Alpha-mannosidosis caused by toxic plants in ruminants of Argentina

Autores
Cholich, Luciana Andrea; Martinez, Agustin; Micheloud, Juan Francisco; Pistán, Maria Elena; Garcia, Enrique Nicolas; Robles, Carlos Alejandro; Ortega, Hugo Hector; Gimeno, Eduardo Juan
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
It is well known that several of the swainsonine-containing plant species found widespread around the world have a negative economic impact in each country. In Argentina, most of the information on the poisonous plant species that produce α-mannosidosis is published in Spanish and thus not available to most English speaking researchers interested in toxic plants. Therefore, the aim of this review is to summarize the information about swainsonine-containing plants in Argentina, which are extensively distributed throughout different ecoregions of the country. To date, five species from three genera have been shown to induce α-mannosidosis in livestock in Argentina: Ipomoea carnea subsp. fi stulosa, Ipomoea hieronymi subsp. calchaquina (Convolvulaceae), Astragalus garbancillo, Astragalus pehuenches (Fabaceae), and Sida rodrigoi (Malvaceae). These species contain the indolizidine alkaloid swainsonine, which inhibits the lysosomal enzyme α-mannosidase and consequently affects glycoprotein metabolism, resulting in partially metabolized sugars. The prolonged consumption of these poisonous plants produces progressive weight loss and clinical signs related to a nervous disorder, characterized by tremors of head and neck, abnormalities of gait, difficulty in standing, ataxia and wide-based stance. Histological lesions are mainly characterized by vacuolation of different cells, especially neurons of the central nervous system. The main animal model used to study α-mannosidosis is the guinea pig because, when experimentally poisoned, it exhibits many of the characteristics of naturally intoxicated livestock.
Estación Experimental Agropecuaria Bariloche
Fil: Cholich, Luciana Andrea. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina
Fil: Cholich, Luciana Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Martinez, Agustin. Instituto Nacional de Tecnologia Agropecuaria (INTA). Estacion Experimental Agropecuaria Bariloche. Grupo de Sanidad Animal; Argentina
Fil: Micheloud, Juan Francisco. Universidad Católica de Salta. Facultad de Ciencias Veterinarias y Agronomía; Argentina
Fil: Micheloud, Juan Francisco. Instituto Nacional de Tecnologia Agropecuaria (INTA). Instituto de Investigación Animal del Chaco Semiárido. Área de Sanidad Animal; Argentina
Fil: Pistán, Maria Elena. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina
Fil: Garcia, Enrique Nicolas. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina
Fil: Robles, Carlos Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Grupo de Sanidad Animal; Argentina
Fil: Ortega, Hugo Hector. Universidad Nacional del Litoral. Instituto de Ciencias Veterinarias del Litoral; Argentina
Fil: Ortega, Hugo Hector. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gimeno, Eduardo Juan. Universidad Nacional de la Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Gimeno, Eduardo Juan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fuente
Anais da Academia Brasileira de Ciencias 93 (sup. 3) : e20191496 (2021)
Materia
Plantas Tóxicas
Inmunodeficiencia
Astragalus
Envenenamiento
Poisonous Plants
Immunodeficiency
Poisoning
Swainsonine
Alfa-manosidosis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/10720

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oai_identifier_str oai:localhost:20.500.12123/10720
network_acronym_str INTADig
repository_id_str l
network_name_str INTA Digital (INTA)
spelling Alpha-mannosidosis caused by toxic plants in ruminants of ArgentinaCholich, Luciana AndreaMartinez, AgustinMicheloud, Juan FranciscoPistán, Maria ElenaGarcia, Enrique NicolasRobles, Carlos AlejandroOrtega, Hugo HectorGimeno, Eduardo JuanPlantas TóxicasInmunodeficienciaAstragalusEnvenenamientoPoisonous PlantsImmunodeficiencyPoisoningSwainsonineAlfa-manosidosisIt is well known that several of the swainsonine-containing plant species found widespread around the world have a negative economic impact in each country. In Argentina, most of the information on the poisonous plant species that produce α-mannosidosis is published in Spanish and thus not available to most English speaking researchers interested in toxic plants. Therefore, the aim of this review is to summarize the information about swainsonine-containing plants in Argentina, which are extensively distributed throughout different ecoregions of the country. To date, five species from three genera have been shown to induce α-mannosidosis in livestock in Argentina: Ipomoea carnea subsp. fi stulosa, Ipomoea hieronymi subsp. calchaquina (Convolvulaceae), Astragalus garbancillo, Astragalus pehuenches (Fabaceae), and Sida rodrigoi (Malvaceae). These species contain the indolizidine alkaloid swainsonine, which inhibits the lysosomal enzyme α-mannosidase and consequently affects glycoprotein metabolism, resulting in partially metabolized sugars. The prolonged consumption of these poisonous plants produces progressive weight loss and clinical signs related to a nervous disorder, characterized by tremors of head and neck, abnormalities of gait, difficulty in standing, ataxia and wide-based stance. Histological lesions are mainly characterized by vacuolation of different cells, especially neurons of the central nervous system. The main animal model used to study α-mannosidosis is the guinea pig because, when experimentally poisoned, it exhibits many of the characteristics of naturally intoxicated livestock.Estación Experimental Agropecuaria BarilocheFil: Cholich, Luciana Andrea. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; ArgentinaFil: Cholich, Luciana Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Martinez, Agustin. Instituto Nacional de Tecnologia Agropecuaria (INTA). Estacion Experimental Agropecuaria Bariloche. Grupo de Sanidad Animal; ArgentinaFil: Micheloud, Juan Francisco. Universidad Católica de Salta. Facultad de Ciencias Veterinarias y Agronomía; ArgentinaFil: Micheloud, Juan Francisco. Instituto Nacional de Tecnologia Agropecuaria (INTA). Instituto de Investigación Animal del Chaco Semiárido. Área de Sanidad Animal; ArgentinaFil: Pistán, Maria Elena. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; ArgentinaFil: Garcia, Enrique Nicolas. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; ArgentinaFil: Robles, Carlos Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Grupo de Sanidad Animal; ArgentinaFil: Ortega, Hugo Hector. Universidad Nacional del Litoral. Instituto de Ciencias Veterinarias del Litoral; ArgentinaFil: Ortega, Hugo Hector. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gimeno, Eduardo Juan. Universidad Nacional de la Plata. Facultad de Ciencias Veterinarias; ArgentinaFil: Gimeno, Eduardo Juan. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaAcademia Brasileira de Ciencias2021-11-09T12:06:04Z2021-11-09T12:06:04Z2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/10720https://www.scielo.br/j/aabc/a/phRKSPsNW73QJN8C7jWTjnL/?lang=en0001-37651678-2690https://doi.org/10.1590/0001-3765202120191496Anais da Academia Brasileira de Ciencias 93 (sup. 3) : e20191496 (2021)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repograntAgreement/INTA/PATNOR-1281102/AR./Aportes a la recuperación y desarrollo territorial del semiárido sur de la provincia de Rio Negro.info:eu-repograntAgreement/INTA/PNSA-1115054/AR./Enfermedades parasitarias, infecciosas y tóxico metabólicas que afectan la productividad de los bóvidos para producción de carne y leche.info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-29T13:45:23Zoai:localhost:20.500.12123/10720instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-29 13:45:24.321INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Alpha-mannosidosis caused by toxic plants in ruminants of Argentina
title Alpha-mannosidosis caused by toxic plants in ruminants of Argentina
spellingShingle Alpha-mannosidosis caused by toxic plants in ruminants of Argentina
Cholich, Luciana Andrea
Plantas Tóxicas
Inmunodeficiencia
Astragalus
Envenenamiento
Poisonous Plants
Immunodeficiency
Poisoning
Swainsonine
Alfa-manosidosis
title_short Alpha-mannosidosis caused by toxic plants in ruminants of Argentina
title_full Alpha-mannosidosis caused by toxic plants in ruminants of Argentina
title_fullStr Alpha-mannosidosis caused by toxic plants in ruminants of Argentina
title_full_unstemmed Alpha-mannosidosis caused by toxic plants in ruminants of Argentina
title_sort Alpha-mannosidosis caused by toxic plants in ruminants of Argentina
dc.creator.none.fl_str_mv Cholich, Luciana Andrea
Martinez, Agustin
Micheloud, Juan Francisco
Pistán, Maria Elena
Garcia, Enrique Nicolas
Robles, Carlos Alejandro
Ortega, Hugo Hector
Gimeno, Eduardo Juan
author Cholich, Luciana Andrea
author_facet Cholich, Luciana Andrea
Martinez, Agustin
Micheloud, Juan Francisco
Pistán, Maria Elena
Garcia, Enrique Nicolas
Robles, Carlos Alejandro
Ortega, Hugo Hector
Gimeno, Eduardo Juan
author_role author
author2 Martinez, Agustin
Micheloud, Juan Francisco
Pistán, Maria Elena
Garcia, Enrique Nicolas
Robles, Carlos Alejandro
Ortega, Hugo Hector
Gimeno, Eduardo Juan
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Plantas Tóxicas
Inmunodeficiencia
Astragalus
Envenenamiento
Poisonous Plants
Immunodeficiency
Poisoning
Swainsonine
Alfa-manosidosis
topic Plantas Tóxicas
Inmunodeficiencia
Astragalus
Envenenamiento
Poisonous Plants
Immunodeficiency
Poisoning
Swainsonine
Alfa-manosidosis
dc.description.none.fl_txt_mv It is well known that several of the swainsonine-containing plant species found widespread around the world have a negative economic impact in each country. In Argentina, most of the information on the poisonous plant species that produce α-mannosidosis is published in Spanish and thus not available to most English speaking researchers interested in toxic plants. Therefore, the aim of this review is to summarize the information about swainsonine-containing plants in Argentina, which are extensively distributed throughout different ecoregions of the country. To date, five species from three genera have been shown to induce α-mannosidosis in livestock in Argentina: Ipomoea carnea subsp. fi stulosa, Ipomoea hieronymi subsp. calchaquina (Convolvulaceae), Astragalus garbancillo, Astragalus pehuenches (Fabaceae), and Sida rodrigoi (Malvaceae). These species contain the indolizidine alkaloid swainsonine, which inhibits the lysosomal enzyme α-mannosidase and consequently affects glycoprotein metabolism, resulting in partially metabolized sugars. The prolonged consumption of these poisonous plants produces progressive weight loss and clinical signs related to a nervous disorder, characterized by tremors of head and neck, abnormalities of gait, difficulty in standing, ataxia and wide-based stance. Histological lesions are mainly characterized by vacuolation of different cells, especially neurons of the central nervous system. The main animal model used to study α-mannosidosis is the guinea pig because, when experimentally poisoned, it exhibits many of the characteristics of naturally intoxicated livestock.
