Bioprospecting of microbial strains for biofuel production: metabolic engineering, applications, and challenges

Autores
Adegboye, Mobolaji Felicia; Ojuederie, Omena Bernard; Talia, Paola Mónica; Babalola, Olubukola Oluranti
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The issues of global warming, coupled with fossil fuel depletion, have undoubtedly led to renewed interest in other sources of commercial fuels. The search for renewable fuels has motivated research into the biological degradation of lignocellulosic biomass feedstock to produce biofuels such as bioethanol, biodiesel, and biohydrogen. The model strain for biofuel production needs the capability to utilize a high amount of substrate, transportation of sugar through fast and deregulated pathways, ability to tolerate inhibitory compounds and end products, and increased metabolic fluxes to produce an improved fermentation product. Engineering microbes might be a great approach to produce biofuel from lignocellulosic biomass by exploiting metabolic pathways economically. Metabolic engineering is an advanced technology for the construction of highly effective microbial cell factories and a key component for the next-generation bioeconomy. It has been extensively used to redirect the biosynthetic pathway to produce desired products in several native or engineered hosts. A wide range of novel compounds has been manufactured through engineering metabolic pathways or endogenous metabolism optimizations by metabolic engineers. This review is focused on the potential utilization of engineered strains to produce biofuel and gives prospects for improvement in metabolic engineering for new strain development using advanced technologies.
Instituto de Biotecnología
Fil: Adegboye, Mobolaji Felicia. North-West University. Faculty of Natural and Agricultural Sciences. Food Security and Safety Niche Area; Sudáfrica
Fil: Ojuederie, Omena Bernard. North-West University. Faculty of Natural and Agricultural Sciences. Food Security and Safety Niche Area; Sudáfrica
Fil: Ojuederie, Omena Bernard. Kings University. Faculty of Science. Department of Biological Sciences; Nigeria
Fil: Talia, Paola Mónica. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular (IABIMO); Argentina
Fil: Talia, Paola Mónica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Babalola, Olubukola Oluranti. North-West University. Faculty of Natural and Agricultural Sciences. Food Security and Safety Niche Area; Sudáfrica
Fuente
Biotechnology for Biofuels 14 : Article number: 5 (06 January 2021)
Materia
Biocarburante
Lignocelulosa
Producción
Biofuels
Lignocellulose
Production
Biocombustibles
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
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spelling Bioprospecting of microbial strains for biofuel production: metabolic engineering, applications, and challengesAdegboye, Mobolaji FeliciaOjuederie, Omena BernardTalia, Paola MónicaBabalola, Olubukola OlurantiBiocarburanteLignocelulosaProducciónBiofuelsLignocelluloseProductionBiocombustiblesThe issues of global warming, coupled with fossil fuel depletion, have undoubtedly led to renewed interest in other sources of commercial fuels. The search for renewable fuels has motivated research into the biological degradation of lignocellulosic biomass feedstock to produce biofuels such as bioethanol, biodiesel, and biohydrogen. The model strain for biofuel production needs the capability to utilize a high amount of substrate, transportation of sugar through fast and deregulated pathways, ability to tolerate inhibitory compounds and end products, and increased metabolic fluxes to produce an improved fermentation product. Engineering microbes might be a great approach to produce biofuel from lignocellulosic biomass by exploiting metabolic pathways economically. Metabolic engineering is an advanced technology for the construction of highly effective microbial cell factories and a key component for the next-generation bioeconomy. It has been extensively used to redirect the biosynthetic pathway to produce desired products in several native or engineered hosts. A wide range of novel compounds has been manufactured through engineering metabolic pathways or endogenous metabolism optimizations by metabolic engineers. This review is focused on the potential utilization of engineered strains to produce biofuel and gives prospects for improvement in metabolic engineering for new strain development using advanced technologies.Instituto de BiotecnologíaFil: Adegboye, Mobolaji Felicia. North-West University. Faculty of Natural and Agricultural Sciences. Food Security and Safety Niche Area; SudáfricaFil: Ojuederie, Omena Bernard. North-West University. Faculty of Natural and Agricultural Sciences. Food Security and Safety Niche Area; SudáfricaFil: Ojuederie, Omena Bernard. Kings University. Faculty of Science. Department of Biological Sciences; NigeriaFil: Talia, Paola Mónica. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular (IABIMO); ArgentinaFil: Talia, Paola Mónica. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Babalola, Olubukola Oluranti. North-West University. Faculty of Natural and Agricultural Sciences. Food Security and Safety Niche Area; SudáfricaBMC2021-11-11T11:42:46Z2021-11-11T11:42:46Z2021-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/10746https://biotechnologyforbiofuels.biomedcentral.com/articles/10.1186/s13068-020-01853-21754-6834https://doi.org/10.1186/s13068-020-01853-2Biotechnology for Biofuels 14 : Article number: 5 (06 January 2021)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repograntAgreement/INTA/PNAIyAV-1130034/AR./Desarrollo de procesos para la transformación de biomasa en bioenergía.info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-04T09:49:10Zoai:localhost:20.500.12123/10746instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-04 09:49:11.113INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Bioprospecting of microbial strains for biofuel production: metabolic engineering, applications, and challenges
title Bioprospecting of microbial strains for biofuel production: metabolic engineering, applications, and challenges
