Recombinant veterinary vaccines against rabies : state of art and perspectives

Autores
Del Medico Zajac, Maria Paula; Garanzini, Debora Patricia; Perez, Oscar; Calamante, Gabriela
Año de publicación
2020
Idioma
inglés
Tipo de recurso
parte de libro
Estado
versión publicada
Descripción
The “One Health” concept summarized the idea that the health both of human and animal is interdependent and is bound to the health of the ecosystems in which they exist. This notion is supported and implemented by the World Organization for Animal Health to understand risks for human and animal health (including companion animals, livestock and wildlife) and ecosystem health as a whole. In this context, the best strategy to control zoonotic pathogens (transmitted by domestic or wild animals to humans and vice versa) is vaccination of the animal source, together with an adequate epidemiological surveillance program. Rabies is a zoonotic disease that affects humans, wildlife, companion animals, and livestock. Even though there are pre- and postrabies exposure treatments available for humans, it is more cost-effective over the long term to eliminate rabies in its natural terrestrial reservoirs. Currently, dogs are vaccinated with conventional inactivated vaccines while a viral vector–based vaccine (canarypox virus) is being used for cats. Several countries from the northern hemisphere control the sylvatic rabies reservoirs (coyotes, red foxes, raccoon dogs, and raccoons) using attenuated rabies vaccines or recombinant viral-vectored vaccines (based on vaccinia virus or human adenovirus). Lastly, vaccination of calves, horses, and other domestic livestock species (African and South American camels, goats, and pigs) is performed with inactivated conventional vaccines. Inactivated vaccines against rabies are effective but present several disadvantages such as uncertain antigen composition, manipulation of the pathogen during the vaccine manufacturing, need of cold chain during storage, and transportation and inability to differentiate vaccinated from infected animals. To overcome these inconveniences, the actual tendency is the rational design of recombinant immunogens (viral-vectored or subunit vaccines) that are safe and efficacious against pathogens. This chapter presents a revision of viral-vectored vaccines against rabies currently used in the veterinary field and the perspectives of new recombinant immunogens.
Instituto de Biotecnología
Fil: Del Medico Zajac, Maria Paula. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina
Fil: Del Medico Zajac, Maria Paula. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Garanzini, Debora Patricia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina
Fil: Garanzini, Debora Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Garanzini, Debora Patricia. Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Producción de Biológicos. Servicio de Vacunas Antirrábicas; Argentina
Fil: Perez, Oscar. Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán”. Instituto Nacional de Producción de Biológicos. Servicio de Vacunas Antirrábicas; Argentina
Fil: Calamante, Gabriela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina
Fil: Calamante, Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fuente
Emerging and Reemerging Viral Pathogens Volume 2 : Applied Virology Approaches Related to Human, Animal and Environmental Pathogens / Edited by: Moulay Mustapha Ennaji. Elsevier, 2020. Chapter 12, p. 225-242
Materia
Synthetic Vaccines
Rabies
Rhabdoviridae
Lyssavirus
Human Diseases
Zoonoses
One Health Approach
Immunogenetics
Vacuna Sintética
Rabia
Enfermedades Humanas
Zoonosis
Enfoque Una Salud
Inmunogenética
Nivel de accesibilidad
acceso restringido
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/23045
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oai_identifier_str oai:localhost:20.500.12123/23045
network_acronym_str INTADig
repository_id_str l
network_name_str INTA Digital (INTA)
spelling Recombinant veterinary vaccines against rabies : state of art and perspectivesDel Medico Zajac, Maria PaulaGaranzini, Debora PatriciaPerez, OscarCalamante, GabrielaSynthetic VaccinesRabiesRhabdoviridaeLyssavirusHuman DiseasesZoonosesOne Health ApproachImmunogeneticsVacuna SintéticaRabiaEnfermedades HumanasZoonosisEnfoque Una SaludInmunogenéticaThe “One Health” concept summarized the idea that the health both of human and animal is interdependent and is bound to the health of the ecosystems in which they exist. This notion is supported and implemented by the World Organization for Animal Health to understand risks for human and animal health (including companion animals, livestock and wildlife) and ecosystem health as a whole. In this context, the best strategy to control zoonotic pathogens (transmitted by domestic or wild animals to humans and vice versa) is vaccination of the animal source, together with an adequate epidemiological surveillance program. Rabies is a zoonotic disease that affects humans, wildlife, companion animals, and livestock. Even though there are pre- and postrabies exposure treatments available for humans, it is more cost-effective over the long term to eliminate rabies in its natural terrestrial reservoirs. Currently, dogs are vaccinated with conventional inactivated vaccines while a viral vector–based vaccine (canarypox virus) is being used for cats. Several countries from the northern hemisphere control the sylvatic rabies reservoirs (coyotes, red foxes, raccoon dogs, and raccoons) using attenuated rabies vaccines or recombinant viral-vectored vaccines (based on vaccinia virus or human adenovirus). Lastly, vaccination of calves, horses, and other domestic livestock species (African and South American camels, goats, and pigs) is performed with inactivated conventional vaccines. Inactivated vaccines against rabies are effective but present several disadvantages such as uncertain antigen composition, manipulation of the pathogen during the vaccine manufacturing, need of cold chain during storage, and transportation and inability to differentiate vaccinated from infected animals. To overcome these inconveniences, the actual tendency is the rational design of recombinant immunogens (viral-vectored or subunit vaccines) that are safe and efficacious against pathogens. This chapter presents a revision of viral-vectored vaccines against rabies currently used in the veterinary field and the perspectives of new recombinant immunogens.Instituto de BiotecnologíaFil: Del Medico Zajac, Maria Paula. