Abortion associated with Brucella abortus strain RB51 vaccination during gestation in a dairy cow immunized with strain 19 as a calf

Autores
Cabaña, Enzo; Rejf, Paula; Zbrun, Maria Virginia; Marini, Maria del Rocio; Ilardo, Andres; Machado, Selva; Garnero, Oscar; Foster, Camila Nayla; Novoa, María Belén
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Bovine brucellosis, caused by Brucella abortus, is a zoonotic disease that leads to abortions in cattle and poses a public health risk. Vaccination with live attenuated strains, including S19 and RB51, is part of control programs. Both vaccines are recommended in calves, and RB51 is used for adult cattle in endemic herds due to its lack of interference with serological diagnosis. Experimental studies suggest prior S19 vaccination may protect against abortion following RB51 administration during gestation. Here, we report a case of abortion in a dairy cow, sero-negative to Brucella diagnostic assays, previously vaccinated with S19 as a calf and subsequently immunized with RB51 during the first trimester of pregnancy. The cow belongs to a herd infected with B. abortus five years ago, where a plan for eradication of brucellosis is being implemented. The abortion occurred at seven months of gestation, five months after RB51 immunization. Necropsy and histopathology of the fetus revealed systemic lesions consistent with brucellosis. Brucella was isolated from fetal lung and abomasal fluid, and PCR confirmed the isolate as RB51. Serological tests performed on the cow were negative, highlighting the diagnostic limitations in RB51-vaccinated animals. This case represents the first documented abortion caused by RB51 in a cow previously immunized with S19. These findings support the recommendation to avoid RB51 vaccination in pregnant cows to prevent abortion and potential zoonotic transmission.
EEA Rafaela
Fil: Cabaña, Enzo. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; Argentina
Fil: Rejf, Paula. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; Argentina
Fil: Zbrun, Maria Virginia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela. Instituto de Investigación de la Cadena Láctea (IDICAL); Argentina
Fil: Zbrun, Maria Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación de la Cadena Láctea (IDICAL); Argentina
Fil: Marini, Maria del Rocio. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; Argentina
Fil: Ilardo, Andres. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; Argentina
Fil: Machado, Selva. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; Argentina
Fil: Garnero, Oscar. Veterinario de Actividad Privada, Santa Fé; Argentina
Fil: Foster, Camila Nayla. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela. Instituto de Investigación de la Cadena Láctea (IDICAL); Argentina
Fil: Foster, Camila Nayla. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación de la Cadena Láctea (IDICAL); Argentina
Fil: Novoa, María Belen. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela. Instituto de Investigación de la Cadena Láctea (IDICAL); Argentina
Fil: Novoa, María Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación de la Cadena Láctea (IDICAL); Argentina
Fuente
Research in Veterinary Science 197 : 105944. (December 2025)
Materia
Ganado de Leche
Vacas Lecheras
Enfermedades de los Animales
Brucelosis
Vacunación
Aborto
Dairy Cattle
Dairy Cows
Animal Diseases
Brucellosis
Brucella abortus
Vaccination
Abortion
Nivel de accesibilidad
acceso restringido
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/24503
Acceder
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oai_identifier_str oai:localhost:20.500.12123/24503
network_acronym_str INTADig
repository_id_str l
network_name_str INTA Digital (INTA)
spelling Abortion associated with Brucella abortus strain RB51 vaccination during gestation in a dairy cow immunized with strain 19 as a calfCabaña, EnzoRejf, PaulaZbrun, Maria VirginiaMarini, Maria del RocioIlardo, AndresMachado, SelvaGarnero, OscarFoster, Camila NaylaNovoa, María BelénGanado de LecheVacas LecherasEnfermedades de los AnimalesBrucelosisVacunaciónAbortoDairy CattleDairy CowsAnimal DiseasesBrucellosisBrucella abortusVaccinationAbortionBovine brucellosis, caused by Brucella abortus, is a zoonotic disease that leads to abortions in cattle and poses a public health risk. Vaccination with live attenuated strains, including S19 and RB51, is part of control programs. Both vaccines are recommended in calves, and RB51 is used for adult cattle in endemic herds due to its lack of interference with serological diagnosis. Experimental studies suggest prior S19 vaccination may protect against abortion following RB51 administration during gestation. Here, we report a case of abortion in a dairy cow, sero-negative to Brucella diagnostic assays, previously vaccinated with S19 as a calf and subsequently immunized with RB51 during the first trimester of pregnancy. The cow belongs to a herd infected with B. abortus five years ago, where a plan for eradication of brucellosis is being implemented. The abortion occurred at seven months of gestation, five months after RB51 immunization. Necropsy and histopathology of the fetus revealed systemic lesions consistent with brucellosis. Brucella was isolated from fetal lung and abomasal fluid, and PCR confirmed the isolate as RB51. Serological tests performed on the cow were negative, highlighting the diagnostic limitations in RB51-vaccinated animals. This case represents the first documented abortion caused by RB51 in a cow previously immunized with S19. These findings support the recommendation to avoid RB51 vaccination in pregnant cows to prevent abortion and potential zoonotic transmission.EEA RafaelaFil: Cabaña, Enzo. