Evidence of a fixed internal gene constellation in influenza A viruses isolated from wild birds in Argentina (2006–2016)

Autores
Rimondi, Agustina; Gonzalez Reiche, Ana Silvia; Olivera, Valeria Soledad; Decarre, Julieta; Castresana, Gabriel Julián; Romano, Marcelo; Nelson, Martha I.; van Bakel, Harm; Pereda, Ariel Julian; Ferreri, Lucas; Geiger, Ginger; Perez, Daniel Roberto
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Wild aquatic birds are the major reservoir of influenza A virus. Cloacal swabs and feces samples (n = 6595) were collected from 62 bird species in Argentina from 2006 to 2016 and screened for influenza A virus. Full genome sequencing of 15 influenza isolates from 6 waterfowl species revealed subtypes combinations that were previously described in South America (H1N1, H4N2, H4N6 (n = 3), H5N3, H6N2 (n = 4), and H10N7 (n = 2)), and new ones not previously identified in the region (H4N8, H7N7 and H7N9). Notably, the internal gene segments of all 15 Argentine isolates belonged to the South American lineage, showing a divergent evolution of these viruses in the Southern Hemisphere. Time-scaled phylogenies indicated that South American gene segments diverged between ~ 30 and ~ 140 years ago from the most closely related influenza lineages, which include the avian North American (PB1, HA, NA, MP, and NS-B) and Eurasian lineage (PB2), and the equine H3N8 lineage (PA, NP, and NS-A). Phylogenetic analyses of the hemagglutinin and neuraminidase gene segments of the H4, H6, and N8 subtypes revealed recent introductions and reassortment between viruses from the Northern and Southern Hemispheres in the Americas. Remarkably and despite evidence of recent hemagglutinin and neuraminidase subtype introductions, the phylogenetic composition of internal gene constellation of these influenza A viruses has remained unchanged. Considering the extended time and the number of sampled species of the current study, and the paucity of previously available data, our results contribute to a better understanding of the ecology and evolution of influenza virus in South America.
Instituto de Virología
Fil: Rimondi, Agustina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina
Fil: Gonzalez Reiche, Ana Silvia. University of Georgia. College of Veterinary Medicine. Poultry Diagnostic and Research Center; Estados Unidos. Icahn School of Medicine at Mount Sinai. Department of Genetics and Genomic Sciences; Estados Unidos
Fil: Olivera, Valeria Soledad. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina
Fil: Decarre, Julieta. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Recursos Biológicos; Argentina
Fil: Castresana, Gabriel Julián. Buenos Aires. Organismo Provincial para el Desarrollo Sostenible. Dirección de Áreas Naturales Protegidas; Argentina
Fil: Romano, Marcelo. Centro de Investigaciones en Biodiversidad y Ambiente, Rosario; Argentina
Fil: Nelson, Martha I. National Institutes of Health. Fogarty International Center; Estados Unidos
Fil: van Bakel, Harm. Icahn School of Medicine at Mount Sinai. Department of Genetics and Genomic Sciences; Estados Unidos
Fil: Pereda, Ariel Julian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina
Fil: Ferreri, Lucas. University of Georgia. College of Veterinary Medicine. Diagnostic and Research Center; Estados Unidos
Fil: Geiger, Ginger. University of Georgia. College of Veterinary Medicine. Poultry Diagnostic and Research Center; Estados Unidos
Fil: Perez, Daniel Roberto. University of Georgia. College of Veterinary Medicine. Poultry Diagnostic and Research Center; Estados Unidos
Fuente
Emerging microbes & infections 7, article number 194. (2018)
Materia
Virus de la Influenza Aviar
Avian Influenzavirus
Aves
Genes
Aves Acuáticas
Waterfowl
Phylogeny
Filogenia
Argentina
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/4476
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oai_identifier_str oai:localhost:20.500.12123/4476
network_acronym_str INTADig
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network_name_str INTA Digital (INTA)
