Pathology of cattle experimentally intoxicated with ground Ricinus communis seeds

Autores
Marin, Raul Eduardo; Schild, Carlos; Garcia, Juan; Canton, German Jose; Micheloud, Juan Francisco; Morrell, Eleonora Lidia; Uzal, Francisco Aleja
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Five Aberdeen Angus calves were inoculated intra-ruminally with ground seeds of Ricinus communis at doses of 1, 1.5, 2 or 3 gr per kg of body weight, or with saline solution (control), respectively. Grossly, all intoxicated animals showed hemorrhages in abdominal serosas, epicardium, endocardium, spleen, pre-stomachs, abomasum, and small and large intestine, and diffuse edema of the ruminal mucosa. Microscopically, in all animals inoculated with R. communis seeds, the main feature was the presence of pyknotic and karyorrhectic nuclei in the endothelium of central nervous system, hepatic, ruminal, intestinal, glomerular and alveolar capillaries, and in lymphoid cells of multiple organs. Apoptosis, confirmed by activated caspase-3 immunohistochemistry, was observed in these cells. No gross or microscopic lesions were observed in the control animal. The results of this study suggest that apoptosis is the main mechanism of cell death in cattle intoxicated with R. communis seeds.
EEA Balcarce
Fil: Marin, Raúl. Universidad Nacional de Jujuy; Argentina.
Fil: Schild, Carlos. Instituto Nacional de Investigación Agropecuaria (INIA); Uruguay.
Fil: García, Juan. Universidad de la República. Centro Universitario de la Región del Este; Uruguay.
Fil: Cantón, Germán. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina.
Fil: Micheloud, Juan. INTA, Estación Experimental Agropecuaria Salta; Argentina.
Fil: Morrell, Eleonora. INTA, Estación Experimental Agropecuaria Balcarce; Argentina.
Fil: Uzal, Francisco. Universidad de California; Estados Unidos.
Fuente
Brazilian Journal of Veterinary Pathology 11 (3) : 86-91 (November 2018)
Materia
Apoptosis
Ganado Bovino
Experimentación
Ricinus Communis
Cattle
Experimentation
Poisoning
Envenenamiento
Intoxicación
Ricino
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/5667
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network_name_str INTA Digital (INTA)
spelling Pathology of cattle experimentally intoxicated with ground Ricinus communis seedsMarin, Raul EduardoSchild, CarlosGarcia, JuanCanton, German JoseMicheloud, Juan FranciscoMorrell, Eleonora LidiaUzal, Francisco AlejaApoptosisGanado BovinoExperimentaciónRicinus CommunisCattleExperimentationPoisoningEnvenenamientoIntoxicaciónRicinoFive Aberdeen Angus calves were inoculated intra-ruminally with ground seeds of Ricinus communis at doses of 1, 1.5, 2 or 3 gr per kg of body weight, or with saline solution (control), respectively. Grossly, all intoxicated animals showed hemorrhages in abdominal serosas, epicardium, endocardium, spleen, pre-stomachs, abomasum, and small and large intestine, and diffuse edema of the ruminal mucosa. Microscopically, in all animals inoculated with R. communis seeds, the main feature was the presence of pyknotic and karyorrhectic nuclei in the endothelium of central nervous system, hepatic, ruminal, intestinal, glomerular and alveolar capillaries, and in lymphoid cells of multiple organs. Apoptosis, confirmed by activated caspase-3 immunohistochemistry, was observed in these cells. No gross or microscopic lesions were observed in the control animal. The results of this study suggest that apoptosis is the main mechanism of cell death in cattle intoxicated with R. communis seeds.EEA BalcarceFil: Marin, Raúl. Universidad Nacional de Jujuy; Argentina.Fil: Schild, Carlos. Instituto Nacional de Investigación Agropecuaria (INIA); Uruguay.Fil: García, Juan. Universidad de la República. Centro Universitario de la Región del Este; Uruguay.Fil: Cantón, Germán. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina.Fil: Micheloud, Juan. INTA, Estación Experimental Agropecuaria Salta; Argentina.Fil: Morrell, Eleonora. INTA, Estación Experimental Agropecuaria Balcarce; Argentina.Fil: Uzal, Francisco. Universidad de California; Estados Unidos.Brazilian Association of Veterinary Pathology2019-08-22T13:09:06Z2019-08-22T13:09:06Z2018-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/5667https://bjvp.org.br/bjvp-archive/2018/11/vol-11-n-3-november-2018/1983-0246http://dx.doi.org/10.24070/bjvp.1983-0246.v11i3p86-91Brazilian Journal of Veterinary Pathology 11 (3) : 86-91 (November 2018)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-10-23T11:17:01Zoai:localhost:20.500.12123/5667instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-10-23 11:17:02.195INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Pathology of cattle experimentally intoxicated with ground Ricinus communis seeds
title Pathology of cattle experimentally intoxicated with ground Ricinus communis seeds
spellingShingle Pathology of cattle experimentally intoxicated with ground Ricinus communis seeds
