Intoxication by Astragalus garbancillo var. garbancillo in llamas

Autores
Marín, Raúl Eduardo; Micheloud, Juan Francisco; Vignales, Nilda D.; Gimeno, Eduardo Juan; O"Toole, Donal; Gardner, Dale R.; Woods, Leslie.; Uzal, Francisco A.
Año de publicación
2020
Idioma
español castellano
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Lysosomal storage diseases are inherited and acquired disorders characterized by dysfunctional lysosomes. Intracytoplasmic accumulation of undegraded substrates leads to impaired cellular function and death. Several plant species are toxic to livestock because of the presence of indolizidine alkaloids, including swainsonine, which cause a storage disease. Swainsonine-induced nervous disease (i.e., locoism) of sheep and cattle is well recognized in several parts of the world, particularly in the western United States and in parts of Australia. Spontaneous intoxication by Astragalus garbancillo var. garbancillo was suspected in a group of 70 llamas (Lama glama) in Jujuy Province, northwestern Argentina. The animals grazed an area dominated by stands of A. garbancillo var. garbancillo. Clinical signs were staggering, ataxia, hypermetria, and progressive weight loss. The clinical course in individual animals was ~50 d. The main microscopic changes were Purkinje cell degeneration, necrosis, and loss, associated with intracytoplasmic vacuolation, meganeurite formation, and Wallerian degeneration. Specific positive labeling for ubiquitin was observed in axonal spheroids. Composite leaf and stem samples of A. garbancillo var. garbancillo analyzed by high-performance liquid chromatography contained 0.03% swainsonine. Based on the microscopic lesions, clinical history, and plant analysis, a diagnosis was made of storage disease caused by consumption of swainsonine-containing A. garbancillo var. garbancillo.
EEA Salta
Fil: Marín, Raúl E. Universidad Nacional de Jujuy. Facultad de Ciencia Agrarias; Argentina.
Fil: Micheloud, Juan Francisco. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Salta. Área de Sanidad Animal; Argentina.
Fil: Vignale, Nilda D. Universidad Nacional de Jujuy. Facultad de Ciencias Agrarias; Argentina.
Fil: Gimeno, Eduardo Juan. Universidad Nacional de la Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General;Argentina.
Fil: O'Toole, Donal. Wyoming State Veterinary Laboratory ; Estados Unidos
Fil: Gardner, Dale R. USDA-ARS Poisonous Plant Research Laboratory; Estados Unidos
Fil: Woods, Leslies. University of California–Davis. California Animal Health and Food Safety Laboratory System; Estados Unidos
Fil: Uzal, Francisco A. University of California–Davis. California Animal Health and Food Safety Laboratory System, San Bernardino; Estados Unidos
Fuente
Journal of Veterinary Diagnostic Investigation 32 (3) : 467-470 (May 2020)
Materia
Astragalus
Plantas Tóxicas
Llama
Envenenamiento
Poisonous Plants
Llamas
Poisoning
Astragalus garbancillo
Intoxicación
Intoxication
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/9947
Acceder
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oai_identifier_str oai:localhost:20.500.12123/9947
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spelling Intoxication by Astragalus garbancillo var. garbancillo in llamasMarín, Raúl EduardoMicheloud, Juan FranciscoVignales, Nilda D.Gimeno, Eduardo JuanO"Toole, DonalGardner, Dale R.Woods, Leslie.Uzal, Francisco A.AstragalusPlantas TóxicasLlamaEnvenenamientoPoisonous PlantsLlamasPoisoningAstragalus garbancilloIntoxicaciónIntoxicationLysosomal storage diseases are inherited and acquired disorders characterized by dysfunctional lysosomes. Intracytoplasmic accumulation of undegraded substrates leads to impaired cellular function and death. Several plant species are toxic to livestock because of the presence of indolizidine alkaloids, including swainsonine, which cause a storage disease. Swainsonine-induced nervous disease (i.e., locoism) of sheep and cattle is well recognized in several parts of the world, particularly in the western United States and in parts of Australia. Spontaneous intoxication by Astragalus garbancillo var. garbancillo was suspected in a group of 70 llamas (Lama glama) in Jujuy Province, northwestern Argentina. The animals grazed an area dominated by stands of A. garbancillo var. garbancillo. Clinical signs were staggering, ataxia, hypermetria, and progressive weight loss. The clinical course in individual animals was ~50 d. The main microscopic changes were Purkinje cell degeneration, necrosis, and loss, associated with intracytoplasmic vacuolation, meganeurite formation, and Wallerian degeneration. Specific positive labeling for ubiquitin was observed in axonal spheroids. Composite leaf and stem samples of A. garbancillo var. garbancillo analyzed by high-performance liquid chromatography contained 0.03% swainsonine. Based on the microscopic lesions, clinical history, and plant analysis, a diagnosis was made of storage disease caused by consumption of swainsonine-containing A. garbancillo var. garbancillo.EEA SaltaFil: Marín, Raúl E. Universidad Nacional de Jujuy. Facultad de Ciencia Agrarias; Argentina.Fil: Micheloud, Juan Francisco. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Salta. Área de Sanidad Animal; Argentina.Fil: Vignale, Nilda D. Universidad Nacional de Jujuy. Facultad de Ciencias Agrarias; Argentina.Fil: Gimeno, Eduardo Juan. Universidad Nacional de la Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General;Argentina.Fil: O'Toole, Donal. Wyoming State Veterinary Laboratory ; Estados UnidosFil: Gardner, Dale R. USDA-ARS Poisonous Plant Research Laboratory; Estados UnidosFil: Woods, Leslies. University of California–Davis. California Animal Health and Food Safety Laboratory System; Estados UnidosFil: Uzal, Francisco A. University of California–Davis. California Animal Health and Food Safety Laboratory System, San Bernardino; Estados UnidosAmerican Association of Veterinary Laboratory Diagnosticians2021-08-03T16:25:36Z2021-08-03T16:25:36Z2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/9947https://journals.sagepub.com/doi/full/10.1177/10406387209143381040-63871943-4936https://doi.org/10.1177/1040638720914338Journal of Veterinary Diagnostic Investigation 32 (3) : 467-470 (May 2020)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaspainfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-10-16T09:30:10Zoai:localhost:20.500.12123/9947instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-10-16 09:30:10.591INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Intoxication by Astragalus garbancillo var. garbancillo in llamas
title Intoxication by Astragalus garbancillo var. garbancillo in llamas
spellingShingle Intoxication by Astragalus garbancillo var. garbancillo in llamas
Marín, Raúl Eduardo
Astragalus
Plantas Tóxicas
Llama
Envenenamiento
Poisonous Plants
Llamas
Poisoning
Astragalus garbancillo
Intoxicación
Intoxication
title_short Intoxication by Astragalus garbancillo var. garbancillo in llamas
title_full Intoxication by Astragalus garbancillo var. garbancillo in llamas
title_fullStr Intoxication by Astragalus garbancillo var. garbancillo in llamas
title_full_unstemmed Intoxication by Astragalus garbancillo var. garbancillo in llamas
title_sort Intoxication by Astragalus garbancillo var. garbancillo in llamas
dc.creator.none.fl_str_mv Marín, Raúl Eduardo
Micheloud, Juan Francisco
Vignales, Nilda D.
Gimeno, Eduardo Juan
O"Toole, Donal
Gardner, Dale R.
Woods, Leslie.
Uzal, Francisco A.
author Marín, Raúl Eduardo
author_facet Marín, Raúl Eduardo
Micheloud, Juan Francisco
Vignales, Nilda D.
Gimeno, Eduardo Juan
O"Toole, Donal
Gardner, Dale R.
Woods, Leslie.
Uzal, Francisco A.
author_role author
author2 Micheloud, Juan Francisco
Vignales, Nilda D.
Gimeno, Eduardo Juan
O"Toole, Donal
Gardner, Dale R.
Woods, Leslie.
