Genome-wide identification of the mutation uderlying fleece variation and discriminating ancestral hairy species from modern woolly sheep

Autores
Demars, Julie; Cano, Ema Margarita; Drouilhet, Laurence; Plisson-Petit, Florence; Bardou, Philippe; Fabre, Stéphane; Servin, Bertrand; Sarry, Julien; Woloszyn, Florent; Mulsant, Philippe; Foulquier, Didier; Carriere, Fabien; Aletru, Mathias; Rodde, Nathalie; Cauet, Stéphane; Bouchez, Olivier; Pirson, Maarten; Tosser-Klopp, Gwenola; Allain, Daniel
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The composition and structure of fleece variation observedin mammals is a consequence of a strong selective pressure for fiber production after domestication. In sheep, fleece variation discriminates ancestral species carrying a long and hairy fleece from modern domestic sheep (Ovis aries) owning a short and woolly fleece.Here, we report that the “woolly” allele results from the insertion of an antisenseEIF2S2retrogene (calledasEIF2S2)intothe3 0 UTR of theIRF2BP2 gene leading to an abnormal IRF2BP2 transcript. We provide evidence that this chimeric IRF2BP2/asEIF2S2 messenger 1) targets the genuine sense EIF2S2 RNA and 2) creates a long endogenous double-stranded RNA which alters the expression of both EIF2S2 and IRF2BP2 mRNA. This represents a unique example of a phenotype arising via a RNA-RNA hybrid, itself generated through a retroposition mechanism. Our results bring new insights on the sheep population history thanks to the identification of the molecular origin of an evolutionary phenotypic variation.
Instituto de Genética
Fil: Demars, Julie. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
Fil: Cano, Ema Margarita. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina
Fil: Drouilhet, Laurence. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
Fil: Plisson-Petit, Florence. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
Fil: Bardou, Philippe. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
Fil: Fabre, Stéphane. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
Fil: Servin, Bertrand. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
Fil: Sarry, Julien. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
Fil: Woloszyn, Florent. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
Fil: Mulsant, Philippe. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
Fil: Foulquier, Didier. Institut National de la Recherche Agronomique; Francia
Fil: Carriere, Fabien. Institut National de la Recherche Agronomique; Francia
Fil: Aletru, Mathias. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
Fil: Rodde, Nathalie. Institut National de la Recherche Agronomique; Francia
Fil: Cauet, Stéphane. Institut National de la Recherche Agronomique; Francia
Fil: Bouchez, Olivier. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
Fil: Pirson, Maarten. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
Fil: Tosser-Klopp, Gwenola. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
Fil: Allain, Daniel. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
Fuente
Molecular Biology and Evolution 34 (7) : 1722-1729 (July 2017)
Materia
Genética
Ovinos
Mutación
Genetics
Sheep
Mutation
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/1007
Acceder
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oai_identifier_str oai:localhost:20.500.12123/1007
network_acronym_str INTADig
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network_name_str INTA Digital (INTA)
spelling Genome-wide identification of the mutation uderlying fleece variation and discriminating ancestral hairy species from modern woolly sheepDemars, JulieCano, Ema MargaritaDrouilhet, LaurencePlisson-Petit, FlorenceBardou, PhilippeFabre, StéphaneServin, BertrandSarry, JulienWoloszyn, FlorentMulsant, PhilippeFoulquier, DidierCarriere, FabienAletru, MathiasRodde, NathalieCauet, StéphaneBouchez, OlivierPirson, MaartenTosser-Klopp, GwenolaAllain, DanielGenéticaOvinosMutaciónGeneticsSheepMutationThe composition and structure of fleece variation observedin mammals is a consequence of a strong selective pressure for fiber production after domestication. In sheep, fleece variation discriminates ancestral species carrying a long and hairy fleece from modern domestic sheep (Ovis aries) owning a short and woolly fleece.Here, we report that the “woolly” allele results from the insertion of an antisenseEIF2S2retrogene (calledasEIF2S2)intothe3 0 UTR of theIRF2BP2 gene leading to an abnormal IRF2BP2 transcript. We provide evidence that this chimeric IRF2BP2/asEIF2S2 messenger 1) targets the genuine sense EIF2S2 RNA and 2) creates a long endogenous double-stranded RNA which alters the expression of both EIF2S2 and IRF2BP2 mRNA. This represents a unique example of a phenotype arising via a RNA-RNA hybrid, itself generated through a retroposition mechanism. Our results bring new insights on the sheep population history thanks to the identification of the molecular origin of an evolutionary phenotypic variation.Instituto de GenéticaFil: Demars, Julie. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; FranciaFil: Cano, Ema Margarita. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; ArgentinaFil: Drouilhet, Laurence. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; FranciaFil: Plisson-Petit, Florence. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; FranciaFil: Bardou, Philippe. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; FranciaFil: Fabre, Stéphane. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; FranciaFil: Servin, Bertrand. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; FranciaFil: Sarry, Julien. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; FranciaFil: Woloszyn, Florent. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; FranciaFil: Mulsant, Philippe. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; FranciaFil: Foulquier, Didier. Institut National de la Recherche Agronomique; FranciaFil: Carriere, Fabien. Institut National de la Recherche Agronomique; FranciaFil: Aletru, Mathias. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; FranciaFil: Rodde, Nathalie. Institut National de la Recherche Agronomique; FranciaFil: Cauet, Stéphane. Institut National de la Recherche Agronomique; FranciaFil: Bouchez, Olivier. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; FranciaFil: Pirson, Maarten. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; FranciaFil: Tosser-Klopp, Gwenola. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; FranciaFil: Allain, Daniel. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; FranciaOxford university press2017-08-22T17:11:50Z2017-08-22T17:11:50Z2017-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/1007https://academic.oup.com/mbe/article/34/7/1722/30911051537-1719https://doi.org/10.1093/molbev/msx114Molecular Biology and Evolution 34 (7) : 1722-1729 (July 2017)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-10-23T11:16:21Zoai:localhost:20.500.12123/1007instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-10-23 11:16:21.343INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Genome-wide identification of the mutation uderlying fleece variation and discriminating ancestral hairy species from modern woolly sheep
title Genome-wide identification of the mutation uderlying fleece variation and discriminating ancestral hairy species from modern woolly sheep
spellingShingle Genome-wide identification of the mutation uderlying fleece variation and discriminating ancestral hairy species from modern woolly sheep
Demars, Julie
Genética
Ovinos
Mutación
Genetics
Sheep
Mutation
title_short Genome-wide identification of the mutation uderlying fleece variation and discriminating ancestral hairy species from modern woolly sheep
title_full Genome-wide identification of the mutation uderlying fleece variation and discriminating ancestral hairy species from modern woolly sheep
title_fullStr Genome-wide identification of the mutation uderlying fleece variation and discriminating ancestral hairy species from modern woolly sheep
title_full_unstemmed Genome-wide identification of the mutation uderlying fleece variation and discriminating ancestral hairy species from modern woolly sheep
title_sort Genome-wide identification of the mutation uderlying fleece variation and discriminating ancestral hairy species from modern woolly sheep
dc.creator.none.fl_str_mv Demars, Julie
Cano, Ema Margarita
Drouilhet, Laurence
Plisson-Petit, Florence
Bardou, Philippe
Fabre, Stéphane
Servin, Bertrand
Sarry, Julien
Woloszyn, Florent
Mulsant, Philippe
Foulquier, Didier
Carriere, Fabien
Aletru, Mathias
Rodde, Nathalie
Cauet, Stéphane
Bouchez, Olivier
Pirson, Maarten
Tosser-Klopp, Gwenola
Allain, Daniel
author Demars, Julie
author_facet Demars, Julie
Cano, Ema Margarita
Drouilhet, Laurence
Plisson-Petit, Florence
Bardou, Philippe
Fabre, Stéphane
Servin, Bertrand
Sarry, Julien
Woloszyn, Florent
Mulsant, Philippe
Foulquier, Didier
Carriere, Fabien
Aletru, Mathias
Rodde, Nathalie
Cauet, Stéphane
Bouchez, Olivier
Pirson, Maarten
Tosser-Klopp, Gwenola
Allain, Daniel
author_role author
author2 Cano, Ema Margarita
Drouilhet, Laurence
Plisson-Petit, Florence
Bardou, Philippe
Fabre, Stéphane
Servin, Bertrand
Sarry, Julien
Woloszyn, Florent
Mulsant, Philippe
Foulquier, Didier
Carriere, Fabien
