Evidence for extensive genetic diversity and substructuring of the Babesia bovis metapopulation

Autores
Flores, Daniela; Minichiello, Y.; Araujo, Flabio Ribeiro de; Shkap, V.; Benitez, Daniel Francisco; Echaide, Ignacio Eduardo; Rolls, P.; Mosqueda, J.; Pacheco, Maria Gabriela; Petterson, Maria Elizabeth; Florin-Christensen, Mónica; Schnittger, Leonhard
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Babesia bovis is a tick-transmitted haemoprotozoan and a causative agent of bovine babesiosis, a cattle disease that causes significant economic loss in tropical and subtropical regions. A panel of nineteen micro- and minisatellite markers was used to estimate population genetic parameters of eighteen parasite isolates originating from different continents, countries and geographic regions including North America (Mexico, USA), South America (Argentina, Brazil), the Middle East (Israel) and Australia. For eleven of the eighteen isolates, a unique haplotype was inferred suggesting selection of a single genotype by either in vitro cultivation or amplification in splenectomized calves. Furthermore, a high genetic diversity (H = 0.780) over all marker loci was estimated. Linkage disequilibrium was observed in the total study group but also in sample subgroups from the Americas, Brazil, and Israel and Australia. In contrast, corresponding to their more confined geographic origin, samples from Israel and Argentina were each found to be in equilibrium suggestive of random mating and frequent genetic exchange. The genetic differentiation (FST) of the total study group over all nineteen loci was estimated by analysis of variance (Θ) and Nei's estimation of heterozygosity (GST') as 0.296 and 0.312, respectively. Thus, about 30% of the genetic diversity of the parasite population is associated with genetic differences between parasite isolates sampled from the different geographic regions. The pairwise similarity of multilocus genotypes (MLGs) was assessed and a neighbour-joining dendrogram generated. MLGs were found to cluster according to the country/continent of origin of isolates, but did not distinguish the attenuated from the pathogenic parasite state. The distant geographic origin of the isolates studied allows an initial glimpse into the large extent of genetic diversity and differentiation of the B. bovis population on a global scale.
Fil: Flores, Daniela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
Fil: Minichiello, Y. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
Fil: Araujo, Flabio R. EMBRAPA ; Brasil
Fil: Shkap, V. Kimron Veterinary Institute; Israel
Fil: Benitez, Daniel Francisco. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mercedes; Argentina
Fil: Echaide, Ignacio Eduardo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina
Fil: Rolls, P. Tick Fever Centre; Australia
Fil: Mosqueda, J. Universidad Autónoma de Querétaro; México
Fil: Pacheco, Maria Gabriela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina
Fil: Petterson, Maria Elizabeth. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina
Fil: Florin-Christensen, Mónica. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Schnittger, Leonhard. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fuente
Transboundary and Emerging Diseases 60 (s2) : 131–136 (November 2013)
Materia
Babesia Bovis
Variación Genética
Genetic Variation
Genetic Markers
Population Structure
Babesiosis
Marcadores Genéticos
Estructura de la Población
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/1756

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spelling Evidence for extensive genetic diversity and substructuring of the Babesia bovis metapopulationFlores, DanielaMinichiello, Y.Araujo, Flabio Ribeiro deShkap, V.Benitez, Daniel FranciscoEchaide, Ignacio EduardoRolls, P.Mosqueda, J.Pacheco, Maria GabrielaPetterson, Maria ElizabethFlorin-Christensen, MónicaSchnittger, LeonhardBabesia BovisVariación GenéticaGenetic VariationGenetic MarkersPopulation StructureBabesiosisMarcadores GenéticosEstructura de la PoblaciónBabesia bovis is a tick-transmitted haemoprotozoan and a causative agent of bovine babesiosis, a cattle disease that causes significant economic loss in tropical and subtropical regions. A panel of nineteen micro- and minisatellite markers was used to estimate population genetic parameters of eighteen parasite isolates originating from different continents, countries and geographic regions including North America (Mexico, USA), South America (Argentina, Brazil), the Middle East (Israel) and Australia. For eleven of the