spelling Evidence of a fixed internal gene constellation in influenza A viruses isolated from wild birds in Argentina (2006–2016)Rimondi, AgustinaGonzalez Reiche, Ana SilviaOlivera, Valeria SoledadDecarre, JulietaCastresana, Gabriel JuliánRomano, MarceloNelson, Martha I.van Bakel, HarmPereda, Ariel JulianFerreri, LucasGeiger, GingerPerez, Daniel RobertoVirus de la Influenza AviarAvian InfluenzavirusAvesGenesAves AcuáticasWaterfowlPhylogenyFilogeniaArgentinaWild aquatic birds are the major reservoir of influenza A virus. Cloacal swabs and feces samples (n = 6595) were collected from 62 bird species in Argentina from 2006 to 2016 and screened for influenza A virus. Full genome sequencing of 15 influenza isolates from 6 waterfowl species revealed subtypes combinations that were previously described in South America (H1N1, H4N2, H4N6 (n = 3), H5N3, H6N2 (n = 4), and H10N7 (n = 2)), and new ones not previously identified in the region (H4N8, H7N7 and H7N9). Notably, the internal gene segments of all 15 Argentine isolates belonged to the South American lineage, showing a divergent evolution of these viruses in the Southern Hemisphere. Time-scaled phylogenies indicated that South American gene segments diverged between ~ 30 and ~ 140 years ago from the most closely related influenza lineages, which include the avian North American (PB1, HA, NA, MP, and NS-B) and Eurasian lineage (PB2), and the equine H3N8 lineage (PA, NP, and NS-A). Phylogenetic analyses of the hemagglutinin and neuraminidase gene segments of the H4, H6, and N8 subtypes revealed recent introductions and reassortment between viruses from the Northern and Southern Hemispheres in the Americas. Remarkably and despite evidence of recent hemagglutinin and neuraminidase subtype introductions, the phylogenetic composition of internal gene constellation of these influenza A viruses has remained unchanged. Considering the extended time and the number of sampled species of the current study, and the paucity of previously available data, our results contribute to a better understanding of the ecology and evolution of influenza virus in South America.Instituto de VirologíaFil: Rimondi, Agustina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; ArgentinaFil: Gonzalez Reiche, Ana Silvia. University of Georgia. College of Veterinary Medicine. Poultry Diagnostic and Research Center; Estados Unidos. Icahn School of Medicine at Mount Sinai. Department of Genetics and Genomic Sciences; Estados UnidosFil: Olivera, Valeria Soledad. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; ArgentinaFil: Decarre, Julieta. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Recursos Biológicos; ArgentinaFil: Castresana, Gabriel Julián. Buenos Aires. Organismo Provincial para el Desarrollo Sostenible. Dirección de Áreas Naturales Protegidas; ArgentinaFil: Romano, Marcelo. Centro de Investigaciones en Biodiversidad y Ambiente, Rosario; ArgentinaFil: Nelson, Martha I. National Institutes of Health. Fogarty International Center; Estados UnidosFil: van Bakel, Harm. Icahn School of Medicine at Mount Sinai. Department of Genetics and Genomic Sciences; Estados UnidosFil: Pereda, Ariel Julian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; ArgentinaFil: Ferreri, Lucas. University of Georgia. College of Veterinary Medicine. Diagnostic and Research Center; Estados UnidosFil: Geiger, Ginger. University of Georgia. College of Veterinary Medicine. Poultry Diagnostic and Research Center; Estados UnidosFil: Perez, Daniel Roberto. University of Georgia. College of Veterinary Medicine. Poultry Diagnostic and Research Center; Estados UnidosSpringer Nature2019-02-20T17:26:19Z2019-02-20T17:26:19Z2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/4476https://www.tandfonline.com/doi/full/10.1038/s41426-018-0190-2https://doi.org/10.1038/s41426-018-0190-2Emerging microbes & infections 7, article number 194. (2018)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología AgropecuariaengArgentina (nation)2006/2016info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-10-23T11:16:50Zoai:localhost:20.500.12123/4476instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-10-23 11:16:50.81INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Evidence of a fixed internal gene constellation in influenza A viruses isolated from wild birds in Argentina (2006–2016)
