Bovine coronavirus in Uruguay: genetic diversity, risk factors and transboundary introductions from neighboring countries

Autores
Castells, Matias; Giannitti, Federico; Caffarena, Rubén Darío; Casaux, María Laura; Schild, Carlos; Castells, Daniel; Riet‑Correa, Franklin; Victoria, Matias; Parreño, Gladys; Colina, Rodney
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Bovine coronavirus (BCoV) is a recognized cause of severe neonatal calf diarrhea, with a negative impact on animal welfare, leading to economic losses to the livestock industry. Cattle production is one of the most important economic sectors in Uruguay. The aim of this study was to determine the frequency of BCoV infections and their genetic diversity in Uruguayan calves and to describe the evolutionary history of the virus in South America. The overall detection rate of BCoV in Uruguay was 7.8% (64/824): 7.7% (60/782) in dairy cattle and 9.5% (4/42) in beef cattle. The detection rate of BCoV in samples from deceased and live calves was 10.0% (6/60) and 7.6% (58/763), respectively. Interestingly, there was a lower frequency of BCoV detection in calves born to vaccinated dams (3.3%, 8/240) than in calves born to unvaccinated dams (12.2%, 32/263) (OR: 4.02, 95%CI: 1.81–8.90; p = 0.00026). The frequency of BCoV detection was higher in colder months (11.8%, 44/373) than in warmer months (1.5%, 3/206) (OR: 9.05, 95%CI: 2.77–29.53, p = 0.000013). Uruguayan strains grouped together in two different lineages: one with Argentinean strains and the other with Brazilian strains. Both BCoV lineages were estimated to have entered Uruguay in 2013: one of them from Brazil (95%HPD interval: 2011–2014) and the other from Argentina (95%HPD interval: 2010–2014). The lineages differed by four amino acid changes, and both were divergent from the Mebus reference strain. Surveillance should be maintained to detect possible emerging strains that can clearly diverge at the antigenic level from vaccine strains.
Instituto de Virología
Fil: Giannitti, Federico. Instituto Nacional de Investigación Agropecuaria (INIA). Plataforma de Investigación en Salud Animal; Uruguay.
Fil: Caffarena, Rubén Darío. Instituto Nacional de Investigación Agropecuaria (INIA). Plataforma de Investigación en Salud Animal. Universidad de la República. Facultad de Veterinaria; Uruguay.
Fil: Casaux, María Laura. Instituto Nacional de Investigación Agropecuaria (INIA). Plataforma de Investigación en Salud Animal; Uruguay.
Fil: Schild, Carlos. Instituto Nacional de Investigación Agropecuaria (INIA). Plataforma de Investigación en Salud Animal; Uruguay.
Fil: Castells, Daniel. Secretariado Uruguayo de la Lana. Centro de Investigación y Experimentación Dr. Alejandro Gallinal; Uruguay.
Fil: Riet‑Correa, Franklin. Instituto Nacional de Investigación Agropecuaria (INIA). Plataforma de Investigación en Salud Animal; Uruguay.
Fil: Victoria, Matías. Universidad de la República. Centro Universitario de Salto. CENUR Litoral Norte. Laboratorio de Virología Molecular; Uruguay.
Fil: Parreño, Viviana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología. Argentina.
Fil: Colina, Rodney. Universidad de la República. Centro Universitario de Salto. CENUR Litoral Norte. Laboratorio de Virología Molecular; Uruguay.
Fil: Castells_Matías. Universidad de la República. Centro Universitario de Salto. CENUR Litoral Norte. Laboratorio de Virología Molecular; Uruguay.
