Phylogeographic analysis of the 2000-2002 foot-and-mouth disease epidemic in Argentina

Autores
Brito, Barbara Patricia; Konig, Guido Alberto; Cabanne, Gustavo Sebastian; Perez Beascoechea, Claudia; Rodriguez, Luis; Perez, Andres
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión aceptada
Descripción
Foot-and-mouth disease (FMD) is a highly transmissible disease of hooved livestock. Although FMD has been eradicated from many countries, economic and social consequences of FMD reintroductions are devastating. After achieving disease eradication, Argentina was affected by a major epidemic in 2000-2002, and within few months, FMD virus spread throughout most of the country and affected >2500 herds. Available records and viral strains allowed us to assess the origins, spread and progression of this FMD epidemic, which remained uncertain. We used whole genome viral sequences and a continuous phylogeographic diffusion approach, which revealed that the viruses that caused the outbreaks spread fast in different directions from a central area in Argentina. The analysis also suggests that the virus that caused the outbreaks in the year 2000 was different from those found during the 2001 epidemic. To estimate if the approximate overall genetic diversity of the virus was related to disease transmission, we reconstructed the viral demographic variation in time using Bayesian Skygrid approach and compared it with the epidemic curve and the within-herd transmission rate and showed that the genetic temporal diversity of the virus was associated with the increasing number of outbreaks in the exponential phase of the epidemic. Results here provide new evidence of how the disease entered and spread throughout the country. We further demonstrate that genetic data collected during a FMD epidemic can be informative indicators of the progression of an ongoing epidemic
Inst. de Biotecnología
Fil: Brito, Barbara. USDA/ARS Foreign Animal Disease Research Unit, Plum Island Animal Disease Center; Estados Unidos
Fil: Konig, Guido Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina
Fil: Cabanne, Gustavo Sebastian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina
Fil: Perez Beascoechea, Claudia. Servicio Nacional de Sanidad y Calidad Agroalimentaria. Dirección de Laboratorio Animal, Argentina
Fil: Rodriguez, Luis. USDA/ARS Foreign Animal Disease Research Unit, Plum Island Animal Disease Center; Estados Unidos
Fil: Perez, Andres. University of Minnesota. College of Veterinary Medicine. Department of Veterinary Population Medicine; Argentina
Fuente
Infection, genetics and evolution 41 : 93–99. (July 2016)
Materia
Enfermedades de los Animales
Fiebre Aftosa
Animal Diseases
Foot and Mouth Disease
Nivel de accesibilidad
acceso restringido
Condiciones de uso
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/1190
Acceder
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network_name_str INTA Digital (INTA)
spelling Phylogeographic analysis of the 2000-2002 foot-and-mouth disease epidemic in ArgentinaBrito, Barbara PatriciaKonig, Guido AlbertoCabanne, Gustavo SebastianPerez Beascoechea, ClaudiaRodriguez, LuisPerez, AndresEnfermedades de los AnimalesFiebre AftosaAnimal DiseasesFoot and Mouth DiseaseFoot-and-mouth disease (FMD) is a highly transmissible disease of hooved livestock. Although FMD has been eradicated from many countries, economic and social consequences of FMD reintroductions are devastating. After achieving disease eradication, Argentina was affected by a major epidemic in 2000-2002, and within few months, FMD virus spread throughout most of the country and affected >2500 herds. Available records and viral strains allowed us to assess the origins, spread and progression of this FMD epidemic, which remained uncertain. We used whole genome viral sequences and a continuous phylogeographic diffusion approach, which revealed that the viruses that caused the outbreaks spread fast in different directions from a central area in Argentina. The analysis also suggests that the virus that caused the outbreaks in the year 2000 was different from those found during the 2001 epidemic. To estimate if the approximate overall genetic diversity of the virus was related to disease transmission, we reconstructed the viral demographic variation in time using Bayesian Skygrid approach and compared it with the epidemic curve and the within-herd transmission rate and showed that the genetic temporal diversity of the virus was associated with the increasing number of outbreaks in the exponential phase of the epidemic. Results here provide new evidence of how the disease entered and spread throughout the country. We further demonstrate that genetic data collected during a FMD epidemic can be informative indicators of the progression of an ongoing epidemicInst. de BiotecnologíaFil: Brito, Barbara. USDA/ARS Foreign Animal Disease Research Unit, Plum Island Animal Disease Center; Estados UnidosFil: Konig, Guido Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; ArgentinaFil: Cabanne, Gustavo Sebastian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; ArgentinaFil: Perez Beascoechea, Claudia. Servicio Nacional de Sanidad y Calidad Agroalimentaria. Dirección de Laboratorio Animal, ArgentinaFil: Rodriguez, Luis. USDA/ARS Foreign Animal Disease Research Unit, Plum Island Animal Disease Center; Estados UnidosFil: Perez, Andres. University of Minnesota. College of Veterinary Medicine. Department of Veterinary Population Medicine; Argentina2017-09-11T14:13:44Z2017-09-11T14:13:44Z2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/1190http://www.sciencedirect.com/science/article/pii/S15671348163010711567-1348 (Print)1567-7257 (Online)https://doi.org/10.1016/j.meegid.2016.03.026Infection, genetics and evolution 41 : 93–99. (July 2016)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología AgropecuariaengArgentina (nation)2000-2002info:eu-repo/semantics/restrictedAccess2025-09-18T10:06:58Zoai:localhost:20.500.12123/1190instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-18 10:06:59.279INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Phylogeographic analysis of the 2000-2002 foot-and-mouth disease epidemic in Argentina
title Phylogeographic analysis of the 2000-2002 foot-and-mouth disease epidemic in Argentina
