Characterization of lesions of nutritional congenital goitre in cattle

Autores
Colque Caro, Luis Adrián; Acuña, Francisco; Aguirre Castro, Laura Sabrina; Avellaneda Cáceres, Agustín; Barbeito, Claudio Gustavo; Signorini Porchiett, Marcelo Lisandro; Moore, Prando Dadin; Micheloud, Juan Francisco
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
There are few studies that classify and characterize the morphometric and immunohistochemical features of goitre in bovine thyroid glands (TGs). We investigated 39 bovine TGs (fetuses [9], stillbirths [18], neonates [12]) born to dams with low T4 hormone levels and no iodine supplementation and 10 (fetuses [3], stillbirths [3], neonates [4]) born to dams with normal T4 levels and supplemented with iodine. Body weight (BW), TG weight (TGW), TGW:BW ratio and histological lesions were determined. The TGs were classified histopathologically as normal gland (G0), mild goitre (G1), moderate goitre (G2) or severe goitre (G3). Various morphological and morphometric parameters were calculated from microscopic images using image analysis software. Immunohistochemistry was performed to detect proliferating cell nuclear antigen (PCNA). There were significant differences in the TGW:BW ratio among groups (P <0.05): 0.3 ± 0.1 in G0, 0.5 ± 0.3 in G1, 0.8 ± 0.3 in G2 and 1.3 ± 0.7 in G3. In G0, large homogeneous follicles with eosinophilic colloid were seen. In the groups with lesions (G1, G2 and G3), heterogeneity in follicle shape and size, height and area of thyroid follicular cells, height of thyroid follicular epithelium and PCNA immunolabelling were directly related to histopathological grade, with significant differences among groups (P <0.001), gradually increasing from G1 to G3 compared with G0. The TGW:BW ratio and histological grade were positively correlated (P = 0.008).
Instituto de Investigación Animal del Chaco Semiárido
Fil: Colque Caro, Luis Adrián. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal del Chaco Semiárido. Área de Sanidad Animal; Argentina
Fil: Colque Caro, Luis Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. CCT Salta - Jujuy; Argentina
Fil: Acuña, Francisco. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Laboratorio de Histología y Embriología Descriptiva, Experimental y Comparada; Argentina
Fil: Acuña, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. CCT La Plata; Argentina
Fil: Aguirre Castro, Laura Sabrina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal del Chaco Semiárido. Área de Sanidad Animal; Argentina
Fil: Aguirre Castro, Laura Sabrina. Consejo Nacional de Investigaciones Científicas y Técnicas. CCT Salta - Jujuy; Argentina
Fil: Avellaneda Cáceres, Agustín. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal del Chaco Semiárido. Área de Sanidad Animal; Argentina
Fil: Avellaneda Cáceres, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. CCT Salta - Jujuy; Argentina
Fil: Barbeito, Claudio G.Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Experimental y Comparada. Laboratorio de Histología y Embriología Descriptiva; Argentina
Fil: Barbeito, Claudio G. Consejo Nacional de Investigaciones Científicas y Técnicas. CCT La Plata; Argentina
Fil: Signorini Porchiett, Marcelo Lisandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina
Fil: Signorini Porchiett, Marcelo Lisandro.Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación de la Cadena Láctea; Argentina
Fil: Moore, Prando Dadin. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina
Fil: Moore, Prando Dadin. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina
Fil: Micheloud, Juan Francisco. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal del Chaco Semiárido. Área de Sanidad Animal; Argentina
Fil: Micheloud, Juan Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. CCT Salta - Jujuy; Argentina
Fil: Micheloud, Juan Francisco. Universidad Católica de Salta. Facultad de Ciencias Agrarias y Veterinarias; Argentina
Fuente
Journal of Comparative Pathology 206 : 1-8 (October 2023)
Materia
Hyperplasia
Hypertrophy
Thyroid Gland
Cattle
Hiperplasia
Hipertrofia
Ganado Bovino
Glándula Tiroide
Morphometry
