Bioprospecting of microbial strains for biofuel production: metabolic engineering, applications, and challenges

Autores
Adegboye, Mobolaji Felicia; Ojuederie, Omena Bernard; Talia, Paola Monica; Babalola, Olubukola Oluranti
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The issues of global warming, coupled with fossil fuel depletion, have undoubtedly led to renewed interest in other sources of commercial fuels. The search for renewable fuels has motivated research into the biological degradation of lignocellulosic biomass feedstock to produce biofuels such as bioethanol, biodiesel, and biohydrogen. The model strain for biofuel production needs the capability to utilize a high amount of substrate, transportation of sugar through fast and deregulated pathways, ability to tolerate inhibitory compounds and end products, and increased metabolic fluxes to produce an improved fermentation product. Engineering microbes might be a great approach to produce biofuel from lignocellulosic biomass by exploiting metabolic pathways economically. Metabolic engineering is an advanced technology for the construction of highly effective microbial cell factories and a key component for the next-generation bioeconomy. It has been extensively used to redirect the biosynthetic pathway to produce desired products in several native or engineered hosts. A wide range of novel compounds has been manufactured through engineering metabolic pathways or endogenous metabolism optimizations by metabolic engineers. This review is focused on the potential utilization of engineered strains to produce biofuel and gives prospects for improvement in metabolic engineering for new strain development using advanced technologies.
Fil: Adegboye, Mobolaji Felicia. North-West University; Sudáfrica
Fil: Ojuederie, Omena Bernard. North-West University; Sudáfrica. Kings University; Nigeria
Fil: Talia, Paola Monica. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Agrobiotecnología y Biología Molecular. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Agrobiotecnología y Biología Molecular; Argentina
Fil: Babalola, Olubukola Oluranti. North-West University; Sudáfrica
Materia
CRISPER/CAS9
FERMENTATION
LIGNOCELLULOSE
METABOLIC PATHWAYS
MICROBIAL CELL FACTORIES
MODEL STRAINS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/184984
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Bioprospecting of microbial strains for biofuel production: metabolic engineering, applications, and challengesAdegboye, Mobolaji FeliciaOjuederie, Omena BernardTalia, Paola MonicaBabalola, Olubukola OlurantiCRISPER/CAS9FERMENTATIONLIGNOCELLULOSEMETABOLIC PATHWAYSMICROBIAL CELL FACTORIESMODEL STRAINShttps://purl.org/becyt/ford/4.1https://purl.org/becyt/ford/4The issues of global warming, coupled with fossil fuel depletion, have undoubtedly led to renewed interest in other sources of commercial fuels. The search for renewable fuels has motivated research into the biological degradation of lignocellulosic biomass feedstock to produce biofuels such as bioethanol, biodiesel, and biohydrogen. The model strain for biofuel production needs the capability to utilize a high amount of substrate, transportation of sugar through fast and deregulated pathways, ability to tolerate inhibitory compounds and end products, and increased metabolic fluxes to produce an improved fermentation product. Engineering microbes might be a great approach to produce biofuel from lignocellulosic biomass by exploiting metabolic pathways economically. Metabolic engineering is an advanced technology for the construction of highly effective microbial cell factories and a key component for the next-generation bioeconomy. It has been extensively used to redirect the biosynthetic pathway to produce desired products in several native or engineered hosts. A wide range of novel compounds has been manufactured through engineering metabolic pathways or endogenous metabolism optimizations by metabolic engineers. This review is focused on the potential utilization of engineered strains to produce biofuel and gives prospects for improvement in metabolic engineering for new strain development using advanced technologies.Fil: Adegboye, Mobolaji Felicia. North-West University; SudáfricaFil: Ojuederie, Omena Bernard. North-West University; Sudáfrica. Kings University; NigeriaFil: Talia, Paola Monica. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Agrobiotecnología y Biología Molecular. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Agrobiotecnología y Biología Molecular; ArgentinaFil: Babalola, Olubukola Oluranti. North-West University; SudáfricaBioMed Central2021-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/184984Adegboye, Mobolaji Felicia; Ojuederie, Omena Bernard; Talia, Paola Monica; Babalola, Olubukola Oluranti; Bioprospecting of microbial strains for biofuel production: metabolic engineering, applications, and challenges; BioMed Central; Biotechnology For Biofuels; 14; 1; 1-2021; 1-211754-6834CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://biotechnologyforbiofuels.biomedcentral.com/articles/10.1186/s13068-020-01853-2info:eu-repo/semantics/altIdentifier/doi/10.1186/s13068-020-01853-2info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:52:38Zoai:ri.conicet.gov.ar:11336/184984instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:52:38.52CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Bioprospecting of microbial strains for biofuel production: metabolic engineering, applications, and challenges
title Bioprospecting of microbial strains for biofuel production: metabolic engineering, applications, and challenges
spellingShingle Bioprospecting of microbial strains for biofuel production: metabolic engineering, applications, and challenges
Adegboye, Mobolaji Felicia
CRISPER/CAS9
FERMENTATION
LIGNOCELLULOSE
