First Case Reports of Nontuberculous Mycobacterial (NTM) Lung Disease in Ecuador: Important Lessons to Learn

Autores
Echeverria, Gustavo; Rueda, Veronica; Espinoza, Wilson; Rosero, Carlos; Zumarraga, Martin Jose; Waard, Jacobus H. de
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Nontuberculous mycobacteria (NTM) lung infections are often misdiagnosed as tuberculosis, which can lead to ineffective antibiotic treatments. In this report, we present three cases of NTM lung infections in Ecuador that were initially diagnosed and treated as tuberculosis based on the results of sputum smear microscopy. The patients, all male, included two immunocompetent individuals and one HIV-positive subject. Unfortunately, sputum culture was not initiated until late in the course of the disease and the cause of the lung infection, Mycobacterium avium complex (MAC), was only identified after the patients had either passed away or were lost to follow-up. These cases are the first documented cases of NTM lung infections in the English medical literature from Ecuador. We emphasize the importance of accurate diagnosis of NTM infections by culture and identification to species level. Sputum smear staining alone cannot differentiate between mycobacterial species, which can lead to misidentification and ineffective treatments. Additionally, reporting NTM pulmonary disease as a notifiable disease to national TB control programs is recommended to obtain accurate prevalence data. These data are critical in determining the importance of this public health problem and the necessary actions needed to address it.
Instituto de Biotecnología
Fil: Echeverria, Gustavo. Universidad Central del Ecuador. Instituto de Investigación en Zoonosis-CIZ; Ecuador
Fil: Echeverria, Gustavo. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Programa de Doctorado; Argentina
Fil: Echeverria, Gustavo. BioGENA. División Investigación y Desarrollo; Ecuador
Fil: Rueda, Veronica. Universidad Central del Ecuador. Instituto de Investigación en Zoonosis-CIZ; Ecuador
Fil: Espinoza, Wilson. Hospital de Especialidades Eugenio Espejo. Departamento de Tuberculosis; Ecuador
Fil: Rosero, Carlos. Hospital de Especialidades Eugenio Espejo. Departamento de Tuberculosis; Ecuador
Fil: Zumarraga, Martin Jose. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina
Fil: Zumarraga, Martin Jose. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Waard, Jacobus H. de. Universidad Central de Venezuela. Instituto de Biomedicina “Jacinto Convit”. Departamento de Tuberculosis; Venezuela
Fil: Waard, Jacobus H. de. Universidad de Las Américas. Facultad de Ciencias de la Salud. One Health Research Group; Ecuador
Fuente
Pathogens 12 (4) : 507. (April 2023)
Materia
Mycobacterium
Enfermedades Pulmonares
Diagnóstico
Ecuador
Pulmonary Diseases
Tuberculosis
Diagnosis
Nontuberculous Mycobacteria
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
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spelling First Case Reports of Nontuberculous Mycobacterial (NTM) Lung Disease in Ecuador: Important Lessons to LearnEcheverria, GustavoRueda, VeronicaEspinoza, WilsonRosero, CarlosZumarraga, Martin JoseWaard, Jacobus H. deMycobacteriumEnfermedades PulmonaresDiagnósticoEcuadorPulmonary DiseasesTuberculosisDiagnosisNontuberculous MycobacteriaNontuberculous mycobacteria (NTM) lung infections are often misdiagnosed as tuberculosis, which can lead to ineffective antibiotic treatments. In this report, we present three cases of NTM lung infections in Ecuador that were initially diagnosed and treated as tuberculosis based on the results of sputum smear microscopy. The patients, all male, included two immunocompetent individuals and one HIV-positive subject. Unfortunately, sputum culture was not initiated until late in the course of the disease and the cause of the lung infection, Mycobacterium avium complex (MAC), was only identified after the patients had either passed away or were lost to follow-up. These cases are the first documented cases of NTM lung infections in the English medical literature from Ecuador. We emphasize the importance of accurate diagnosis of NTM infections by culture and identification to species level. Sputum smear staining alone cannot differentiate between mycobacterial species, which can lead to misidentification and ineffective treatments. Additionally, reporting NTM pulmonary disease as a notifiable disease to national TB control programs is recommended to obtain accurate prevalence data. These data are critical in determining the importance of this public health problem and the necessary actions needed to address it.Instituto de BiotecnologíaFil: Echeverria, Gustavo. Universidad Central del Ecuador. Instituto de Investigación en Zoonosis-CIZ; EcuadorFil: Echeverria, Gustavo. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Programa de Doctorado; ArgentinaFil: Echeverria, Gustavo. BioGENA. División Investigación y Desarrollo; EcuadorFil: Rueda, Veronica. Universidad Central del Ecuador. Instituto de Investigación en Zoonosis-CIZ; EcuadorFil: Espinoza, Wilson. Hospital de Especialidades Eugenio Espejo. Departamento de Tuberculosis; EcuadorFil: Rosero, Carlos. Hospital de Especialidades Eugenio Espejo. Departamento de Tuberculosis; EcuadorFil: Zumarraga, Martin Jose. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; ArgentinaFil: Zumarraga, Martin Jose. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Waard, Jacobus H. de. Universidad Central de Venezuela. Instituto de Biomedicina “Jacinto Convit”. Departamento de Tuberculosis; VenezuelaFil: Waard, Jacobus H. de. Universidad de Las Américas. Facultad de Ciencias de la Salud. One Health Research Group; EcuadorMDPI2023-04-12T16:31:59Z2023-04-12T16:31:59Z2023-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/14457https://www.mdpi.com/2076-0817/12/4/5072076-0817https://doi.org/10.3390/pathogens12040507Pathogens 12 (4) : 507. (April 2023)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología AgropecuariaengEcuador .......... (nation) (World, South America)1000051info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-29T13:45:57Zoai:localhost:20.500.12123/14457instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-29 13:45:57.903INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv First Case Reports of Nontuberculous Mycobacterial (NTM) Lung Disease in Ecuador: Important Lessons to Learn
title First Case Reports of Nontuberculous Mycobacterial (NTM) Lung Disease in Ecuador: Important Lessons to Learn
spellingShingle First Case Reports of Nontuberculous Mycobacterial (NTM) Lung Disease in Ecuador: Important Lessons to Learn
Echeverria, Gustavo
Mycobacterium
Enfermedades Pulmonares
Diagnóstico
Ecuador
Pulmonary Diseases
Tuberculosis
Diagnosis
Nontuberculous Mycobacteria
title_short First Case Reports of Nontuberculous Mycobacterial (NTM) Lung Disease in Ecuador: Important Lessons to Learn
title_full First Case Reports of Nontuberculous Mycobacterial (NTM) Lung Disease in Ecuador: Important Lessons to Learn
title_fullStr First Case Reports of Nontuberculous Mycobacterial (NTM) Lung Disease in Ecuador: Important Lessons to Learn
title_full_unstemmed First Case Reports of Nontuberculous Mycobacterial (NTM) Lung Disease in Ecuador: Important Lessons to Learn
title_sort First Case Reports of Nontuberculous Mycobacterial (NTM) Lung Disease in Ecuador: Important Lessons to Learn
dc.creator.none.fl_str_mv Echeverria, Gustavo
Rueda, Veronica
Espinoza, Wilson
Rosero, Carlos
Zumarraga, Martin Jose
Waard, Jacobus H. de
author Echeverria, Gustavo
author_facet Echeverria, Gustavo
Rueda, Veronica
Espinoza, Wilson
Rosero, Carlos
Zumarraga, Martin Jose
Waard, Jacobus H. de
author_role author
author2 Rueda, Veronica
Espinoza, Wilson
Rosero, Carlos
Zumarraga, Martin Jose
Waard, Jacobus H. de
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Mycobacterium
Enfermedades Pulmonares
Diagnóstico
Ecuador
Pulmonary Diseases
Tuberculosis
Diagnosis
Nontuberculous Mycobacteria
topic Mycobacterium
Enfermedades Pulmonares
Diagnóstico
Ecuador
Pulmonary Diseases
Tuberculosis
Diagnosis
Nontuberculous Mycobacteria
dc.description.none.fl_txt_mv Nontuberculous mycobacteria (NTM) lung infections are often misdiagnosed as tuberculosis, which can lead to ineffective antibiotic treatments. In this report, we present three cases of NTM lung infections in Ecuador that were initially diagnosed and treated as tuberculosis based on the results of sputum smear microscopy. The patients, all male, included two immunocompetent individuals and one HIV-positive subject. Unfortunately, sputum culture was not initiated until late in the course of the disease and the cause of the lung infection, Mycobacterium avium complex (MAC), was only identified after the patients had either passed away or were lost to follow-up. These cases are the first documented cases of NTM lung infections in the English medical literature from Ecuador. We emphasize the importance of accurate diagnosis of NTM infections by culture and identification to species level. Sputum smear staining alone cannot differentiate between mycobacterial species, which can lead to misidentification and ineffective treatments. Additionally, reporting NTM pulmonary disease as a notifiable disease to national TB control programs is recommended to obtain accurate prevalence data. These data are critical in determining the importance of this public health problem and the necessary actions needed to address it.
