Cystic endometrial hyperplasia in dairy goats: morphological changes and expressions of estrogen receptor-α and progesterone receptor
- Autores
- Avellaneda Cáceres, Agustín; Aguirre Castro, Laura Sabrina; Sandoval, Gabriela Virginia; Medina, Diego Martin; Quintana, Ana Laura; Acuña, Francisco; Gomez Castro, Gimena; Barbeito, Claudio Gustavo; Micheloud, Juan Francisco
- Año de publicación
- 2026
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Cystic endometrial hyperplasia (CEH), often associated with hydrometra or mucometra, is a serious condition of subfertility and infertility in dairy goats, severely affecting herd productivity. Although there are many clinical reports of hydrometra in goats, research specifically addressing the molecular pathogenesis of CEH in this species remains notably limited. The objective of this study was to describe the morphological alterations in the endometrium of goats with CHE and to evaluate the immunohistochemical expression patterns of estrogen (ER-α) and progesterone receptor (PR) in the uterine wall by comparing them with those of healthy control goats. Gross pathological examination showed bilateral uterine distension, with both uterine horns symmetrically distended. Histological examination revealed extensive cystic dilatation of the endometrial glands. Immunoreactivity was objectively quantified using digital image analysis (H-score). The most significant molecular finding was an overexpression of both PR and ER-α in the affected group. Specifically, PR H-scores were significantly higher in the surface epithelium, stromal cells, and normal glands of affected goats (p = 0.0043). Furthermore, digital quantification revealed a significant up-regulation of ER-α in cystic glands (p = 0.0010) compared to control tissues. (p = 0.0043). These results suggest that CEH in dairy goats is associated with a localized hormonal dysregulation involving a concomitant increase in steroid receptor expression. These findings contribute to a better understanding of the complex hormonal environment involved in uterine diseases of small ruminants.
Instituto de Investigaciòn Animal de Chaco Semiàrido
Fil: Avellaneda Cáceres, Agustín. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal Chaco Semiárido. Área de Salud Animal; Argentina
Fil: Avellaneda Cáceres, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Avellaneda Cáceres, Agustín. Universidad Nacional de Salta. Facultad de Ciencias Naturales; Argentina
Fil: Aguirre Castro, Laura Sabrina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Aguirre Castro, Laura Sabrina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal del Chaco Semiárido. Área de Salud Animal; Argentina
Fil: Aguirre Castro, Laura Sabrina.Universidad Católica de Salta. Facultad de Ciencias Agrarias y Veterinarias; Argentina
Fil: Sandoval, Gabriela Virginia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal del Chaco Semiárido. Área de Salud Animal; Argentina
Fil: Sandoval, Gabriela Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sandoval, Gabriela Virginia. Universidad Católica de Salta. Facultad de Ciencias Agrarias y Veterinarias; Argentina
Fil: Medina, Diego Martin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Medina, Diego Martin. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal del Chaco Semiárido. Área de Salud Animal; Argentina
Fil: Medina, Diego Martin. Universidad Católica de Salta. Facultad de Ciencias Agrarias y Veterinarias; Argentina
Fil: Quintana, Ana L. Universidad Nacional de Jujuy. Facultad de Ciencias Agrarias; Argentina
Fil: Acuña, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Acuña, Francisco. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Morfología y Patología Animal; Argentina
Fil: Gomez Castro, Gimena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gomez Castro, Gimena. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Morfología y Patología Animal; Argentina
Fil: Barbeito, Claudio G. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Barbeito, Claudio G. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Morfología y Patología Animal; Argentina
Fil: Micheloud, Juan Francisco. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal del Chaco Semiárido. Área de Salud Animal; Argentina
Fil: Micheloud, Juan Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Micheloud, Juan Francisco. Universidad Católica de Salta. Facultad de Ciencias Agrarias y Veterinarias; Argentina - Fuente
- Research in Veterinary Science 205 : 106171 (June 2026)
- Materia
-
Dairy Goats
Hyperplasia
Progesterone
Oestrogens
Cabras Lecheras
Hiperplasia
Progesterona
Estrógenos
Estrogen Alpha Receptor
Progesterone Receptor
Endometrial Hyperplasia
Estrogens - Nivel de accesibilidad
- acceso restringido
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
.jpg)
- Institución
- Instituto Nacional de Tecnología Agropecuaria
- OAI Identificador
- oai:localhost:20.500.12123/25785
Ver los metadatos del registro completo