Fuente
Archives of Virology 164 (11): 2715–2724 (November 2019)
Materia
Coronavirus
Uruguay
Genetic Diversity
Animal Diseases
Cattle
Enfermedades de los Animales
Ganado Bovino
Diversidad Genética
Nivel de accesibilidad
acceso restringido
Condiciones de uso
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/6501
Acceder
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oai_identifier_str oai:localhost:20.500.12123/6501
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spelling Bovine coronavirus in Uruguay: genetic diversity, risk factors and transboundary introductions from neighboring countriesCastells, MatiasGiannitti, FedericoCaffarena, Rubén DaríoCasaux, María LauraSchild, CarlosCastells, DanielRiet‑Correa, FranklinVictoria, MatiasParreño, GladysColina, RodneyCoronavirusUruguayGenetic DiversityAnimal DiseasesCattleEnfermedades de los AnimalesGanado BovinoDiversidad GenéticaBovine coronavirus (BCoV) is a recognized cause of severe neonatal calf diarrhea, with a negative impact on animal welfare, leading to economic losses to the livestock industry. Cattle production is one of the most important economic sectors in Uruguay. The aim of this study was to determine the frequency of BCoV infections and their genetic diversity in Uruguayan calves and to describe the evolutionary history of the virus in South America. The overall detection rate of BCoV in Uruguay was 7.8% (64/824): 7.7% (60/782) in dairy cattle and 9.5% (4/42) in beef cattle. The detection rate of BCoV in samples from deceased and live calves was 10.0% (6/60) and 7.6% (58/763), respectively. Interestingly, there was a lower frequency of BCoV detection in calves born to vaccinated dams (3.3%, 8/240) than in calves born to unvaccinated dams (12.2%, 32/263) (OR: 4.02, 95%CI: 1.81–8.90; p = 0.00026). The frequency of BCoV detection was higher in colder months (11.8%, 44/373) than in warmer months (1.5%, 3/206) (OR: 9.05, 95%CI: 2.77–29.53, p = 0.000013). Uruguayan strains grouped together in two different lineages: one with Argentinean strains and the other with Brazilian strains. Both BCoV lineages were estimated to have entered Uruguay in 2013: one of them from Brazil (95%HPD interval: 2011–2014) and the other from Argentina (95%HPD interval: 2010–2014). The lineages differed by four amino acid changes, and both were divergent from the Mebus reference strain. Surveillance should be maintained to detect possible emerging strains that can clearly diverge at the antigenic level from vaccine strains.Instituto de VirologíaFil: Giannitti, Federico. Instituto Nacional de Investigación Agropecuaria (INIA). Plataforma de Investigación en Salud Animal; Uruguay.Fil: Caffarena, Rubén Darío. Instituto Nacional de Investigación Agropecuaria (INIA). Plataforma de Investigación en Salud Animal. Universidad de la República. Facultad de Veterinaria; Uruguay.Fil: Casaux, María Laura. Instituto Nacional de Investigación Agropecuaria (INIA). Plataforma de Investigación en Salud Animal; Uruguay.Fil: Schild, Carlos. Instituto Nacional de Investigación Agropecuaria (INIA). Plataforma de Investigación en Salud Animal; Uruguay.Fil: Castells, Daniel. Secretariado Uruguayo de la Lana. Centro de Investigación y Experimentación Dr. Alejandro Gallinal; Uruguay.Fil: Riet‑Correa, Franklin. Instituto Nacional de Investigación Agropecuaria (INIA). Plataforma de Investigación en Salud Animal; Uruguay.Fil: Victoria, Matías. Universidad de la República. Centro Universitario de Salto. CENUR Litoral Norte. Laboratorio de Virología Molecular; Uruguay.Fil: Parreño, Viviana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología. Argentina.Fil: Colina, Rodney. Universidad de la República. Centro Universitario de Salto. CENUR Litoral Norte. Laboratorio de Virología Molecular; Uruguay.Fil: Castells_Matías. Universidad de la República. Centro Universitario de Salto. CENUR Litoral Norte. Laboratorio de Virología Molecular; Uruguay.Springer2019-12-12T18:10:06Z2019-12-12T18:10:06Z2019-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://link.springer.com/article/10.1007%2Fs00705-019-04384-whttp://hdl.handle.net/20.500.12123/65010304-86081432-8798https://doi.org/10.1007/s00705-019-04384-wArchives of Virology 164 (11): 2715–2724 (November 2019)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccess2025-10-23T11:17:09Zoai:localhost:20.500.12123/6501instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-10-23 11:17:10.192INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Bovine coronavirus in Uruguay: genetic diversity, risk factors and transboundary introductions from neighboring countries
