Immune mediators of pathology in neurobrucellosis: from blood to central nervous system
- Autores
- Rodriguez, Ana María; Delpino, María Victoria; Miraglia, María Cruz; Giambartolomei, Guillermo Hernán
- Año de publicación
- 2019
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Neurobrucellosis, which is the most morbid form of brucellosis disease, presents with inflammatory signs and symptoms. Recent experimental evidence clearly indicates that deregulation of astrocytes and microglia caused by Brucella infection creates a microenvironment in the central nervous system (CNS) in which secretion of pro-inflammatory mediators lead to destabilization of the glial structure, the damage of the blood brain barrier (BBB) and neuronal demise. This review of Brucella interactions with cells of the CNS and the BBB is intended to present recent immunological findings that can explain, at least in part, the basis for the inflammatory pathogenesis of the nervous system that takes place upon Brucella infection.
Instituto de Virología
Fil: Rodriguez, Ana María. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Inmunología, Genética y Metabolismo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Delpino, María Victoria. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Inmunología, Genética y Metabolismo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Miraglia, María Cruz. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina
Fil: Giambartolomei, Guillermo Hernán. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Inmunología, Genética y Metabolismo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina - Fuente
- Neuroscience 410 : 264-273 (2019)
- Materia
-
Brucellosis
Central Nervous System
Pathogenesis
Immunology
Nervous System Diseases
Brucelosis
Sistema Nervioso Central
Patogénesis
Inmunología
Trastornos del Sistema Nervioso - Nivel de accesibilidad
- acceso restringido
- Condiciones de uso
- Repositorio
- Institución
- Instituto Nacional de Tecnología Agropecuaria
- OAI Identificador
- oai:localhost:20.500.12123/6331
Ver los metadatos del registro completo
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Immune mediators of pathology in neurobrucellosis: from blood to central nervous systemRodriguez, Ana MaríaDelpino, María VictoriaMiraglia, María CruzGiambartolomei, Guillermo HernánBrucellosisCentral Nervous SystemPathogenesisImmunologyNervous System DiseasesBrucelosisSistema Nervioso CentralPatogénesisInmunologíaTrastornos del Sistema NerviosoNeurobrucellosis, which is the most morbid form of brucellosis disease, presents with inflammatory signs and symptoms. Recent experimental evidence clearly indicates that deregulation of astrocytes and microglia caused by Brucella infection creates a microenvironment in the central nervous system (CNS) in which secretion of pro-inflammatory mediators lead to destabilization of the glial structure, the damage of the blood brain barrier (BBB) and neuronal demise. This review of Brucella interactions with cells of the CNS and the BBB is intended to present recent immunological findings that can explain, at least in part, the basis for the inflammatory pathogenesis of the nervous system that takes place upon Brucella infection.Instituto de VirologíaFil: Rodriguez, Ana María. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Inmunología, Genética y Metabolismo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Delpino, María Victoria. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Inmunología, Genética y Metabolismo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Miraglia, María Cruz. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; ArgentinaFil: Giambartolomei, Guillermo Hernán. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Inmunología, Genética y Metabolismo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier2019-11-19T13:46:04Z2019-11-19T13:46:04Z2019-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://www.sciencedirect.com/science/article/pii/S0306452219303343?via%3Dihubhttp://hdl.handle.net/20.500.12123/63310306-4522https://doi.org/10.1016/j.neuroscience.2019.05.018Neuroscience 410 : 264-273 (2019)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccess2025-09-04T09:48:16Zoai:localhost:20.500.12123/6331instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-04 09:48:17.071INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse |
dc.title.none.fl_str_mv |
Immune mediators of pathology in neurobrucellosis: from blood to central nervous system |
title |
Immune mediators of pathology in neurobrucellosis: from blood to central nervous system |
spellingShingle |
Immune mediators of pathology in neurobrucellosis: from blood to central nervous system Rodriguez, Ana María Brucellosis Central Nervous System Pathogenesis Immunology Nervous System Diseases Brucelosis Sistema Nervioso Central Patogénesis Inmunología Trastornos del Sistema Nervioso |