Aletru, Mathias
Rodde, Nathalie
Cauet, Stéphane
Bouchez, Olivier
Pirson, Maarten
Tosser-Klopp, Gwenola
Allain, Daniel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Genética
Ovinos
Mutación
Genetics
Sheep
Mutation
topic Genética
Ovinos
Mutación
Genetics
Sheep
Mutation
dc.description.none.fl_txt_mv The composition and structure of fleece variation observedin mammals is a consequence of a strong selective pressure for fiber production after domestication. In sheep, fleece variation discriminates ancestral species carrying a long and hairy fleece from modern domestic sheep (Ovis aries) owning a short and woolly fleece.Here, we report that the “woolly” allele results from the insertion of an antisenseEIF2S2retrogene (calledasEIF2S2)intothe3 0 UTR of theIRF2BP2 gene leading to an abnormal IRF2BP2 transcript. We provide evidence that this chimeric IRF2BP2/asEIF2S2 messenger 1) targets the genuine sense EIF2S2 RNA and 2) creates a long endogenous double-stranded RNA which alters the expression of both EIF2S2 and IRF2BP2 mRNA. This represents a unique example of a phenotype arising via a RNA-RNA hybrid, itself generated through a retroposition mechanism. Our results bring new insights on the sheep population history thanks to the identification of the molecular origin of an evolutionary phenotypic variation.
Instituto de Genética
Fil: Demars, Julie. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
Fil: Cano, Ema Margarita. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina
Fil: Drouilhet, Laurence. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
Fil: Plisson-Petit, Florence. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
Fil: Bardou, Philippe. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
Fil: Fabre, Stéphane. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
Fil: Servin, Bertrand. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
Fil: Sarry, Julien. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
Fil: Woloszyn, Florent. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
Fil: Mulsant, Philippe. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
Fil: Foulquier, Didier. Institut National de la Recherche Agronomique; Francia
Fil: Carriere, Fabien. Institut National de la Recherche Agronomique; Francia
Fil: Aletru, Mathias. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
Fil: Rodde, Nathalie. Institut National de la Recherche Agronomique; Francia
Fil: Cauet, Stéphane. Institut National de la Recherche Agronomique; Francia
Fil: Bouchez, Olivier. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
Fil: Pirson, Maarten. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
Fil: Tosser-Klopp, Gwenola. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
Fil: Allain, Daniel. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
description The composition and structure of fleece variation observedin mammals is a consequence of a strong selective pressure for fiber production after domestication. In sheep, fleece variation discriminates ancestral species carrying a long and hairy fleece from modern domestic sheep (Ovis aries) owning a short and woolly fleece.Here, we report that the “woolly” allele results from the insertion of an antisenseEIF2S2retrogene (calledasEIF2S2)intothe3 0 UTR of theIRF2BP2 gene leading to an abnormal IRF2BP2 transcript. We provide evidence that this chimeric IRF2BP2/asEIF2S2 messenger 1) targets the genuine sense EIF2S2 RNA and 2) creates a long endogenous double-stranded RNA which alters the expression of both EIF2S2 and IRF2BP2 mRNA. This represents a unique example of a phenotype arising via a RNA-RNA hybrid, itself generated through a retroposition mechanism. Our results bring new insights on the sheep population history thanks to the identification of the molecular origin of an evolutionary phenotypic variation.
publishDate 2017
dc.date.none.fl_str_mv 2017-08-22T17:11:50Z
2017-08-22T17:11:50Z
2017-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/1007
https://academic.oup.com/mbe/article/34/7/1722/3091105
1537-1719
https://doi.org/10.1093/molbev/msx114
url http://hdl.handle.net/20.500.12123/1007
https://academic.oup.com/mbe/article/34/7/1722/3091105
https://doi.org/10.1093/molbev/msx114
identifier_str_mv 1537-1719
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford university press
publisher.none.fl_str_mv Oxford university press
dc.source.none.fl_str_mv Molecular Biology and Evolution 34 (7) : 1722-1729 (July 2017)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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score 12.982451

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