title Bovine coronavirus in Uruguay: genetic diversity, risk factors and transboundary introductions from neighboring countries
spellingShingle Bovine coronavirus in Uruguay: genetic diversity, risk factors and transboundary introductions from neighboring countries
Castells, Matias
Coronavirus
Uruguay
Genetic Diversity
Animal Diseases
Cattle
Enfermedades de los Animales
Ganado Bovino
Diversidad Genética
title_short Bovine coronavirus in Uruguay: genetic diversity, risk factors and transboundary introductions from neighboring countries
title_full Bovine coronavirus in Uruguay: genetic diversity, risk factors and transboundary introductions from neighboring countries
title_fullStr Bovine coronavirus in Uruguay: genetic diversity, risk factors and transboundary introductions from neighboring countries
title_full_unstemmed Bovine coronavirus in Uruguay: genetic diversity, risk factors and transboundary introductions from neighboring countries
title_sort Bovine coronavirus in Uruguay: genetic diversity, risk factors and transboundary introductions from neighboring countries
dc.creator.none.fl_str_mv Castells, Matias
Giannitti, Federico
Caffarena, Rubén Darío
Casaux, María Laura
Schild, Carlos
Castells, Daniel
Riet‑Correa, Franklin
Victoria, Matias
Parreño, Gladys
Colina, Rodney
author Castells, Matias
author_facet Castells, Matias
Giannitti, Federico
Caffarena, Rubén Darío
Casaux, María Laura
Schild, Carlos
Castells, Daniel
Riet‑Correa, Franklin
Victoria, Matias
Parreño, Gladys
Colina, Rodney
author_role author
author2 Giannitti, Federico
Caffarena, Rubén Darío
Casaux, María Laura
Schild, Carlos
Castells, Daniel
Riet‑Correa, Franklin
Victoria, Matias
Parreño, Gladys
Colina, Rodney
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Coronavirus
Uruguay
Genetic Diversity
Animal Diseases
Cattle
Enfermedades de los Animales
Ganado Bovino
Diversidad Genética
topic Coronavirus
Uruguay
Genetic Diversity
Animal Diseases
Cattle
Enfermedades de los Animales
Ganado Bovino
Diversidad Genética
dc.description.none.fl_txt_mv Bovine coronavirus (BCoV) is a recognized cause of severe neonatal calf diarrhea, with a negative impact on animal welfare, leading to economic losses to the livestock industry. Cattle production is one of the most important economic sectors in Uruguay. The aim of this study was to determine the frequency of BCoV infections and their genetic diversity in Uruguayan calves and to describe the evolutionary history of the virus in South America. The overall detection rate of BCoV in Uruguay was 7.8% (64/824): 7.7% (60/782) in dairy cattle and 9.5% (4/42) in beef cattle. The detection rate of BCoV in samples from deceased and live calves was 10.0% (6/60) and 7.6% (58/763), respectively. Interestingly, there was a lower frequency of BCoV detection in calves born to vaccinated dams (3.3%, 8/240) than in calves born to unvaccinated dams (12.2%, 32/263) (OR: 4.02, 95%CI: 1.81–8.90; p = 0.00026). The frequency of BCoV detection was higher in colder months (11.8%, 44/373) than in warmer months (1.5%, 3/206) (OR: 9.05, 95%CI: 2.77–29.53, p = 0.000013). Uruguayan strains grouped together in two different lineages: one with Argentinean strains and the other with Brazilian strains. Both BCoV lineages were estimated to have entered Uruguay in 2013: one of them from Brazil (95%HPD interval: 2011–2014) and the other from Argentina (95%HPD interval: 2010–2014). The lineages differed by four amino acid changes, and both were divergent from the Mebus reference strain. Surveillance should be maintained to detect possible emerging strains that can clearly diverge at the antigenic level from vaccine strains.