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; ArgentinaFil: Del Medico Zajac, Maria Paula. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Garanzini, Debora Patricia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; ArgentinaFil: Garanzini, Debora Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Garanzini, Debora Patricia. Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Producción de Biológicos. Servicio de Vacunas Antirrábicas; ArgentinaFil: Perez, Oscar. Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán”. Instituto Nacional de Producción de Biológicos. Servicio de Vacunas Antirrábicas; ArgentinaFil: Calamante, Gabriela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; ArgentinaFil: Calamante, Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier2025-07-16T14:17:25Z2025-07-16T14:17:25Z2020info:eu-repo/semantics/bookPartinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_3248info:ar-repo/semantics/parteDeLibroapplication/pdfhttp://hdl.handle.net/20.500.12123/23045https://www.sciencedirect.com/science/article/abs/pii/B9780128149669000123978-0-12-814966-9https://doi.org/10.1016/B978-0-12-814966-9.00012-3Emerging and Reemerging Viral Pathogens Volume 2 : Applied Virology Approaches Related to Human, Animal and Environmental Pathogens / Edited by: Moulay Mustapha Ennaji. Elsevier, 2020. Chapter 12, p. 225-242reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-04T09:51:11Zoai:localhost:20.500.12123/23045instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-04 09:51:11.671INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Recombinant veterinary vaccines against rabies : state of art and perspectives
title Recombinant veterinary vaccines against rabies : state of art and perspectives
spellingShingle Recombinant veterinary vaccines against rabies : state of art and perspectives
Del Medico Zajac, Maria Paula
Synthetic Vaccines
Rabies
Rhabdoviridae
Lyssavirus
Human Diseases
Zoonoses
One Health Approach
Immunogenetics
Vacuna Sintética
Rabia
Enfermedades Humanas
Zoonosis
Enfoque Una Salud
Inmunogenética
title_short Recombinant veterinary vaccines against rabies : state of art and perspectives
title_full Recombinant veterinary vaccines against rabies : state of art and perspectives
title_fullStr Recombinant veterinary vaccines against rabies : state of art and perspectives
title_full_unstemmed Recombinant veterinary vaccines against rabies : state of art and perspectives
title_sort Recombinant veterinary vaccines against rabies : state of art and perspectives
dc.creator.none.fl_str_mv Del Medico Zajac, Maria Paula
Garanzini, Debora Patricia
Perez, Oscar
Calamante, Gabriela
author Del Medico Zajac, Maria Paula
author_facet Del Medico Zajac, Maria Paula
Garanzini, Debora Patricia
Perez, Oscar
Calamante, Gabriela
author_role author
author2 Garanzini, Debora Patricia
Perez, Oscar
Calamante, Gabriela
author2_role author
author
author
dc.subject.none.fl_str_mv Synthetic Vaccines
Rabies
Rhabdoviridae
Lyssavirus
Human Diseases
Zoonoses
One Health Approach
Immunogenetics
Vacuna Sintética
Rabia
Enfermedades Humanas
Zoonosis
Enfoque Una Salud
Inmunogenética
topic Synthetic Vaccines
Rabies
Rhabdoviridae
Lyssavirus
Human Diseases
Zoonoses
One Health Approach
Immunogenetics
Vacuna Sintética
Rabia
Enfermedades Humanas
Zoonosis
Enfoque Una Salud
Inmunogenética
dc.description.none.fl_txt_mv The “One Health” concept summarized the idea that the health both of human and animal is interdependent and is bound to the health of the ecosystems in which they exist. This notion is supported and implemented by the World Organization for Animal Health to understand risks for human and animal health (including companion animals, livestock and wildlife) and ecosystem health as a whole. In this context, the best strategy to control zoonotic pathogens (transmitted by domestic or wild animals to humans and vice versa) is vaccination of the animal source, together with an adequate epidemiological surveillance program. Rabies is a zoonotic disease that affects humans, wildlife, companion animals, and livestock. Even though there are pre- and postrabies exposure treatments available for humans, it is more cost-effective over the long term to eliminate rabies in its natural terrestrial reservoirs. Currently, dogs are vaccinated with conventional inactivated vaccines while a viral vector–based vaccine (canarypox virus) is being used for cats. Several countries from the northern hemisphere control the sylvatic rabies reservoirs (coyotes, red foxes, raccoon dogs, and raccoons) using attenuated rabies vaccines or recombinant viral-vectored vaccines (based on vaccinia virus or human adenovirus). Lastly, vaccination of calves, horses, and other domestic livestock species (African and South American camels, goats, and pigs) is performed with inactivated conventional vaccines. Inactivated vaccines against rabies are effective but present several disadvantages such as uncertain antigen composition, manipulation of the pathogen during the vaccine manufacturing, need of cold chain during storage, and transportation and inability to differentiate vaccinated from infected animals. To overcome these inconveniences, the actual tendency is the rational design of recombinant immunogens (viral-vectored or subunit vaccines) that are safe and efficacious against pathogens. This chapter presents a revision of viral-vectored vaccines against rabies currently used in the veterinary field and the perspectives of new recombinant immunogens.
