A byproduct from the Valles Calchaquíes vineyards (Argentina) rich in phenolic compounds: a tool against endemic Leishmania dissemination

Autores
Salazar, Paula Belén; Fanzone, Martín Leandro; Zabala, Brenda Adriana; Rodriguez Vaquero, María José; Cilli, Eduardo; Barroso, Paola Andrea; Minahk, Carlos Javier; Acuña, Leonardo
Año de publicación
2023
Idioma
español castellano
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Vineyard-derived pomace is a byproduct of the wine industry that can have a negative impact on the environment if it is only disposed of or used as a fertilizer. Owing to its polyphenol content, grape pomace is an alternative to biocontrol undesir able microorganisms. In the present study, we characterized the phenolic composition of red and white grape pomace from Valles Calchaquíes, Argentina, and explored its activity against Leishmania (Leishmania) amazonensis, an etiological agent of American tegumentary leishmaniasis, a neglected endemic disease in northern Argentina. Red and white pomace extracts similarly reduced Leishmania viability after a 48-h treatment, with the fractions containing a higher proportion of phenolic compounds being more active. Both extracts stimulated ATPase activity on the parasite plasma membranes, with white grape pomace having a stronger effect than red grape pomace. In addition, the extracts displayed fairly good anticholinesterase activity, which may have contributed to their anti-Leishmania activity. These results reinforce the potential applicability of grape pomace as an antimicrobial agent for the development of biopesticides.
EEA Mendoza
Fil: Salazar, Paula Belén. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto Superior de Investigaciones Biológicas (INSIBIO); Argentina
Fil: Salazar, Paula Belén. Universidad Nacional de Tucumán (UNT). Instituto Superior de Investigaciones Biológicas (INSIBIO); Argentina
Fil: Salazar, Paula Belén. Universidad Nacional de Tucumán (UNT). Facultad de Bioquímica, Química y Farmacia. Instituto de Química Biológica; Argentina
Fil: Fanzone, Martín Leandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mendoza; Argentina
Fil: Zabala, Brenda Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Patología Experimental; Argentina
Fil: Zabala, Brenda Adriana. Universidad Nacional de Salta (UNSa). Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina
Fil: Rodriguez Vaquero, Maria José. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina
Fil: Rodriguez Vaquero, Maria José. Universidad Nacional de Tucumán (UNT). Facultad de Bioquímica, Química y Farmacia; Argentina
Fil: Cilli, Eduardo. Universidade Estadual Paulista (Unesp); Brasil
Fil: Barroso, Paola Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Patología Experimental; Argentina
Fil: Barroso, Paola Andrea. Universidad Nacional de Salta (UNSa). Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina
Fil: Minahk, Carlos Javier. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto Superior de Investigaciones Biológicas (INSIBIO); Argentina
Fil: Minahk, Carlos Javier. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán (UNT). Facultad de Bioquímica, Química y Farmacia. Instituto de Química Biológica (INSIBIO); Argentina
Fil: Acuña, Leonardo. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Patología Experimental; Argentina
Fil: Acuña, Leonardo. Universidad Nacional de Salta (UNSa). Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina
Fuente
Environmental Science and Pollution Research 30 (43) : 97377-97385 (august 2023)
Materia
Grape Pomace
Polyphenols
Phenolic Content
Leishmaniosis
Vineyards
Orujo de Uva
Polifenol
Contenido Fenólico
Leishmaniosis
Viña
Valles Calchaquíes
Nivel de accesibilidad
acceso restringido
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/25848
Acceder
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oai_identifier_str oai:localhost:20.500.12123/25848
network_acronym_str INTADig
repository_id_str l
network_name_str INTA Digital (INTA)
spelling A byproduct from the Valles Calchaquíes vineyards (Argentina) rich in phenolic compounds: a tool against endemic Leishmania disseminationSalazar, Paula BelénFanzone, Martín LeandroZabala, Brenda AdrianaRodriguez Vaquero, María JoséCilli, EduardoBarroso, Paola AndreaMinahk, Carlos JavierAcuña, LeonardoGrape PomacePolyphenolsPhenolic ContentLeishmaniosisVineyardsOrujo de UvaPolifenolContenido FenólicoLeishmaniosisViñaValles CalchaquíesVineyard-derived pomace is a byproduct of the wine industry that can have a negative impact on the environment if it is only disposed of or used as a fertilizer. Owing to its polyphenol content, grape pomace is an alternative to biocontrol undesir able microorganisms. In the present study, we characterized the phenolic composition of red and white grape pomace from Valles Calchaquíes, Argentina, and explored its activity against Leishmania (Leishmania) amazonensis, an etiological agent of American tegumentary leishmaniasis, a neglected endemic disease in northern Argentina. Red and white pomace extracts similarly reduced Leishmania viability after a 48-h treatment, with the fractions containing a higher proportion of phenolic compounds being more active. Both extracts stimulated ATPase activity on the parasite plasma membranes, with white grape pomace having a stronger effect than red grape pomace. In addition, the extracts displayed fairly good anticholinesterase activity, which may have contributed to their anti-Leishmania activity. These results reinforce the potential applicability of grape pomace as an antimicrobial agent for the development of biopesticides.EEA MendozaFil: Salazar, Paula Belén. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto Superior de Investigaciones Biológicas (INSIBIO); ArgentinaFil: Salazar, Paula Belén. Universidad Nacional de Tucumán (UNT). Instituto Superior de Investigaciones Biológicas (INSIBIO); ArgentinaFil: Salazar, Paula Belén. Universidad Nacional de Tucumán (UNT). Facultad de Bioquímica, Química y Farmacia. Instituto de Química Biológica; ArgentinaFil: Fanzone, Martín Leandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mendoza; ArgentinaFil: Zabala, Brenda Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Patología Experimental; ArgentinaFil: Zabala, Brenda Adriana. Universidad Nacional de Salta (UNSa). Facultad de Ciencias de la Salud. Instituto de Patología Experimental; ArgentinaFil: Rodriguez Vaquero, Maria José. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); ArgentinaFil: Rodriguez Vaquero, Maria José. Universidad Nacional de Tucumán (UNT). Facultad de Bioquímica, Química y Farmacia; ArgentinaFil: Cilli, Eduardo. Universidade Estadual Paulista (Unesp); BrasilFil: Barroso, Paola Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Patología Experimental; ArgentinaFil: Barroso, Paola Andrea. Universidad Nacional de Salta (UNSa). Facultad de Ciencias de la Salud. Instituto de Patología Experimental; ArgentinaFil: Minahk, Carlos Javier. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto Superior de Investigaciones Biológicas (INSIBIO); ArgentinaFil: Minahk, Carlos Javier. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán (UNT). Facultad de Bioquímica, Química y Farmacia. Instituto de Química Biológica (INSIBIO); ArgentinaFil: Acuña, Leonardo. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Patología Experimental; ArgentinaFil: Acuña, Leonardo. Universidad Nacional de Salta (UNSa). Facultad de Ciencias de la Salud. Instituto de Patología Experimental; ArgentinaSpringer2026-04-17T13:37:47Z2026-04-17T13:37:47Z2023-08-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/25848https://link.springer.com/article/10.1007/s11356-023-29276-01614-7499https://doi.org/10.1007/s11356-023-29276-0Environmental Science and Pollution Research 30 (43) : 97377-97385 (august 2023)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaspainfo:eu-repo/semantics/restrictedAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2026-04-23T10:40:35Zoai:localhost:20.500.12123/25848instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2026-04-23 10:40:36.169INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv A byproduct from the Valles Calchaquíes vineyards (Argentina) rich in phenolic compounds: a tool against endemic Leishmania dissemination
title A byproduct from the Valles Calchaquíes vineyards (Argentina) rich in phenolic compounds: a tool against endemic Leishmania dissemination
spellingShingle A byproduct from the Valles Calchaquíes vineyards (Argentina) rich in phenolic compounds: a tool against endemic Leishmania dissemination
Salazar, Paula Belén
Grape Pomace
Polyphenols
Phenolic Content
Leishmaniosis
Vineyards
Orujo de Uva
Polifenol
Contenido Fenólico
Leishmaniosis
Viña
Valles Calchaquíes
title_short A byproduct from the Valles Calchaquíes vineyards (Argentina) rich in phenolic compounds: a tool against endemic Leishmania dissemination
title_full A byproduct from the Valles Calchaquíes vineyards (Argentina) rich in phenolic compounds: a tool against endemic Leishmania dissemination
title_fullStr A byproduct from the Valles Calchaquíes vineyards (Argentina) rich in phenolic compounds: a tool against endemic Leishmania dissemination
title_full_unstemmed A byproduct from the Valles Calchaquíes vineyards (Argentina) rich in phenolic compounds: a tool against endemic Leishmania dissemination
title_sort A byproduct from the Valles Calchaquíes vineyards (Argentina) rich in phenolic compounds: a tool against endemic Leishmania dissemination
dc.creator.none.fl_str_mv Salazar, Paula Belén
Fanzone, Martín Leandro
Zabala, Brenda Adriana
Rodriguez Vaquero, María José
Cilli, Eduardo
Barroso, Paola Andrea
Minahk, Carlos Javier
Acuña, Leonardo
author Salazar, Paula Belén
author_facet Salazar, Paula Belén
Fanzone, Martín Leandro
Zabala, Brenda Adriana
Rodriguez Vaquero, María José
Cilli, Eduardo
Barroso, Paola Andrea
Minahk, Carlos Javier
Acuña, Leonardo
author_role author
author2 Fanzone, Martín Leandro
Zabala, Brenda Adriana
Rodriguez Vaquero, María José
Cilli, Eduardo
Barroso, Paola Andrea
Minahk, Carlos Javier
Acuña, Leonardo
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Grape Pomace
Polyphenols
Phenolic Content
Leishmaniosis
Vineyards
Orujo de Uva
Polifenol
Contenido Fenólico
Leishmaniosis
Viña
Valles Calchaquíes
topic Grape Pomace
Polyphenols
Phenolic Content
Leishmaniosis
Vineyards
Orujo de Uva
Polifenol
Contenido Fenólico