Instituto de Virología
Fil: Giannitti, Federico. Instituto Nacional de Investigación Agropecuaria (INIA). Plataforma de Investigación en Salud Animal; Uruguay.
Fil: Caffarena, Rubén Darío. Instituto Nacional de Investigación Agropecuaria (INIA). Plataforma de Investigación en Salud Animal. Universidad de la República. Facultad de Veterinaria; Uruguay.
Fil: Casaux, María Laura. Instituto Nacional de Investigación Agropecuaria (INIA). Plataforma de Investigación en Salud Animal; Uruguay.
Fil: Schild, Carlos. Instituto Nacional de Investigación Agropecuaria (INIA). Plataforma de Investigación en Salud Animal; Uruguay.
Fil: Castells, Daniel. Secretariado Uruguayo de la Lana. Centro de Investigación y Experimentación Dr. Alejandro Gallinal; Uruguay.
Fil: Riet‑Correa, Franklin. Instituto Nacional de Investigación Agropecuaria (INIA). Plataforma de Investigación en Salud Animal; Uruguay.
Fil: Victoria, Matías. Universidad de la República. Centro Universitario de Salto. CENUR Litoral Norte. Laboratorio de Virología Molecular; Uruguay.
Fil: Parreño, Viviana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología. Argentina.
Fil: Colina, Rodney. Universidad de la República. Centro Universitario de Salto. CENUR Litoral Norte. Laboratorio de Virología Molecular; Uruguay.
Fil: Castells_Matías. Universidad de la República. Centro Universitario de Salto. CENUR Litoral Norte. Laboratorio de Virología Molecular; Uruguay.
description Bovine coronavirus (BCoV) is a recognized cause of severe neonatal calf diarrhea, with a negative impact on animal welfare, leading to economic losses to the livestock industry. Cattle production is one of the most important economic sectors in Uruguay. The aim of this study was to determine the frequency of BCoV infections and their genetic diversity in Uruguayan calves and to describe the evolutionary history of the virus in South America. The overall detection rate of BCoV in Uruguay was 7.8% (64/824): 7.7% (60/782) in dairy cattle and 9.5% (4/42) in beef cattle. The detection rate of BCoV in samples from deceased and live calves was 10.0% (6/60) and 7.6% (58/763), respectively. Interestingly, there was a lower frequency of BCoV detection in calves born to vaccinated dams (3.3%, 8/240) than in calves born to unvaccinated dams (12.2%, 32/263) (OR: 4.02, 95%CI: 1.81–8.90; p = 0.00026). The frequency of BCoV detection was higher in colder months (11.8%, 44/373) than in warmer months (1.5%, 3/206) (OR: 9.05, 95%CI: 2.77–29.53, p = 0.000013). Uruguayan strains grouped together in two different lineages: one with Argentinean strains and the other with Brazilian strains. Both BCoV lineages were estimated to have entered Uruguay in 2013: one of them from Brazil (95%HPD interval: 2011–2014) and the other from Argentina (95%HPD interval: 2010–2014). The lineages differed by four amino acid changes, and both were divergent from the Mebus reference strain. Surveillance should be maintained to detect possible emerging strains that can clearly diverge at the antigenic level from vaccine strains.
publishDate 2019
dc.date.none.fl_str_mv 2019-12-12T18:10:06Z
2019-12-12T18:10:06Z
2019-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://link.springer.com/article/10.1007%2Fs00705-019-04384-w
http://hdl.handle.net/20.500.12123/6501
0304-8608
1432-8798
https://doi.org/10.1007/s00705-019-04384-w
url https://link.springer.com/article/10.1007%2Fs00705-019-04384-w
http://hdl.handle.net/20.500.12123/6501
https://doi.org/10.1007/s00705-019-04384-w
identifier_str_mv 0304-8608
1432-8798
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/restrictedAccess
eu_rights_str_mv restrictedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv Archives of Virology 164 (11): 2715–2724 (November 2019)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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