Key Aspects to Consider about Beneficial and Harmful Effects on the Central Nervous System by the Endocannabinoid Modulation Linked to New Cardiovascular Therapies

Autores
Martín Giménez, Virna Margarita; Mocayar Maron, Feres Jose; Kassuha, Diego Enrique; Ferder, Leon Fernando; Manucha, Walter Ariel Fernando
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The endocannabinoid system (ECS) is closely related to the central nervous system (CNS) and exerts a promising therapeutic potential on the cardiovascular system, mainly through its neuromodulatory, neuroprotective, and neuroinflammatory effects. For this reason, when designing new treatments for different cardiovascular pathologies, it is necessary to consider the side effects that such therapies can cause at the neurological level. ObjectiveTo deepens the knowledge of each cannabinoid (CB) and the molecular mechanisms that can lead to undesired results to analyze its possible use in cardiovascular therapy.MethodsThe present review analyzes the psychoactive consequences of anandamide and other similar substances such as other endocannabinoids, phytocannabinoids, and synthetic cannabinoids, to assess their little-explored therapeutic potential in clinical investigations. Finally, the major behavioral tests most used until the moment to predict possible changes in the conduct of animals treated with various substances of cannabinoid nature are summarized. It has been observed that endocannabinoids have few adverse central nervous effects, unlike the phytocannabinoids, synthetic cannabinoids and antagonists of CB receptors. These molecules act on typical receptors due to a similar spatial configuration; however, their structure is not identical between them. For this reason, the competition and displacement of endogenous ligands of the ECS by exogenous cannabinoids provokes an alteration in the CNS normal functioning, leading to the associated side effects. An exhaustive analysis of each cannabinoid and the molecular mechanisms that can lead to undesired results is necessary at the time of proposing them as news cardiovascular therapeutic alternatives.
Fil: Martín Giménez, Virna Margarita. Universidad Catolica de Cuyo - Sede San Juan. Facultad de Ciencias de la Alimentación, Bioquímicas y Farmacéuticas. Instituto de Investigación en Ciencias Químicas; Argentina
Fil: Mocayar Maron, Feres Jose. Universidad Nacional de Cuyo.Facultad de Ciencias Médicas; Argentina
Fil: Kassuha, Diego Enrique. Universidad Catolica de Cuyo - Sede San Juan. Facultad de Ciencias de la Alimentación, Bioquímicas y Farmacéuticas. Instituto de Investigación en Ciencias Químicas; Argentina
Fil: Ferder, Leon Fernando. Universidad de Miami; Estados Unidos
Fil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
Materia
ENDOCANNABINOIDS
ANANDAMIDE
CENTRAL NERVOUS SYSTEM
BEHAVIORAL TESTS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/118469
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Key Aspects to Consider about Beneficial and Harmful Effects on the Central Nervous System by the Endocannabinoid Modulation Linked to New Cardiovascular TherapiesMartín Giménez, Virna MargaritaMocayar Maron, Feres JoseKassuha, Diego EnriqueFerder, Leon FernandoManucha, Walter Ariel FernandoENDOCANNABINOIDSANANDAMIDECENTRAL NERVOUS SYSTEMBEHAVIORAL TESTShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The endocannabinoid system (ECS) is closely related to the central nervous system (CNS) and exerts a promising therapeutic potential on the cardiovascular system, mainly through its neuromodulatory, neuroprotective, and neuroinflammatory effects. For this reason, when designing new treatments for different cardiovascular pathologies, it is necessary to consider the side effects that such therapies can cause at the neurological level. ObjectiveTo deepens the knowledge of each cannabinoid (CB) and the molecular mechanisms that can lead to undesired results to analyze its possible use in cardiovascular therapy.MethodsThe present review analyzes the psychoactive consequences of anandamide and other similar substances such as other endocannabinoids, phytocannabinoids, and synthetic cannabinoids, to assess their little-explored therapeutic potential in clinical investigations. Finally, the major behavioral tests most used until the moment to predict possible changes in the conduct of animals treated with various substances of cannabinoid nature are summarized. It has been observed that endocannabinoids have few adverse central nervous effects, unlike the phytocannabinoids, synthetic cannabinoids and antagonists of CB receptors. These molecules act on typical receptors due to a similar spatial configuration; however, their structure is not identical between them. For this reason, the competition and displacement of endogenous ligands of the ECS by exogenous cannabinoids provokes an alteration in the CNS normal functioning, leading to the associated side effects. An exhaustive analysis of each cannabinoid and the molecular mechanisms that can lead to undesired results is necessary at the time of proposing them as news cardiovascular therapeutic alternatives.Fil: Martín Giménez, Virna Margarita. Universidad Catolica de Cuyo - Sede San Juan. Facultad de Ciencias de la Alimentación, Bioquímicas y Farmacéuticas. Instituto de