Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis
- Autores
- Bos, Kirsten I.; Harkins, Kelly M.; Herbig, Alexander; Coscolla, Mireia; Weber, Nico; Comas, Iñaki; Forrest, Stephen A.; Bryant, Josephine M.; Harris, Simon R.; Schuenemann, Verena J.; Campbell, Tessa J.; Majander, Kerttu; Wilbur, Alicia K.; Guichon, Ricardo Anibal; Steadman, Dawnie L. Wolfe; Cook, Della Collins; Niemann, Stefan; Behr, Marcel A.; Zumárraga, Martín José; Bastida, Ricardo; Huson, Daniel; Nieselt, Kay; Young, Douglas; Parkhill, Julian; Buikstra, Jane E.; Gagneux, Sebastien; Stone, Anne C.; Krause, Johannes
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Modern strains of Mycobacterium tuberculosis from the Americas are closely related to those fromEurope, supporting the assumption that human tuberculosis was introduced post-contact1. This notion, however, is incompatible with archaeological evidence of pre-contact tuberculosis in the New World2. Comparative genomics of modern isolates suggests that M. tuberculosis attained its worldwide distribution following human dispersals out of Africa during the Pleistocene epoch3, although this has yet to be confirmed with ancient calibration points. Here we present three 1,000-year-oldmycobacterial genomesfromPeruvianhuman skeletons, revealing that amember of the M. tuberculosis complex caused human disease before contact.The ancient strains are distinct fromknownhuman-adapted forms and are most closely related to those adapted to seals and sea lions. Two independent dating approaches suggest a most recent common ancestor for the M. tuberculosis complex less than 6,000 years ago, which supports a Holocene dispersal of the disease. Our results implicate sea mammals as having played a role in transmitting the disease to humans across the ocean.
Fil: Bos, Kirsten I.. Universitat Tubingen; Alemania
Fil: Harkins, Kelly M.. Arizona State University; Estados Unidos
Fil: Herbig, Alexander. Universitat Tubingen; Alemania
Fil: Coscolla, Mireia. University of Basel; Suiza. Swiss Tropical and Public Health Institute; Suiza
Fil: Weber, Nico. University of Tübingen; Alemania
Fil: Comas, Iñaki. FISABIO-Public Health; España. Universidad Carlos III de Madrid. Instituto de Salud; España
Fil: Forrest, Stephen A.. University of Tübingen; Alemania
Fil: Bryant, Josephine M.. Wellcome Trust Sanger Institute; Reino Unido
Fil: Harris, Simon R.. Wellcome Trust Sanger Institute; Reino Unido
Fil: Schuenemann, Verena J.. University of Tübingen; Alemania
Fil: Campbell, Tessa J.. University Of Cape Town; Estados Unidos
Fil: Majander, Kerttu. University of Tübingen; Alemania
Fil: Wilbur, Alicia K.. Arizona State University; Estados Unidos
Fil: Guichon, Ricardo Anibal. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Mar del Plata; Argentina
Fil: Steadman, Dawnie L. Wolfe. University of Tennessee; Estados Unidos
Fil: Cook, Della Collins. Indiana University; Estados Unidos
Fil: Niemann, Stefan. Forschungszentrum Borstel - Zentrum Fur Medizin Und Biowissenschaften; Alemania
Fil: Behr, Marcel A.. Mcgill University; Canadá
Fil: Zumárraga, Martín José. Biotechnology Institute; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; Argentina
Fil: Bastida, Ricardo. Universidad Nacional de Mar del Plata; Argentina
Fil: Huson, Daniel. University of Tübingen; Alemania
Fil: Nieselt, Kay. University of Tübingen; Alemania
Fil: Young, Douglas. Imperial College London; Reino Unido. National Institute for Medical Research; Reino Unido
Fil: Parkhill, Julian. Wellcome Trust Sanger Institute; Reino Unido
Fil: Buikstra, Jane E.. Arizona State University; Estados Unidos
Fil: Gagneux, Sebastien. Universitat Basel; Suiza. Swiss Tropical and Public Health Institute; Suiza
Fil: Stone, Anne C.. Arizona State University; Estados Unidos
Fil: Krause, Johannes. Max Planck Institute for Science and History; Alemania. University of Tübingen; Alemania - Materia
-
Human Tuberculosis
Pre-Columbian Mycobacterial Genomes
New World - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/37055
Ver los metadatos del registro completo
