Immune mediators of pathology in neurobrucellosis: from blood to central nervous system

Autores
Rodriguez, Ana María; Delpino, María Victoria; Miraglia, Maria Cruz; Giambartolomei, Guillermo Hernán
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Neurobrucellosis, which is the most morbid form of brucellosis disease, presents with inflammatory signs and symptoms. Recent experimental evidence clearly indicates that deregulation of astrocytes and microglia caused by Brucella infection creates a microenvironment in the central nervous system (CNS) in which secretion of pro-inflammatory mediators lead to destabilization of the glial structure, the damage of the blood brain barrier (BBB) and neuronal demise. This review of Brucella interactions with cells of the CNS and the BBB is intended to present recent immunological findings that can explain, at least in part, the basis for the inflammatory pathogenesis of the nervous system that takes place upon Brucella infection.
Instituto de Virología
Fil: Rodriguez, Ana María. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Inmunología, Genética y Metabolismo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Delpino, María Victoria. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Inmunología, Genética y Metabolismo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Miraglia, María Cruz. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina
Fil: Giambartolomei, Guillermo Hernán. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Inmunología, Genética y Metabolismo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fuente
Neuroscience 410 : 264-273 (2019)
Materia
Brucellosis
Central Nervous System
Pathogenesis
Immunology
Nervous System Diseases
Brucelosis
Sistema Nervioso Central
Patogénesis
Inmunología
Trastornos del Sistema Nervioso
Nivel de accesibilidad
acceso restringido
Condiciones de uso
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/6331
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spelling Immune mediators of pathology in neurobrucellosis: from blood to central nervous systemRodriguez, Ana MaríaDelpino, María VictoriaMiraglia, Maria CruzGiambartolomei, Guillermo HernánBrucellosisCentral Nervous SystemPathogenesisImmunologyNervous System DiseasesBrucelosisSistema Nervioso CentralPatogénesisInmunologíaTrastornos del Sistema NerviosoNeurobrucellosis, which is the most morbid form of brucellosis disease, presents with inflammatory signs and symptoms. Recent experimental evidence clearly indicates that deregulation of astrocytes and microglia caused by Brucella infection creates a microenvironment in the central nervous system (CNS) in which secretion of pro-inflammatory mediators lead to destabilization of the glial structure, the damage of the blood brain barrier (BBB) and neuronal demise. This review of Brucella interactions with cells of the CNS and the BBB is intended to present recent immunological findings that can explain, at least in part, the basis for the inflammatory pathogenesis of the nervous system that takes place upon Brucella infection.Instituto de VirologíaFil: Rodriguez, Ana María. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Inmunología, Genética y Metabolismo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Delpino, María Victoria. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Inmunología, Genética y Metabolismo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Miraglia, María Cruz. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; ArgentinaFil: Giambartolomei, Guillermo Hernán. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Inmunología, Genética y Metabolismo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier2019-11-19T13:46:04Z2019-11-19T13:46:04Z2019-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/6331https://www.sciencedirect.com/science/article/pii/S03064522193033430306-4522https://doi.org/10.1016/j.neuroscience.2019.05.018Neuroscience 410 : 264-273 (2019)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccess2025-09-29T13:44:49Zoai:localhost:20.500.12123/6331instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-29 13:44:49.972INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Immune mediators of pathology in neurobrucellosis: from blood to central nervous system
title Immune mediators of pathology in neurobrucellosis: from blood to central nervous system
spellingShingle Immune mediators of pathology in neurobrucellosis: from blood to central nervous system
Rodriguez, Ana María
Brucellosis
Central Nervous System
Pathogenesis
Immunology
Nervous System Diseases
Brucelosis
Sistema Nervioso Central
Patogénesis
Inmunología
Trastornos del Sistema Nervioso
title_short Immune mediators of pathology in neurobrucellosis: from blood to central nervous system
title_full Immune mediators of pathology in neurobrucellosis: from blood to central nervous system
title_fullStr Immune mediators of pathology in neurobrucellosis: from blood to central nervous system
title_full_unstemmed Immune mediators of pathology in neurobrucellosis: from blood to central nervous system
title_sort Immune mediators of pathology in neurobrucellosis: from blood to central nervous system
dc.creator.none.fl_str_mv Rodriguez, Ana María
Delpino, María Victoria
Miraglia, Maria Cruz
Giambartolomei, Guillermo Hernán
author Rodriguez, Ana María
author_facet Rodriguez, Ana María
Delpino, María Victoria
Miraglia, Maria Cruz
Giambartolomei, Guillermo Hernán
author_role author
author2 Delpino, María Victoria
Miraglia, Maria Cruz
Giambartolomei, Guillermo Hernán
author2_role author
author
author
dc.subject.none.fl_str_mv Brucellosis
Central Nervous System
Pathogenesis
Immunology
Nervous System Diseases
Brucelosis
Sistema Nervioso Central
Patogénesis
Inmunología
Trastornos del Sistema Nervioso
topic Brucellosis
Central Nervous System
Pathogenesis
Immunology
Nervous System Diseases
Brucelosis
Sistema Nervioso Central
Patogénesis
Inmunología
Trastornos del Sistema Nervioso
dc.description.none.fl_txt_mv Neurobrucellosis, which is the most morbid form of brucellosis disease, presents with inflammatory signs and symptoms. Recent experimental evidence clearly indicates that deregulation of astrocytes and microglia caused by Brucella infection creates a microenvironment in the central nervous system (CNS) in which secretion of pro-inflammatory mediators lead to destabilization of the glial structure, the damage of the blood brain barrier (BBB) and neuronal demise. This review of Brucella interactions with cells of the CNS and the BBB is intended to present recent immunological findings that can explain, at least in part, the basis for the inflammatory pathogenesis of the nervous system that takes place upon Brucella infection.
Instituto de Virología
Fil: Rodriguez, Ana María. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Inmunología, Genética y Metabolismo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Delpino, María Victoria. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Inmunología, Genética y Metabolismo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Miraglia, María Cruz. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina
Fil: Giambartolomei, Guillermo Hernán. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Inmunología, Genética y Metabolismo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Neurobrucellosis, which is the most morbid form of brucellosis disease, presents with inflammatory signs and symptoms. Recent experimental evidence clearly indicates that deregulation of astrocytes and microglia caused by Brucella infection creates a microenvironment in the central nervous system (CNS) in which secretion of pro-inflammatory mediators lead to destabilization of the glial structure, the damage of the blood brain barrier (BBB) and neuronal demise. This review of Brucella interactions with cells of the CNS and the BBB is intended to present recent immunological findings that can explain, at least in part, the basis for the inflammatory pathogenesis of the nervous system that takes place upon Brucella infection.
publishDate 2019
dc.date.none.fl_str_mv 2019-11-19T13:46:04Z
2019-11-19T13:46:04Z
2019-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/6331
https://www.sciencedirect.com/science/article/pii/S0306452219303343
0306-4522
https://doi.org/10.1016/j.neuroscience.2019.05.018
url http://hdl.handle.net/20.500.12123/6331
https://www.sciencedirect.com/science/article/pii/S0306452219303343
https://doi.org/10.1016/j.neuroscience.2019.05.018
identifier_str_mv 0306-4522
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/restrictedAccess
eu_rights_str_mv restrictedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Neuroscience 410 : 264-273 (2019)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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score 12.558318

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