Exploring the association between polymorphisms at 3’UTR SLC11A1 gene microsatellites and resistance to tuberculosis: A case-control study in Bos taurus dairy cattle

Autores
Hasenauer, Flavia Carolina; Garbaccio, Sergio Gabriel; Caffaro, María Eugenia; Garro, Carlos Javier; Huertas, Pablo Sebastian; Poli, Mario Andres; Rossetti, Carlos Alberto
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Bovine tuberculosis is a contagious infectious disease that causes significant economic impact in dairy and meat farms throughout the world. Multiple factors, including host genome, determine the outcome of the infection. Several studies have associated polymorphisms at the two microsatellites (Ms) -Ms1 and Ms2- at the 3´unstranslated (UTR) region of the SLC11A1 bovine gene with innate resistance or susceptibility to some facultative intracellular bacterial infections, such as Brucella abortus and Mycobacterium avium subsp. paratuberculosis. Today, the few studies that investigated the association of those polymorphisms with innate resistance or susceptibility to tuberculosis in cattle, have shown opposite results. The aim of this study was to evaluate the role, if any, of the Ms1 and/or Ms2 polymorphisms at the 3´UTR of the SLC11A1 gene in Mycobacterium bovis infection phenotypes in Bos taurus dairy cattle. Jersey (n = 149) and Holstein (n = 427) cattle under risk of natural M. bovis infection were classified like controls (n = 326) and cases (n = 250) based on the response to caudal fold tuberculin skin test. Cattle population was genotyped by capillary electrophoresis based on polymorphisms in Ms1 and Ms2 at the 3´UTR SLC11A1 gene. The results presented here showed a lack of association (p > .05) between polymorphisms at the 3´UTR SLC11A1 gene and the response to tuberculin skin test in dairy Bos taurus cattle. Further studies are necessary to establish robustly genes or genome regions determining the innate R/S phenotype to Mycobacterium bovis.
Instituto de Patobiología
Fil: Hasenauer, Flavia Carolina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Garbaccio, Sergio Gabriel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
Fil: Caffaro, Marí­a Eugenia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina
Fil: Garro, Carlos Javier. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
Fil: Huertas, Pablo Sebastian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
Fil: Poli, Mario Andres. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina
Fil: Rossetti, Carlos Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
Fuente
Livestock science 210 : 1-7. (April 2018)
Materia
Ganado de Leche
Enfermedades de los Animales
Microsatélites
Bos Taurus
Resistencia a la Enfermedad
Tuberculosis
Dairy Cattle
Animal Diseases
Microsatellites
Disease Resistance
Nivel de accesibilidad
acceso restringido
Condiciones de uso
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/2539
Acceder
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oai_identifier_str oai:localhost:20.500.12123/2539
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network_name_str INTA Digital (INTA)
spelling Exploring the association between polymorphisms at 3’UTR SLC11A1 gene microsatellites and resistance to tuberculosis: A case-control study in Bos taurus dairy cattleHasenauer, Flavia CarolinaGarbaccio, Sergio GabrielCaffaro, María EugeniaGarro, Carlos JavierHuertas, Pablo SebastianPoli, Mario AndresRossetti, Carlos AlbertoGanado de LecheEnfermedades de los AnimalesMicrosatélitesBos TaurusResistencia a la EnfermedadTuberculosisDairy CattleAnimal DiseasesMicrosatellitesDisease ResistanceBovine tuberculosis is a contagious infectious disease that causes significant economic impact in dairy and meat farms throughout the world. Multiple factors, including host genome, determine the outcome of the infection. Several studies have associated polymorphisms at the two microsatellites (Ms) -Ms1 and Ms2- at the 3´unstranslated (UTR) region of the SLC11A1 bovine gene with innate resistance or susceptibility to some facultative intracellular bacterial infections, such as Brucella abortus and Mycobacterium avium subsp. paratuberculosis. Today, the few studies that investigated the association of those polymorphisms with innate resistance or susceptibility to tuberculosis in cattle, have shown opposite results. The aim of this study was to evaluate the role, if any, of the Ms1 and/or Ms2 polymorphisms at the 3´UTR of the SLC11A1 gene in Mycobacterium bovis infection phenotypes in Bos taurus dairy