Estación Experimental Agropecuaria Bariloche
Fil: Cholich, Luciana Andrea. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina
Fil: Cholich, Luciana Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Martinez, Agustin. Instituto Nacional de Tecnologia Agropecuaria (INTA). Estacion Experimental Agropecuaria Bariloche. Grupo de Sanidad Animal; Argentina
Fil: Micheloud, Juan Francisco. Universidad Católica de Salta. Facultad de Ciencias Veterinarias y Agronomía; Argentina
Fil: Micheloud, Juan Francisco. Instituto Nacional de Tecnologia Agropecuaria (INTA). Instituto de Investigación Animal del Chaco Semiárido. Área de Sanidad Animal; Argentina
Fil: Pistán, Maria Elena. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina
Fil: Garcia, Enrique Nicolas. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina
Fil: Robles, Carlos Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Grupo de Sanidad Animal; Argentina
Fil: Ortega, Hugo Hector. Universidad Nacional del Litoral. Instituto de Ciencias Veterinarias del Litoral; Argentina
Fil: Ortega, Hugo Hector. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gimeno, Eduardo Juan. Universidad Nacional de la Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Gimeno, Eduardo Juan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description It is well known that several of the swainsonine-containing plant species found widespread around the world have a negative economic impact in each country. In Argentina, most of the information on the poisonous plant species that produce α-mannosidosis is published in Spanish and thus not available to most English speaking researchers interested in toxic plants. Therefore, the aim of this review is to summarize the information about swainsonine-containing plants in Argentina, which are extensively distributed throughout different ecoregions of the country. To date, five species from three genera have been shown to induce α-mannosidosis in livestock in Argentina: Ipomoea carnea subsp. fi stulosa, Ipomoea hieronymi subsp. calchaquina (Convolvulaceae), Astragalus garbancillo, Astragalus pehuenches (Fabaceae), and Sida rodrigoi (Malvaceae). These species contain the indolizidine alkaloid swainsonine, which inhibits the lysosomal enzyme α-mannosidase and consequently affects glycoprotein metabolism, resulting in partially metabolized sugars. The prolonged consumption of these poisonous plants produces progressive weight loss and clinical signs related to a nervous disorder, characterized by tremors of head and neck, abnormalities of gait, difficulty in standing, ataxia and wide-based stance. Histological lesions are mainly characterized by vacuolation of different cells, especially neurons of the central nervous system. The main animal model used to study α-mannosidosis is the guinea pig because, when experimentally poisoned, it exhibits many of the characteristics of naturally intoxicated livestock.
publishDate 2021
dc.date.none.fl_str_mv 2021-11-09T12:06:04Z
2021-11-09T12:06:04Z
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/10720
https://www.scielo.br/j/aabc/a/phRKSPsNW73QJN8C7jWTjnL/?lang=en
0001-3765
1678-2690
https://doi.org/10.1590/0001-3765202120191496
url http://hdl.handle.net/20.500.12123/10720
https://www.scielo.br/j/aabc/a/phRKSPsNW73QJN8C7jWTjnL/?lang=en
https://doi.org/10.1590/0001-3765202120191496
identifier_str_mv 0001-3765
1678-2690
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repograntAgreement/INTA/PATNOR-1281102/AR./Aportes a la recuperación y desarrollo territorial del semiárido sur de la provincia de Rio Negro.
info:eu-repograntAgreement/INTA/PNSA-1115054/AR./Enfermedades parasitarias, infecciosas y tóxico metabólicas que afectan la productividad de los bóvidos para producción de carne y leche.
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Academia Brasileira de Ciencias
publisher.none.fl_str_mv Academia Brasileira de Ciencias
dc.source.none.fl_str_mv Anais da Academia Brasileira de Ciencias 93 (sup. 3) : e20191496 (2021)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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