Genome-wide identification of the mutation uderlying fleece variation and discriminating ancestral hairy species from modern woolly sheep
- Autores
- Demars, Julie; Cano, Ema Margarita; Drouilhet, Laurence; Plisson-Petit, Florence; Bardou, Philippe; Fabre, Stéphane; Servin, Bertrand; Sarry, Julien; Woloszyn, Florent; Mulsant, Philippe; Foulquier, Didier; Carriere, Fabien; Aletru, Mathias; Rodde, Nathalie; Cauet, Stéphane; Bouchez, Olivier; Pirson, Maarten; Tosser-Klopp, Gwenola; Allain, Daniel
- Año de publicación
- 2017
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The composition and structure of fleece variation observedin mammals is a consequence of a strong selective pressure for fiber production after domestication. In sheep, fleece variation discriminates ancestral species carrying a long and hairy fleece from modern domestic sheep (Ovis aries) owning a short and woolly fleece.Here, we report that the “woolly” allele results from the insertion of an antisenseEIF2S2retrogene (calledasEIF2S2)intothe3 0 UTR of theIRF2BP2 gene leading to an abnormal IRF2BP2 transcript. We provide evidence that this chimeric IRF2BP2/asEIF2S2 messenger 1) targets the genuine sense EIF2S2 RNA and 2) creates a long endogenous double-stranded RNA which alters the expression of both EIF2S2 and IRF2BP2 mRNA. This represents a unique example of a phenotype arising via a RNA-RNA hybrid, itself generated through a retroposition mechanism. Our results bring new insights on the sheep population history thanks to the identification of the molecular origin of an evolutionary phenotypic variation.
Instituto de Genética
Fil: Demars, Julie. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
Fil: Cano, Ema Margarita. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina
Fil: Drouilhet, Laurence. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
Fil: Plisson-Petit, Florence. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
Fil: Bardou, Philippe. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
Fil: Fabre, Stéphane. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
Fil: Servin, Bertrand. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
Fil: Sarry, Julien. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
Fil: Woloszyn, Florent. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
Fil: Mulsant, Philippe. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
Fil: Foulquier, Didier. Institut National de la Recherche Agronomique; Francia
Fil: Carriere, Fabien. Institut National de la Recherche Agronomique; Francia
Fil: Aletru, Mathias. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
Fil: Rodde, Nathalie. Institut National de la Recherche Agronomique; Francia
Fil: Cauet, Stéphane. Institut National de la Recherche Agronomique; Francia
Fil: Bouchez, Olivier. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
Fil: Pirson, Maarten. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
Fil: Tosser-Klopp, Gwenola. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
Fil: Allain, Daniel. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia - Fuente
- Molecular Biology and Evolution 34 (7) : 1722-1729 (July 2017)
- Materia
-
Genética
Ovinos
Mutación
Genetics
Sheep
Mutation - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Instituto Nacional de Tecnología Agropecuaria
- OAI Identificador
- oai:localhost:20.500.12123/1007
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Genome-wide identification of the mutation uderlying fleece variation and discriminating ancestral hairy species from modern woolly sheepDemars, JulieCano, Ema MargaritaDrouilhet, LaurencePlisson-Petit, FlorenceBardou, PhilippeFabre, StéphaneServin, BertrandSarry, JulienWoloszyn, FlorentMulsant, PhilippeFoulquier, DidierCarriere, FabienAletru, MathiasRodde, NathalieCauet, StéphaneBouchez, OlivierPirson, MaartenTosser-Klopp, GwenolaAllain, DanielGenéticaOvinosMutaciónGeneticsSheepMutationThe composition and structure of fleece variation observedin mammals is a consequence of a strong selective pressure for fiber production after domestication. In sheep, fleece variation discriminates ancestral species carrying a long and hairy fleece from modern domestic sheep (Ovis aries) owning a short and woolly fleece.Here, we report that the “woolly” allele results from the insertion of an antisenseEIF2S2retrogene (calledasEIF2S2)intothe3 0 UTR of theIRF2BP2 gene leading to an abnormal IRF2BP2 transcript. We provide evidence that this chimeric IRF2BP2/asEIF2S2 messenger 1) targets the genuine sense EIF2S2 RNA and 2) creates a long endogenous double-stranded RNA which alters the expression of both EIF2S2 and IRF2BP2 mRNA. This represents a unique example of a phenotype arising via a RNA-RNA hybrid, itself generated through a retroposition mechanism. Our results bring new insights on the sheep population history thanks to the identification of the molecular origin of an evolutionary phenotypic variation.Instituto de GenéticaFil: Demars, Julie. