Evidence of a fixed internal gene constellation in influenza A viruses isolated from wild birds in Argentina (2006–2016)

Autores
Rimondi, Agustina; Gonzalez Reiche, Ana S.; Olivera, Valeria; Decarre, Julieta; Castresana, Gabriel J.; Romano, Marcelo; Nelson, Martha I.; van Bakel, Harm; Pereda, Ariel Julián; Ferreri, Lucas; Geiger, Ginger; Perez, Daniel R.
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Wild aquatic birds are the major reservoir of influenza A virus. Cloacal swabs and feces samples (n = 6595) were collected from 62 bird species in Argentina from 2006 to 2016 and screened for influenza A virus. Full genome sequencing of 15 influenza isolates from 6 waterfowl species revealed subtypes combinations that were previously described in South America (H1N1, H4N2, H4N6 (n = 3), H5N3, H6N2 (n = 4), and H10N7 (n = 2)), and new ones not previously identified in the region (H4N8, H7N7 and H7N9). Notably, the internal gene segments of all 15 Argentine isolates belonged to the South American lineage, showing a divergent evolution of these viruses in the Southern Hemisphere. Time-scaled phylogenies indicated that South American gene segments diverged between ~ 30 and~ 140 years ago from the most closely related influenza lineages, which include the avian North American (PB1, HA, NA, MP, and NS-B) and Eurasian lineage (PB2), and the equine H3N8 lineage (PA, NP, and NS-A). Phylogenetic analyses of the hemagglutinin and neuraminidase gene segments of the H4, H6, and N8 subtypes revealed recent introductions and reassortment between viruses from the Northern and Southern Hemispheres in the Americas. Remarkably and despite evidence of recent hemagglutinin and neuraminidase subtype introductions, the phylogenetic composition of internal gene constellation of these influenza A viruses has remained unchanged. Considering the extended time and the number of sampled species of the current study, and the paucity of previously available data, our results contribute to a better understanding of the ecology and evolution of influenza virus in South America.
Fil: Rimondi, Agustina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gonzalez Reiche, Ana S.. University of Georgia; Estados Unidos
Fil: Olivera, Valeria. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología; Argentina
Fil: Decarre, Julieta. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación de Recursos Naturales. Instituto de Recursos Biológicos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Castresana, Gabriel J.. Gobierno de la Provincia de Buenos Aires. Organismo Provincial Para El Desarrollo Sostenible.; Argentina
Fil: Romano, Marcelo. Centro de Investigaciones en Biodiversidad y Ambiente; Argentina
Fil: Nelson, Martha I.. National Institutes of Health; Estados Unidos
Fil: van Bakel, Harm. Icahn School of Medicine at Mount Sina; Estados Unidos
Fil: Pereda, Ariel Julián. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ferreri, Lucas. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. University of Georgia; Estados Unidos
Fil: Geiger, Ginger. University of Georgia; Estados Unidos
Fil: Perez, Daniel R.. University of Georgia; Estados Unidos
Materia
INFLUENZA
ARGENTINA
EVOLUTION
ECOLOGY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/102894
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/102894
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Evidence of a fixed internal gene constellation in influenza A viruses isolated from wild birds in Argentina (2006–2016)Rimondi, AgustinaGonzalez Reiche, Ana S.Olivera, ValeriaDecarre, JulietaCastresana, Gabriel J.Romano, MarceloNelson, Martha I.van Bakel, HarmPereda, Ariel JuliánFerreri, LucasGeiger, GingerPerez, Daniel R.INFLUENZAARGENTINAEVOLUTIONECOLOGYhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Wild aquatic birds are the major reservoir of influenza A virus. Cloacal swabs and feces samples (n = 6595) were collected from 62 bird species in Argentina from 2006 to 2016 and screened for influenza A virus. Full genome sequencing of 15 influenza isolates from 6 waterfowl species revealed subtypes combinations that were previously described in South America (H1N1, H4N2, H4N6 (n = 3), H5N3, H6N2 (n = 4), and H10N7 (n = 2)), and new ones not previously identified in the region (H4N8, H7N7 and H7N9). Notably, the internal gene segments of all 15 Argentine isolates belonged to the South American lineage, showing a divergent evolution of these viruses in the Southern Hemisphere. Time-scaled phylogenies indicated that South American gene