Research Note : Characterization and phylodynamic analysis of new infectious bursal disease virus variants circulating in Argentina

Autores
Jaton, Juan Marcelo; Lozano Calderon, Laura Camila; Gambini, Pablo; Ponti, Marina; Gomez, Evangelina Raquel; Konig, Guido Alberto; Chimeno Zoth, Silvina Andrea
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Infectious Bursal Disease is a highly contagious disease that affects young chickens and leads to significant economic losses. Its causal agent is a double-stranded RNA virus that, due to its high error rate during the replication process, gives rise to a constant generation of new virus variants. Until 2014, strains of Infectious Bursal Diseases Virus (IBDV) belonging to genogroup 4 predominated in Argentina, but there have been no reports since then regarding the circulating genogroups in poultry. In this study, 11 recent sequences of Argentine from the hypervariable region of VP2 protein (hvVP2) were analyzed to determine their genogroup, origin, evolution, and amino acid sequence. Samples from chickens showing signs of IBDV infection were collected, and the hvVP2 region was amplified using RT-PCR, followed by sequencing. The results indicated that the analyzed strains belong to genogroup 2, with an estimated evolutionary rate of 1.74 × 10−3 substitutions/site/year. It is speculated that the predominant group of sequences began to spread in Argentina around 2014 and had its origins in China. Another sample is related to strains from South Korea and is not closely linked to the main group. Furthermore, the predicted amino acid sequences show similarity to strains that can evade vaccine-induced immunity. These findings underscore the importance of active surveillance in poultry to mitigate losses caused by IBDV.
Instituto de Biotecnología
Fil: Jaton, Juan Marcelo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular. Laboratorio de Inmunología y Vacunas Aviares; Argentina
Fil: Jaton, Juan Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Lozano Calderon, Laura Camila. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular. Laboratorio de Epidemiología Molecular y Evolución Viral; Argentina
Fil: Lozano Calderon, Laura Camila. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gambini, Pablo. HIPRA Argentina S.A.; Argentina
Fil: Ponti, Marina. HIPRA Argentina S.A.; Argentina
Fil: Gomez, Evangelina Raquel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular. Laboratorio de Inmunología y Vacunas Aviares; Argentina
Fil: Gomez, Evangelina Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Konig, Guido Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular. Laboratorio de Epidemiología Molecular y Evolución Viral; Argentina
Fil: Konig, Guido Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Chimeno Zoth, Silvina Andrea. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular. Laboratorio de Inmunología y Vacunas Aviares; Argentina
Fil: Chimeno Zoth, Silvina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fuente
Poultry Science 103 (6) : 103623 (June 2024)
Materia
Epidemiology
Infectious Bursal Disease Virus
Molecular Phylogenetics
Phylogeography
Epidemiología
Virus Bursitis Infecciosa
Filogenética Molecular
Filogeografía
Argentina
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/18215
Acceder
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oai_identifier_str oai:localhost:20.500.12123/18215
network_acronym_str INTADig
repository_id_str l
network_name_str INTA Digital (INTA)
spelling Research Note : Characterization and phylodynamic analysis of new infectious bursal disease virus variants circulating in ArgentinaJaton, Juan MarceloLozano Calderon, Laura CamilaGambini, PabloPonti, MarinaGomez, Evangelina RaquelKonig, Guido AlbertoChimeno Zoth, Silvina AndreaEpidemiologyInfectious Bursal Disease VirusMolecular PhylogeneticsPhylogeographyEpidemiologíaVirus Bursitis InfecciosaFilogenética MolecularFilogeografíaArgentinaInfectious Bursal Disease is a highly contagious disease that affects young chickens and leads to significant economic losses. Its causal agent is a double-stranded RNA virus that, due to its high error rate during the replication process, gives rise to a constant generation of new virus variants. Until 2014, strains of Infectious Bursal Diseases Virus (IBDV) belonging to genogroup 4 predominated in Argentina, but there have been no reports since then regarding the circulating genogroups in poultry. In this study, 11 recent sequences of Argentine from the hypervariable region of VP2 protein (hvVP2) were analyzed to determine their genogroup, origin, evolution, and amino acid sequence. Samples from chickens showing signs of IBDV infection were collected, and the hvVP2 region was amplified using RT-PCR, followed by sequencing. The results indicated that the analyzed strains