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Cystic endometrial hyperplasia in dairy goats: morphological changes and expressions of estrogen receptor-α and progesterone receptorAvellaneda Cáceres, AgustínAguirre Castro, Laura SabrinaSandoval, Gabriela VirginiaMedina, Diego MartinQuintana, Ana LauraAcuña, FranciscoGomez Castro, GimenaBarbeito, Claudio GustavoMicheloud, Juan FranciscoDairy GoatsHyperplasiaProgesteroneOestrogensCabras LecherasHiperplasiaProgesteronaEstrógenosEstrogen Alpha ReceptorProgesterone ReceptorEndometrial HyperplasiaEstrogensCystic endometrial hyperplasia (CEH), often associated with hydrometra or mucometra, is a serious condition of subfertility and infertility in dairy goats, severely affecting herd productivity. Although there are many clinical reports of hydrometra in goats, research specifically addressing the molecular pathogenesis of CEH in this species remains notably limited. The objective of this study was to describe the morphological alterations in the endometrium of goats with CHE and to evaluate the immunohistochemical expression patterns of estrogen (ER-α) and progesterone receptor (PR) in the uterine wall by comparing them with those of healthy control goats. Gross pathological examination showed bilateral uterine distension, with both uterine horns symmetrically distended. Histological examination revealed extensive cystic dilatation of the endometrial glands. Immunoreactivity was objectively quantified using digital image analysis (H-score). The most significant molecular finding was an overexpression of both PR and ER-α in the affected group. Specifically, PR H-scores were significantly higher in the surface epithelium, stromal cells, and normal glands of affected goats (p = 0.0043). Furthermore, digital quantification revealed a significant up-regulation of ER-α in cystic glands (p = 0.0010) compared to control tissues. (p = 0.0043). These results suggest that CEH in dairy goats is associated with a localized hormonal dysregulation involving a concomitant increase in steroid receptor expression. These findings contribute to a better understanding of the complex hormonal environment involved in uterine diseases of small ruminants.Instituto de Investigaciòn Animal de Chaco SemiàridoFil: Avellaneda Cáceres, Agustín. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal Chaco Semiárido. Área de Salud Animal; ArgentinaFil: Avellaneda Cáceres, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Avellaneda Cáceres, Agustín. Universidad Nacional de Salta. Facultad de Ciencias Naturales; ArgentinaFil: Aguirre Castro, Laura Sabrina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Aguirre Castro, Laura Sabrina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal del Chaco Semiárido. Área de Salud Animal; ArgentinaFil: Aguirre Castro, Laura Sabrina.Universidad Católica de Salta. Facultad de Ciencias Agrarias y Veterinarias; ArgentinaFil: Sandoval, Gabriela Virginia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal del Chaco Semiárido. Área de Salud Animal; ArgentinaFil: Sandoval, Gabriela Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sandoval, Gabriela Virginia. Universidad Católica de Salta. Facultad de Ciencias Agrarias y Veterinarias; ArgentinaFil: Medina, Diego Martin. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Medina, Diego Martin. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal del Chaco Semiárido. Área de Salud Animal; ArgentinaFil: Medina, Diego Martin. Universidad Católica de Salta. Facultad de Ciencias Agrarias y Veterinarias; ArgentinaFil: Quintana, Ana L. Universidad Nacional de Jujuy. Facultad de Ciencias Agrarias; ArgentinaFil: Acuña, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Acuña, Francisco. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Morfología y Patología Animal; ArgentinaFil: Gomez Castro, Gimena. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gomez Castro, Gimena. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Morfología y Patología Animal; ArgentinaFil: Barbeito, Claudio G. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Barbeito, Claudio G. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Morfología y Patología Animal; ArgentinaFil: Micheloud, Juan Francisco. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal del Chaco Semiárido. Área de Salud Animal; ArgentinaFil: Micheloud, Juan Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Micheloud, Juan Francisco. Universidad Católica de Salta. Facultad de Ciencias Agrarias y Veterinarias; ArgentinaElsevier2026-04-14T10:03:40Z2026-04-14T10:03:40Z2026-04-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/25785https://www.sciencedirect.com/science/article/abs/pii/S00345288260012440034-52881532-2661https://doi.org/10.1016/j.rvsc.2026.106171Research in Veterinary Science 205 : 106171 (June 2026)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2026-04-16T09:53:31Zoai:localhost:20.500.12123/25785instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2026-04-16 09:53:32.06INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse |