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; ArgentinaFil: Rejf, Paula. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; ArgentinaFil: Zbrun, Maria Virginia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela. Instituto de Investigación de la Cadena Láctea (IDICAL); ArgentinaFil: Zbrun, Maria Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación de la Cadena Láctea (IDICAL); ArgentinaFil: Marini, Maria del Rocio. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; ArgentinaFil: Ilardo, Andres. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; ArgentinaFil: Machado, Selva. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; ArgentinaFil: Garnero, Oscar. Veterinario de Actividad Privada, Santa Fé; ArgentinaFil: Foster, Camila Nayla. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela. Instituto de Investigación de la Cadena Láctea (IDICAL); ArgentinaFil: Foster, Camila Nayla. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación de la Cadena Láctea (IDICAL); ArgentinaFil: Novoa, María Belen. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela. Instituto de Investigación de la Cadena Láctea (IDICAL); ArgentinaFil: Novoa, María Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación de la Cadena Láctea (IDICAL); ArgentinaElsevier2025-11-07T11:55:14Z2025-11-07T11:55:14Z2025-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/24503https://www.sciencedirect.com/science/article/abs/pii/S00345288250041870034-52881532-2661https://doi.org/10.1016/j.rvsc.2025.105944Research in Veterinary Science 197 : 105944. (December 2025)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-11-27T08:40:52Zoai:localhost:20.500.12123/24503instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-11-27 08:40:52.976INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Abortion associated with Brucella abortus strain RB51 vaccination during gestation in a dairy cow immunized with strain 19 as a calf
title Abortion associated with Brucella abortus strain RB51 vaccination during gestation in a dairy cow immunized with strain 19 as a calf
spellingShingle Abortion associated with Brucella abortus strain RB51 vaccination during gestation in a dairy cow immunized with strain 19 as a calf
Cabaña, Enzo
Ganado de Leche
Vacas Lecheras
Enfermedades de los Animales
Brucelosis
Vacunación
Aborto
Dairy Cattle
Dairy Cows
Animal Diseases
Brucellosis
Brucella abortus
Vaccination
Abortion
title_short Abortion associated with Brucella abortus strain RB51 vaccination during gestation in a dairy cow immunized with strain 19 as a calf
title_full Abortion associated with Brucella abortus strain RB51 vaccination during gestation in a dairy cow immunized with strain 19 as a calf
title_fullStr Abortion associated with Brucella abortus strain RB51 vaccination during gestation in a dairy cow immunized with strain 19 as a calf
title_full_unstemmed Abortion associated with Brucella abortus strain RB51 vaccination during gestation in a dairy cow immunized with strain 19 as a calf
title_sort Abortion associated with Brucella abortus strain RB51 vaccination during gestation in a dairy cow immunized with strain 19 as a calf
dc.creator.none.fl_str_mv Cabaña, Enzo
Rejf, Paula
Zbrun, Maria Virginia
Marini, Maria del Rocio
Ilardo, Andres
Machado, Selva
Garnero, Oscar
Foster, Camila Nayla
Novoa, María Belén
author Cabaña, Enzo
author_facet Cabaña, Enzo
Rejf, Paula
Zbrun, Maria Virginia
Marini, Maria del Rocio
Ilardo, Andres
Machado, Selva
Garnero, Oscar
Foster, Camila Nayla
Novoa, María Belén
author_role author
author2 Rejf, Paula
Zbrun, Maria Virginia
Marini, Maria del Rocio
Ilardo, Andres
Machado, Selva
Garnero, Oscar
Foster, Camila Nayla
Novoa, María Belén
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ganado de Leche
Vacas Lecheras
Enfermedades de los Animales
Brucelosis
Vacunación
Aborto
Dairy Cattle
Dairy Cows
Animal Diseases
Brucellosis
Brucella abortus
Vaccination
Abortion
topic Ganado de Leche
Vacas Lecheras
Enfermedades de los Animales
Brucelosis
Vacunación
Aborto
Dairy Cattle
Dairy Cows
Animal Diseases
Brucellosis
Brucella abortus
Vaccination
Abortion