title_short |
Immune mediators of pathology in neurobrucellosis: from blood to central nervous system |
title_full |
Immune mediators of pathology in neurobrucellosis: from blood to central nervous system |
title_fullStr |
Immune mediators of pathology in neurobrucellosis: from blood to central nervous system |
title_full_unstemmed |
Immune mediators of pathology in neurobrucellosis: from blood to central nervous system |
title_sort |
Immune mediators of pathology in neurobrucellosis: from blood to central nervous system |
dc.creator.none.fl_str_mv |
Rodriguez, Ana María Delpino, María Victoria Miraglia, María Cruz Giambartolomei, Guillermo Hernán |
author |
Rodriguez, Ana María |
author_facet |
Rodriguez, Ana María Delpino, María Victoria Miraglia, María Cruz Giambartolomei, Guillermo Hernán |
author_role |
author |
author2 |
Delpino, María Victoria Miraglia, María Cruz Giambartolomei, Guillermo Hernán |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
Brucellosis Central Nervous System Pathogenesis Immunology Nervous System Diseases Brucelosis Sistema Nervioso Central Patogénesis Inmunología Trastornos del Sistema Nervioso |
topic |
Brucellosis Central Nervous System Pathogenesis Immunology Nervous System Diseases Brucelosis Sistema Nervioso Central Patogénesis Inmunología Trastornos del Sistema Nervioso |
dc.description.none.fl_txt_mv |
Neurobrucellosis, which is the most morbid form of brucellosis disease, presents with inflammatory signs and symptoms. Recent experimental evidence clearly indicates that deregulation of astrocytes and microglia caused by Brucella infection creates a microenvironment in the central nervous system (CNS) in which secretion of pro-inflammatory mediators lead to destabilization of the glial structure, the damage of the blood brain barrier (BBB) and neuronal demise. This review of Brucella interactions with cells of the CNS and the BBB is intended to present recent immunological findings that can explain, at least in part, the basis for the inflammatory pathogenesis of the nervous system that takes place upon Brucella infection. Instituto de Virología Fil: Rodriguez, Ana María. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Inmunología, Genética y Metabolismo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Delpino, María Victoria. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Inmunología, Genética y Metabolismo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Miraglia, María Cruz. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina Fil: Giambartolomei, Guillermo Hernán. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Inmunología, Genética y Metabolismo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
description |
Neurobrucellosis, which is the most morbid form of brucellosis disease, presents with inflammatory signs and symptoms. Recent experimental evidence clearly indicates that deregulation of astrocytes and microglia caused by Brucella infection creates a microenvironment in the central nervous system (CNS) in which secretion of pro-inflammatory mediators lead to destabilization of the glial structure, the damage of the blood brain barrier (BBB) and neuronal demise. This review of Brucella interactions with cells of the CNS and the BBB is intended to present recent immunological findings that can explain, at least in part, the basis for the inflammatory pathogenesis of the nervous system that takes place upon Brucella infection. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-11-19T13:46:04Z 2019-11-19T13:46:04Z 2019-07 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
https://www.sciencedirect.com/science/article/pii/S0306452219303343?via%3Dihub http://hdl.handle.net/20.500.12123/6331 0306-4522 https://doi.org/10.1016/j.neuroscience.2019.05.018 |
url |
https://www.sciencedirect.com/science/article/pii/S0306452219303343?via%3Dihub http://hdl.handle.net/20.500.12123/6331 https://doi.org/10.1016/j.neuroscience.2019.05.018 |
identifier_str_mv |
0306-4522 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/restrictedAccess |
eu_rights_str_mv |
restrictedAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
Neuroscience 410 : 264-273 (2019) reponame:INTA Digital (INTA) instname:Instituto Nacional de Tecnología Agropecuaria |
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INTA Digital (INTA) |
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INTA Digital (INTA) |
instname_str |
Instituto Nacional de Tecnología Agropecuaria |
repository.name.fl_str_mv |
INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria |
repository.mail.fl_str_mv |
tripaldi.nicolas@inta.gob.ar |
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