Instituto de Biotecnología
Fil: Del Medico Zajac, Maria Paula. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina
Fil: Del Medico Zajac, Maria Paula. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Garanzini, Debora Patricia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina
Fil: Garanzini, Debora Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Garanzini, Debora Patricia. Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Producción de Biológicos. Servicio de Vacunas Antirrábicas; Argentina
Fil: Perez, Oscar. Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán”. Instituto Nacional de Producción de Biológicos. Servicio de Vacunas Antirrábicas; Argentina
Fil: Calamante, Gabriela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina
Fil: Calamante, Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description The “One Health” concept summarized the idea that the health both of human and animal is interdependent and is bound to the health of the ecosystems in which they exist. This notion is supported and implemented by the World Organization for Animal Health to understand risks for human and animal health (including companion animals, livestock and wildlife) and ecosystem health as a whole. In this context, the best strategy to control zoonotic pathogens (transmitted by domestic or wild animals to humans and vice versa) is vaccination of the animal source, together with an adequate epidemiological surveillance program. Rabies is a zoonotic disease that affects humans, wildlife, companion animals, and livestock. Even though there are pre- and postrabies exposure treatments available for humans, it is more cost-effective over the long term to eliminate rabies in its natural terrestrial reservoirs. Currently, dogs are vaccinated with conventional inactivated vaccines while a viral vector–based vaccine (canarypox virus) is being used for cats. Several countries from the northern hemisphere control the sylvatic rabies reservoirs (coyotes, red foxes, raccoon dogs, and raccoons) using attenuated rabies vaccines or recombinant viral-vectored vaccines (based on vaccinia virus or human adenovirus). Lastly, vaccination of calves, horses, and other domestic livestock species (African and South American camels, goats, and pigs) is performed with inactivated conventional vaccines. Inactivated vaccines against rabies are effective but present several disadvantages such as uncertain antigen composition, manipulation of the pathogen during the vaccine manufacturing, need of cold chain during storage, and transportation and inability to differentiate vaccinated from infected animals. To overcome these inconveniences, the actual tendency is the rational design of recombinant immunogens (viral-vectored or subunit vaccines) that are safe and efficacious against pathogens. This chapter presents a revision of viral-vectored vaccines against rabies currently used in the veterinary field and the perspectives of new recombinant immunogens.
publishDate 2020
dc.date.none.fl_str_mv 2020
2025-07-16T14:17:25Z
2025-07-16T14:17:25Z
dc.type.none.fl_str_mv info:eu-repo/semantics/bookPart
info:eu-repo/semantics/publishedVersion
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info:ar-repo/semantics/parteDeLibro
format bookPart
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/23045
https://www.sciencedirect.com/science/article/abs/pii/B9780128149669000123
978-0-12-814966-9
https://doi.org/10.1016/B978-0-12-814966-9.00012-3
url http://hdl.handle.net/20.500.12123/23045
https://www.sciencedirect.com/science/article/abs/pii/B9780128149669000123
https://doi.org/10.1016/B978-0-12-814966-9.00012-3
identifier_str_mv 978-0-12-814966-9
dc.language.none.fl_str_mv eng
language eng
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Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv restrictedAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Emerging and Reemerging Viral Pathogens Volume 2 : Applied Virology Approaches Related to Human, Animal and Environmental Pathogens / Edited by: Moulay Mustapha Ennaji. Elsevier, 2020. Chapter 12, p. 225-242
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