belong to genogroup 2, with an estimated evolutionary rate of 1.74 × 10−3 substitutions/site/year. It is speculated that the predominant group of sequences began to spread in Argentina around 2014 and had its origins in China. Another sample is related to strains from South Korea and is not closely linked to the main group. Furthermore, the predicted amino acid sequences show similarity to strains that can evade vaccine-induced immunity. These findings underscore the importance of active surveillance in poultry to mitigate losses caused by IBDV.Instituto de BiotecnologíaFil: Jaton, Juan Marcelo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular. Laboratorio de Inmunología y Vacunas Aviares; ArgentinaFil: Jaton, Juan Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Lozano Calderon, Laura Camila. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular. Laboratorio de Epidemiología Molecular y Evolución Viral; ArgentinaFil: Lozano Calderon, Laura Camila. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gambini, Pablo. HIPRA Argentina S.A.; ArgentinaFil: Ponti, Marina. HIPRA Argentina S.A.; ArgentinaFil: Gomez, Evangelina Raquel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular. Laboratorio de Inmunología y Vacunas Aviares; ArgentinaFil: Gomez, Evangelina Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Konig, Guido Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular. Laboratorio de Epidemiología Molecular y Evolución Viral; ArgentinaFil: Konig, Guido Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Chimeno Zoth, Silvina Andrea. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular. Laboratorio de Inmunología y Vacunas Aviares; ArgentinaFil: Chimeno Zoth, Silvina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier2024-06-19T13:37:50Z2024-06-19T13:37:50Z2024-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/18215https://www.sciencedirect.com/science/article/pii/S00325791240020251525-3171https://doi.org/10.1016/j.psj.2024.103623Poultry Science 103 (6) : 103623 (June 2024)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repograntAgreement/INTA/2023-PD-L01-I089, Microbiomas en ecosistemas agropecuarios: la conexión integradora del enfoque Una Saludinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-29T13:46:36Zoai:localhost:20.500.12123/18215instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-29 13:46:36.883INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Research Note : Characterization and phylodynamic analysis of new infectious bursal disease virus variants circulating in Argentina
title Research Note : Characterization and phylodynamic analysis of new infectious bursal disease virus variants circulating in Argentina
spellingShingle Research Note : Characterization and phylodynamic analysis of new infectious bursal disease virus variants circulating in Argentina
Jaton, Juan Marcelo
Epidemiology
Infectious Bursal Disease Virus
Molecular Phylogenetics
Phylogeography
Epidemiología
Virus Bursitis Infecciosa
Filogenética Molecular
Filogeografía
Argentina
title_short Research Note : Characterization and phylodynamic analysis of new infectious bursal disease virus variants circulating in Argentina
title_full Research Note : Characterization and phylodynamic analysis of new infectious bursal disease virus variants circulating in Argentina
title_fullStr Research Note : Characterization and phylodynamic analysis of new infectious bursal disease virus variants circulating in Argentina
title_full_unstemmed Research Note : Characterization and phylodynamic analysis of new infectious bursal disease virus variants circulating in Argentina
title_sort Research Note : Characterization and phylodynamic analysis of new infectious bursal disease virus variants circulating in Argentina
dc.creator.none.fl_str_mv Jaton, Juan Marcelo
Lozano Calderon, Laura Camila
Gambini, Pablo
Ponti, Marina
Gomez, Evangelina Raquel
Konig, Guido Alberto
Chimeno Zoth, Silvina Andrea
author Jaton, Juan Marcelo
author_facet Jaton, Juan Marcelo
Lozano Calderon, Laura Camila
Gambini, Pablo
Ponti, Marina
Gomez, Evangelina Raquel
Konig, Guido Alberto
Chimeno Zoth, Silvina Andrea
author_role author
author2 Lozano Calderon, Laura Camila
Gambini, Pablo
Ponti, Marina
Gomez, Evangelina Raquel
Konig, Guido Alberto
Chimeno Zoth, Silvina Andrea
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Epidemiology
Infectious Bursal Disease Virus
Molecular Phylogenetics
Phylogeography
Epidemiología
Virus Bursitis Infecciosa
Filogenética Molecular
Filogeografía
Argentina
topic Epidemiology
Infectious Bursal Disease Virus
Molecular Phylogenetics
Phylogeography
Epidemiología
Virus Bursitis Infecciosa
Filogenética Molecular
Filogeografía
Argentina