segments diverged between ~ 30 and~ 140 years ago from the most closely related influenza lineages, which include the avian North American (PB1, HA, NA, MP, and NS-B) and Eurasian lineage (PB2), and the equine H3N8 lineage (PA, NP, and NS-A). Phylogenetic analyses of the hemagglutinin and neuraminidase gene segments of the H4, H6, and N8 subtypes revealed recent introductions and reassortment between viruses from the Northern and Southern Hemispheres in the Americas. Remarkably and despite evidence of recent hemagglutinin and neuraminidase subtype introductions, the phylogenetic composition of internal gene constellation of these influenza A viruses has remained unchanged. Considering the extended time and the number of sampled species of the current study, and the paucity of previously available data, our results contribute to a better understanding of the ecology and evolution of influenza virus in South America.Fil: Rimondi, Agustina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gonzalez Reiche, Ana S.. University of Georgia; Estados UnidosFil: Olivera, Valeria. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología; ArgentinaFil: Decarre, Julieta. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación de Recursos Naturales. Instituto de Recursos Biológicos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Castresana, Gabriel J.. Gobierno de la Provincia de Buenos Aires. Organismo Provincial Para El Desarrollo Sostenible.; ArgentinaFil: Romano, Marcelo. Centro de Investigaciones en Biodiversidad y Ambiente; ArgentinaFil: Nelson, Martha I.. National Institutes of Health; Estados UnidosFil: van Bakel, Harm. Icahn School of Medicine at Mount Sina; Estados UnidosFil: Pereda, Ariel Julián. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ferreri, Lucas. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. University of Georgia; Estados UnidosFil: Geiger, Ginger. University of Georgia; Estados UnidosFil: Perez, Daniel R.. University of Georgia; Estados UnidosNature2018-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/102894Rimondi, Agustina; Gonzalez Reiche, Ana S.; Olivera, Valeria; Decarre, Julieta; Castresana, Gabriel J.; et al.; Evidence of a fixed internal gene constellation in influenza A viruses isolated from wild birds in Argentina (2006–2016); Nature; Emerging Microbes & Infections; 7; 1; 11-2018; 1-132222-1751CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1038/s41426-018-0190-2info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258671/info:eu-repo/semantics/altIdentifier/doi/10.1038/s41426-018-0190-2info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:57:32Zoai:ri.conicet.gov.ar:11336/102894instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:57:32.648CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Evidence of a fixed internal gene constellation in influenza A viruses isolated from wild birds in Argentina (2006–2016)
title Evidence of a fixed internal gene constellation in influenza A viruses isolated from wild birds in Argentina (2006–2016)
spellingShingle Evidence of a fixed internal gene constellation in influenza A viruses isolated from wild birds in Argentina (2006–2016)
Rimondi, Agustina
INFLUENZA
ARGENTINA
EVOLUTION
ECOLOGY
title_short Evidence of a fixed internal gene constellation in influenza A viruses isolated from wild birds in Argentina (2006–2016)
title_full Evidence of a fixed internal gene constellation in influenza A viruses isolated from wild birds in Argentina (2006–2016)
title_fullStr Evidence of a fixed internal gene constellation in influenza A viruses isolated from wild birds in Argentina (2006–2016)
title_full_unstemmed Evidence of a fixed internal gene constellation in influenza A viruses isolated from wild birds in Argentina (2006–2016)
title_sort Evidence of a fixed internal gene constellation in influenza A viruses isolated from wild birds in Argentina (2006–2016)
dc.creator.none.fl_str_mv Rimondi, Agustina
Gonzalez Reiche, Ana S.
Olivera, Valeria
Decarre, Julieta
Castresana, Gabriel J.
Romano, Marcelo
Nelson, Martha I.
van Bakel, Harm
Pereda, Ariel Julián
Ferreri, Lucas
Geiger, Ginger
Perez, Daniel R.
author Rimondi, Agustina
author_facet Rimondi, Agustina
Gonzalez Reiche, Ana S.
Olivera, Valeria
Decarre, Julieta
Castresana, Gabriel J.
Romano, Marcelo
Nelson, Martha I.
van Bakel, Harm
Pereda, Ariel Julián
Ferreri, Lucas
Geiger, Ginger
Perez, Daniel R.
author_role author
author2 Gonzalez Reiche, Ana S.
Olivera, Valeria
Decarre, Julieta
Castresana, Gabriel J.
Romano, Marcelo
Nelson, Martha I.
