What Do We Know about Surface Proteins of Chicken Parasites Eimeria?

Autores
Britez, Jesica Daiana; Rodriguez, Anabel Elisa; Di Ciaccio, Lucia Soledad; Marugán-Hernandez, Virginia; Tomazic, Mariela Luján
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Poultry is the first source of animal protein for human consumption. In a changing world, this sector is facing new challenges, such as a projected increase in demand, higher standards of food quality and safety, and reduction of environmental impact. Chicken coccidiosis is a highly widespread enteric disease caused by Eimeria spp. which causes significant economic losses to the poultry industry worldwide; however, the impact on family poultry holders or backyard production—which plays a key role in food security in small communities and involves mainly rural women—has been little explored. Coccidiosis disease is controlled by good husbandry measures, chemoprophylaxis, and/or live vaccination. The first live vaccines against chicken coccidiosis were developed in the 1950s; however, after more than seven decades, none has reached the market. Current limitations on their use have led to research in next-generation vaccines based on recombinant or live-vectored vaccines. Next-generation vaccines are required to control this complex parasitic disease, and for this purpose, protective antigens need to be identified. In this review, we have scrutinised surface proteins identified so far in Eimeria spp. affecting chickens. Most of these surface proteins are anchored to the parasite membrane by a glycosylphosphatidylinositol (GPI) molecule. The biosynthesis of GPIs, as well as the role of currently identified surface proteins and interest as vaccine candidates has been summarised. The potential role of surface proteins in drug resistance and immune escape and how these could limit the efficacy of control strategies was also discussed.
Instituto de Patobiología
Fil: Britez, Jesica Daiana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
Fil: Britez, Jesica Daiana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rodriguez, Anabel Elisa. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
Fil: Rodriguez, Anabel Elisa. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Di Ciaccio, Lucí­a Soledad. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
Fil: Di Ciaccio, Lucí­a Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Marugán-Hernandez, Virginia. University of London. Royal Veterinary College; Reino Unido
Fil: Tomazic, Mariela Luján. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
Fil: Tomazic, Mariela Luján. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Tomazic, Mariela Luján. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Biotecnología; Argentina
Fuente
Life 13 (6) : 1295 (May 2023)
Materia
Aves de Corral
Pollo
Parásitos
Proteínas
Enfoque Una salud
Poultry
Chickens
Parasites
Eimeria
Proteins
Coccidiosis
One Health Approach
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/14702
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oai_identifier_str oai:localhost:20.500.12123/14702
network_acronym_str INTADig
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network_name_str INTA Digital (INTA)
spelling What Do We Know about Surface Proteins of Chicken Parasites Eimeria?Britez, Jesica DaianaRodriguez, Anabel ElisaDi Ciaccio, Lucia SoledadMarugán-Hernandez, VirginiaTomazic, Mariela LujánAves de CorralPolloParásitosProteínasEnfoque Una saludPoultryChickensParasitesEimeriaProteinsCoccidiosisOne Health ApproachPoultry is the first source of animal protein for human consumption. In a changing world, this sector is facing new challenges, such as a projected increase in demand, higher standards of food quality and safety, and reduction of environmental impact. Chicken coccidiosis is a highly widespread enteric disease caused by Eimeria spp. which causes significant economic losses to the poultry industry worldwide; however, the impact on family poultry holders or backyard production—which plays a key role in food security in small communities and involves mainly rural women—has been little explored. Coccidiosis disease is controlled by good husbandry measures, chemoprophylaxis, and/or live vaccination. The first live vaccines against chicken coccidiosis were developed in the 1950s; however, after more than seven decades, none has reached the market. Current limitations on their use have led to research in next-generation vaccines based on recombinant or live-vectored vaccines. Next-generation vaccines are required to control this complex parasitic disease, and for this purpose, protective antigens need to be identified. In this review, we have scrutinised surface proteins identified so far in Eimeria spp. affecting chickens. Most of these surface proteins are anchored to the parasite membrane by a glycosylphosphatidylinositol (GPI) molecule. The biosynthesis of GPIs, as well as the role of currently identified surface proteins and interest as vaccine candidates has been summarised. The potential role of surface proteins in drug resistance and immune escape and how these could limit the efficacy of control strategies was also discussed.Instituto de PatobiologíaFil: Britez, Jesica Daiana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; ArgentinaFil: Britez, Jesica Daiana. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Rodriguez, Anabel Elisa. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; ArgentinaFil: Rodriguez, Anabel Elisa. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Di Ciaccio, Lucí­a Soledad. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; ArgentinaFil: Di Ciaccio, Lucí­a Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Marugán-Hernandez, Virginia. University of London. Royal Veterinary College; Reino UnidoFil: Tomazic, Mariela Luján. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; ArgentinaFil: Tomazic, Mariela Luján. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Tomazic, Mariela Luján. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Biotecnología; ArgentinaMDPI2023-07-05T16:36:51Z2023-07-05T16:36:51Z2023-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/14702https://www.mdpi.com/2075-1729/13/6/12952075-1729https://doi.org/10.3390/life13061295Life 13 (6) : 1295 (May 2023)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repograntAgreement/INTA/2019-PE-E6-I113-001/2019-PE-E6-I113-001, Abordaje integral para la conservación, mejoramiento y rescate de especies amenazadas de importancia para el SAAA en diferentes ambientesinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-04T09:49:50Zoai:localhost:20.500.12123/14702instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-04 09:49:51.011INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv What Do We Know about Surface Proteins of Chicken Parasites Eimeria?
title What Do We Know about Surface Proteins of Chicken Parasites Eimeria?
spellingShingle What Do We Know about Surface Proteins of Chicken Parasites Eimeria?