cattle. Jersey (n = 149) and Holstein (n = 427) cattle under risk of natural M. bovis infection were classified like controls (n = 326) and cases (n = 250) based on the response to caudal fold tuberculin skin test. Cattle population was genotyped by capillary electrophoresis based on polymorphisms in Ms1 and Ms2 at the 3´UTR SLC11A1 gene. The results presented here showed a lack of association (p > .05) between polymorphisms at the 3´UTR SLC11A1 gene and the response to tuberculin skin test in dairy Bos taurus cattle. Further studies are necessary to establish robustly genes or genome regions determining the innate R/S phenotype to Mycobacterium bovis.Instituto de PatobiologíaFil: Hasenauer, Flavia Carolina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Garbaccio, Sergio Gabriel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; ArgentinaFil: Caffaro, Marí­a Eugenia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; ArgentinaFil: Garro, Carlos Javier. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; ArgentinaFil: Huertas, Pablo Sebastian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; ArgentinaFil: Poli, Mario Andres. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; ArgentinaFil: Rossetti, Carlos Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina2018-06-04T13:38:52Z2018-06-04T13:38:52Z2018-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://www.sciencedirect.com/science/article/pii/S1871141318300192http://hdl.handle.net/20.500.12123/25391871-1413https://doi.org/10.1016/j.livsci.2018.01.012Livestock science 210 : 1-7. (April 2018)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccess2025-09-18T10:07:10Zoai:localhost:20.500.12123/2539instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-18 10:07:10.952INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Exploring the association between polymorphisms at 3’UTR SLC11A1 gene microsatellites and resistance to tuberculosis: A case-control study in Bos taurus dairy cattle
title Exploring the association between polymorphisms at 3’UTR SLC11A1 gene microsatellites and resistance to tuberculosis: A case-control study in Bos taurus dairy cattle
spellingShingle Exploring the association between polymorphisms at 3’UTR SLC11A1 gene microsatellites and resistance to tuberculosis: A case-control study in Bos taurus dairy cattle
Hasenauer, Flavia Carolina
Ganado de Leche
Enfermedades de los Animales
Microsatélites
Bos Taurus
Resistencia a la Enfermedad
Tuberculosis
Dairy Cattle
Animal Diseases
Microsatellites
Disease Resistance
title_short Exploring the association between polymorphisms at 3’UTR SLC11A1 gene microsatellites and resistance to tuberculosis: A case-control study in Bos taurus dairy cattle
title_full Exploring the association between polymorphisms at 3’UTR SLC11A1 gene microsatellites and resistance to tuberculosis: A case-control study in Bos taurus dairy cattle
title_fullStr Exploring the association between polymorphisms at 3’UTR SLC11A1 gene microsatellites and resistance to tuberculosis: A case-control study in Bos taurus dairy cattle
title_full_unstemmed Exploring the association between polymorphisms at 3’UTR SLC11A1 gene microsatellites and resistance to tuberculosis: A case-control study in Bos taurus dairy cattle
title_sort Exploring the association between polymorphisms at 3’UTR SLC11A1 gene microsatellites and resistance to tuberculosis: A case-control study in Bos taurus dairy cattle
dc.creator.none.fl_str_mv Hasenauer, Flavia Carolina
Garbaccio, Sergio Gabriel
Caffaro, María Eugenia
Garro, Carlos Javier
Huertas, Pablo Sebastian
Poli, Mario Andres
Rossetti, Carlos Alberto
author Hasenauer, Flavia Carolina
author_facet Hasenauer, Flavia Carolina
Garbaccio, Sergio Gabriel
Caffaro, María Eugenia
Garro, Carlos Javier
Huertas, Pablo Sebastian
Poli, Mario Andres
Rossetti, Carlos Alberto
author_role author
author2 Garbaccio, Sergio Gabriel
Caffaro, María Eugenia
Garro, Carlos Javier
Huertas, Pablo Sebastian
Poli, Mario Andres
Rossetti, Carlos Alberto
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Ganado de Leche
Enfermedades de los Animales
Microsatélites
Bos Taurus
Resistencia a la Enfermedad
Tuberculosis
Dairy Cattle
Animal Diseases
Microsatellites
Disease Resistance
topic Ganado de Leche
Enfermedades de los Animales
Microsatélites
Bos Taurus
Resistencia a la Enfermedad
Tuberculosis
Dairy Cattle
Animal Diseases
Microsatellites
Disease Resistance