eighteen isolates, a unique haplotype was inferred suggesting selection of a single genotype by either in vitro cultivation or amplification in splenectomized calves. Furthermore, a high genetic diversity (H = 0.780) over all marker loci was estimated. Linkage disequilibrium was observed in the total study group but also in sample subgroups from the Americas, Brazil, and Israel and Australia. In contrast, corresponding to their more confined geographic origin, samples from Israel and Argentina were each found to be in equilibrium suggestive of random mating and frequent genetic exchange. The genetic differentiation (FST) of the total study group over all nineteen loci was estimated by analysis of variance (Θ) and Nei's estimation of heterozygosity (GST') as 0.296 and 0.312, respectively. Thus, about 30% of the genetic diversity of the parasite population is associated with genetic differences between parasite isolates sampled from the different geographic regions. The pairwise similarity of multilocus genotypes (MLGs) was assessed and a neighbour-joining dendrogram generated. MLGs were found to cluster according to the country/continent of origin of isolates, but did not distinguish the attenuated from the pathogenic parasite state. The distant geographic origin of the isolates studied allows an initial glimpse into the large extent of genetic diversity and differentiation of the B. bovis population on a global scale.Fil: Flores, Daniela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; ArgentinaFil: Minichiello, Y. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; ArgentinaFil: Araujo, Flabio R. EMBRAPA ; BrasilFil: Shkap, V. Kimron Veterinary Institute; IsraelFil: Benitez, Daniel Francisco. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mercedes; ArgentinaFil: Echaide, Ignacio Eduardo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; ArgentinaFil: Rolls, P. Tick Fever Centre; AustraliaFil: Mosqueda, J. Universidad Autónoma de Querétaro; MéxicoFil: Pacheco, Maria Gabriela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; ArgentinaFil: Petterson, Maria Elizabeth. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; ArgentinaFil: Florin-Christensen, Mónica. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Schnittger, Leonhard. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina2017-11-13T16:55:40Z2017-11-13T16:55:40Z2013-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/1756http://onlinelibrary.wiley.com/doi/10.1111/tbed.12121/abstract1865-1674 (Print)1865-1682 (Online)DOI: 10.1111/tbed.12121Transboundary and Emerging Diseases 60 (s2) : 131–136 (November 2013)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-29T13:44:13Zoai:localhost:20.500.12123/1756instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-29 13:44:14.248INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Evidence for extensive genetic diversity and substructuring of the Babesia bovis metapopulation
title Evidence for extensive genetic diversity and substructuring of the Babesia bovis metapopulation
spellingShingle Evidence for extensive genetic diversity and substructuring of the Babesia bovis metapopulation
Flores, Daniela
Babesia Bovis
Variación Genética
Genetic Variation
Genetic Markers
Population Structure
Babesiosis
Marcadores Genéticos
Estructura de la Población
title_short Evidence for extensive genetic diversity and substructuring of the Babesia bovis metapopulation
title_full Evidence for extensive genetic diversity and substructuring of the Babesia bovis metapopulation
title_fullStr Evidence for extensive genetic diversity and substructuring of the Babesia bovis metapopulation
title_full_unstemmed Evidence for extensive genetic diversity and substructuring of the Babesia bovis metapopulation
title_sort Evidence for extensive genetic diversity and substructuring of the Babesia bovis metapopulation
dc.creator.none.fl_str_mv Flores, Daniela
Minichiello, Y.
Araujo, Flabio Ribeiro de
Shkap, V.
Benitez, Daniel Francisco
Echaide, Ignacio Eduardo
Rolls, P.
Mosqueda, J.
Pacheco, Maria Gabriela
Petterson, Maria Elizabeth
Florin-Christensen, Mónica
Schnittger, Leonhard
author Flores, Daniela
author_facet Flores, Daniela
Minichiello, Y.
Araujo, Flabio Ribeiro de
Shkap, V.
Benitez, Daniel Francisco
Echaide, Ignacio Eduardo
Rolls, P.
Mosqueda, J.
Pacheco, Maria Gabriela
Petterson, Maria Elizabeth
Florin-Christensen, Mónica
Schnittger, Leonhard
author_role author
author2 Minichiello, Y.
Araujo, Flabio Ribeiro de
Shkap, V.
Benitez, Daniel Francisco
Echaide, Ignacio Eduardo
Rolls, P.
Mosqueda, J.