Perinatal Deaths
Thyroid
Tiroides
Nivel de accesibilidad
acceso restringido
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/15310
Acceder
id INTADig_3c495ded7c1c9f2e0861a88411d1c65f
oai_identifier_str oai:localhost:20.500.12123/15310
network_acronym_str INTADig
repository_id_str l
network_name_str INTA Digital (INTA)
spelling Characterization of lesions of nutritional congenital goitre in cattleColque Caro, Luis AdriánAcuña, FranciscoAguirre Castro, Laura SabrinaAvellaneda Cáceres, AgustínBarbeito, Claudio GustavoSignorini Porchiett, Marcelo LisandroMoore, Prando DadinMicheloud, Juan FranciscoHyperplasiaHypertrophyThyroid GlandCattleHiperplasiaHipertrofiaGanado BovinoGlándula TiroideMorphometryPerinatal DeathsThyroidTiroidesThere are few studies that classify and characterize the morphometric and immunohistochemical features of goitre in bovine thyroid glands (TGs). We investigated 39 bovine TGs (fetuses [9], stillbirths [18], neonates [12]) born to dams with low T4 hormone levels and no iodine supplementation and 10 (fetuses [3], stillbirths [3], neonates [4]) born to dams with normal T4 levels and supplemented with iodine. Body weight (BW), TG weight (TGW), TGW:BW ratio and histological lesions were determined. The TGs were classified histopathologically as normal gland (G0), mild goitre (G1), moderate goitre (G2) or severe goitre (G3). Various morphological and morphometric parameters were calculated from microscopic images using image analysis software. Immunohistochemistry was performed to detect proliferating cell nuclear antigen (PCNA). There were significant differences in the TGW:BW ratio among groups (P <0.05): 0.3 ± 0.1 in G0, 0.5 ± 0.3 in G1, 0.8 ± 0.3 in G2 and 1.3 ± 0.7 in G3. In G0, large homogeneous follicles with eosinophilic colloid were seen. In the groups with lesions (G1, G2 and G3), heterogeneity in follicle shape and size, height and area of thyroid follicular cells, height of thyroid follicular epithelium and PCNA immunolabelling were directly related to histopathological grade, with significant differences among groups (P <0.001), gradually increasing from G1 to G3 compared with G0. The TGW:BW ratio and histological grade were positively correlated (P = 0.008).Instituto de Investigación Animal del Chaco SemiáridoFil: Colque Caro, Luis Adrián. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal del Chaco Semiárido. Área de Sanidad Animal; ArgentinaFil: Colque Caro, Luis Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. CCT Salta - Jujuy; ArgentinaFil: Acuña, Francisco. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Laboratorio de Histología y Embriología Descriptiva, Experimental y Comparada; ArgentinaFil: Acuña, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. CCT La Plata; ArgentinaFil: Aguirre Castro, Laura Sabrina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal del Chaco Semiárido. Área de Sanidad Animal; ArgentinaFil: Aguirre Castro, Laura Sabrina. Consejo Nacional de Investigaciones Científicas y Técnicas. CCT Salta - Jujuy; ArgentinaFil: Avellaneda Cáceres, Agustín. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal del Chaco Semiárido. Área de Sanidad Animal; ArgentinaFil: Avellaneda Cáceres, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. CCT Salta - Jujuy; ArgentinaFil: Barbeito, Claudio G.Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Experimental y Comparada. Laboratorio de Histología y Embriología Descriptiva; ArgentinaFil: Barbeito, Claudio G. Consejo Nacional de Investigaciones Científicas y Técnicas. CCT La Plata; ArgentinaFil: Signorini Porchiett, Marcelo Lisandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; ArgentinaFil: Signorini Porchiett, Marcelo Lisandro.Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación de la Cadena Láctea; ArgentinaFil: Moore, Prando Dadin. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; ArgentinaFil: Moore, Prando Dadin. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; ArgentinaFil: Micheloud, Juan Francisco. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal del Chaco Semiárido. Área de Sanidad Animal; ArgentinaFil: Micheloud, Juan Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. CCT Salta - Jujuy; ArgentinaFil: Micheloud, Juan Francisco. Universidad Católica de Salta. Facultad de Ciencias Agrarias y Veterinarias; ArgentinaElsevier2023-09-26T10:48:02Z2023-09-26T10:48:02Z2023-08-18info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/15310https://www.sciencedirect.com/science/article/pii/S00219975230025910021-99751532-3129 (online)https://doi.org/10.1016/j.jcpa.2023.08.002Journal of Comparative Pathology 206 : 1-8 (October 2023)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-11T10:24:43Zoai:localhost:20.500.12123/15310instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-11 10:24:44.117INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Characterization of lesions of nutritional congenital goitre in cattle
title Characterization of lesions of nutritional congenital goitre in cattle
spellingShingle Characterization of lesions of nutritional congenital goitre in cattle
Colque Caro, Luis Adrián
Hyperplasia
Hypertrophy
Thyroid Gland
Cattle
Hiperplasia
Hipertrofia
Ganado Bovino
Glándula Tiroide
Morphometry
Perinatal Deaths
Thyroid
Tiroides
title_short Characterization of lesions of nutritional congenital goitre in cattle
title_full Characterization of lesions of nutritional congenital goitre in cattle
title_fullStr Characterization of lesions of nutritional congenital goitre in cattle
title_full_unstemmed Characterization of lesions of nutritional congenital goitre in cattle
title_sort Characterization of lesions of nutritional congenital goitre in cattle
dc.creator.none.fl_str_mv Colque Caro, Luis Adrián
Acuña, Francisco
Aguirre Castro, Laura Sabrina
Avellaneda Cáceres, Agustín
Barbeito, Claudio Gustavo
Signorini Porchiett, Marcelo Lisandro
Moore, Prando Dadin
Micheloud, Juan Francisco
author Colque Caro, Luis Adrián
author_facet Colque Caro, Luis Adrián
Acuña, Francisco
Aguirre Castro, Laura Sabrina
Avellaneda Cáceres, Agustín
Barbeito, Claudio Gustavo
Signorini Porchiett, Marcelo Lisandro
Moore, Prando Dadin
Micheloud, Juan Francisco
author_role author
author2 Acuña, Francisco
Aguirre Castro, Laura Sabrina
Avellaneda Cáceres, Agustín
Barbeito, Claudio Gustavo
Signorini Porchiett, Marcelo Lisandro
Moore, Prando Dadin
Micheloud, Juan Francisco
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Hyperplasia
Hypertrophy
Thyroid Gland
Cattle
Hiperplasia
Hipertrofia
Ganado Bovino
Glándula Tiroide
Morphometry
Perinatal Deaths
Thyroid
Tiroides
topic Hyperplasia
Hypertrophy
Thyroid Gland
Cattle
Hiperplasia
Hipertrofia
Ganado Bovino
Glándula Tiroide
Morphometry
Perinatal Deaths
Thyroid
Tiroides
dc.description.none.fl_txt_mv There are few studies that classify and characterize the morphometric and immunohistochemical features of goitre in bovine thyroid glands (TGs). We investigated 39 bovine TGs (fetuses [9], stillbirths [18], neonates [12]) born to dams with low T4 hormone levels and no iodine supplementation and 10 (fetuses [3], stillbirths [3], neonates [4]) born to dams with normal T4 levels and supplemented with iodine. Body weight (BW), TG weight (TGW), TGW:BW ratio and histological lesions were determined. The TGs were classified histopathologically as normal gland (G0), mild goitre (G1), moderate goitre (G2) or severe goitre (G3). Various morphological and morphometric parameters were calculated from microscopic images using image analysis software. Immunohistochemistry was performed to detect proliferating cell nuclear antigen (PCNA). There were significant differences in the TGW:BW ratio among groups (P <0.05): 0.3 ± 0.1 in G0, 0.5 ± 0.3 in G1, 0.8 ± 0.3 in G2 and 1.3 ± 0.7 in G3. In G0, large homogeneous follicles with eosinophilic colloid were seen. In the groups with lesions (G1, G2 and G3), heterogeneity in follicle shape and size, height and area of thyroid follicular cells, height of thyroid follicular epithelium and PCNA immunolabelling were directly related to histopathological grade, with significant differences among groups (P <0.001), gradually increasing from G1 to G3 compared with G0. The TGW:BW ratio and histological grade were positively correlated (P = 0.008).
