Membrane-permeable trehalose 6-phosphate precursor spray increases wheat yields in field trials

Autores
Griffiths, Cara A.; Xiaochao, Xue; Miret, Javier A.; Salvagiotti, Fernando; Acevedo-Siaca, Liana G.; Gimeno, Jacinta; Reynolds, Matthew P.; Hassall, Kirsty L.; Halsey, Kirstie; Puranik, Swati; Oszvald, Maria; Kurup, Smita; Davis, Benjamin G.; Paul, Matthew J.
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Trehalose 6-phosphate (T6P) is an endogenous sugar signal in plants that promotes growth, yet it cannot be introduced directly into crops or fully genetically controlled. Here we show that wheat yields were improved using a timed microdose of a plant-permeable, sunlight-activated T6P signaling precursor, DMNB-T6P, under a variety of agricultural conditions. Under both well-watered and water-stressed conditions over 4 years, DMNB-T6P stimulated yield of three elite varieties. Yield increases were an order of magnitude larger than average annual genetic gains of breeding programs and occurred without additional water or fertilizer. Mechanistic analyses reveal that these benefits arise from increased CO2 fixation and linear electron flow (‘source’) as well as from increased starchy endosperm volume, enhanced grain sieve tube development and upregulation of genes for starch, amino acid and protein synthesis (‘sink’). These data demonstrate a step-change, scalable technology with net benefit to the environment that could provide sustainable yield improvements of diverse staple cereal crops.
EEA Oliveros
Fil: Griffiths, Cara A. Rothamsted Research; Reino Unido
Fil: Xiaochao, Xue. University of Oxford. Department of Chemistry; Reino Unido
Fil: Miret, Javier A. Rothamsted Research; Reino Unido
Fil: Salvagiotti, Fernando. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Oliveros; Argentina
Fil: Salvagiotti, Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Acevedo-Siaca, Liana G. Wageningen University. Horticulture and Product Physiology; Países Bajos
Fil: Acevedo-Siaca, Liana G. International Maize and Wheat Improvement Centre (CIMMYT). Global Wheat Program; México
Fil: Gimeno, Jacinta. International Maize and Wheat Improvement Centre (CIMMYT). Global Wheat Program; México
Fil: Reynolds, Matthew P. International Maize and Wheat Improvement Centre (CIMMYT). Global Wheat Program; México
Fil: Hassall, Kirsty L. University of Warwick. Department of Statistics; Reino Unido
Fil: Hassall, Kirsty L. Rothamsted Research; Reino Unido
Fil: Halsey, Kirstie. Rothamsted Research; Reino Unido
Fil: Puranik, Swati. Rothamsted Research; Reino Unido
Fil: Oszvald, Maria. Rothamsted Research; Reino Unido
Fil: Kurup, Smita. Rothamsted Research; Reino Unido
Fil: Davis, Benjamin G. University of Oxford. Department of Chemistry; Reino Unido
Fil: Davis, Benjamin G. University of Oxford. Department of Pharmacology; Reino Unido
Fil: Davis, Benjamin G. Rosalind Franklin Institute; Reino Unido
Fil: Paul, Matthew J. Rothamsted Research; Reino Unido
Fuente
Nature Biotechnology : 1-29. (Published: 29 April 2025)
Materia
Trigo
Rendimiento
Fitomejoramiento
Trehalosa
Variedades
Wheat
Yields
Plant Breeding
Trehalose
Varieties
Trehalose 6-phosphate
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/22352
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oai_identifier_str oai:localhost:20.500.12123/22352
network_acronym_str INTADig
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network_name_str INTA Digital (INTA)
spelling Membrane-permeable trehalose 6-phosphate precursor spray increases wheat yields in field trialsGriffiths, Cara A.Xiaochao, XueMiret, Javier A.Salvagiotti, FernandoAcevedo-Siaca, Liana G.Gimeno, JacintaReynolds, Matthew P.Hassall, Kirsty L.Halsey, KirstiePuranik, SwatiOszvald, MariaKurup, SmitaDavis, Benjamin G.Paul, Matthew J.TrigoRendimientoFitomejoramientoTrehalosaVariedadesWheatYieldsPlant BreedingTrehaloseVarietiesTrehalose 6-phosphateTrehalose 6-phosphate (T6P) is an endogenous sugar signal in plants that promotes growth, yet it cannot be introduced directly into crops or fully genetically controlled. Here we show that wheat yields were improved using a timed microdose of a plant-permeable, sunlight-activated T6P signaling precursor, DMNB-T6P, under a variety of agricultural conditions. Under both well-watered and water-stressed conditions over 4 years, DMNB-T6P