dc.description.none.fl_txt_mv Bovine brucellosis, caused by Brucella abortus, is a zoonotic disease that leads to abortions in cattle and poses a public health risk. Vaccination with live attenuated strains, including S19 and RB51, is part of control programs. Both vaccines are recommended in calves, and RB51 is used for adult cattle in endemic herds due to its lack of interference with serological diagnosis. Experimental studies suggest prior S19 vaccination may protect against abortion following RB51 administration during gestation. Here, we report a case of abortion in a dairy cow, sero-negative to Brucella diagnostic assays, previously vaccinated with S19 as a calf and subsequently immunized with RB51 during the first trimester of pregnancy. The cow belongs to a herd infected with B. abortus five years ago, where a plan for eradication of brucellosis is being implemented. The abortion occurred at seven months of gestation, five months after RB51 immunization. Necropsy and histopathology of the fetus revealed systemic lesions consistent with brucellosis. Brucella was isolated from fetal lung and abomasal fluid, and PCR confirmed the isolate as RB51. Serological tests performed on the cow were negative, highlighting the diagnostic limitations in RB51-vaccinated animals. This case represents the first documented abortion caused by RB51 in a cow previously immunized with S19. These findings support the recommendation to avoid RB51 vaccination in pregnant cows to prevent abortion and potential zoonotic transmission.
EEA Rafaela
Fil: Cabaña, Enzo. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; Argentina
Fil: Rejf, Paula. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; Argentina
Fil: Zbrun, Maria Virginia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela. Instituto de Investigación de la Cadena Láctea (IDICAL); Argentina
Fil: Zbrun, Maria Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación de la Cadena Láctea (IDICAL); Argentina
Fil: Marini, Maria del Rocio. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; Argentina
Fil: Ilardo, Andres. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; Argentina
Fil: Machado, Selva. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; Argentina
Fil: Garnero, Oscar. Veterinario de Actividad Privada, Santa Fé; Argentina
Fil: Foster, Camila Nayla. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela. Instituto de Investigación de la Cadena Láctea (IDICAL); Argentina
Fil: Foster, Camila Nayla. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación de la Cadena Láctea (IDICAL); Argentina
Fil: Novoa, María Belen. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela. Instituto de Investigación de la Cadena Láctea (IDICAL); Argentina
Fil: Novoa, María Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación de la Cadena Láctea (IDICAL); Argentina
description Bovine brucellosis, caused by Brucella abortus, is a zoonotic disease that leads to abortions in cattle and poses a public health risk. Vaccination with live attenuated strains, including S19 and RB51, is part of control programs. Both vaccines are recommended in calves, and RB51 is used for adult cattle in endemic herds due to its lack of interference with serological diagnosis. Experimental studies suggest prior S19 vaccination may protect against abortion following RB51 administration during gestation. Here, we report a case of abortion in a dairy cow, sero-negative to Brucella diagnostic assays, previously vaccinated with S19 as a calf and subsequently immunized with RB51 during the first trimester of pregnancy. The cow belongs to a herd infected with B. abortus five years ago, where a plan for eradication of brucellosis is being implemented. The abortion occurred at seven months of gestation, five months after RB51 immunization. Necropsy and histopathology of the fetus revealed systemic lesions consistent with brucellosis. Brucella was isolated from fetal lung and abomasal fluid, and PCR confirmed the isolate as RB51. Serological tests performed on the cow were negative, highlighting the diagnostic limitations in RB51-vaccinated animals. This case represents the first documented abortion caused by RB51 in a cow previously immunized with S19. These findings support the recommendation to avoid RB51 vaccination in pregnant cows to prevent abortion and potential zoonotic transmission.
publishDate 2025
dc.date.none.fl_str_mv 2025-11-07T11:55:14Z
2025-11-07T11:55:14Z
2025-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/24503
https://www.sciencedirect.com/science/article/abs/pii/S0034528825004187
0034-5288
1532-2661
https://doi.org/10.1016/j.rvsc.2025.105944
url http://hdl.handle.net/20.500.12123/24503
https://www.sciencedirect.com/science/article/abs/pii/S0034528825004187
https://doi.org/10.1016/j.rvsc.2025.105944
identifier_str_mv 0034-5288
1532-2661
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/restrictedAccess
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Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv restrictedAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Research in Veterinary Science 197 : 105944. (December 2025)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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