title Evidence of a fixed internal gene constellation in influenza A viruses isolated from wild birds in Argentina (2006–2016)
spellingShingle Evidence of a fixed internal gene constellation in influenza A viruses isolated from wild birds in Argentina (2006–2016)
Rimondi, Agustina
Virus de la Influenza Aviar
Avian Influenzavirus
Aves
Genes
Aves Acuáticas
Waterfowl
Phylogeny
Filogenia
Argentina
title_short Evidence of a fixed internal gene constellation in influenza A viruses isolated from wild birds in Argentina (2006–2016)
title_full Evidence of a fixed internal gene constellation in influenza A viruses isolated from wild birds in Argentina (2006–2016)
title_fullStr Evidence of a fixed internal gene constellation in influenza A viruses isolated from wild birds in Argentina (2006–2016)
title_full_unstemmed Evidence of a fixed internal gene constellation in influenza A viruses isolated from wild birds in Argentina (2006–2016)
title_sort Evidence of a fixed internal gene constellation in influenza A viruses isolated from wild birds in Argentina (2006–2016)
dc.creator.none.fl_str_mv Rimondi, Agustina
Gonzalez Reiche, Ana Silvia
Olivera, Valeria Soledad
Decarre, Julieta
Castresana, Gabriel Julián
Romano, Marcelo
Nelson, Martha I.
van Bakel, Harm
Pereda, Ariel Julian
Ferreri, Lucas
Geiger, Ginger
Perez, Daniel Roberto
author Rimondi, Agustina
author_facet Rimondi, Agustina
Gonzalez Reiche, Ana Silvia
Olivera, Valeria Soledad
Decarre, Julieta
Castresana, Gabriel Julián
Romano, Marcelo
Nelson, Martha I.
van Bakel, Harm
Pereda, Ariel Julian
Ferreri, Lucas
Geiger, Ginger
Perez, Daniel Roberto
author_role author
author2 Gonzalez Reiche, Ana Silvia
Olivera, Valeria Soledad
Decarre, Julieta
Castresana, Gabriel Julián
Romano, Marcelo
Nelson, Martha I.
van Bakel, Harm
Pereda, Ariel Julian
Ferreri, Lucas
Geiger, Ginger
Perez, Daniel Roberto
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Virus de la Influenza Aviar
Avian Influenzavirus
Aves
Genes
Aves Acuáticas
Waterfowl
Phylogeny
Filogenia
Argentina
topic Virus de la Influenza Aviar
Avian Influenzavirus
Aves
Genes
Aves Acuáticas
Waterfowl
Phylogeny
Filogenia
Argentina
dc.description.none.fl_txt_mv Wild aquatic birds are the major reservoir of influenza A virus. Cloacal swabs and feces samples (n = 6595) were collected from 62 bird species in Argentina from 2006 to 2016 and screened for influenza A virus. Full genome sequencing of 15 influenza isolates from 6 waterfowl species revealed subtypes combinations that were previously described in South America (H1N1, H4N2, H4N6 (n = 3), H5N3, H6N2 (n = 4), and H10N7 (n = 2)), and new ones not previously identified in the region (H4N8, H7N7 and H7N9). Notably, the internal gene segments of all 15 Argentine isolates belonged to the South American lineage, showing a divergent evolution of these viruses in the Southern Hemisphere. Time-scaled phylogenies indicated that South American gene segments diverged between ~ 30 and ~ 140 years ago from the most closely related influenza lineages, which include the avian North American (PB1, HA, NA, MP, and NS-B) and Eurasian lineage (PB2), and the equine H3N8 lineage (PA, NP, and NS-A). Phylogenetic analyses of the hemagglutinin and neuraminidase gene segments of the H4, H6, and N8 subtypes revealed recent introductions and reassortment between viruses from the Northern and Southern Hemispheres in the Americas. Remarkably and despite evidence of recent hemagglutinin and neuraminidase subtype introductions, the phylogenetic composition of internal gene constellation of these influenza A viruses has remained unchanged. Considering the extended time and the number of sampled species of the current study, and the paucity of previously available data, our results contribute to a better understanding of the ecology and evolution of influenza virus in South America.
