracts
Zuccagnia
Zuccagnia punctata
topic Propóleos
Calcona
Propiedades Medicinales
Fabaceae
Extractos Vegetales
Propolis
Chalcones
Medicinal Properties
Plant Extracts
Zuccagnia
Zuccagnia punctata
dc.description.none.fl_txt_mv Propolis with a botanic origin in Zuccagnia punctata Cav. (Fabaceae), a plant species widely distributed in the Argentinean Monte region, was used to produce a standardized propolis extract by biological activity and chemical composition. In this paper the effect on microorganisms isolated from otitis was determined. The extract was active against different Staphylococcus strains with MIC and MBC values (75 and 150 μg DE/mL, 200 and 600 μg DE/mL, respectively) and with MIC values of 800 μg DE/mL against Proteus mirabilis. A pharmaceutical product, ear drops containing this extract as bioactive was developed. Stability of ear drops was evaluated for 6 months, and their biological activity, physical and phytochemical properties were preserved. Ear drops showed inhibitory activity on pro-inflammatory enzymes such as lipoxygenase (IC50 values 90 and 100 μg DE/mL), free radical-scavenging effect (SC50 values 23 and 30 μg DE/mL), antihelmintic (LC50 values 70 and 71 μg DE/mL), anti-candida (400 μg DE/mL) and antibacterial activity against Gram-positive bacteria (200 μg DE/mL) at zero time and during six month-storage, respectively. The content of two chalcones, chemical markers of Zuccagnia -type propolis was quantified and its level was maintained while stored at room temperature. Its toxicity was also assayed. Our results are interesting since the extract and ear drops of Zuccagnia -type propolis developed could be promising for use in alternative medicine or phytomedicine as antibacterial, anti-candida, antihelmintic, anti-inflammatory and antioxidant.
EEA Famaillá
Fil: Salas, Ana Lilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Bioprospección y Fisiología Vegetal; Argentina
Fil: Salas, Ana Lilia. Universidad Nacional de Tucumán. Instituto de Bioprospección y Fisiología Vegetal; Argentina
Fil: Zampini, Iris Catiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Bioprospección y Fisiología Vegetal; Argentina
Fil: Zampini, Iris Catiana. Universidad Nacional de Tucumán. Instituto de Bioprospección y Fisiología Vegetal; Argentina
Fil: Zampini, Iris Catiana. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina
Fil: Maldonado, Luis Maria. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Famaillá; Argentina
Fil: Isla, María Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Bioprospección y Fisiología Vegetal; Argentina
Fil: Isla, María Inés. Universidad Nacional de Tucumán. Instituto de Bioprospección y Fisiología Vegetal; Argentina
Fil: Isla, María Inés. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina
description Propolis with a botanic origin in Zuccagnia punctata Cav. (Fabaceae), a plant species widely distributed in the Argentinean Monte region, was used to produce a standardized propolis extract by biological activity and chemical composition. In this paper the effect on microorganisms isolated from otitis was determined. The extract was active against different Staphylococcus strains with MIC and MBC values (75 and 150 μg DE/mL, 200 and 600 μg DE/mL, respectively) and with MIC values of 800 μg DE/mL against Proteus mirabilis. A pharmaceutical product, ear drops containing this extract as bioactive was developed. Stability of ear drops was evaluated for 6 months, and their biological activity, physical and phytochemical properties were preserved. Ear drops showed inhibitory activity on pro-inflammatory enzymes such as lipoxygenase (IC50 values 90 and 100 μg DE/mL), free radical-scavenging effect (SC50 values 23 and 30 μg DE/mL), antihelmintic (LC50 values 70 and 71 μg DE/mL), anti-candida (400 μg DE/mL) and antibacterial activity against Gram-positive bacteria (200 μg DE/mL) at zero time and during six month-storage, respectively. The content of two chalcones, chemical markers of Zuccagnia -type propolis was quantified and its level was maintained while stored at room temperature. Its toxicity was also assayed. Our results are interesting since the extract and ear drops of Zuccagnia -type propolis developed could be promising for use in alternative medicine or phytomedicine as antibacterial, anti-candida, antihelmintic, anti-inflammatory and antioxidant.
publishDate 2018
dc.date.none.fl_str_mv 2018-02
2022-07-18T13:39:43Z
2022-07-18T13:39:43Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/12342
https://journals.sagepub.com/doi/abs/10.1177/1934578X1801300214
1934-578X
1555-9475
https://doi.org/10.1177/1934578X1801300214
url http://hdl.handle.net/20.500.12123/12342
https://journals.sagepub.com/doi/abs/10.1177/1934578X1801300214
https://doi.org/10.1177/1934578X1801300214
identifier_str_mv 1934-578X
1555-9475
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sage Publishing
publisher.none.fl_str_mv Sage Publishing
dc.source.none.fl_str_mv Natural Product Communications 13 (2) : 167-170 (February 2018)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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