Marin, Raul Eduardo
Apoptosis
Ganado Bovino
Experimentación
Ricinus Communis
Cattle
Experimentation
Poisoning
Envenenamiento
Intoxicación
Ricino
title_short Pathology of cattle experimentally intoxicated with ground Ricinus communis seeds
title_full Pathology of cattle experimentally intoxicated with ground Ricinus communis seeds
title_fullStr Pathology of cattle experimentally intoxicated with ground Ricinus communis seeds
title_full_unstemmed Pathology of cattle experimentally intoxicated with ground Ricinus communis seeds
title_sort Pathology of cattle experimentally intoxicated with ground Ricinus communis seeds
dc.creator.none.fl_str_mv Marin, Raul Eduardo
Schild, Carlos
Garcia, Juan
Canton, German Jose
Micheloud, Juan Francisco
Morrell, Eleonora Lidia
Uzal, Francisco Aleja
author Marin, Raul Eduardo
author_facet Marin, Raul Eduardo
Schild, Carlos
Garcia, Juan
Canton, German Jose
Micheloud, Juan Francisco
Morrell, Eleonora Lidia
Uzal, Francisco Aleja
author_role author
author2 Schild, Carlos
Garcia, Juan
Canton, German Jose
Micheloud, Juan Francisco
Morrell, Eleonora Lidia
Uzal, Francisco Aleja
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Apoptosis
Ganado Bovino
Experimentación
Ricinus Communis
Cattle
Experimentation
Poisoning
Envenenamiento
Intoxicación
Ricino
topic Apoptosis
Ganado Bovino
Experimentación
Ricinus Communis
Cattle
Experimentation
Poisoning
Envenenamiento
Intoxicación
Ricino
dc.description.none.fl_txt_mv Five Aberdeen Angus calves were inoculated intra-ruminally with ground seeds of Ricinus communis at doses of 1, 1.5, 2 or 3 gr per kg of body weight, or with saline solution (control), respectively. Grossly, all intoxicated animals showed hemorrhages in abdominal serosas, epicardium, endocardium, spleen, pre-stomachs, abomasum, and small and large intestine, and diffuse edema of the ruminal mucosa. Microscopically, in all animals inoculated with R. communis seeds, the main feature was the presence of pyknotic and karyorrhectic nuclei in the endothelium of central nervous system, hepatic, ruminal, intestinal, glomerular and alveolar capillaries, and in lymphoid cells of multiple organs. Apoptosis, confirmed by activated caspase-3 immunohistochemistry, was observed in these cells. No gross or microscopic lesions were observed in the control animal. The results of this study suggest that apoptosis is the main mechanism of cell death in cattle intoxicated with R. communis seeds.
EEA Balcarce
Fil: Marin, Raúl. Universidad Nacional de Jujuy; Argentina.
Fil: Schild, Carlos. Instituto Nacional de Investigación Agropecuaria (INIA); Uruguay.
Fil: García, Juan. Universidad de la República. Centro Universitario de la Región del Este; Uruguay.
Fil: Cantón, Germán. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina.
Fil: Micheloud, Juan. INTA, Estación Experimental Agropecuaria Salta; Argentina.
Fil: Morrell, Eleonora. INTA, Estación Experimental Agropecuaria Balcarce; Argentina.
Fil: Uzal, Francisco. Universidad de California; Estados Unidos.
description Five Aberdeen Angus calves were inoculated intra-ruminally with ground seeds of Ricinus communis at doses of 1, 1.5, 2 or 3 gr per kg of body weight, or with saline solution (control), respectively. Grossly, all intoxicated animals showed hemorrhages in abdominal serosas, epicardium, endocardium, spleen, pre-stomachs, abomasum, and small and large intestine, and diffuse edema of the ruminal mucosa. Microscopically, in all animals inoculated with R. communis seeds, the main feature was the presence of pyknotic and karyorrhectic nuclei in the endothelium of central nervous system, hepatic, ruminal, intestinal, glomerular and alveolar capillaries, and in lymphoid cells of multiple organs. Apoptosis, confirmed by activated caspase-3 immunohistochemistry, was observed in these cells. No gross or microscopic lesions were observed in the control animal. The results of this study suggest that apoptosis is the main mechanism of cell death in cattle intoxicated with R. communis seeds.
publishDate 2018
dc.date.none.fl_str_mv 2018-11
2019-08-22T13:09:06Z
2019-08-22T13:09:06Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/5667
https://bjvp.org.br/bjvp-archive/2018/11/vol-11-n-3-november-2018/
1983-0246
http://dx.doi.org/10.24070/bjvp.1983-0246.v11i3p86-91
url http://hdl.handle.net/20.500.12123/5667
https://bjvp.org.br/bjvp-archive/2018/11/vol-11-n-3-november-2018/
http://dx.doi.org/10.24070/bjvp.1983-0246.v11i3p86-91
identifier_str_mv 1983-0246
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Brazilian Association of Veterinary Pathology
publisher.none.fl_str_mv Brazilian Association of Veterinary Pathology
dc.source.none.fl_str_mv Brazilian Journal of Veterinary Pathology 11 (3) : 86-91 (November 2018)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
_version_ 1846787525018910720
score 12.982451

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