Effect of dexamethasone in Neospora Caninum seropositive calves

Autores
Idarraga Bedoya, Samuel; Armendano, Joaquín Ignacio; Gual, Ignacio; Hecker, Yanina; Leunda, Maria Rosa; Pereyra, Susana Beatriz; Verna, Andrea Elizabeth; Campero, Carlos Manuel; Odeon, Anselmo Carlos; Moore, Prando Dadin
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of this study was to evaluate the effect of Dexamethasone (DXM) on clinical parameters, absolute and differential leukocyte count, specific IgG titers, IFN-γ production and parasitemia in beef calves seropositive to Neospora caninum. Fifteen calves were assigned to four experimental groups as follow: group A: 4 sero- positive calves treated with DXM; group B: 4 seropositive calves without DXM; group C: 3 seronegative calves treated with DXM, and group D: 4 seronegative calves without DXM treatment. The absolute leukocyte count was higher in both groups A and C in the 3rd day after the first dose of DXM mainly due to a significant neutrophilia (p<0.05). No changes in the total specific IgG titers or ratios between their subisotypes or antibodies against NcGRA7 and NcSAG4 antigens were observed in calves from group A com- pared with those in group B (p>0.05). Similarly, IFN-γ levels did not change among experimental groups (p>0.05). DNA was de- tected in calves from groups A and B at 7 Days Post Administra- tion (dpa) and from group A at 14 dpa. Even when DXM adminis- tration induced hemotological parameter changes, no reactivation of Neospora-infection was observed according to specific IgG titers and presence of the parasite on leukocytes in naturally seropositive beef male calves.
Fil: Idarraga-Bedoya Samuel. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina.
Fil: Armendano Joaquin Ignacio. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina.
Fil: Gual, Ignacio. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina.
Fil: Hecker Yanina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
Fil: Leunda María Rosa. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina.
Fil: Pereyra Susana. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina.
Fil: Verna Andrea Elizabeth. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina.
Fil: Campero Carlos Manuel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina.
Fil: Odeon Anselmo Carlos. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina.
Fil: Moore Dadin Prando. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
Fuente
Korean Journal of Clinical Medicine 1 (1) : 1-6 (2020)
Materia
Ternero
Dexametasona
Neospora Caninum
Inmunología
Serología
Enfermedades de los Animales
Calves
Dexamethasone
Immunology
Serology
Animal Diseases
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/7460
Acceder
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oai_identifier_str oai:localhost:20.500.12123/7460
network_acronym_str INTADig
repository_id_str l
network_name_str INTA Digital (INTA)
spelling Effect of dexamethasone in Neospora Caninum seropositive calvesIdarraga Bedoya, SamuelArmendano, Joaquín IgnacioGual, IgnacioHecker, YaninaLeunda, Maria RosaPereyra, Susana BeatrizVerna, Andrea ElizabethCampero, Carlos ManuelOdeon, Anselmo CarlosMoore, Prando DadinTerneroDexametasonaNeospora CaninumInmunologíaSerologíaEnfermedades de los AnimalesCalvesDexamethasoneImmunologySerologyAnimal DiseasesThe aim of this study was to evaluate the effect of Dexamethasone (DXM) on clinical parameters, absolute and differential leukocyte count, specific IgG titers, IFN-γ production and parasitemia in beef calves seropositive to Neospora caninum. Fifteen calves were assigned to four experimental groups as follow: group A: 4 sero- positive calves treated with DXM; group B: 4 seropositive calves without DXM; group C: 3 seronegative calves treated with DXM, and group D: 4 seronegative calves without DXM treatment. The absolute leukocyte count was higher in both groups A and C in the 3rd day after the first dose of DXM mainly due to a significant neutrophilia (p<0.05). No changes in the total specific IgG titers or ratios between their subisotypes or antibodies against NcGRA7 and NcSAG4 antigens were observed in calves from group A com- pared with those in group B (p>0.05). Similarly, IFN-γ levels did not change among experimental groups (p>0.05). DNA was de- tected in calves from groups A and B at 7 Days Post Administra- tion (dpa) and from group A at 14 dpa. Even when DXM adminis- tration induced hemotological parameter changes, no reactivation of Neospora-infection was observed according to specific IgG titers and presence of the parasite on leukocytes in naturally seropositive beef male calves.Fil: Idarraga-Bedoya Samuel. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina.Fil: Armendano Joaquin Ignacio. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina.Fil: Gual, Ignacio. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina.Fil: Hecker Yanina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.Fil: Leunda María Rosa. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina.Fil: Pereyra Susana. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina.Fil: Verna Andrea Elizabeth. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina.Fil: Campero Carlos Manuel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina.Fil: Odeon Anselmo Carlos. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina.Fil: Moore Dadin Prando. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.Multidisciplinary Digital Publishing Institute (MDPI)2020-06-23T16:28:47Z2020-06-23T16:28:47Z2020-03-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/7460http://kjclinicalmedicine.org/files/KJCM-1004.pdf2077-0383Korean Journal of Clinical Medicine 1 (1) : 1-6 (2020)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-11T10:23:27Zoai:localhost:20.500.12123/7460instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-11 10:23:27.499INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Effect of dexamethasone in Neospora Caninum seropositive calves