Instituto de Investigación Animal del Chaco Semiárido
Fil: Colque Caro, Luis Adrián. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal del Chaco Semiárido. Área de Sanidad Animal; Argentina
Fil: Colque Caro, Luis Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. CCT Salta - Jujuy; Argentina
Fil: Acuña, Francisco. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Laboratorio de Histología y Embriología Descriptiva, Experimental y Comparada; Argentina
Fil: Acuña, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. CCT La Plata; Argentina
Fil: Aguirre Castro, Laura Sabrina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal del Chaco Semiárido. Área de Sanidad Animal; Argentina
Fil: Aguirre Castro, Laura Sabrina. Consejo Nacional de Investigaciones Científicas y Técnicas. CCT Salta - Jujuy; Argentina
Fil: Avellaneda Cáceres, Agustín. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal del Chaco Semiárido. Área de Sanidad Animal; Argentina
Fil: Avellaneda Cáceres, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. CCT Salta - Jujuy; Argentina
Fil: Barbeito, Claudio G.Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Experimental y Comparada. Laboratorio de Histología y Embriología Descriptiva; Argentina
Fil: Barbeito, Claudio G. Consejo Nacional de Investigaciones Científicas y Técnicas. CCT La Plata; Argentina
Fil: Signorini Porchiett, Marcelo Lisandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina
Fil: Signorini Porchiett, Marcelo Lisandro.Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación de la Cadena Láctea; Argentina
Fil: Moore, Prando Dadin. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina
Fil: Moore, Prando Dadin. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina
Fil: Micheloud, Juan Francisco. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal del Chaco Semiárido. Área de Sanidad Animal; Argentina
Fil: Micheloud, Juan Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. CCT Salta - Jujuy; Argentina
Fil: Micheloud, Juan Francisco. Universidad Católica de Salta. Facultad de Ciencias Agrarias y Veterinarias; Argentina
description There are few studies that classify and characterize the morphometric and immunohistochemical features of goitre in bovine thyroid glands (TGs). We investigated 39 bovine TGs (fetuses [9], stillbirths [18], neonates [12]) born to dams with low T4 hormone levels and no iodine supplementation and 10 (fetuses [3], stillbirths [3], neonates [4]) born to dams with normal T4 levels and supplemented with iodine. Body weight (BW), TG weight (TGW), TGW:BW ratio and histological lesions were determined. The TGs were classified histopathologically as normal gland (G0), mild goitre (G1), moderate goitre (G2) or severe goitre (G3). Various morphological and morphometric parameters were calculated from microscopic images using image analysis software. Immunohistochemistry was performed to detect proliferating cell nuclear antigen (PCNA). There were significant differences in the TGW:BW ratio among groups (P <0.05): 0.3 ± 0.1 in G0, 0.5 ± 0.3 in G1, 0.8 ± 0.3 in G2 and 1.3 ± 0.7 in G3. In G0, large homogeneous follicles with eosinophilic colloid were seen. In the groups with lesions (G1, G2 and G3), heterogeneity in follicle shape and size, height and area of thyroid follicular cells, height of thyroid follicular epithelium and PCNA immunolabelling were directly related to histopathological grade, with significant differences among groups (P <0.001), gradually increasing from G1 to G3 compared with G0. The TGW:BW ratio and histological grade were positively correlated (P = 0.008).
publishDate 2023
dc.date.none.fl_str_mv 2023-09-26T10:48:02Z
2023-09-26T10:48:02Z
2023-08-18
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/15310
https://www.sciencedirect.com/science/article/pii/S0021997523002591
0021-9975
1532-3129 (online)
https://doi.org/10.1016/j.jcpa.2023.08.002
url http://hdl.handle.net/20.500.12123/15310
https://www.sciencedirect.com/science/article/pii/S0021997523002591
https://doi.org/10.1016/j.jcpa.2023.08.002
identifier_str_mv 0021-9975
1532-3129 (online)
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/restrictedAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv restrictedAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Journal of Comparative Pathology 206 : 1-8 (October 2023)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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score 12.993085

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