Instituto de Virología
Fil: Rimondi, Agustina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina
Fil: Gonzalez Reiche, Ana Silvia. University of Georgia. College of Veterinary Medicine. Poultry Diagnostic and Research Center; Estados Unidos. Icahn School of Medicine at Mount Sinai. Department of Genetics and Genomic Sciences; Estados Unidos
Fil: Olivera, Valeria Soledad. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina
Fil: Decarre, Julieta. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Recursos Biológicos; Argentina
Fil: Castresana, Gabriel Julián. Buenos Aires. Organismo Provincial para el Desarrollo Sostenible. Dirección de Áreas Naturales Protegidas; Argentina
Fil: Romano, Marcelo. Centro de Investigaciones en Biodiversidad y Ambiente, Rosario; Argentina
Fil: Nelson, Martha I. National Institutes of Health. Fogarty International Center; Estados Unidos
Fil: van Bakel, Harm. Icahn School of Medicine at Mount Sinai. Department of Genetics and Genomic Sciences; Estados Unidos
Fil: Pereda, Ariel Julian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina
Fil: Ferreri, Lucas. University of Georgia. College of Veterinary Medicine. Diagnostic and Research Center; Estados Unidos
Fil: Geiger, Ginger. University of Georgia. College of Veterinary Medicine. Poultry Diagnostic and Research Center; Estados Unidos
Fil: Perez, Daniel Roberto. University of Georgia. College of Veterinary Medicine. Poultry Diagnostic and Research Center; Estados Unidos
description Wild aquatic birds are the major reservoir of influenza A virus. Cloacal swabs and feces samples (n = 6595) were collected from 62 bird species in Argentina from 2006 to 2016 and screened for influenza A virus. Full genome sequencing of 15 influenza isolates from 6 waterfowl species revealed subtypes combinations that were previously described in South America (H1N1, H4N2, H4N6 (n = 3), H5N3, H6N2 (n = 4), and H10N7 (n = 2)), and new ones not previously identified in the region (H4N8, H7N7 and H7N9). Notably, the internal gene segments of all 15 Argentine isolates belonged to the South American lineage, showing a divergent evolution of these viruses in the Southern Hemisphere. Time-scaled phylogenies indicated that South American gene segments diverged between ~ 30 and ~ 140 years ago from the most closely related influenza lineages, which include the avian North American (PB1, HA, NA, MP, and NS-B) and Eurasian lineage (PB2), and the equine H3N8 lineage (PA, NP, and NS-A). Phylogenetic analyses of the hemagglutinin and neuraminidase gene segments of the H4, H6, and N8 subtypes revealed recent introductions and reassortment between viruses from the Northern and Southern Hemispheres in the Americas. Remarkably and despite evidence of recent hemagglutinin and neuraminidase subtype introductions, the phylogenetic composition of internal gene constellation of these influenza A viruses has remained unchanged. Considering the extended time and the number of sampled species of the current study, and the paucity of previously available data, our results contribute to a better understanding of the ecology and evolution of influenza virus in South America.
publishDate 2018
dc.date.none.fl_str_mv 2018
2019-02-20T17:26:19Z
2019-02-20T17:26:19Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/4476
https://www.tandfonline.com/doi/full/10.1038/s41426-018-0190-2
https://doi.org/10.1038/s41426-018-0190-2
url http://hdl.handle.net/20.500.12123/4476
https://www.tandfonline.com/doi/full/10.1038/s41426-018-0190-2
https://doi.org/10.1038/s41426-018-0190-2
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.coverage.none.fl_str_mv Argentina (nation)
2006/2016
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv Emerging microbes & infections 7, article number 194. (2018)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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