Pacheco, Maria Gabriela
Petterson, Maria Elizabeth
Florin-Christensen, Mónica
Schnittger, Leonhard
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Babesia Bovis
Variación Genética
Genetic Variation
Genetic Markers
Population Structure
Babesiosis
Marcadores Genéticos
Estructura de la Población
topic Babesia Bovis
Variación Genética
Genetic Variation
Genetic Markers
Population Structure
Babesiosis
Marcadores Genéticos
Estructura de la Población
dc.description.none.fl_txt_mv Babesia bovis is a tick-transmitted haemoprotozoan and a causative agent of bovine babesiosis, a cattle disease that causes significant economic loss in tropical and subtropical regions. A panel of nineteen micro- and minisatellite markers was used to estimate population genetic parameters of eighteen parasite isolates originating from different continents, countries and geographic regions including North America (Mexico, USA), South America (Argentina, Brazil), the Middle East (Israel) and Australia. For eleven of the eighteen isolates, a unique haplotype was inferred suggesting selection of a single genotype by either in vitro cultivation or amplification in splenectomized calves. Furthermore, a high genetic diversity (H = 0.780) over all marker loci was estimated. Linkage disequilibrium was observed in the total study group but also in sample subgroups from the Americas, Brazil, and Israel and Australia. In contrast, corresponding to their more confined geographic origin, samples from Israel and Argentina were each found to be in equilibrium suggestive of random mating and frequent genetic exchange. The genetic differentiation (FST) of the total study group over all nineteen loci was estimated by analysis of variance (Θ) and Nei's estimation of heterozygosity (GST') as 0.296 and 0.312, respectively. Thus, about 30% of the genetic diversity of the parasite population is associated with genetic differences between parasite isolates sampled from the different geographic regions. The pairwise similarity of multilocus genotypes (MLGs) was assessed and a neighbour-joining dendrogram generated. MLGs were found to cluster according to the country/continent of origin of isolates, but did not distinguish the attenuated from the pathogenic parasite state. The distant geographic origin of the isolates studied allows an initial glimpse into the large extent of genetic diversity and differentiation of the B. bovis population on a global scale.
Fil: Flores, Daniela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
Fil: Minichiello, Y. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
Fil: Araujo, Flabio R. EMBRAPA ; Brasil
Fil: Shkap, V. Kimron Veterinary Institute; Israel
Fil: Benitez, Daniel Francisco. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mercedes; Argentina
Fil: Echaide, Ignacio Eduardo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina
Fil: Rolls, P. Tick Fever Centre; Australia
Fil: Mosqueda, J. Universidad Autónoma de Querétaro; México
Fil: Pacheco, Maria Gabriela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina
Fil: Petterson, Maria Elizabeth. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina
Fil: Florin-Christensen, Mónica. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Schnittger, Leonhard. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Babesia bovis is a tick-transmitted haemoprotozoan and a causative agent of bovine babesiosis, a cattle disease that causes significant economic loss in tropical and subtropical regions. A panel of nineteen micro- and minisatellite markers was used to estimate population genetic parameters of eighteen parasite isolates originating from different continents, countries and geographic regions including North America (Mexico, USA), South America (Argentina, Brazil), the Middle East (Israel) and Australia. For eleven of the eighteen isolates, a unique haplotype was inferred suggesting selection of a single genotype by either in vitro cultivation or amplification in splenectomized calves. Furthermore, a high genetic diversity (H = 0.780) over all marker loci was estimated. Linkage disequilibrium was observed in the total study group but also in sample subgroups from the Americas, Brazil, and Israel and Australia. In contrast, corresponding to their more confined geographic origin, samples from Israel and Argentina were each found to be in equilibrium suggestive of random mating and frequent genetic exchange. The genetic differentiation (FST) of the total study group over all nineteen loci was estimated by analysis of variance (Θ) and Nei's estimation of heterozygosity (GST') as 0.296 and 0.312, respectively. Thus, about 30% of the genetic diversity of the parasite population is associated with genetic differences between parasite isolates sampled from the different geographic regions. The pairwise similarity of multilocus genotypes (MLGs) was assessed and a neighbour-joining dendrogram generated. MLGs were found to cluster according to the country/continent of origin of isolates, but did not distinguish the attenuated from the pathogenic parasite state. The distant geographic origin of the isolates studied allows an initial glimpse into the large extent of genetic diversity and differentiation of the B. bovis population on a global scale.
publishDate 2013
dc.date.none.fl_str_mv 2013-11
2017-11-13T16:55:40Z
2017-11-13T16:55:40Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/1756
http://onlinelibrary.wiley.com/doi/10.1111/tbed.12121/abstract
1865-1674 (Print)
1865-1682 (Online)
DOI: 10.1111/tbed.12121
url http://hdl.handle.net/20.500.12123/1756
http://onlinelibrary.wiley.com/doi/10.1111/tbed.12121/abstract
identifier_str_mv 1865-1674 (Print)
1865-1682 (Online)
DOI: 10.1111/tbed.12121
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Transboundary and Emerging Diseases 60 (s2) : 131–136 (November 2013)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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