Britez, Jesica Daiana
Aves de Corral
Pollo
Parásitos
Proteínas
Enfoque Una salud
Poultry
Chickens
Parasites
Eimeria
Proteins
Coccidiosis
One Health Approach
title_short What Do We Know about Surface Proteins of Chicken Parasites Eimeria?
title_full What Do We Know about Surface Proteins of Chicken Parasites Eimeria?
title_fullStr What Do We Know about Surface Proteins of Chicken Parasites Eimeria?
title_full_unstemmed What Do We Know about Surface Proteins of Chicken Parasites Eimeria?
title_sort What Do We Know about Surface Proteins of Chicken Parasites Eimeria?
dc.creator.none.fl_str_mv Britez, Jesica Daiana
Rodriguez, Anabel Elisa
Di Ciaccio, Lucia Soledad
Marugán-Hernandez, Virginia
Tomazic, Mariela Luján
author Britez, Jesica Daiana
author_facet Britez, Jesica Daiana
Rodriguez, Anabel Elisa
Di Ciaccio, Lucia Soledad
Marugán-Hernandez, Virginia
Tomazic, Mariela Luján
author_role author
author2 Rodriguez, Anabel Elisa
Di Ciaccio, Lucia Soledad
Marugán-Hernandez, Virginia
Tomazic, Mariela Luján
author2_role author
author
author
author
dc.subject.none.fl_str_mv Aves de Corral
Pollo
Parásitos
Proteínas
Enfoque Una salud
Poultry
Chickens
Parasites
Eimeria
Proteins
Coccidiosis
One Health Approach
topic Aves de Corral
Pollo
Parásitos
Proteínas
Enfoque Una salud
Poultry
Chickens
Parasites
Eimeria
Proteins
Coccidiosis
One Health Approach
dc.description.none.fl_txt_mv Poultry is the first source of animal protein for human consumption. In a changing world, this sector is facing new challenges, such as a projected increase in demand, higher standards of food quality and safety, and reduction of environmental impact. Chicken coccidiosis is a highly widespread enteric disease caused by Eimeria spp. which causes significant economic losses to the poultry industry worldwide; however, the impact on family poultry holders or backyard production—which plays a key role in food security in small communities and involves mainly rural women—has been little explored. Coccidiosis disease is controlled by good husbandry measures, chemoprophylaxis, and/or live vaccination. The first live vaccines against chicken coccidiosis were developed in the 1950s; however, after more than seven decades, none has reached the market. Current limitations on their use have led to research in next-generation vaccines based on recombinant or live-vectored vaccines. Next-generation vaccines are required to control this complex parasitic disease, and for this purpose, protective antigens need to be identified. In this review, we have scrutinised surface proteins identified so far in Eimeria spp. affecting chickens. Most of these surface proteins are anchored to the parasite membrane by a glycosylphosphatidylinositol (GPI) molecule. The biosynthesis of GPIs, as well as the role of currently identified surface proteins and interest as vaccine candidates has been summarised. The potential role of surface proteins in drug resistance and immune escape and how these could limit the efficacy of control strategies was also discussed.
Instituto de Patobiología
Fil: Britez, Jesica Daiana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
Fil: Britez, Jesica Daiana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rodriguez, Anabel Elisa. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
Fil: Rodriguez, Anabel Elisa. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Di Ciaccio, Lucí­a Soledad. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
Fil: Di Ciaccio, Lucí­a Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Marugán-Hernandez, Virginia. University of London. Royal Veterinary College; Reino Unido
Fil: Tomazic, Mariela Luján. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
Fil: Tomazic, Mariela Luján. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Tomazic, Mariela Luján. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Biotecnología; Argentina
description Poultry is the first source of animal protein for human consumption. In a changing world, this sector is facing new challenges, such as a projected increase in demand, higher standards of food quality and safety, and reduction of environmental impact. Chicken coccidiosis is a highly widespread enteric disease caused by Eimeria spp. which causes significant economic losses to the poultry industry worldwide; however, the impact on family poultry holders or backyard production—which plays a key role in food security in small communities and involves mainly rural women—has been little explored. Coccidiosis disease is controlled by good husbandry measures, chemoprophylaxis, and/or live vaccination. The first live vaccines against chicken coccidiosis were developed in the 1950s; however, after more than seven decades, none has reached the market. Current limitations on their use have led to research in next-generation vaccines based on recombinant or live-vectored vaccines. Next-generation vaccines are required to control this complex parasitic disease, and for this purpose, protective antigens need to be identified. In this review, we have scrutinised surface proteins identified so far in Eimeria spp. affecting chickens. Most of these surface proteins are anchored to the parasite membrane by a glycosylphosphatidylinositol (GPI) molecule. The biosynthesis of GPIs, as well as the role of currently identified surface proteins and interest as vaccine candidates has been summarised. The potential role of surface proteins in drug resistance and immune escape and how these could limit the efficacy of control strategies was also discussed.
publishDate 2023
dc.date.none.fl_str_mv 2023-07-05T16:36:51Z
2023-07-05T16:36:51Z
2023-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/14702
https://www.mdpi.com/2075-1729/13/6/1295
2075-1729
https://doi.org/10.3390/life13061295
url http://hdl.handle.net/20.500.12123/14702
https://www.mdpi.com/2075-1729/13/6/1295
https://doi.org/10.3390/life13061295
identifier_str_mv 2075-1729
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repograntAgreement/INTA/2019-PE-E6-I113-001/2019-PE-E6-I113-001, Abordaje integral para la conservación, mejoramiento y rescate de especies amenazadas de importancia para el SAAA en diferentes ambientes
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Life 13 (6) : 1295 (May 2023)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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