spellingShingle Phylogeographic analysis of the 2000-2002 foot-and-mouth disease epidemic in Argentina
Brito, Barbara Patricia
Enfermedades de los Animales
Fiebre Aftosa
Animal Diseases
Foot and Mouth Disease
title_short Phylogeographic analysis of the 2000-2002 foot-and-mouth disease epidemic in Argentina
title_full Phylogeographic analysis of the 2000-2002 foot-and-mouth disease epidemic in Argentina
title_fullStr Phylogeographic analysis of the 2000-2002 foot-and-mouth disease epidemic in Argentina
title_full_unstemmed Phylogeographic analysis of the 2000-2002 foot-and-mouth disease epidemic in Argentina
title_sort Phylogeographic analysis of the 2000-2002 foot-and-mouth disease epidemic in Argentina
dc.creator.none.fl_str_mv Brito, Barbara Patricia
Konig, Guido Alberto
Cabanne, Gustavo Sebastian
Perez Beascoechea, Claudia
Rodriguez, Luis
Perez, Andres
author Brito, Barbara Patricia
author_facet Brito, Barbara Patricia
Konig, Guido Alberto
Cabanne, Gustavo Sebastian
Perez Beascoechea, Claudia
Rodriguez, Luis
Perez, Andres
author_role author
author2 Konig, Guido Alberto
Cabanne, Gustavo Sebastian
Perez Beascoechea, Claudia
Rodriguez, Luis
Perez, Andres
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Enfermedades de los Animales
Fiebre Aftosa
Animal Diseases
Foot and Mouth Disease
topic Enfermedades de los Animales
Fiebre Aftosa
Animal Diseases
Foot and Mouth Disease
dc.description.none.fl_txt_mv Foot-and-mouth disease (FMD) is a highly transmissible disease of hooved livestock. Although FMD has been eradicated from many countries, economic and social consequences of FMD reintroductions are devastating. After achieving disease eradication, Argentina was affected by a major epidemic in 2000-2002, and within few months, FMD virus spread throughout most of the country and affected >2500 herds. Available records and viral strains allowed us to assess the origins, spread and progression of this FMD epidemic, which remained uncertain. We used whole genome viral sequences and a continuous phylogeographic diffusion approach, which revealed that the viruses that caused the outbreaks spread fast in different directions from a central area in Argentina. The analysis also suggests that the virus that caused the outbreaks in the year 2000 was different from those found during the 2001 epidemic. To estimate if the approximate overall genetic diversity of the virus was related to disease transmission, we reconstructed the viral demographic variation in time using Bayesian Skygrid approach and compared it with the epidemic curve and the within-herd transmission rate and showed that the genetic temporal diversity of the virus was associated with the increasing number of outbreaks in the exponential phase of the epidemic. Results here provide new evidence of how the disease entered and spread throughout the country. We further demonstrate that genetic data collected during a FMD epidemic can be informative indicators of the progression of an ongoing epidemic
Inst. de Biotecnología
Fil: Brito, Barbara. USDA/ARS Foreign Animal Disease Research Unit, Plum Island Animal Disease Center; Estados Unidos
Fil: Konig, Guido Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina
Fil: Cabanne, Gustavo Sebastian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina
Fil: Perez Beascoechea, Claudia. Servicio Nacional de Sanidad y Calidad Agroalimentaria. Dirección de Laboratorio Animal, Argentina
Fil: Rodriguez, Luis. USDA/ARS Foreign Animal Disease Research Unit, Plum Island Animal Disease Center; Estados Unidos
Fil: Perez, Andres. University of Minnesota. College of Veterinary Medicine. Department of Veterinary Population Medicine; Argentina
description Foot-and-mouth disease (FMD) is a highly transmissible disease of hooved livestock. Although FMD has been eradicated from many countries, economic and social consequences of FMD reintroductions are devastating. After achieving disease eradication, Argentina was affected by a major epidemic in 2000-2002, and within few months, FMD virus spread throughout most of the country and affected >2500 herds. Available records and viral strains allowed us to assess the origins, spread and progression of this FMD epidemic, which remained uncertain. We used whole genome viral sequences and a continuous phylogeographic diffusion approach, which revealed that the viruses that caused the outbreaks spread fast in different directions from a central area in Argentina. The analysis also suggests that the virus that caused the outbreaks in the year 2000 was different from those found during the 2001 epidemic. To estimate if the approximate overall genetic diversity of the virus was related to disease transmission, we reconstructed the viral demographic variation in time using Bayesian Skygrid approach and compared it with the epidemic curve and the within-herd transmission rate and showed that the genetic temporal diversity of the virus was associated with the increasing number of outbreaks in the exponential phase of the epidemic. Results here provide new evidence of how the disease entered and spread throughout the country. We further demonstrate that genetic data collected during a FMD epidemic can be informative indicators of the progression of an ongoing epidemic
publishDate 2016
dc.date.none.fl_str_mv 2016
2017-09-11T14:13:44Z
2017-09-11T14:13:44Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/1190
http://www.sciencedirect.com/science/article/pii/S1567134816301071
1567-1348 (Print)
1567-7257 (Online)
https://doi.org/10.1016/j.meegid.2016.03.026
url http://hdl.handle.net/20.500.12123/1190
http://www.sciencedirect.com/science/article/pii/S1567134816301071
https://doi.org/10.1016/j.meegid.2016.03.026
identifier_str_mv 1567-1348 (Print)
1567-7257 (Online)
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/restrictedAccess
eu_rights_str_mv restrictedAccess
dc.format.none.fl_str_mv application/pdf
dc.coverage.none.fl_str_mv Argentina (nation)
2000-2002
dc.source.none.fl_str_mv Infection, genetics and evolution 41 : 93–99. (July 2016)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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score 13.001348

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