Bovine autosomal recessive alpha-mannosidosis in an Aberdeen Angus herd from Argentina

Autores
Morris, Winston Eduardo; Delgado, Fernando Oscar; Micheloud, Juan Francisco; Garro, Carlos Javier; Olguin Perglione, Cecilia; Ebinger, Marem; Gimeno, Eduardo Juan; Garbaccio, Sergio Gabriel; Vilte, Daniel Alejandro
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
An outbreak of α-mannosidosis in a bovine herd from Buenos Aires province is reported. Postmortem examination, histology, lectin histochemistry and electron microscopy were performed on five calves born with nervous signs. Hair samples from dams and calves were genetically analysed. The α-mannosidase gene including exon 7 was amplified and sequenced. At postmortem examination, no gross changes were evident. Histologically, cytoplasmic neuronal vacuolation in the brain and cerebellum of the five calves, staining moderately to intensively, with lectin histochemistry was evident. Ultrastructurally, vacuoles containing finely granulated material in the cytoplasm of neurons, myelin degeneration and axonal swelling were seen in the brain. Genetic analysis revealed a heterozygous carrier state for 961T→C transition in the exon 7 of α-mannosidosis gene of four cows, and a recessive homozygous state for 961T→C transition in the same genes in the calves analysed. This highlights the importance of identifying and removing animals carrying the α-mannosidosis mutated gene.
EEA Mercedes
Fil: Morris, Winston Eduardo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Pergamino. Agencia de Extensión Rural Mercedes; Argentina
Fil: Delgado, Fernando Oscar. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina
Fil: Micheloud, Juan Francisco. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Salta; Argentina.
Fil: Garro, Carlos Javier. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina
Fil: Olguin Perglione, Cecilia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina
Fil: Ebinger, Maren. Actividad privada; Argentina
Fil: Gimeno, Eduardo Juan. Universidad Nacional de La Plata; Argentina
Fil: Garbaccio, Sergio Gabriel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina
Fil: Vilte, Daniel Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina
Fuente
Vet Record Case Reports : e687 (2023)
Materia
Ganado Bovino
Razas (animales)
Enfermedades de los Animales
Argentina
Cattle
Breeds (animals)
Animal Diseases
Raza Aberdeen Angus
Nivel de accesibilidad
acceso restringido
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/15008
Acceder
id INTADig_77b26e039a2df4962a07b083913e8d0a
oai_identifier_str oai:localhost:20.500.12123/15008
network_acronym_str INTADig
repository_id_str l
network_name_str INTA Digital (INTA)
spelling Bovine autosomal recessive alpha-mannosidosis in an Aberdeen Angus herd from ArgentinaMorris, Winston EduardoDelgado, Fernando OscarMicheloud, Juan FranciscoGarro, Carlos JavierOlguin Perglione, CeciliaEbinger, MaremGimeno, Eduardo JuanGarbaccio, Sergio GabrielVilte, Daniel AlejandroGanado BovinoRazas (animales)Enfermedades de los AnimalesArgentinaCattleBreeds (animals)Animal DiseasesRaza Aberdeen AngusAn outbreak of α-mannosidosis in a bovine herd from Buenos Aires province is reported. Postmortem examination, histology, lectin histochemistry and electron microscopy were performed on five calves born with nervous signs. Hair samples from dams and calves were genetically analysed. The α-mannosidase gene including exon 7 was amplified and sequenced. At postmortem examination, no gross changes were evident. Histologically, cytoplasmic neuronal vacuolation in the brain and cerebellum of the five calves, staining moderately to intensively, with lectin histochemistry was evident. Ultrastructurally, vacuoles containing finely granulated material in the cytoplasm of neurons, myelin degeneration and axonal swelling were seen in the brain. Genetic analysis revealed a heterozygous carrier state for 961T→C transition in the exon 7 of α-mannosidosis gene of four cows, and a recessive homozygous state for 961T→C transition in the same genes in the calves analysed. This highlights the importance of identifying and removing animals carrying the α-mannosidosis mutated gene.EEA MercedesFil: Morris, Winston Eduardo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Pergamino. Agencia de Extensión Rural Mercedes; ArgentinaFil: Delgado, Fernando Oscar. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; ArgentinaFil: Micheloud, Juan Francisco. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Salta; Argentina.Fil: Garro, Carlos Javier. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; ArgentinaFil: Olguin Perglione, Cecilia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; ArgentinaFil: Ebinger, Maren. Actividad privada; ArgentinaFil: Gimeno, Eduardo Juan. Universidad Nacional de La Plata; ArgentinaFil: Garbaccio, Sergio Gabriel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; ArgentinaFil: Vilte, Daniel Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; ArgentinaWiley2023-08-24T17:11:55Z2023-08-24T17:11:55Z2023-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/15008https://bvajournals.onlinelibrary.wiley.com/doi/10.1002/vrc2.6872052-6121https://doi.org/10.1002/vrc2.687Vet Record Case Reports : e687 (2023)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología AgropecuariaengArgentina .......... (nation) (World, South America)7006477info:eu-repo/semantics/restrictedAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-11T10:24:41Zoai:localhost:20.500.12123/15008instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-11 10:24:41.487INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Bovine autosomal recessive alpha-mannosidosis in an Aberdeen Angus herd from Argentina