dc.description.none.fl_txt_mv Infectious Bursal Disease is a highly contagious disease that affects young chickens and leads to significant economic losses. Its causal agent is a double-stranded RNA virus that, due to its high error rate during the replication process, gives rise to a constant generation of new virus variants. Until 2014, strains of Infectious Bursal Diseases Virus (IBDV) belonging to genogroup 4 predominated in Argentina, but there have been no reports since then regarding the circulating genogroups in poultry. In this study, 11 recent sequences of Argentine from the hypervariable region of VP2 protein (hvVP2) were analyzed to determine their genogroup, origin, evolution, and amino acid sequence. Samples from chickens showing signs of IBDV infection were collected, and the hvVP2 region was amplified using RT-PCR, followed by sequencing. The results indicated that the analyzed strains belong to genogroup 2, with an estimated evolutionary rate of 1.74 × 10−3 substitutions/site/year. It is speculated that the predominant group of sequences began to spread in Argentina around 2014 and had its origins in China. Another sample is related to strains from South Korea and is not closely linked to the main group. Furthermore, the predicted amino acid sequences show similarity to strains that can evade vaccine-induced immunity. These findings underscore the importance of active surveillance in poultry to mitigate losses caused by IBDV.
Instituto de Biotecnología
Fil: Jaton, Juan Marcelo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular. Laboratorio de Inmunología y Vacunas Aviares; Argentina
Fil: Jaton, Juan Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Lozano Calderon, Laura Camila. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular. Laboratorio de Epidemiología Molecular y Evolución Viral; Argentina
Fil: Lozano Calderon, Laura Camila. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gambini, Pablo. HIPRA Argentina S.A.; Argentina
Fil: Ponti, Marina. HIPRA Argentina S.A.; Argentina
Fil: Gomez, Evangelina Raquel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular. Laboratorio de Inmunología y Vacunas Aviares; Argentina
Fil: Gomez, Evangelina Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Konig, Guido Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular. Laboratorio de Epidemiología Molecular y Evolución Viral; Argentina
Fil: Konig, Guido Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Chimeno Zoth, Silvina Andrea. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular. Laboratorio de Inmunología y Vacunas Aviares; Argentina
Fil: Chimeno Zoth, Silvina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Infectious Bursal Disease is a highly contagious disease that affects young chickens and leads to significant economic losses. Its causal agent is a double-stranded RNA virus that, due to its high error rate during the replication process, gives rise to a constant generation of new virus variants. Until 2014, strains of Infectious Bursal Diseases Virus (IBDV) belonging to genogroup 4 predominated in Argentina, but there have been no reports since then regarding the circulating genogroups in poultry. In this study, 11 recent sequences of Argentine from the hypervariable region of VP2 protein (hvVP2) were analyzed to determine their genogroup, origin, evolution, and amino acid sequence. Samples from chickens showing signs of IBDV infection were collected, and the hvVP2 region was amplified using RT-PCR, followed by sequencing. The results indicated that the analyzed strains belong to genogroup 2, with an estimated evolutionary rate of 1.74 × 10−3 substitutions/site/year. It is speculated that the predominant group of sequences began to spread in Argentina around 2014 and had its origins in China. Another sample is related to strains from South Korea and is not closely linked to the main group. Furthermore, the predicted amino acid sequences show similarity to strains that can evade vaccine-induced immunity. These findings underscore the importance of active surveillance in poultry to mitigate losses caused by IBDV.
publishDate 2024
dc.date.none.fl_str_mv 2024-06-19T13:37:50Z
2024-06-19T13:37:50Z
2024-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/18215
https://www.sciencedirect.com/science/article/pii/S0032579124002025
1525-3171
https://doi.org/10.1016/j.psj.2024.103623
url http://hdl.handle.net/20.500.12123/18215
https://www.sciencedirect.com/science/article/pii/S0032579124002025
https://doi.org/10.1016/j.psj.2024.103623
identifier_str_mv 1525-3171
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repograntAgreement/INTA/2023-PD-L01-I089, Microbiomas en ecosistemas agropecuarios: la conexión integradora del enfoque Una Salud
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Poultry Science 103 (6) : 103623 (June 2024)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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