Instituto de Biotecnología
Fil: Echeverria, Gustavo. Universidad Central del Ecuador. Instituto de Investigación en Zoonosis-CIZ; Ecuador
Fil: Echeverria, Gustavo. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Programa de Doctorado; Argentina
Fil: Echeverria, Gustavo. BioGENA. División Investigación y Desarrollo; Ecuador
Fil: Rueda, Veronica. Universidad Central del Ecuador. Instituto de Investigación en Zoonosis-CIZ; Ecuador
Fil: Espinoza, Wilson. Hospital de Especialidades Eugenio Espejo. Departamento de Tuberculosis; Ecuador
Fil: Rosero, Carlos. Hospital de Especialidades Eugenio Espejo. Departamento de Tuberculosis; Ecuador
Fil: Zumarraga, Martin Jose. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina
Fil: Zumarraga, Martin Jose. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Waard, Jacobus H. de. Universidad Central de Venezuela. Instituto de Biomedicina “Jacinto Convit”. Departamento de Tuberculosis; Venezuela
Fil: Waard, Jacobus H. de. Universidad de Las Américas. Facultad de Ciencias de la Salud. One Health Research Group; Ecuador
description Nontuberculous mycobacteria (NTM) lung infections are often misdiagnosed as tuberculosis, which can lead to ineffective antibiotic treatments. In this report, we present three cases of NTM lung infections in Ecuador that were initially diagnosed and treated as tuberculosis based on the results of sputum smear microscopy. The patients, all male, included two immunocompetent individuals and one HIV-positive subject. Unfortunately, sputum culture was not initiated until late in the course of the disease and the cause of the lung infection, Mycobacterium avium complex (MAC), was only identified after the patients had either passed away or were lost to follow-up. These cases are the first documented cases of NTM lung infections in the English medical literature from Ecuador. We emphasize the importance of accurate diagnosis of NTM infections by culture and identification to species level. Sputum smear staining alone cannot differentiate between mycobacterial species, which can lead to misidentification and ineffective treatments. Additionally, reporting NTM pulmonary disease as a notifiable disease to national TB control programs is recommended to obtain accurate prevalence data. These data are critical in determining the importance of this public health problem and the necessary actions needed to address it.
publishDate 2023
dc.date.none.fl_str_mv 2023-04-12T16:31:59Z
2023-04-12T16:31:59Z
2023-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/14457
https://www.mdpi.com/2076-0817/12/4/507
2076-0817
https://doi.org/10.3390/pathogens12040507
url http://hdl.handle.net/20.500.12123/14457
https://www.mdpi.com/2076-0817/12/4/507
https://doi.org/10.3390/pathogens12040507
identifier_str_mv 2076-0817
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.coverage.none.fl_str_mv Ecuador .......... (nation) (World, South America)
1000051
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Pathogens 12 (4) : 507. (April 2023)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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score 12.559606

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