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; FranciaFil: Cano, Ema Margarita. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; ArgentinaFil: Drouilhet, Laurence. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; FranciaFil: Plisson-Petit, Florence. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; FranciaFil: Bardou, Philippe. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; FranciaFil: Fabre, Stéphane. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; FranciaFil: Servin, Bertrand. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; FranciaFil: Sarry, Julien. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; FranciaFil: Woloszyn, Florent. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; FranciaFil: Mulsant, Philippe. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; FranciaFil: Foulquier, Didier. Institut National de la Recherche Agronomique; FranciaFil: Carriere, Fabien. Institut National de la Recherche Agronomique; FranciaFil: Aletru, Mathias. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; FranciaFil: Rodde, Nathalie. Institut National de la Recherche Agronomique; FranciaFil: Cauet, Stéphane. Institut National de la Recherche Agronomique; FranciaFil: Bouchez, Olivier. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; FranciaFil: Pirson, Maarten. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; FranciaFil: Tosser-Klopp, Gwenola. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; FranciaFil: Allain, Daniel. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; FranciaOxford university press2017-08-22T17:11:50Z2017-08-22T17:11:50Z2017-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/1007https://academic.oup.com/mbe/article/34/7/1722/30911051537-1719https://doi.org/10.1093/molbev/msx114Molecular Biology and Evolution 34 (7) : 1722-1729 (July 2017)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-29T13:44:09Zoai:localhost:20.500.12123/1007instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-29 13:44:09.353INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse |
dc.title.none.fl_str_mv |
Genome-wide identification of the mutation uderlying fleece variation and discriminating ancestral hairy species from modern woolly sheep |
title |
Genome-wide identification of the mutation uderlying fleece variation and discriminating ancestral hairy species from modern woolly sheep |
spellingShingle |
Genome-wide identification of the mutation uderlying fleece variation and discriminating ancestral hairy species from modern woolly sheep Demars, Julie Genética Ovinos Mutación Genetics Sheep Mutation |
title_short |
Genome-wide identification of the mutation uderlying fleece variation and discriminating ancestral hairy species from modern woolly sheep |
title_full |
Genome-wide identification of the mutation uderlying fleece variation and discriminating ancestral hairy species from modern woolly sheep |
title_fullStr |
Genome-wide identification of the mutation uderlying fleece variation and discriminating ancestral hairy species from modern woolly sheep |
title_full_unstemmed |
Genome-wide identification of the mutation uderlying fleece variation and discriminating ancestral hairy species from modern woolly sheep |
title_sort |
Genome-wide identification of the mutation uderlying fleece variation and discriminating ancestral hairy species from modern woolly sheep |
dc.creator.none.fl_str_mv |
Demars, Julie Cano, Ema Margarita Drouilhet, Laurence Plisson-Petit, Florence Bardou, Philippe Fabre, Stéphane Servin, Bertrand Sarry, Julien Woloszyn, Florent Mulsant, Philippe Foulquier, Didier Carriere, Fabien Aletru, Mathias Rodde, Nathalie Cauet, Stéphane Bouchez, Olivier Pirson, Maarten Tosser-Klopp, Gwenola Allain, Daniel |
author |
Demars, Julie |
author_facet |
Demars, Julie Cano, Ema Margarita Drouilhet, Laurence Plisson-Petit, Florence Bardou, Philippe Fabre, Stéphane Servin, Bertrand Sarry, Julien Woloszyn, Florent Mulsant, Philippe Foulquier, Didier Carriere, Fabien Aletru, Mathias Rodde, Nathalie Cauet, Stéphane Bouchez, Olivier Pirson, Maarten Tosser-Klopp, Gwenola Allain, Daniel |
author_role |
author |
author2 |
Cano, Ema Margarita Drouilhet, Laurence Plisson-Petit, Florence Bardou, Philippe Fabre, Stéphane Servin, Bertrand Sarry, Julien Woloszyn, Florent Mulsant, Philippe Foulquier, Didier Carriere, Fabien Aletru, Mathias Rodde, Nathalie Cauet, Stéphane Bouchez, Olivier Pirson, Maarten Tosser-Klopp, Gwenola Allain, Daniel |
author2_role |
author author author author author author author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
Genética Ovinos Mutación Genetics Sheep Mutation |