Leishmaniosis
Viña
Valles Calchaquíes
dc.description.none.fl_txt_mv Vineyard-derived pomace is a byproduct of the wine industry that can have a negative impact on the environment if it is only disposed of or used as a fertilizer. Owing to its polyphenol content, grape pomace is an alternative to biocontrol undesir able microorganisms. In the present study, we characterized the phenolic composition of red and white grape pomace from Valles Calchaquíes, Argentina, and explored its activity against Leishmania (Leishmania) amazonensis, an etiological agent of American tegumentary leishmaniasis, a neglected endemic disease in northern Argentina. Red and white pomace extracts similarly reduced Leishmania viability after a 48-h treatment, with the fractions containing a higher proportion of phenolic compounds being more active. Both extracts stimulated ATPase activity on the parasite plasma membranes, with white grape pomace having a stronger effect than red grape pomace. In addition, the extracts displayed fairly good anticholinesterase activity, which may have contributed to their anti-Leishmania activity. These results reinforce the potential applicability of grape pomace as an antimicrobial agent for the development of biopesticides.
EEA Mendoza
Fil: Salazar, Paula Belén. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto Superior de Investigaciones Biológicas (INSIBIO); Argentina
Fil: Salazar, Paula Belén. Universidad Nacional de Tucumán (UNT). Instituto Superior de Investigaciones Biológicas (INSIBIO); Argentina
Fil: Salazar, Paula Belén. Universidad Nacional de Tucumán (UNT). Facultad de Bioquímica, Química y Farmacia. Instituto de Química Biológica; Argentina
Fil: Fanzone, Martín Leandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mendoza; Argentina
Fil: Zabala, Brenda Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Patología Experimental; Argentina
Fil: Zabala, Brenda Adriana. Universidad Nacional de Salta (UNSa). Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina
Fil: Rodriguez Vaquero, Maria José. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina
Fil: Rodriguez Vaquero, Maria José. Universidad Nacional de Tucumán (UNT). Facultad de Bioquímica, Química y Farmacia; Argentina
Fil: Cilli, Eduardo. Universidade Estadual Paulista (Unesp); Brasil
Fil: Barroso, Paola Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Patología Experimental; Argentina
Fil: Barroso, Paola Andrea. Universidad Nacional de Salta (UNSa). Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina
Fil: Minahk, Carlos Javier. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto Superior de Investigaciones Biológicas (INSIBIO); Argentina
Fil: Minahk, Carlos Javier. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán (UNT). Facultad de Bioquímica, Química y Farmacia. Instituto de Química Biológica (INSIBIO); Argentina
Fil: Acuña, Leonardo. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Patología Experimental; Argentina
Fil: Acuña, Leonardo. Universidad Nacional de Salta (UNSa). Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina
description Vineyard-derived pomace is a byproduct of the wine industry that can have a negative impact on the environment if it is only disposed of or used as a fertilizer. Owing to its polyphenol content, grape pomace is an alternative to biocontrol undesir able microorganisms. In the present study, we characterized the phenolic composition of red and white grape pomace from Valles Calchaquíes, Argentina, and explored its activity against Leishmania (Leishmania) amazonensis, an etiological agent of American tegumentary leishmaniasis, a neglected endemic disease in northern Argentina. Red and white pomace extracts similarly reduced Leishmania viability after a 48-h treatment, with the fractions containing a higher proportion of phenolic compounds being more active. Both extracts stimulated ATPase activity on the parasite plasma membranes, with white grape pomace having a stronger effect than red grape pomace. In addition, the extracts displayed fairly good anticholinesterase activity, which may have contributed to their anti-Leishmania activity. These results reinforce the potential applicability of grape pomace as an antimicrobial agent for the development of biopesticides.
publishDate 2023
dc.date.none.fl_str_mv 2023-08-17
2026-04-17T13:37:47Z
2026-04-17T13:37:47Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/25848
https://link.springer.com/article/10.1007/s11356-023-29276-0
1614-7499
https://doi.org/10.1007/s11356-023-29276-0
url http://hdl.handle.net/20.500.12123/25848
https://link.springer.com/article/10.1007/s11356-023-29276-0
https://doi.org/10.1007/s11356-023-29276-0
identifier_str_mv 1614-7499
dc.language.none.fl_str_mv spa
language spa
dc.rights.none.fl_str_mv info:eu-repo/semantics/restrictedAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv restrictedAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv Environmental Science and Pollution Research 30 (43) : 97377-97385 (august 2023)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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score 13.05261

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