Investigación en Ciencias Químicas; ArgentinaFil: Mocayar Maron, Feres Jose. Universidad Nacional de Cuyo.Facultad de Ciencias Médicas; ArgentinaFil: Kassuha, Diego Enrique. Universidad Catolica de Cuyo - Sede San Juan. Facultad de Ciencias de la Alimentación, Bioquímicas y Farmacéuticas. Instituto de Investigación en Ciencias Químicas; ArgentinaFil: Ferder, Leon Fernando. Universidad de Miami; Estados UnidosFil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; ArgentinaRemedy Publications2019-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/118469Martín Giménez, Virna Margarita; Mocayar Maron, Feres Jose; Kassuha, Diego Enrique; Ferder, Leon Fernando; Manucha, Walter Ariel Fernando; Key Aspects to Consider about Beneficial and Harmful Effects on the Central Nervous System by the Endocannabinoid Modulation Linked to New Cardiovascular Therapies; Remedy Publications; Annals of Pharmacology and Pharmaceutics; 4; 2; 12-2019; 1-102573-6051CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.remedypublications.com/annals-of-pharmacology-and-pharmaceutics-abstract.php?aid=5519info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:04:36Zoai:ri.conicet.gov.ar:11336/118469instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:04:36.369CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Key Aspects to Consider about Beneficial and Harmful Effects on the Central Nervous System by the Endocannabinoid Modulation Linked to New Cardiovascular Therapies
title Key Aspects to Consider about Beneficial and Harmful Effects on the Central Nervous System by the Endocannabinoid Modulation Linked to New Cardiovascular Therapies
spellingShingle Key Aspects to Consider about Beneficial and Harmful Effects on the Central Nervous System by the Endocannabinoid Modulation Linked to New Cardiovascular Therapies
Martín Giménez, Virna Margarita
ENDOCANNABINOIDS
ANANDAMIDE
CENTRAL NERVOUS SYSTEM
BEHAVIORAL TESTS
title_short Key Aspects to Consider about Beneficial and Harmful Effects on the Central Nervous System by the Endocannabinoid Modulation Linked to New Cardiovascular Therapies
title_full Key Aspects to Consider about Beneficial and Harmful Effects on the Central Nervous System by the Endocannabinoid Modulation Linked to New Cardiovascular Therapies
title_fullStr Key Aspects to Consider about Beneficial and Harmful Effects on the Central Nervous System by the Endocannabinoid Modulation Linked to New Cardiovascular Therapies
title_full_unstemmed Key Aspects to Consider about Beneficial and Harmful Effects on the Central Nervous System by the Endocannabinoid Modulation Linked to New Cardiovascular Therapies
title_sort Key Aspects to Consider about Beneficial and Harmful Effects on the Central Nervous System by the Endocannabinoid Modulation Linked to New Cardiovascular Therapies
dc.creator.none.fl_str_mv Martín Giménez, Virna Margarita
Mocayar Maron, Feres Jose
Kassuha, Diego Enrique
Ferder, Leon Fernando
Manucha, Walter Ariel Fernando
author Martín Giménez, Virna Margarita
author_facet Martín Giménez, Virna Margarita
Mocayar Maron, Feres Jose
Kassuha, Diego Enrique
Ferder, Leon Fernando
Manucha, Walter Ariel Fernando
author_role author
author2 Mocayar Maron, Feres Jose
Kassuha, Diego Enrique
Ferder, Leon Fernando
Manucha, Walter Ariel Fernando
author2_role author
author
author
author
dc.subject.none.fl_str_mv ENDOCANNABINOIDS
ANANDAMIDE
CENTRAL NERVOUS SYSTEM
BEHAVIORAL TESTS
topic ENDOCANNABINOIDS
ANANDAMIDE
CENTRAL NERVOUS SYSTEM
BEHAVIORAL TESTS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The endocannabinoid system (ECS) is closely related to the central nervous system (CNS) and exerts a promising therapeutic potential on the cardiovascular system, mainly through its neuromodulatory, neuroprotective, and neuroinflammatory effects. For this reason, when designing new treatments for different cardiovascular pathologies, it is necessary to consider the side effects that such therapies can cause at the neurological level. ObjectiveTo deepens the knowledge of each cannabinoid (CB) and the molecular mechanisms that can lead to undesired results to analyze its possible use in cardiovascular therapy.MethodsThe present review analyzes the psychoactive consequences of anandamide and other similar substances such as other endocannabinoids, phytocannabinoids, and synthetic cannabinoids, to assess their little-explored therapeutic potential in clinical investigations. Finally, the major behavioral tests most used until the moment to predict possible changes in the conduct of animals treated with various substances of cannabinoid nature are summarized. It has been observed that endocannabinoids have few adverse central nervous effects, unlike the phytocannabinoids, synthetic cannabinoids and antagonists of CB receptors. These molecules act on typical receptors due to a similar spatial configuration; however, their structure is not identical between them. For this reason, the competition and displacement of endogenous ligands of the ECS by exogenous cannabinoids provokes an alteration in the CNS normal functioning, leading to the associated side effects. An exhaustive analysis of each cannabinoid and the molecular mechanisms that can lead to undesired results is necessary at the time of proposing them as news cardiovascular therapeutic alternatives.