title Effect of dexamethasone in Neospora Caninum seropositive calves
spellingShingle Effect of dexamethasone in Neospora Caninum seropositive calves
Idarraga Bedoya, Samuel
Ternero
Dexametasona
Neospora Caninum
Inmunología
Serología
Enfermedades de los Animales
Calves
Dexamethasone
Immunology
Serology
Animal Diseases
title_short Effect of dexamethasone in Neospora Caninum seropositive calves
title_full Effect of dexamethasone in Neospora Caninum seropositive calves
title_fullStr Effect of dexamethasone in Neospora Caninum seropositive calves
title_full_unstemmed Effect of dexamethasone in Neospora Caninum seropositive calves
title_sort Effect of dexamethasone in Neospora Caninum seropositive calves
dc.creator.none.fl_str_mv Idarraga Bedoya, Samuel
Armendano, Joaquín Ignacio
Gual, Ignacio
Hecker, Yanina
Leunda, Maria Rosa
Pereyra, Susana Beatriz
Verna, Andrea Elizabeth
Campero, Carlos Manuel
Odeon, Anselmo Carlos
Moore, Prando Dadin
author Idarraga Bedoya, Samuel
author_facet Idarraga Bedoya, Samuel
Armendano, Joaquín Ignacio
Gual, Ignacio
Hecker, Yanina
Leunda, Maria Rosa
Pereyra, Susana Beatriz
Verna, Andrea Elizabeth
Campero, Carlos Manuel
Odeon, Anselmo Carlos
Moore, Prando Dadin
author_role author
author2 Armendano, Joaquín Ignacio
Gual, Ignacio
Hecker, Yanina
Leunda, Maria Rosa
Pereyra, Susana Beatriz
Verna, Andrea Elizabeth
Campero, Carlos Manuel
Odeon, Anselmo Carlos
Moore, Prando Dadin
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ternero
Dexametasona
Neospora Caninum
Inmunología
Serología
Enfermedades de los Animales
Calves
Dexamethasone
Immunology
Serology
Animal Diseases
topic Ternero
Dexametasona
Neospora Caninum
Inmunología
Serología
Enfermedades de los Animales
Calves
Dexamethasone
Immunology
Serology
Animal Diseases
dc.description.none.fl_txt_mv The aim of this study was to evaluate the effect of Dexamethasone (DXM) on clinical parameters, absolute and differential leukocyte count, specific IgG titers, IFN-γ production and parasitemia in beef calves seropositive to Neospora caninum. Fifteen calves were assigned to four experimental groups as follow: group A: 4 sero- positive calves treated with DXM; group B: 4 seropositive calves without DXM; group C: 3 seronegative calves treated with DXM, and group D: 4 seronegative calves without DXM treatment. The absolute leukocyte count was higher in both groups A and C in the 3rd day after the first dose of DXM mainly due to a significant neutrophilia (p<0.05). No changes in the total specific IgG titers or ratios between their subisotypes or antibodies against NcGRA7 and NcSAG4 antigens were observed in calves from group A com- pared with those in group B (p>0.05). Similarly, IFN-γ levels did not change among experimental groups (p>0.05). DNA was de- tected in calves from groups A and B at 7 Days Post Administra- tion (dpa) and from group A at 14 dpa. Even when DXM adminis- tration induced hemotological parameter changes, no reactivation of Neospora-infection was observed according to specific IgG titers and presence of the parasite on leukocytes in naturally seropositive beef male calves.
Fil: Idarraga-Bedoya Samuel. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina.
Fil: Armendano Joaquin Ignacio. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina.
Fil: Gual, Ignacio. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina.
Fil: Hecker Yanina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
Fil: Leunda María Rosa. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina.
Fil: Pereyra Susana. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina.
Fil: Verna Andrea Elizabeth. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina.
Fil: Campero Carlos Manuel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina.
Fil: Odeon Anselmo Carlos. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina.
Fil: Moore Dadin Prando. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
description The aim of this study was to evaluate the effect of Dexamethasone (DXM) on clinical parameters, absolute and differential leukocyte count, specific IgG titers, IFN-γ production and parasitemia in beef calves seropositive to Neospora caninum. Fifteen calves were assigned to four experimental groups as follow: group A: 4 sero- positive calves treated with DXM; group B: 4 seropositive calves without DXM; group C: 3 seronegative calves treated with DXM, and group D: 4 seronegative calves without DXM treatment. The absolute leukocyte count was higher in both groups A and C in the 3rd day after the first dose of DXM mainly due to a significant neutrophilia (p<0.05). No changes in the total specific IgG titers or ratios between their subisotypes or antibodies against NcGRA7 and NcSAG4 antigens were observed in calves from group A com- pared with those in group B (p>0.05). Similarly, IFN-γ levels did not change among experimental groups (p>0.05). DNA was de- tected in calves from groups A and B at 7 Days Post Administra- tion (dpa) and from group A at 14 dpa. Even when DXM adminis- tration induced hemotological parameter changes, no reactivation of Neospora-infection was observed according to specific IgG titers and presence of the parasite on leukocytes in naturally seropositive beef male calves.
publishDate 2020
dc.date.none.fl_str_mv 2020-06-23T16:28:47Z
2020-06-23T16:28:47Z
2020-03-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/7460
http://kjclinicalmedicine.org/files/KJCM-1004.pdf
2077-0383
url http://hdl.handle.net/20.500.12123/7460
http://kjclinicalmedicine.org/files/KJCM-1004.pdf
identifier_str_mv 2077-0383
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv Korean Journal of Clinical Medicine 1 (1) : 1-6 (2020)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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score 12.993085

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