stimulated yield of three elite varieties. Yield increases were an order of magnitude larger than average annual genetic gains of breeding programs and occurred without additional water or fertilizer. Mechanistic analyses reveal that these benefits arise from increased CO2 fixation and linear electron flow (‘source’) as well as from increased starchy endosperm volume, enhanced grain sieve tube development and upregulation of genes for starch, amino acid and protein synthesis (‘sink’). These data demonstrate a step-change, scalable technology with net benefit to the environment that could provide sustainable yield improvements of diverse staple cereal crops.EEA OliverosFil: Griffiths, Cara A. Rothamsted Research; Reino UnidoFil: Xiaochao, Xue. University of Oxford. Department of Chemistry; Reino UnidoFil: Miret, Javier A. Rothamsted Research; Reino UnidoFil: Salvagiotti, Fernando. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Oliveros; ArgentinaFil: Salvagiotti, Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Acevedo-Siaca, Liana G. Wageningen University. Horticulture and Product Physiology; Países BajosFil: Acevedo-Siaca, Liana G. International Maize and Wheat Improvement Centre (CIMMYT). Global Wheat Program; MéxicoFil: Gimeno, Jacinta. International Maize and Wheat Improvement Centre (CIMMYT). Global Wheat Program; MéxicoFil: Reynolds, Matthew P. International Maize and Wheat Improvement Centre (CIMMYT). Global Wheat Program; MéxicoFil: Hassall, Kirsty L. University of Warwick. Department of Statistics; Reino UnidoFil: Hassall, Kirsty L. Rothamsted Research; Reino UnidoFil: Halsey, Kirstie. Rothamsted Research; Reino UnidoFil: Puranik, Swati. Rothamsted Research; Reino UnidoFil: Oszvald, Maria. Rothamsted Research; Reino UnidoFil: Kurup, Smita. Rothamsted Research; Reino UnidoFil: Davis, Benjamin G. University of Oxford. Department of Chemistry; Reino UnidoFil: Davis, Benjamin G. University of Oxford. Department of Pharmacology; Reino UnidoFil: Davis, Benjamin G. Rosalind Franklin Institute; Reino UnidoFil: Paul, Matthew J. Rothamsted Research; Reino UnidoSpringer Nature2025-05-20T12:25:26Z2025-05-20T12:25:26Z2025-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/22352https://www.nature.com/articles/s41587-025-02611-11087-01561546-1696https://doi.org/10.1038/s41587-025-02611-1Nature Biotechnology : 1-29. (Published: 29 April 2025)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-29T13:47:18Zoai:localhost:20.500.12123/22352instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-29 13:47:18.73INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Membrane-permeable trehalose 6-phosphate precursor spray increases wheat yields in field trials
title Membrane-permeable trehalose 6-phosphate precursor spray increases wheat yields in field trials
spellingShingle Membrane-permeable trehalose 6-phosphate precursor spray increases wheat yields in field trials
Griffiths, Cara A.
Trigo
Rendimiento
Fitomejoramiento
Trehalosa
Variedades
Wheat
Yields
Plant Breeding
Trehalose
Varieties
Trehalose 6-phosphate
title_short Membrane-permeable trehalose 6-phosphate precursor spray increases wheat yields in field trials
title_full Membrane-permeable trehalose 6-phosphate precursor spray increases wheat yields in field trials
title_fullStr Membrane-permeable trehalose 6-phosphate precursor spray increases wheat yields in field trials
title_full_unstemmed Membrane-permeable trehalose 6-phosphate precursor spray increases wheat yields in field trials
title_sort Membrane-permeable trehalose 6-phosphate precursor spray increases wheat yields in field trials
dc.creator.none.fl_str_mv Griffiths, Cara A.
Xiaochao, Xue
Miret, Javier A.
Salvagiotti, Fernando
Acevedo-Siaca, Liana G.
Gimeno, Jacinta
Reynolds, Matthew P.
Hassall, Kirsty L.
Halsey, Kirstie
Puranik, Swati
Oszvald, Maria
Kurup, Smita
Davis, Benjamin G.
Paul, Matthew J.
author Griffiths, Cara A.
author_facet Griffiths, Cara A.
Xiaochao, Xue
Miret, Javier A.
Salvagiotti, Fernando
Acevedo-Siaca, Liana G.
Gimeno, Jacinta
Reynolds, Matthew P.
Hassall, Kirsty L.
Halsey, Kirstie
Puranik, Swati
Oszvald, Maria
Kurup, Smita
Davis, Benjamin G.
Paul, Matthew J.
author_role author
author2 Xiaochao, Xue
Miret, Javier A.
Salvagiotti, Fernando
Acevedo-Siaca, Liana G.
Gimeno, Jacinta
Reynolds, Matthew P.
Hassall, Kirsty L.