van Bakel, Harm
Pereda, Ariel Julián
Ferreri, Lucas
Geiger, Ginger
Perez, Daniel R.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv INFLUENZA
ARGENTINA
EVOLUTION
ECOLOGY
topic INFLUENZA
ARGENTINA
EVOLUTION
ECOLOGY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Wild aquatic birds are the major reservoir of influenza A virus. Cloacal swabs and feces samples (n = 6595) were collected from 62 bird species in Argentina from 2006 to 2016 and screened for influenza A virus. Full genome sequencing of 15 influenza isolates from 6 waterfowl species revealed subtypes combinations that were previously described in South America (H1N1, H4N2, H4N6 (n = 3), H5N3, H6N2 (n = 4), and H10N7 (n = 2)), and new ones not previously identified in the region (H4N8, H7N7 and H7N9). Notably, the internal gene segments of all 15 Argentine isolates belonged to the South American lineage, showing a divergent evolution of these viruses in the Southern Hemisphere. Time-scaled phylogenies indicated that South American gene segments diverged between ~ 30 and~ 140 years ago from the most closely related influenza lineages, which include the avian North American (PB1, HA, NA, MP, and NS-B) and Eurasian lineage (PB2), and the equine H3N8 lineage (PA, NP, and NS-A). Phylogenetic analyses of the hemagglutinin and neuraminidase gene segments of the H4, H6, and N8 subtypes revealed recent introductions and reassortment between viruses from the Northern and Southern Hemispheres in the Americas. Remarkably and despite evidence of recent hemagglutinin and neuraminidase subtype introductions, the phylogenetic composition of internal gene constellation of these influenza A viruses has remained unchanged. Considering the extended time and the number of sampled species of the current study, and the paucity of previously available data, our results contribute to a better understanding of the ecology and evolution of influenza virus in South America.
Fil: Rimondi, Agustina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gonzalez Reiche, Ana S.. University of Georgia; Estados Unidos
Fil: Olivera, Valeria. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología; Argentina
Fil: Decarre, Julieta. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación de Recursos Naturales. Instituto de Recursos Biológicos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Castresana, Gabriel J.. Gobierno de la Provincia de Buenos Aires. Organismo Provincial Para El Desarrollo Sostenible.; Argentina
Fil: Romano, Marcelo. Centro de Investigaciones en Biodiversidad y Ambiente; Argentina
Fil: Nelson, Martha I.. National Institutes of Health; Estados Unidos
Fil: van Bakel, Harm. Icahn School of Medicine at Mount Sina; Estados Unidos
Fil: Pereda, Ariel Julián. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ferreri, Lucas. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. University of Georgia; Estados Unidos
Fil: Geiger, Ginger. University of Georgia; Estados Unidos
Fil: Perez, Daniel R.. University of Georgia; Estados Unidos
description Wild aquatic birds are the major reservoir of influenza A virus. Cloacal swabs and feces samples (n = 6595) were collected from 62 bird species in Argentina from 2006 to 2016 and screened for influenza A virus. Full genome sequencing of 15 influenza isolates from 6 waterfowl species revealed subtypes combinations that were previously described in South America (H1N1, H4N2, H4N6 (n = 3), H5N3, H6N2 (n = 4), and H10N7 (n = 2)), and new ones not previously identified in the region (H4N8, H7N7 and H7N9). Notably, the internal gene segments of all 15 Argentine isolates belonged to the South American lineage, showing a divergent evolution of these viruses in the Southern Hemisphere. Time-scaled phylogenies indicated that South American gene segments diverged between ~ 30 and~ 140 years ago from the most closely related influenza lineages, which include the avian North American (PB1, HA, NA, MP, and NS-B) and Eurasian lineage (PB2), and the equine H3N8 lineage (PA, NP, and NS-A). Phylogenetic analyses of the hemagglutinin and neuraminidase gene segments of the H4, H6, and N8 subtypes revealed recent introductions and reassortment between viruses from the Northern and Southern Hemispheres in the Americas. Remarkably and despite evidence of recent hemagglutinin and neuraminidase subtype introductions, the phylogenetic composition of internal gene constellation of these influenza A viruses has remained unchanged. Considering the extended time and the number of sampled species of the current study, and the paucity of previously available data, our results contribute to a better understanding of the ecology and evolution of influenza virus in South America.
publishDate 2018
dc.date.none.fl_str_mv 2018-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/102894
Rimondi, Agustina; Gonzalez Reiche, Ana S.; Olivera, Valeria; Decarre, Julieta; Castresana, Gabriel J.; et al.; Evidence of a fixed internal gene constellation in influenza A viruses isolated from wild birds in Argentina (2006–2016); Nature; Emerging Microbes & Infections; 7; 1; 11-2018; 1-13
2222-1751
CONICET Digital
CONICET
url http://hdl.handle.net/11336/102894
identifier_str_mv Rimondi, Agustina; Gonzalez Reiche, Ana S.; Olivera, Valeria; Decarre, Julieta; Castresana, Gabriel J.; et al.; Evidence of a fixed internal gene constellation in influenza A viruses isolated from wild birds in Argentina (2006–2016); Nature; Emerging Microbes & Infections; 7; 1; 11-2018; 1-13
2222-1751
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1038/s41426-018-0190-2
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258671/
info:eu-repo/semantics/altIdentifier/doi/10.1038/s41426-018-0190-2
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
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application/pdf
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dc.publisher.none.fl_str_mv Nature
publisher.none.fl_str_mv Nature
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repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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