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Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosisBos, Kirsten I.Harkins, Kelly M.Herbig, AlexanderCoscolla, MireiaWeber, NicoComas, IñakiForrest, Stephen A.Bryant, Josephine M.Harris, Simon R.Schuenemann, Verena J.Campbell, Tessa J.Majander, KerttuWilbur, Alicia K.Guichon, Ricardo AnibalSteadman, Dawnie L. WolfeCook, Della CollinsNiemann, StefanBehr, Marcel A.Zumárraga, Martín JoséBastida, RicardoHuson, DanielNieselt, KayYoung, DouglasParkhill, JulianBuikstra, Jane E.Gagneux, SebastienStone, Anne C.Krause, JohannesHuman TuberculosisPre-Columbian Mycobacterial GenomesNew Worldhttps://purl.org/becyt/ford/6.1https://purl.org/becyt/ford/6Modern strains of Mycobacterium tuberculosis from the Americas are closely related to those fromEurope, supporting the assumption that human tuberculosis was introduced post-contact1. This notion, however, is incompatible with archaeological evidence of pre-contact tuberculosis in the New World2. Comparative genomics of modern isolates suggests that M. tuberculosis attained its worldwide distribution following human dispersals out of Africa during the Pleistocene epoch3, although this has yet to be confirmed with ancient calibration points. Here we present three 1,000-year-oldmycobacterial genomesfromPeruvianhuman skeletons, revealing that amember of the M. tuberculosis complex caused human disease before contact.The ancient strains are distinct fromknownhuman-adapted forms and are most closely related to those adapted to seals and sea lions. Two independent dating approaches suggest a most recent common ancestor for the M. tuberculosis complex less than 6,000 years ago, which supports a Holocene dispersal of the disease. Our results implicate sea mammals as having played a role in transmitting the disease to humans across the ocean.Fil: Bos, Kirsten I.. Universitat Tubingen; AlemaniaFil: Harkins, Kelly M.. Arizona State University; Estados UnidosFil: Herbig, Alexander. Universitat Tubingen; AlemaniaFil: Coscolla, Mireia. University of Basel; Suiza. Swiss Tropical and Public Health Institute; SuizaFil: Weber, Nico. University of Tübingen; AlemaniaFil: Comas, Iñaki. FISABIO-Public Health; España. Universidad Carlos III de Madrid. Instituto de Salud; EspañaFil: Forrest, Stephen A.. University of Tübingen; AlemaniaFil: Bryant, Josephine M.. Wellcome Trust Sanger Institute; Reino UnidoFil: Harris, Simon R.. Wellcome Trust Sanger Institute; Reino UnidoFil: Schuenemann, Verena J.. University of Tübingen; AlemaniaFil: Campbell, Tessa J.. University Of Cape Town; Estados UnidosFil: Majander, Kerttu. University of Tübingen; AlemaniaFil: Wilbur, Alicia K.. Arizona State University; Estados UnidosFil: Guichon, Ricardo Anibal. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Mar del Plata; ArgentinaFil: Steadman, Dawnie L. Wolfe. University of Tennessee; Estados UnidosFil: Cook, Della Collins. Indiana University; Estados UnidosFil: Niemann, Stefan. Forschungszentrum Borstel - Zentrum Fur Medizin Und Biowissenschaften; AlemaniaFil: Behr, Marcel A.. Mcgill University; CanadáFil: Zumárraga, Martín José. Biotechnology Institute; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; ArgentinaFil: Bastida, Ricardo. Universidad Nacional de Mar del Plata; ArgentinaFil: Huson, Daniel. University of Tübingen; AlemaniaFil: Nieselt, Kay. University of Tübingen; AlemaniaFil: Young, Douglas. Imperial College London; Reino Unido. National Institute for Medical Research; Reino UnidoFil: Parkhill, Julian. Wellcome Trust Sanger Institute; Reino UnidoFil: Buikstra, Jane E.. Arizona State University; Estados UnidosFil: Gagneux, Sebastien. Universitat Basel; Suiza. Swiss Tropical and Public Health Institute; SuizaFil: Stone, Anne C.. Arizona State University; Estados UnidosFil: Krause, Johannes. Max Planck Institute for Science and History; Alemania. University of Tübingen; AlemaniaNature Publishing Group2014-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/37055Bos, Kirsten I.; Harkins, Kelly M.; Herbig, Alexander; Coscolla, Mireia; Weber, Nico; et al.; Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis; Nature Publishing Group; Nature; 514; 7253; 10-2014; 494-4970028-0836CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.nature.com/nature/journal/v514/n7523/full/nature13591.html#affil-authinfo:eu-repo/semantics/altIdentifier/doi/10.1038/nature13591info:eu-repo/semantics/altIdentifier/url/https://pubmed.ncbi.nlm.nih.gov/25141181/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:43:48Zoai:ri.conicet.gov.ar:11336/37055instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:43:48.927CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis |
| title |
Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis |
| spellingShingle |
Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis Bos, Kirsten I. Human Tuberculosis Pre-Columbian Mycobacterial Genomes New World |
| title_short |
Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis |
| title_full |
Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis |
| title_fullStr |
Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis |
| title_full_unstemmed |
Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis |
| title_sort |
Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis |
| dc.creator.none.fl_str_mv |
Bos, Kirsten I. Harkins, Kelly M. Herbig, Alexander Coscolla, Mireia Weber, Nico Comas, Iñaki Forrest, Stephen A. Bryant, Josephine M. Harris, Simon R. Schuenemann, Verena J. Campbell, Tessa J. Majander, Kerttu Wilbur, Alicia K. Guichon, Ricardo Anibal Steadman, Dawnie L. Wolfe Cook, Della Collins Niemann, Stefan Behr, Marcel A. Zumárraga, Martín José Bastida, Ricardo Huson, Daniel Nieselt, Kay Young, Douglas Parkhill, Julian Buikstra, Jane E. Gagneux, Sebastien Stone, Anne C. Krause, Johannes |
| author |
Bos, Kirsten I. |
| author_facet |
Bos, Kirsten I. Harkins, Kelly M. Herbig, Alexander Coscolla, Mireia Weber, Nico Comas, Iñaki Forrest, Stephen A. Bryant, Josephine M. Harris, Simon R. Schuenemann, Verena J. Campbell, Tessa J. Majander, Kerttu Wilbur, Alicia K. Guichon, Ricardo Anibal Steadman, Dawnie L. Wolfe Cook, Della Collins Niemann, Stefan Behr, Marcel A. Zumárraga, Martín José Bastida, Ricardo Huson, Daniel Nieselt, Kay Young, Douglas Parkhill, Julian Buikstra, Jane E. Gagneux, Sebastien Stone, Anne C. Krause, Johannes |
| author_role |
author |
| author2 |
Harkins, Kelly M. Herbig, Alexander Coscolla, Mireia Weber, Nico Comas, Iñaki Forrest, Stephen A. Bryant, Josephine M. Harris, Simon R. Schuenemann, Verena J. Campbell, Tessa J. Majander, Kerttu Wilbur, Alicia K. Guichon, Ricardo Anibal Steadman, Dawnie L. Wolfe Cook, Della Collins Niemann, Stefan Behr, Marcel A. Zumárraga, Martín José Bastida, Ricardo Huson, Daniel Nieselt, Kay Young, Douglas Parkhill, Julian Buikstra, Jane E. Gagneux, Sebastien Stone, Anne C. Krause, Johannes |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Human Tuberculosis Pre-Columbian Mycobacterial Genomes New World |
| topic |
Human Tuberculosis Pre-Columbian Mycobacterial Genomes New World |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/6.1 https://purl.org/becyt/ford/6 |
| dc.description.none.fl_txt_mv |
Modern strains of Mycobacterium tuberculosis from the Americas are closely related to those fromEurope, supporting the assumption that human tuberculosis was introduced post-contact1. This notion, however, is incompatible with archaeological evidence of pre-contact tuberculosis in the New World2. Comparative genomics of modern isolates suggests that M. tuberculosis attained its worldwide distribution following human dispersals out of Africa during the Pleistocene epoch3, although this has yet to be confirmed with ancient calibration points. Here we present three 1,000-year-oldmycobacterial genomesfromPeruvianhuman skeletons, revealing that amember of the M. tuberculosis complex caused human disease before contact.The ancient strains are distinct fromknownhuman-adapted forms and are most closely related to those adapted to seals and sea lions. Two independent dating approaches suggest a most recent common ancestor for the M. tuberculosis complex less than 6,000 years ago, which supports a Holocene dispersal of the disease. Our results implicate sea mammals as having played a role in transmitting the disease to humans across the ocean. Fil: Bos, Kirsten I.. Universitat Tubingen; Alemania Fil: Harkins, Kelly M.. Arizona State University; Estados Unidos Fil: Herbig, Alexander. Universitat Tubingen; Alemania Fil: Coscolla, Mireia. University of Basel; Suiza. Swiss Tropical and Public Health Institute; Suiza Fil: Weber, Nico. University of Tübingen; Alemania Fil: Comas, Iñaki. FISABIO-Public Health; España. Universidad Carlos III de Madrid. Instituto de Salud; España Fil: Forrest, Stephen A.. University of Tübingen; Alemania Fil: Bryant, Josephine M.. Wellcome Trust Sanger Institute; Reino Unido Fil: Harris, Simon R.. Wellcome Trust Sanger Institute; Reino Unido Fil: Schuenemann, Verena J.. University of Tübingen; Alemania Fil: Campbell, Tessa J.. University Of Cape Town; Estados Unidos Fil: Majander, Kerttu. University of Tübingen; Alemania Fil: Wilbur, Alicia K.. Arizona State University; Estados Unidos Fil: Guichon, Ricardo Anibal. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Mar del Plata; Argentina Fil: Steadman, Dawnie L. Wolfe. University of Tennessee; Estados Unidos Fil: Cook, Della Collins. Indiana University; Estados Unidos Fil: Niemann, Stefan. Forschungszentrum Borstel - Zentrum Fur Medizin Und Biowissenschaften; Alemania Fil: Behr, Marcel A.. Mcgill University; Canadá Fil: Zumárraga, Martín José. Biotechnology Institute; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; Argentina Fil: Bastida, Ricardo. Universidad Nacional de Mar del Plata; Argentina Fil: Huson, Daniel. University of Tübingen; Alemania Fil: Nieselt, Kay. University of Tübingen; Alemania Fil: Young, Douglas. Imperial College London; Reino Unido. National Institute for Medical Research; Reino Unido Fil: Parkhill, Julian. Wellcome Trust Sanger Institute; Reino Unido Fil: Buikstra, Jane E.. Arizona State University; Estados Unidos Fil: Gagneux, Sebastien. Universitat Basel; Suiza. Swiss Tropical and Public Health Institute; Suiza Fil: Stone, Anne C.. Arizona State University; Estados Unidos Fil: Krause, Johannes. Max Planck Institute for Science and History; Alemania. University of Tübingen; Alemania |
| description |
Modern strains of Mycobacterium tuberculosis from the Americas are closely related to those fromEurope, supporting the assumption that human tuberculosis was introduced post-contact1. This notion, however, is incompatible with archaeological evidence of pre-contact tuberculosis in the New World2. Comparative genomics of modern isolates suggests that M. tuberculosis attained its worldwide distribution following human dispersals out of Africa during the Pleistocene epoch3, although this has yet to be confirmed with ancient calibration points. Here we present three 1,000-year-oldmycobacterial genomesfromPeruvianhuman skeletons, revealing that amember of the M. tuberculosis complex caused human disease before contact.The ancient strains are distinct fromknownhuman-adapted forms and are most closely related to those adapted to seals and sea lions. Two independent dating approaches suggest a most recent common ancestor for the M. tuberculosis complex less than 6,000 years ago, which supports a Holocene dispersal of the disease. Our results implicate sea mammals as having played a role in transmitting the disease to humans across the ocean. |
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2014 |
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2014-10 |
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http://hdl.handle.net/11336/37055 Bos, Kirsten I.; Harkins, Kelly M.; Herbig, Alexander; Coscolla, Mireia; Weber, Nico; et al.; Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis; Nature Publishing Group; Nature; 514; 7253; 10-2014; 494-497 0028-0836 CONICET Digital CONICET |
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http://hdl.handle.net/11336/37055 |
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Bos, Kirsten I.; Harkins, Kelly M.; Herbig, Alexander; Coscolla, Mireia; Weber, Nico; et al.; Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis; Nature Publishing Group; Nature; 514; 7253; 10-2014; 494-497 0028-0836 CONICET Digital CONICET |
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