dc.description.none.fl_txt_mv Bovine tuberculosis is a contagious infectious disease that causes significant economic impact in dairy and meat farms throughout the world. Multiple factors, including host genome, determine the outcome of the infection. Several studies have associated polymorphisms at the two microsatellites (Ms) -Ms1 and Ms2- at the 3´unstranslated (UTR) region of the SLC11A1 bovine gene with innate resistance or susceptibility to some facultative intracellular bacterial infections, such as Brucella abortus and Mycobacterium avium subsp. paratuberculosis. Today, the few studies that investigated the association of those polymorphisms with innate resistance or susceptibility to tuberculosis in cattle, have shown opposite results. The aim of this study was to evaluate the role, if any, of the Ms1 and/or Ms2 polymorphisms at the 3´UTR of the SLC11A1 gene in Mycobacterium bovis infection phenotypes in Bos taurus dairy cattle. Jersey (n = 149) and Holstein (n = 427) cattle under risk of natural M. bovis infection were classified like controls (n = 326) and cases (n = 250) based on the response to caudal fold tuberculin skin test. Cattle population was genotyped by capillary electrophoresis based on polymorphisms in Ms1 and Ms2 at the 3´UTR SLC11A1 gene. The results presented here showed a lack of association (p > .05) between polymorphisms at the 3´UTR SLC11A1 gene and the response to tuberculin skin test in dairy Bos taurus cattle. Further studies are necessary to establish robustly genes or genome regions determining the innate R/S phenotype to Mycobacterium bovis.
Instituto de Patobiología
Fil: Hasenauer, Flavia Carolina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Garbaccio, Sergio Gabriel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
Fil: Caffaro, Marí­a Eugenia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina
Fil: Garro, Carlos Javier. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
Fil: Huertas, Pablo Sebastian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
Fil: Poli, Mario Andres. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina
Fil: Rossetti, Carlos Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
description Bovine tuberculosis is a contagious infectious disease that causes significant economic impact in dairy and meat farms throughout the world. Multiple factors, including host genome, determine the outcome of the infection. Several studies have associated polymorphisms at the two microsatellites (Ms) -Ms1 and Ms2- at the 3´unstranslated (UTR) region of the SLC11A1 bovine gene with innate resistance or susceptibility to some facultative intracellular bacterial infections, such as Brucella abortus and Mycobacterium avium subsp. paratuberculosis. Today, the few studies that investigated the association of those polymorphisms with innate resistance or susceptibility to tuberculosis in cattle, have shown opposite results. The aim of this study was to evaluate the role, if any, of the Ms1 and/or Ms2 polymorphisms at the 3´UTR of the SLC11A1 gene in Mycobacterium bovis infection phenotypes in Bos taurus dairy cattle. Jersey (n = 149) and Holstein (n = 427) cattle under risk of natural M. bovis infection were classified like controls (n = 326) and cases (n = 250) based on the response to caudal fold tuberculin skin test. Cattle population was genotyped by capillary electrophoresis based on polymorphisms in Ms1 and Ms2 at the 3´UTR SLC11A1 gene. The results presented here showed a lack of association (p > .05) between polymorphisms at the 3´UTR SLC11A1 gene and the response to tuberculin skin test in dairy Bos taurus cattle. Further studies are necessary to establish robustly genes or genome regions determining the innate R/S phenotype to Mycobacterium bovis.
publishDate 2018
dc.date.none.fl_str_mv 2018-06-04T13:38:52Z
2018-06-04T13:38:52Z
2018-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://www.sciencedirect.com/science/article/pii/S1871141318300192
http://hdl.handle.net/20.500.12123/2539
1871-1413
https://doi.org/10.1016/j.livsci.2018.01.012
url https://www.sciencedirect.com/science/article/pii/S1871141318300192
http://hdl.handle.net/20.500.12123/2539
https://doi.org/10.1016/j.livsci.2018.01.012
identifier_str_mv 1871-1413
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/restrictedAccess
eu_rights_str_mv restrictedAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Livestock science 210 : 1-7. (April 2018)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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score 13.001348

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