spellingShingle Bioprospecting of microbial strains for biofuel production: metabolic engineering, applications, and challenges
Adegboye, Mobolaji Felicia
Biocarburante
Lignocelulosa
Producción
Biofuels
Lignocellulose
Production
Biocombustibles
title_short Bioprospecting of microbial strains for biofuel production: metabolic engineering, applications, and challenges
title_full Bioprospecting of microbial strains for biofuel production: metabolic engineering, applications, and challenges
title_fullStr Bioprospecting of microbial strains for biofuel production: metabolic engineering, applications, and challenges
title_full_unstemmed Bioprospecting of microbial strains for biofuel production: metabolic engineering, applications, and challenges
title_sort Bioprospecting of microbial strains for biofuel production: metabolic engineering, applications, and challenges
dc.creator.none.fl_str_mv Adegboye, Mobolaji Felicia
Ojuederie, Omena Bernard
Talia, Paola Mónica
Babalola, Olubukola Oluranti
author Adegboye, Mobolaji Felicia
author_facet Adegboye, Mobolaji Felicia
Ojuederie, Omena Bernard
Talia, Paola Mónica
Babalola, Olubukola Oluranti
author_role author
author2 Ojuederie, Omena Bernard
Talia, Paola Mónica
Babalola, Olubukola Oluranti
author2_role author
author
author
dc.subject.none.fl_str_mv Biocarburante
Lignocelulosa
Producción
Biofuels
Lignocellulose
Production
Biocombustibles
topic Biocarburante
Lignocelulosa
Producción
Biofuels
Lignocellulose
Production
Biocombustibles
dc.description.none.fl_txt_mv The issues of global warming, coupled with fossil fuel depletion, have undoubtedly led to renewed interest in other sources of commercial fuels. The search for renewable fuels has motivated research into the biological degradation of lignocellulosic biomass feedstock to produce biofuels such as bioethanol, biodiesel, and biohydrogen. The model strain for biofuel production needs the capability to utilize a high amount of substrate, transportation of sugar through fast and deregulated pathways, ability to tolerate inhibitory compounds and end products, and increased metabolic fluxes to produce an improved fermentation product. Engineering microbes might be a great approach to produce biofuel from lignocellulosic biomass by exploiting metabolic pathways economically. Metabolic engineering is an advanced technology for the construction of highly effective microbial cell factories and a key component for the next-generation bioeconomy. It has been extensively used to redirect the biosynthetic pathway to produce desired products in several native or engineered hosts. A wide range of novel compounds has been manufactured through engineering metabolic pathways or endogenous metabolism optimizations by metabolic engineers. This review is focused on the potential utilization of engineered strains to produce biofuel and gives prospects for improvement in metabolic engineering for new strain development using advanced technologies.
Instituto de Biotecnología
Fil: Adegboye, Mobolaji Felicia. North-West University. Faculty of Natural and Agricultural Sciences. Food Security and Safety Niche Area; Sudáfrica
Fil: Ojuederie, Omena Bernard. North-West University. Faculty of Natural and Agricultural Sciences. Food Security and Safety Niche Area; Sudáfrica
Fil: Ojuederie, Omena Bernard. Kings University. Faculty of Science. Department of Biological Sciences; Nigeria
Fil: Talia, Paola Mónica. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular (IABIMO); Argentina
Fil: Talia, Paola Mónica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Babalola, Olubukola Oluranti. North-West University. Faculty of Natural and Agricultural Sciences. Food Security and Safety Niche Area; Sudáfrica
description The issues of global warming, coupled with fossil fuel depletion, have undoubtedly led to renewed interest in other sources of commercial fuels. The search for renewable fuels has motivated research into the biological degradation of lignocellulosic biomass feedstock to produce biofuels such as bioethanol, biodiesel, and biohydrogen. The model strain for biofuel production needs the capability to utilize a high amount of substrate, transportation of sugar through fast and deregulated pathways, ability to tolerate inhibitory compounds and end products, and increased metabolic fluxes to produce an improved fermentation product. Engineering microbes might be a great approach to produce biofuel from lignocellulosic biomass by exploiting metabolic pathways economically. Metabolic engineering is an advanced technology for the construction of highly effective microbial cell factories and a key component for the next-generation bioeconomy. It has been extensively used to redirect the biosynthetic pathway to produce desired products in several native or engineered hosts. A wide range of novel compounds has been manufactured through engineering metabolic pathways or endogenous metabolism optimizations by metabolic engineers. This review is focused on the potential utilization of engineered strains to produce biofuel and gives prospects for improvement in metabolic engineering for new strain development using advanced technologies.
publishDate 2021
dc.date.none.fl_str_mv 2021-11-11T11:42:46Z
2021-11-11T11:42:46Z
2021-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/10746
https://biotechnologyforbiofuels.biomedcentral.com/articles/10.1186/s13068-020-01853-2
1754-6834
https://doi.org/10.1186/s13068-020-01853-2
url http://hdl.handle.net/20.500.12123/10746
https://biotechnologyforbiofuels.biomedcentral.com/articles/10.1186/s13068-020-01853-2
https://doi.org/10.1186/s13068-020-01853-2
identifier_str_mv 1754-6834
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repograntAgreement/INTA/PNAIyAV-1130034/AR./Desarrollo de procesos para la transformación de biomasa en bioenergía.
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv Biotechnology for Biofuels 14 : Article number: 5 (06 January 2021)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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score 12.623145

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