topic |
Genética Ovinos Mutación Genetics Sheep Mutation |
dc.description.none.fl_txt_mv |
The composition and structure of fleece variation observedin mammals is a consequence of a strong selective pressure for fiber production after domestication. In sheep, fleece variation discriminates ancestral species carrying a long and hairy fleece from modern domestic sheep (Ovis aries) owning a short and woolly fleece.Here, we report that the “woolly” allele results from the insertion of an antisenseEIF2S2retrogene (calledasEIF2S2)intothe3 0 UTR of theIRF2BP2 gene leading to an abnormal IRF2BP2 transcript. We provide evidence that this chimeric IRF2BP2/asEIF2S2 messenger 1) targets the genuine sense EIF2S2 RNA and 2) creates a long endogenous double-stranded RNA which alters the expression of both EIF2S2 and IRF2BP2 mRNA. This represents a unique example of a phenotype arising via a RNA-RNA hybrid, itself generated through a retroposition mechanism. Our results bring new insights on the sheep population history thanks to the identification of the molecular origin of an evolutionary phenotypic variation. Instituto de Genética Fil: Demars, Julie. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia Fil: Cano, Ema Margarita. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina Fil: Drouilhet, Laurence. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia Fil: Plisson-Petit, Florence. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia Fil: Bardou, Philippe. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia Fil: Fabre, Stéphane. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia Fil: Servin, Bertrand. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia Fil: Sarry, Julien. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia Fil: Woloszyn, Florent. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia Fil: Mulsant, Philippe. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia Fil: Foulquier, Didier. Institut National de la Recherche Agronomique; Francia Fil: Carriere, Fabien. Institut National de la Recherche Agronomique; Francia Fil: Aletru, Mathias. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia Fil: Rodde, Nathalie. Institut National de la Recherche Agronomique; Francia Fil: Cauet, Stéphane. Institut National de la Recherche Agronomique; Francia Fil: Bouchez, Olivier. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia Fil: Pirson, Maarten. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia Fil: Tosser-Klopp, Gwenola. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia Fil: Allain, Daniel. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia |
description |
The composition and structure of fleece variation observedin mammals is a consequence of a strong selective pressure for fiber production after domestication. In sheep, fleece variation discriminates ancestral species carrying a long and hairy fleece from modern domestic sheep (Ovis aries) owning a short and woolly fleece.Here, we report that the “woolly” allele results from the insertion of an antisenseEIF2S2retrogene (calledasEIF2S2)intothe3 0 UTR of theIRF2BP2 gene leading to an abnormal IRF2BP2 transcript. We provide evidence that this chimeric IRF2BP2/asEIF2S2 messenger 1) targets the genuine sense EIF2S2 RNA and 2) creates a long endogenous double-stranded RNA which alters the expression of both EIF2S2 and IRF2BP2 mRNA. This represents a unique example of a phenotype arising via a RNA-RNA hybrid, itself generated through a retroposition mechanism. Our results bring new insights on the sheep population history thanks to the identification of the molecular origin of an evolutionary phenotypic variation. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-08-22T17:11:50Z 2017-08-22T17:11:50Z 2017-07 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/20.500.12123/1007 https://academic.oup.com/mbe/article/34/7/1722/3091105 1537-1719 https://doi.org/10.1093/molbev/msx114 |
url |
http://hdl.handle.net/20.500.12123/1007 https://academic.oup.com/mbe/article/34/7/1722/3091105 https://doi.org/10.1093/molbev/msx114 |
identifier_str_mv |
1537-1719 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Oxford university press |
publisher.none.fl_str_mv |
Oxford university press |
dc.source.none.fl_str_mv |
Molecular Biology and Evolution 34 (7) : 1722-1729 (July 2017) reponame:INTA Digital (INTA) instname:Instituto Nacional de Tecnología Agropecuaria |
reponame_str |
INTA Digital (INTA) |
collection |
INTA Digital (INTA) |
instname_str |
Instituto Nacional de Tecnología Agropecuaria |
repository.name.fl_str_mv |
INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria |
repository.mail.fl_str_mv |
tripaldi.nicolas@inta.gob.ar |
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1844619116239912960 |
score |
12.559606 |