Alpha-mannosidosis caused by toxic plants in ruminants of Argentina
- Autores
- Cholich, Luciana Andrea; Martinez, Agustin; Micheloud, Juan Francisco; Pistán, Maria Elena; Garcia, Enrique Nicolas; Robles, Carlos Alejandro; Ortega, Hugo Hector; Gimeno, Eduardo Juan
- Año de publicación
- 2021
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- It is well known that several of the swainsonine-containing plant species found widespread around the world have a negative economic impact in each country. In Argentina, most of the information on the poisonous plant species that produce α-mannosidosis is published in Spanish and thus not available to most English speaking researchers interested in toxic plants. Therefore, the aim of this review is to summarize the information about swainsonine-containing plants in Argentina, which are extensively distributed throughout different ecoregions of the country. To date, five species from three genera have been shown to induce α-mannosidosis in livestock in Argentina: Ipomoea carnea subsp. fi stulosa, Ipomoea hieronymi subsp. calchaquina (Convolvulaceae), Astragalus garbancillo, Astragalus pehuenches (Fabaceae), and Sida rodrigoi (Malvaceae). These species contain the indolizidine alkaloid swainsonine, which inhibits the lysosomal enzyme α-mannosidase and consequently affects glycoprotein metabolism, resulting in partially metabolized sugars. The prolonged consumption of these poisonous plants produces progressive weight loss and clinical signs related to a nervous disorder, characterized by tremors of head and neck, abnormalities of gait, difficulty in standing, ataxia and wide-based stance. Histological lesions are mainly characterized by vacuolation of different cells, especially neurons of the central nervous system. The main animal model used to study α-mannosidosis is the guinea pig because, when experimentally poisoned, it exhibits many of the characteristics of naturally intoxicated livestock.
Estación Experimental Agropecuaria Bariloche
Fil: Cholich, Luciana Andrea. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina
Fil: Cholich, Luciana Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Martinez, Agustin. Instituto Nacional de Tecnologia Agropecuaria (INTA). Estacion Experimental Agropecuaria Bariloche. Grupo de Sanidad Animal; Argentina
Fil: Micheloud, Juan Francisco. Universidad Católica de Salta. Facultad de Ciencias Veterinarias y Agronomía; Argentina
Fil: Micheloud, Juan Francisco. Instituto Nacional de Tecnologia Agropecuaria (INTA). Instituto de Investigación Animal del Chaco Semiárido. Área de Sanidad Animal; Argentina
Fil: Pistán, Maria Elena. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina
Fil: Garcia, Enrique Nicolas. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina
Fil: Robles, Carlos Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Grupo de Sanidad Animal; Argentina
Fil: Ortega, Hugo Hector. Universidad Nacional del Litoral. Instituto de Ciencias Veterinarias del Litoral; Argentina
Fil: Ortega, Hugo Hector. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gimeno, Eduardo Juan. Universidad Nacional de la Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Gimeno, Eduardo Juan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina - Fuente
- Anais da Academia Brasileira de Ciencias 93 (sup. 3) : e20191496 (2021)
- Materia
-
Plantas Tóxicas
Inmunodeficiencia
Astragalus
Envenenamiento
Poisonous Plants
Immunodeficiency
Poisoning
Swainsonine
Alfa-manosidosis - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Instituto Nacional de Tecnología Agropecuaria
- OAI Identificador
- oai:localhost:20.500.12123/10720
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Alpha-mannosidosis caused by toxic plants in ruminants of ArgentinaCholich, Luciana AndreaMartinez, AgustinMicheloud, Juan FranciscoPistán, Maria ElenaGarcia, Enrique NicolasRobles, Carlos AlejandroOrtega, Hugo HectorGimeno, Eduardo JuanPlantas TóxicasInmunodeficienciaAstragalusEnvenenamientoPoisonous PlantsImmunodeficiencyPoisoningSwainsonineAlfa-manosidosisIt is well known that several of the swainsonine-containing plant species found widespread around the world have a negative economic impact in each country. In Argentina, most of the information on the poisonous plant species that produce α-mannosidosis is published in Spanish and thus not available to most English speaking researchers interested in toxic plants. Therefore, the aim of this review is to summarize the information about swainsonine-containing plants in Argentina, which are extensively distributed throughout different ecoregions of the country. To date, five species from three genera have been shown to induce α-mannosidosis in livestock in Argentina: Ipomoea carnea subsp. fi stulosa, Ipomoea hieronymi subsp. calchaquina (Convolvulaceae), Astragalus garbancillo, Astragalus pehuenches (Fabaceae), and Sida rodrigoi (Malvaceae). These species contain the indolizidine alkaloid swainsonine, which inhibits the lysosomal enzyme α-mannosidase and consequently affects glycoprotein metabolism, resulting in partially metabolized sugars. The prolonged consumption of these poisonous plants produces progressive weight loss and clinical signs related to a nervous disorder, characterized by tremors of head and neck, abnormalities of gait, difficulty in standing, ataxia and wide-based stance. Histological lesions are mainly characterized by vacuolation of different cells, especially neurons of the central nervous system. The main animal model used to study α-mannosidosis is the guinea pig because, when experimentally poisoned, it exhibits many of the characteristics of naturally intoxicated livestock.Estación Experimental Agropecuaria BarilocheFil: Cholich, Luciana Andrea. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; ArgentinaFil: Cholich, Luciana Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Martinez, Agustin. Instituto Nacional de Tecnologia Agropecuaria (INTA). Estacion Experimental Agropecuaria Bariloche. Grupo de Sanidad Animal; ArgentinaFil: Micheloud, Juan Francisco. Universidad Católica de Salta. Facultad de Ciencias Veterinarias y Agronomía; ArgentinaFil: Micheloud, Juan Francisco. Instituto Nacional de Tecnologia Agropecuaria (INTA). Instituto de Investigación Animal del Chaco Semiárido. Área de Sanidad Animal; ArgentinaFil: Pistán, Maria Elena. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; ArgentinaFil: Garcia, Enrique Nicolas. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; ArgentinaFil: Robles, Carlos Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Grupo de Sanidad Animal; ArgentinaFil: Ortega, Hugo Hector. Universidad Nacional del Litoral. Instituto de Ciencias Veterinarias del Litoral; ArgentinaFil: Ortega, Hugo Hector. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gimeno, Eduardo Juan. Universidad Nacional de la Plata. Facultad de Ciencias Veterinarias; ArgentinaFil: Gimeno, Eduardo Juan. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaAcademia Brasileira de Ciencias2021-11-09T12:06:04Z2021-11-09T12:06:04Z2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/10720https://www.scielo.br/j/aabc/a/phRKSPsNW73QJN8C7jWTjnL/?lang=en0001-37651678-2690https://doi.org/10.1590/0001-3765202120191496Anais da Academia Brasileira de Ciencias 93 (sup. 3) : e20191496 (2021)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repograntAgreement/INTA/PATNOR-1281102/AR./Aportes a la recuperación y desarrollo territorial del semiárido sur de la provincia de Rio Negro.info:eu-repograntAgreement/INTA/PNSA-1115054/AR./Enfermedades parasitarias, infecciosas y tóxico metabólicas que afectan la productividad de los bóvidos para producción de carne y leche.info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-29T13:45:23Zoai:localhost:20.500.12123/10720instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-29 13:45:24.321INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse |
dc.title.none.fl_str_mv |
Alpha-mannosidosis caused by toxic plants in ruminants of Argentina |
title |
Alpha-mannosidosis caused by toxic plants in ruminants of Argentina |
spellingShingle |
Alpha-mannosidosis caused by toxic plants in ruminants of Argentina Cholich, Luciana Andrea Plantas Tóxicas Inmunodeficiencia Astragalus Envenenamiento Poisonous Plants Immunodeficiency Poisoning Swainsonine Alfa-manosidosis |
title_short |
Alpha-mannosidosis caused by toxic plants in ruminants of Argentina |
title_full |
Alpha-mannosidosis caused by toxic plants in ruminants of Argentina |
title_fullStr |
Alpha-mannosidosis caused by toxic plants in ruminants of Argentina |
title_full_unstemmed |
Alpha-mannosidosis caused by toxic plants in ruminants of Argentina |
title_sort |
Alpha-mannosidosis caused by toxic plants in ruminants of Argentina |
dc.creator.none.fl_str_mv |
Cholich, Luciana Andrea Martinez, Agustin Micheloud, Juan Francisco Pistán, Maria Elena Garcia, Enrique Nicolas Robles, Carlos Alejandro Ortega, Hugo Hector Gimeno, Eduardo Juan |
author |
Cholich, Luciana Andrea |
author_facet |
Cholich, Luciana Andrea Martinez, Agustin Micheloud, Juan Francisco Pistán, Maria Elena Garcia, Enrique Nicolas Robles, Carlos Alejandro Ortega, Hugo Hector Gimeno, Eduardo Juan |
author_role |
author |
author2 |
Martinez, Agustin Micheloud, Juan Francisco Pistán, Maria Elena Garcia, Enrique Nicolas Robles, Carlos Alejandro Ortega, Hugo Hector Gimeno, Eduardo Juan |
author2_role |
author author author author author author author |
dc.subject.none.fl_str_mv |
Plantas Tóxicas Inmunodeficiencia Astragalus Envenenamiento Poisonous Plants Immunodeficiency Poisoning Swainsonine Alfa-manosidosis |
topic |
Plantas Tóxicas Inmunodeficiencia Astragalus Envenenamiento Poisonous Plants Immunodeficiency Poisoning Swainsonine Alfa-manosidosis |
dc.description.none.fl_txt_mv |
It is well known that several of the swainsonine-containing plant species found widespread around the world have a negative economic impact in each country. In Argentina, most of the information on the poisonous plant species that produce α-mannosidosis is published in Spanish and thus not available to most English speaking researchers interested in toxic plants. Therefore, the aim of this review is to summarize the information about swainsonine-containing plants in Argentina, which are extensively distributed throughout different ecoregions of the country. To date, five species from three genera have been shown to induce α-mannosidosis in livestock in Argentina: Ipomoea carnea subsp. fi stulosa, Ipomoea hieronymi subsp. calchaquina (Convolvulaceae), Astragalus garbancillo, Astragalus pehuenches (Fabaceae), and Sida rodrigoi (Malvaceae). These species contain the indolizidine alkaloid swainsonine, which inhibits the lysosomal enzyme α-mannosidase and consequently affects glycoprotein metabolism, resulting in partially metabolized sugars. The prolonged consumption of these poisonous plants produces progressive weight loss and clinical signs related to a nervous disorder, characterized by tremors of head and neck, abnormalities of gait, difficulty in standing, ataxia and wide-based stance. Histological lesions are mainly characterized by vacuolation of different cells, especially neurons of the central nervous system. The main animal model used to study α-mannosidosis is the guinea pig because, when experimentally poisoned, it exhibits many of the characteristics of naturally intoxicated livestock. Estación Experimental Agropecuaria Bariloche Fil: Cholich, Luciana Andrea. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina Fil: Cholich, Luciana Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Martinez, Agustin. Instituto Nacional de Tecnologia Agropecuaria (INTA). Estacion Experimental Agropecuaria Bariloche. Grupo de Sanidad Animal; Argentina Fil: Micheloud, Juan Francisco. Universidad Católica de Salta. Facultad de Ciencias Veterinarias y Agronomía; Argentina Fil: Micheloud, Juan Francisco. Instituto Nacional de Tecnologia Agropecuaria (INTA). Instituto de Investigación Animal del Chaco Semiárido. Área de Sanidad Animal; Argentina Fil: Pistán, Maria Elena. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina Fil: Garcia, Enrique Nicolas. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina Fil: Robles, Carlos Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Grupo de Sanidad Animal; Argentina Fil: Ortega, Hugo Hector. Universidad Nacional del Litoral. Instituto de Ciencias Veterinarias del Litoral; Argentina Fil: Ortega, Hugo Hector. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Gimeno, Eduardo Juan. Universidad Nacional de la Plata. Facultad de Ciencias Veterinarias; Argentina Fil: Gimeno, Eduardo Juan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
description |
It is well known that several of the swainsonine-containing plant species found widespread around the world have a negative economic impact in each country. In Argentina, most of the information on the poisonous plant species that produce α-mannosidosis is published in Spanish and thus not available to most English speaking researchers interested in toxic plants. Therefore, the aim of this review is to summarize the information about swainsonine-containing plants in Argentina, which are extensively distributed throughout different ecoregions of the country. To date, five species from three genera have been shown to induce α-mannosidosis in livestock in Argentina: Ipomoea carnea subsp. fi stulosa, Ipomoea hieronymi subsp. calchaquina (Convolvulaceae), Astragalus garbancillo, Astragalus pehuenches (Fabaceae), and Sida rodrigoi (Malvaceae). These species contain the indolizidine alkaloid swainsonine, which inhibits the lysosomal enzyme α-mannosidase and consequently affects glycoprotein metabolism, resulting in partially metabolized sugars. The prolonged consumption of these poisonous plants produces progressive weight loss and clinical signs related to a nervous disorder, characterized by tremors of head and neck, abnormalities of gait, difficulty in standing, ataxia and wide-based stance. Histological lesions are mainly characterized by vacuolation of different cells, especially neurons of the central nervous system. The main animal model used to study α-mannosidosis is the guinea pig because, when experimentally poisoned, it exhibits many of the characteristics of naturally intoxicated livestock. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-11-09T12:06:04Z 2021-11-09T12:06:04Z 2021 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/20.500.12123/10720 https://www.scielo.br/j/aabc/a/phRKSPsNW73QJN8C7jWTjnL/?lang=en 0001-3765 1678-2690 https://doi.org/10.1590/0001-3765202120191496 |
url |
http://hdl.handle.net/20.500.12123/10720 https://www.scielo.br/j/aabc/a/phRKSPsNW73QJN8C7jWTjnL/?lang=en https://doi.org/10.1590/0001-3765202120191496 |
identifier_str_mv |
0001-3765 1678-2690 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repograntAgreement/INTA/PATNOR-1281102/AR./Aportes a la recuperación y desarrollo territorial del semiárido sur de la provincia de Rio Negro. info:eu-repograntAgreement/INTA/PNSA-1115054/AR./Enfermedades parasitarias, infecciosas y tóxico metabólicas que afectan la productividad de los bóvidos para producción de carne y leche. |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Ciencias |
publisher.none.fl_str_mv |
Academia Brasileira de Ciencias |
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Anais da Academia Brasileira de Ciencias 93 (sup. 3) : e20191496 (2021) reponame:INTA Digital (INTA) instname:Instituto Nacional de Tecnología Agropecuaria |
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Instituto Nacional de Tecnología Agropecuaria |
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INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria |
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tripaldi.nicolas@inta.gob.ar |
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