METABOLIC PATHWAYS
MICROBIAL CELL FACTORIES
MODEL STRAINS
title_short Bioprospecting of microbial strains for biofuel production: metabolic engineering, applications, and challenges
title_full Bioprospecting of microbial strains for biofuel production: metabolic engineering, applications, and challenges
title_fullStr Bioprospecting of microbial strains for biofuel production: metabolic engineering, applications, and challenges
title_full_unstemmed Bioprospecting of microbial strains for biofuel production: metabolic engineering, applications, and challenges
title_sort Bioprospecting of microbial strains for biofuel production: metabolic engineering, applications, and challenges
dc.creator.none.fl_str_mv Adegboye, Mobolaji Felicia
Ojuederie, Omena Bernard
Talia, Paola Monica
Babalola, Olubukola Oluranti
author Adegboye, Mobolaji Felicia
author_facet Adegboye, Mobolaji Felicia
Ojuederie, Omena Bernard
Talia, Paola Monica
Babalola, Olubukola Oluranti
author_role author
author2 Ojuederie, Omena Bernard
Talia, Paola Monica
Babalola, Olubukola Oluranti
author2_role author
author
author
dc.subject.none.fl_str_mv CRISPER/CAS9
FERMENTATION
LIGNOCELLULOSE
METABOLIC PATHWAYS
MICROBIAL CELL FACTORIES
MODEL STRAINS
topic CRISPER/CAS9
FERMENTATION
LIGNOCELLULOSE
METABOLIC PATHWAYS
MICROBIAL CELL FACTORIES
MODEL STRAINS
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.1
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv The issues of global warming, coupled with fossil fuel depletion, have undoubtedly led to renewed interest in other sources of commercial fuels. The search for renewable fuels has motivated research into the biological degradation of lignocellulosic biomass feedstock to produce biofuels such as bioethanol, biodiesel, and biohydrogen. The model strain for biofuel production needs the capability to utilize a high amount of substrate, transportation of sugar through fast and deregulated pathways, ability to tolerate inhibitory compounds and end products, and increased metabolic fluxes to produce an improved fermentation product. Engineering microbes might be a great approach to produce biofuel from lignocellulosic biomass by exploiting metabolic pathways economically. Metabolic engineering is an advanced technology for the construction of highly effective microbial cell factories and a key component for the next-generation bioeconomy. It has been extensively used to redirect the biosynthetic pathway to produce desired products in several native or engineered hosts. A wide range of novel compounds has been manufactured through engineering metabolic pathways or endogenous metabolism optimizations by metabolic engineers. This review is focused on the potential utilization of engineered strains to produce biofuel and gives prospects for improvement in metabolic engineering for new strain development using advanced technologies.
Fil: Adegboye, Mobolaji Felicia. North-West University; Sudáfrica
Fil: Ojuederie, Omena Bernard. North-West University; Sudáfrica. Kings University; Nigeria
Fil: Talia, Paola Monica. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Agrobiotecnología y Biología Molecular. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Agrobiotecnología y Biología Molecular; Argentina
Fil: Babalola, Olubukola Oluranti. North-West University; Sudáfrica
description The issues of global warming, coupled with fossil fuel depletion, have undoubtedly led to renewed interest in other sources of commercial fuels. The search for renewable fuels has motivated research into the biological degradation of lignocellulosic biomass feedstock to produce biofuels such as bioethanol, biodiesel, and biohydrogen. The model strain for biofuel production needs the capability to utilize a high amount of substrate, transportation of sugar through fast and deregulated pathways, ability to tolerate inhibitory compounds and end products, and increased metabolic fluxes to produce an improved fermentation product. Engineering microbes might be a great approach to produce biofuel from lignocellulosic biomass by exploiting metabolic pathways economically. Metabolic engineering is an advanced technology for the construction of highly effective microbial cell factories and a key component for the next-generation bioeconomy. It has been extensively used to redirect the biosynthetic pathway to produce desired products in several native or engineered hosts. A wide range of novel compounds has been manufactured through engineering metabolic pathways or endogenous metabolism optimizations by metabolic engineers. This review is focused on the potential utilization of engineered strains to produce biofuel and gives prospects for improvement in metabolic engineering for new strain development using advanced technologies.
publishDate 2021
dc.date.none.fl_str_mv 2021-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/184984
Adegboye, Mobolaji Felicia; Ojuederie, Omena Bernard; Talia, Paola Monica; Babalola, Olubukola Oluranti; Bioprospecting of microbial strains for biofuel production: metabolic engineering, applications, and challenges; BioMed Central; Biotechnology For Biofuels; 14; 1; 1-2021; 1-21
1754-6834
CONICET Digital
CONICET
url http://hdl.handle.net/11336/184984
identifier_str_mv Adegboye, Mobolaji Felicia; Ojuederie, Omena Bernard; Talia, Paola Monica; Babalola, Olubukola Oluranti; Bioprospecting of microbial strains for biofuel production: metabolic engineering, applications, and challenges; BioMed Central; Biotechnology For Biofuels; 14; 1; 1-2021; 1-21
1754-6834
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://biotechnologyforbiofuels.biomedcentral.com/articles/10.1186/s13068-020-01853-2
info:eu-repo/semantics/altIdentifier/doi/10.1186/s13068-020-01853-2
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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