Fil: Martín Giménez, Virna Margarita. Universidad Catolica de Cuyo - Sede San Juan. Facultad de Ciencias de la Alimentación, Bioquímicas y Farmacéuticas. Instituto de Investigación en Ciencias Químicas; Argentina
Fil: Mocayar Maron, Feres Jose. Universidad Nacional de Cuyo.Facultad de Ciencias Médicas; Argentina
Fil: Kassuha, Diego Enrique. Universidad Catolica de Cuyo - Sede San Juan. Facultad de Ciencias de la Alimentación, Bioquímicas y Farmacéuticas. Instituto de Investigación en Ciencias Químicas; Argentina
Fil: Ferder, Leon Fernando. Universidad de Miami; Estados Unidos
Fil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
description The endocannabinoid system (ECS) is closely related to the central nervous system (CNS) and exerts a promising therapeutic potential on the cardiovascular system, mainly through its neuromodulatory, neuroprotective, and neuroinflammatory effects. For this reason, when designing new treatments for different cardiovascular pathologies, it is necessary to consider the side effects that such therapies can cause at the neurological level. ObjectiveTo deepens the knowledge of each cannabinoid (CB) and the molecular mechanisms that can lead to undesired results to analyze its possible use in cardiovascular therapy.MethodsThe present review analyzes the psychoactive consequences of anandamide and other similar substances such as other endocannabinoids, phytocannabinoids, and synthetic cannabinoids, to assess their little-explored therapeutic potential in clinical investigations. Finally, the major behavioral tests most used until the moment to predict possible changes in the conduct of animals treated with various substances of cannabinoid nature are summarized. It has been observed that endocannabinoids have few adverse central nervous effects, unlike the phytocannabinoids, synthetic cannabinoids and antagonists of CB receptors. These molecules act on typical receptors due to a similar spatial configuration; however, their structure is not identical between them. For this reason, the competition and displacement of endogenous ligands of the ECS by exogenous cannabinoids provokes an alteration in the CNS normal functioning, leading to the associated side effects. An exhaustive analysis of each cannabinoid and the molecular mechanisms that can lead to undesired results is necessary at the time of proposing them as news cardiovascular therapeutic alternatives.
publishDate 2019
dc.date.none.fl_str_mv 2019-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/118469
Martín Giménez, Virna Margarita; Mocayar Maron, Feres Jose; Kassuha, Diego Enrique; Ferder, Leon Fernando; Manucha, Walter Ariel Fernando; Key Aspects to Consider about Beneficial and Harmful Effects on the Central Nervous System by the Endocannabinoid Modulation Linked to New Cardiovascular Therapies; Remedy Publications; Annals of Pharmacology and Pharmaceutics; 4; 2; 12-2019; 1-10
2573-6051
CONICET Digital
CONICET
url http://hdl.handle.net/11336/118469
identifier_str_mv Martín Giménez, Virna Margarita; Mocayar Maron, Feres Jose; Kassuha, Diego Enrique; Ferder, Leon Fernando; Manucha, Walter Ariel Fernando; Key Aspects to Consider about Beneficial and Harmful Effects on the Central Nervous System by the Endocannabinoid Modulation Linked to New Cardiovascular Therapies; Remedy Publications; Annals of Pharmacology and Pharmaceutics; 4; 2; 12-2019; 1-10
2573-6051
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.remedypublications.com/annals-of-pharmacology-and-pharmaceutics-abstract.php?aid=5519
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Remedy Publications
publisher.none.fl_str_mv Remedy Publications
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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