Uzal, Francisco A.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Astragalus
Plantas Tóxicas
Llama
Envenenamiento
Poisonous Plants
Llamas
Poisoning
Astragalus garbancillo
Intoxicación
Intoxication
topic Astragalus
Plantas Tóxicas
Llama
Envenenamiento
Poisonous Plants
Llamas
Poisoning
Astragalus garbancillo
Intoxicación
Intoxication
dc.description.none.fl_txt_mv Lysosomal storage diseases are inherited and acquired disorders characterized by dysfunctional lysosomes. Intracytoplasmic accumulation of undegraded substrates leads to impaired cellular function and death. Several plant species are toxic to livestock because of the presence of indolizidine alkaloids, including swainsonine, which cause a storage disease. Swainsonine-induced nervous disease (i.e., locoism) of sheep and cattle is well recognized in several parts of the world, particularly in the western United States and in parts of Australia. Spontaneous intoxication by Astragalus garbancillo var. garbancillo was suspected in a group of 70 llamas (Lama glama) in Jujuy Province, northwestern Argentina. The animals grazed an area dominated by stands of A. garbancillo var. garbancillo. Clinical signs were staggering, ataxia, hypermetria, and progressive weight loss. The clinical course in individual animals was ~50 d. The main microscopic changes were Purkinje cell degeneration, necrosis, and loss, associated with intracytoplasmic vacuolation, meganeurite formation, and Wallerian degeneration. Specific positive labeling for ubiquitin was observed in axonal spheroids. Composite leaf and stem samples of A. garbancillo var. garbancillo analyzed by high-performance liquid chromatography contained 0.03% swainsonine. Based on the microscopic lesions, clinical history, and plant analysis, a diagnosis was made of storage disease caused by consumption of swainsonine-containing A. garbancillo var. garbancillo.
EEA Salta
Fil: Marín, Raúl E. Universidad Nacional de Jujuy. Facultad de Ciencia Agrarias; Argentina.
Fil: Micheloud, Juan Francisco. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Salta. Área de Sanidad Animal; Argentina.
Fil: Vignale, Nilda D. Universidad Nacional de Jujuy. Facultad de Ciencias Agrarias; Argentina.
Fil: Gimeno, Eduardo Juan. Universidad Nacional de la Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General;Argentina.
Fil: O'Toole, Donal. Wyoming State Veterinary Laboratory ; Estados Unidos
Fil: Gardner, Dale R. USDA-ARS Poisonous Plant Research Laboratory; Estados Unidos
Fil: Woods, Leslies. University of California–Davis. California Animal Health and Food Safety Laboratory System; Estados Unidos
Fil: Uzal, Francisco A. University of California–Davis. California Animal Health and Food Safety Laboratory System, San Bernardino; Estados Unidos
description Lysosomal storage diseases are inherited and acquired disorders characterized by dysfunctional lysosomes. Intracytoplasmic accumulation of undegraded substrates leads to impaired cellular function and death. Several plant species are toxic to livestock because of the presence of indolizidine alkaloids, including swainsonine, which cause a storage disease. Swainsonine-induced nervous disease (i.e., locoism) of sheep and cattle is well recognized in several parts of the world, particularly in the western United States and in parts of Australia. Spontaneous intoxication by Astragalus garbancillo var. garbancillo was suspected in a group of 70 llamas (Lama glama) in Jujuy Province, northwestern Argentina. The animals grazed an area dominated by stands of A. garbancillo var. garbancillo. Clinical signs were staggering, ataxia, hypermetria, and progressive weight loss. The clinical course in individual animals was ~50 d. The main microscopic changes were Purkinje cell degeneration, necrosis, and loss, associated with intracytoplasmic vacuolation, meganeurite formation, and Wallerian degeneration. Specific positive labeling for ubiquitin was observed in axonal spheroids. Composite leaf and stem samples of A. garbancillo var. garbancillo analyzed by high-performance liquid chromatography contained 0.03% swainsonine. Based on the microscopic lesions, clinical history, and plant analysis, a diagnosis was made of storage disease caused by consumption of swainsonine-containing A. garbancillo var. garbancillo.
publishDate 2020
dc.date.none.fl_str_mv 2020
2021-08-03T16:25:36Z
2021-08-03T16:25:36Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/9947
https://journals.sagepub.com/doi/full/10.1177/1040638720914338
1040-6387
1943-4936
https://doi.org/10.1177/1040638720914338
url http://hdl.handle.net/20.500.12123/9947
https://journals.sagepub.com/doi/full/10.1177/1040638720914338
https://doi.org/10.1177/1040638720914338
identifier_str_mv 1040-6387
1943-4936
dc.language.none.fl_str_mv spa
language spa
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Association of Veterinary Laboratory Diagnosticians
publisher.none.fl_str_mv American Association of Veterinary Laboratory Diagnosticians
dc.source.none.fl_str_mv Journal of Veterinary Diagnostic Investigation 32 (3) : 467-470 (May 2020)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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