title Bovine autosomal recessive alpha-mannosidosis in an Aberdeen Angus herd from Argentina
spellingShingle Bovine autosomal recessive alpha-mannosidosis in an Aberdeen Angus herd from Argentina
Morris, Winston Eduardo
Ganado Bovino
Razas (animales)
Enfermedades de los Animales
Argentina
Cattle
Breeds (animals)
Animal Diseases
Raza Aberdeen Angus
title_short Bovine autosomal recessive alpha-mannosidosis in an Aberdeen Angus herd from Argentina
title_full Bovine autosomal recessive alpha-mannosidosis in an Aberdeen Angus herd from Argentina
title_fullStr Bovine autosomal recessive alpha-mannosidosis in an Aberdeen Angus herd from Argentina
title_full_unstemmed Bovine autosomal recessive alpha-mannosidosis in an Aberdeen Angus herd from Argentina
title_sort Bovine autosomal recessive alpha-mannosidosis in an Aberdeen Angus herd from Argentina
dc.creator.none.fl_str_mv Morris, Winston Eduardo
Delgado, Fernando Oscar
Micheloud, Juan Francisco
Garro, Carlos Javier
Olguin Perglione, Cecilia
Ebinger, Marem
Gimeno, Eduardo Juan
Garbaccio, Sergio Gabriel
Vilte, Daniel Alejandro
author Morris, Winston Eduardo
author_facet Morris, Winston Eduardo
Delgado, Fernando Oscar
Micheloud, Juan Francisco
Garro, Carlos Javier
Olguin Perglione, Cecilia
Ebinger, Marem
Gimeno, Eduardo Juan
Garbaccio, Sergio Gabriel
Vilte, Daniel Alejandro
author_role author
author2 Delgado, Fernando Oscar
Micheloud, Juan Francisco
Garro, Carlos Javier
Olguin Perglione, Cecilia
Ebinger, Marem
Gimeno, Eduardo Juan
Garbaccio, Sergio Gabriel
Vilte, Daniel Alejandro
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ganado Bovino
Razas (animales)
Enfermedades de los Animales
Argentina
Cattle
Breeds (animals)
Animal Diseases
Raza Aberdeen Angus
topic Ganado Bovino
Razas (animales)
Enfermedades de los Animales
Argentina
Cattle
Breeds (animals)
Animal Diseases
Raza Aberdeen Angus
dc.description.none.fl_txt_mv An outbreak of α-mannosidosis in a bovine herd from Buenos Aires province is reported. Postmortem examination, histology, lectin histochemistry and electron microscopy were performed on five calves born with nervous signs. Hair samples from dams and calves were genetically analysed. The α-mannosidase gene including exon 7 was amplified and sequenced. At postmortem examination, no gross changes were evident. Histologically, cytoplasmic neuronal vacuolation in the brain and cerebellum of the five calves, staining moderately to intensively, with lectin histochemistry was evident. Ultrastructurally, vacuoles containing finely granulated material in the cytoplasm of neurons, myelin degeneration and axonal swelling were seen in the brain. Genetic analysis revealed a heterozygous carrier state for 961T→C transition in the exon 7 of α-mannosidosis gene of four cows, and a recessive homozygous state for 961T→C transition in the same genes in the calves analysed. This highlights the importance of identifying and removing animals carrying the α-mannosidosis mutated gene.
EEA Mercedes
Fil: Morris, Winston Eduardo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Pergamino. Agencia de Extensión Rural Mercedes; Argentina
Fil: Delgado, Fernando Oscar. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina
Fil: Micheloud, Juan Francisco. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Salta; Argentina.
Fil: Garro, Carlos Javier. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina
Fil: Olguin Perglione, Cecilia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina
Fil: Ebinger, Maren. Actividad privada; Argentina
Fil: Gimeno, Eduardo Juan. Universidad Nacional de La Plata; Argentina
Fil: Garbaccio, Sergio Gabriel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina
Fil: Vilte, Daniel Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina
description An outbreak of α-mannosidosis in a bovine herd from Buenos Aires province is reported. Postmortem examination, histology, lectin histochemistry and electron microscopy were performed on five calves born with nervous signs. Hair samples from dams and calves were genetically analysed. The α-mannosidase gene including exon 7 was amplified and sequenced. At postmortem examination, no gross changes were evident. Histologically, cytoplasmic neuronal vacuolation in the brain and cerebellum of the five calves, staining moderately to intensively, with lectin histochemistry was evident. Ultrastructurally, vacuoles containing finely granulated material in the cytoplasm of neurons, myelin degeneration and axonal swelling were seen in the brain. Genetic analysis revealed a heterozygous carrier state for 961T→C transition in the exon 7 of α-mannosidosis gene of four cows, and a recessive homozygous state for 961T→C transition in the same genes in the calves analysed. This highlights the importance of identifying and removing animals carrying the α-mannosidosis mutated gene.
publishDate 2023
dc.date.none.fl_str_mv 2023-08-24T17:11:55Z
2023-08-24T17:11:55Z
2023-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/15008
https://bvajournals.onlinelibrary.wiley.com/doi/10.1002/vrc2.687
2052-6121
https://doi.org/10.1002/vrc2.687
url http://hdl.handle.net/20.500.12123/15008
https://bvajournals.onlinelibrary.wiley.com/doi/10.1002/vrc2.687
https://doi.org/10.1002/vrc2.687
identifier_str_mv 2052-6121
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/restrictedAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv restrictedAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.coverage.none.fl_str_mv Argentina .......... (nation) (World, South America)
7006477
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv Vet Record Case Reports : e687 (2023)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
_version_ 1842975518782128128
score 12.993085

Publicaciones similares