| dc.title.none.fl_str_mv |
Cystic endometrial hyperplasia in dairy goats: morphological changes and expressions of estrogen receptor-α and progesterone receptor |
| title |
Cystic endometrial hyperplasia in dairy goats: morphological changes and expressions of estrogen receptor-α and progesterone receptor |
| spellingShingle |
Cystic endometrial hyperplasia in dairy goats: morphological changes and expressions of estrogen receptor-α and progesterone receptor Avellaneda Cáceres, Agustín Dairy Goats Hyperplasia Progesterone Oestrogens Cabras Lecheras Hiperplasia Progesterona Estrógenos Estrogen Alpha Receptor Progesterone Receptor Endometrial Hyperplasia Estrogens |
| title_short |
Cystic endometrial hyperplasia in dairy goats: morphological changes and expressions of estrogen receptor-α and progesterone receptor |
| title_full |
Cystic endometrial hyperplasia in dairy goats: morphological changes and expressions of estrogen receptor-α and progesterone receptor |
| title_fullStr |
Cystic endometrial hyperplasia in dairy goats: morphological changes and expressions of estrogen receptor-α and progesterone receptor |
| title_full_unstemmed |
Cystic endometrial hyperplasia in dairy goats: morphological changes and expressions of estrogen receptor-α and progesterone receptor |
| title_sort |
Cystic endometrial hyperplasia in dairy goats: morphological changes and expressions of estrogen receptor-α and progesterone receptor |
| dc.creator.none.fl_str_mv |
Avellaneda Cáceres, Agustín Aguirre Castro, Laura Sabrina Sandoval, Gabriela Virginia Medina, Diego Martin Quintana, Ana Laura Acuña, Francisco Gomez Castro, Gimena Barbeito, Claudio Gustavo Micheloud, Juan Francisco |
| author |
Avellaneda Cáceres, Agustín |
| author_facet |
Avellaneda Cáceres, Agustín Aguirre Castro, Laura Sabrina Sandoval, Gabriela Virginia Medina, Diego Martin Quintana, Ana Laura Acuña, Francisco Gomez Castro, Gimena Barbeito, Claudio Gustavo Micheloud, Juan Francisco |
| author_role |
author |
| author2 |
Aguirre Castro, Laura Sabrina Sandoval, Gabriela Virginia Medina, Diego Martin Quintana, Ana Laura Acuña, Francisco Gomez Castro, Gimena Barbeito, Claudio Gustavo Micheloud, Juan Francisco |
| author2_role |
author author author author author author author author |
| dc.subject.none.fl_str_mv |
Dairy Goats Hyperplasia Progesterone Oestrogens Cabras Lecheras Hiperplasia Progesterona Estrógenos Estrogen Alpha Receptor Progesterone Receptor Endometrial Hyperplasia Estrogens |
| topic |
Dairy Goats Hyperplasia Progesterone Oestrogens Cabras Lecheras Hiperplasia Progesterona Estrógenos Estrogen Alpha Receptor Progesterone Receptor Endometrial Hyperplasia Estrogens |
| dc.description.none.fl_txt_mv |
Cystic endometrial hyperplasia (CEH), often associated with hydrometra or mucometra, is a serious condition of subfertility and infertility in dairy goats, severely affecting herd productivity. Although there are many clinical reports of hydrometra in goats, research specifically addressing the molecular pathogenesis of CEH in this species remains notably limited. The objective of this study was to describe the morphological alterations in the endometrium of goats with CHE and to evaluate the immunohistochemical expression patterns of estrogen (ER-α) and progesterone receptor (PR) in the uterine wall by comparing them with those of healthy control goats. Gross pathological examination showed bilateral uterine distension, with both uterine horns symmetrically distended. Histological examination revealed extensive cystic dilatation of the endometrial glands. Immunoreactivity was objectively quantified using digital image analysis (H-score). The most significant molecular finding was an overexpression of both PR and ER-α in the affected group. Specifically, PR H-scores were significantly higher in the surface epithelium, stromal cells, and normal glands of affected goats (p = 0.0043). Furthermore, digital quantification revealed a significant up-regulation of ER-α in cystic glands (p = 0.0010) compared to control tissues. (p = 0.0043). These results suggest that CEH in dairy goats is associated with a localized hormonal dysregulation involving a concomitant increase in steroid receptor expression. These findings contribute to a better understanding of the complex hormonal environment involved in uterine diseases of small ruminants. Instituto de Investigaciòn Animal de Chaco Semiàrido Fil: Avellaneda Cáceres, Agustín. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal Chaco Semiárido. Área de Salud Animal; Argentina Fil: Avellaneda Cáceres, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Avellaneda Cáceres, Agustín. Universidad Nacional de Salta. Facultad de Ciencias Naturales; Argentina Fil: Aguirre Castro, Laura Sabrina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Aguirre Castro, Laura Sabrina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal del Chaco Semiárido. Área de Salud Animal; Argentina Fil: Aguirre Castro, Laura Sabrina.Universidad Católica de Salta. Facultad de Ciencias Agrarias y Veterinarias; Argentina Fil: Sandoval, Gabriela Virginia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal del Chaco Semiárido. Área de Salud Animal; Argentina Fil: Sandoval, Gabriela Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Sandoval, Gabriela Virginia. Universidad Católica de Salta. Facultad de Ciencias Agrarias y Veterinarias; Argentina Fil: Medina, Diego Martin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Medina, Diego Martin. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal del Chaco Semiárido. Área de Salud Animal; Argentina Fil: Medina, Diego Martin. Universidad Católica de Salta. Facultad de Ciencias Agrarias y Veterinarias; Argentina Fil: Quintana, Ana L. Universidad Nacional de Jujuy. Facultad de Ciencias Agrarias; Argentina Fil: Acuña, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Acuña, Francisco. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Morfología y Patología Animal; Argentina Fil: Gomez Castro, Gimena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Gomez Castro, Gimena. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Morfología y Patología Animal; Argentina Fil: Barbeito, Claudio G. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Barbeito, Claudio G. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Morfología y Patología Animal; Argentina Fil: Micheloud, Juan Francisco. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal del Chaco Semiárido. Área de Salud Animal; Argentina Fil: Micheloud, Juan Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Micheloud, Juan Francisco. Universidad Católica de Salta. Facultad de Ciencias Agrarias y Veterinarias; Argentina |
| description |
Cystic endometrial hyperplasia (CEH), often associated with hydrometra or mucometra, is a serious condition of subfertility and infertility in dairy goats, severely affecting herd productivity. Although there are many clinical reports of hydrometra in goats, research specifically addressing the molecular pathogenesis of CEH in this species remains notably limited. The objective of this study was to describe the morphological alterations in the endometrium of goats with CHE and to evaluate the immunohistochemical expression patterns of estrogen (ER-α) and progesterone receptor (PR) in the uterine wall by comparing them with those of healthy control goats. Gross pathological examination showed bilateral uterine distension, with both uterine horns symmetrically distended. Histological examination revealed extensive cystic dilatation of the endometrial glands. Immunoreactivity was objectively quantified using digital image analysis (H-score). The most significant molecular finding was an overexpression of both PR and ER-α in the affected group. Specifically, PR H-scores were significantly higher in the surface epithelium, stromal cells, and normal glands of affected goats (p = 0.0043). Furthermore, digital quantification revealed a significant up-regulation of ER-α in cystic glands (p = 0.0010) compared to control tissues. (p = 0.0043). These results suggest that CEH in dairy goats is associated with a localized hormonal dysregulation involving a concomitant increase in steroid receptor expression. These findings contribute to a better understanding of the complex hormonal environment involved in uterine diseases of small ruminants. |
| publishDate |
2026 |
| dc.date.none.fl_str_mv |
2026-04-14T10:03:40Z 2026-04-14T10:03:40Z 2026-04-04 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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article |
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publishedVersion |
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http://hdl.handle.net/20.500.12123/25785 https://www.sciencedirect.com/science/article/abs/pii/S0034528826001244 0034-5288 1532-2661 https://doi.org/10.1016/j.rvsc.2026.106171 |
| url |
http://hdl.handle.net/20.500.12123/25785 https://www.sciencedirect.com/science/article/abs/pii/S0034528826001244 https://doi.org/10.1016/j.rvsc.2026.106171 |
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0034-5288 1532-2661 |
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eng |
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eng |
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info:eu-repo/semantics/restrictedAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
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http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
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application/pdf |
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Elsevier |
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Elsevier |
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Research in Veterinary Science 205 : 106171 (June 2026) reponame:INTA Digital (INTA) instname:Instituto Nacional de Tecnología Agropecuaria |
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