Halsey, Kirstie
Puranik, Swati
Oszvald, Maria
Kurup, Smita
Davis, Benjamin G.
Paul, Matthew J.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Trigo
Rendimiento
Fitomejoramiento
Trehalosa
Variedades
Wheat
Yields
Plant Breeding
Trehalose
Varieties
Trehalose 6-phosphate
topic Trigo
Rendimiento
Fitomejoramiento
Trehalosa
Variedades
Wheat
Yields
Plant Breeding
Trehalose
Varieties
Trehalose 6-phosphate
dc.description.none.fl_txt_mv Trehalose 6-phosphate (T6P) is an endogenous sugar signal in plants that promotes growth, yet it cannot be introduced directly into crops or fully genetically controlled. Here we show that wheat yields were improved using a timed microdose of a plant-permeable, sunlight-activated T6P signaling precursor, DMNB-T6P, under a variety of agricultural conditions. Under both well-watered and water-stressed conditions over 4 years, DMNB-T6P stimulated yield of three elite varieties. Yield increases were an order of magnitude larger than average annual genetic gains of breeding programs and occurred without additional water or fertilizer. Mechanistic analyses reveal that these benefits arise from increased CO2 fixation and linear electron flow (‘source’) as well as from increased starchy endosperm volume, enhanced grain sieve tube development and upregulation of genes for starch, amino acid and protein synthesis (‘sink’). These data demonstrate a step-change, scalable technology with net benefit to the environment that could provide sustainable yield improvements of diverse staple cereal crops.
EEA Oliveros
Fil: Griffiths, Cara A. Rothamsted Research; Reino Unido
Fil: Xiaochao, Xue. University of Oxford. Department of Chemistry; Reino Unido
Fil: Miret, Javier A. Rothamsted Research; Reino Unido
Fil: Salvagiotti, Fernando. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Oliveros; Argentina
Fil: Salvagiotti, Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Acevedo-Siaca, Liana G. Wageningen University. Horticulture and Product Physiology; Países Bajos
Fil: Acevedo-Siaca, Liana G. International Maize and Wheat Improvement Centre (CIMMYT). Global Wheat Program; México
Fil: Gimeno, Jacinta. International Maize and Wheat Improvement Centre (CIMMYT). Global Wheat Program; México
Fil: Reynolds, Matthew P. International Maize and Wheat Improvement Centre (CIMMYT). Global Wheat Program; México
Fil: Hassall, Kirsty L. University of Warwick. Department of Statistics; Reino Unido
Fil: Hassall, Kirsty L. Rothamsted Research; Reino Unido
Fil: Halsey, Kirstie. Rothamsted Research; Reino Unido
Fil: Puranik, Swati. Rothamsted Research; Reino Unido
Fil: Oszvald, Maria. Rothamsted Research; Reino Unido
Fil: Kurup, Smita. Rothamsted Research; Reino Unido
Fil: Davis, Benjamin G. University of Oxford. Department of Chemistry; Reino Unido
Fil: Davis, Benjamin G. University of Oxford. Department of Pharmacology; Reino Unido
Fil: Davis, Benjamin G. Rosalind Franklin Institute; Reino Unido
Fil: Paul, Matthew J. Rothamsted Research; Reino Unido
description Trehalose 6-phosphate (T6P) is an endogenous sugar signal in plants that promotes growth, yet it cannot be introduced directly into crops or fully genetically controlled. Here we show that wheat yields were improved using a timed microdose of a plant-permeable, sunlight-activated T6P signaling precursor, DMNB-T6P, under a variety of agricultural conditions. Under both well-watered and water-stressed conditions over 4 years, DMNB-T6P stimulated yield of three elite varieties. Yield increases were an order of magnitude larger than average annual genetic gains of breeding programs and occurred without additional water or fertilizer. Mechanistic analyses reveal that these benefits arise from increased CO2 fixation and linear electron flow (‘source’) as well as from increased starchy endosperm volume, enhanced grain sieve tube development and upregulation of genes for starch, amino acid and protein synthesis (‘sink’). These data demonstrate a step-change, scalable technology with net benefit to the environment that could provide sustainable yield improvements of diverse staple cereal crops.
publishDate 2025
dc.date.none.fl_str_mv 2025-05-20T12:25:26Z
2025-05-20T12:25:26Z
2025-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/22352
https://www.nature.com/articles/s41587-025-02611-1
1087-0156
1546-1696
https://doi.org/10.1038/s41587-025-02611-1
url http://hdl.handle.net/20.500.12123/22352
https://www.nature.com/articles/s41587-025-02611-1
https://doi.org/10.1038/s41587-025-02611-1
identifier_str_mv 1087-0156
1546-1696
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv Nature Biotechnology : 1-29. (Published: 29 April 2025)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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score 12.559606

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