Effect of Dexamethasone in Neospora Caninum Seropositive Calves
- Autores
- Idarraga Bedoya, S.; Armendano, Joaquín Ignacio; Gual, Ignacio; Hecker, Yanina Paola; Leunda, M. R.; Pereyra, S.; Verna, Andrea Elizabeth; Campero, C. M.; Odeón, Anselmo Carlos; Moore, Dadin Prando
- Año de publicación
- 2020
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The aim of this study was to evaluate the effect of Dexamethasone (DXM) on clinical parameters, absolute and differential leukocyte count, specific IgG titers, IFN-γ production and parasitemia in beef calves seropositive to Neospora caninum. Fifteen calves were assigned to four experimental groups as follow: group A: 4 sero- positive calves treated with DXM; group B: 4 seropositive calves without DXM; group C: 3 seronegative calves treated with DXM, and group D: 4 seronegative calves without DXM treatment. The absolute leukocyte count was higher in both groups A and C in the 3rd day after the first dose of DXM mainly due to a significant neutrophilia (p<0.05). No changes in the total specific IgG titers or ratios between their subisotypes or antibodies against NcGRA7 and NcSAG4 antigens were observed in calves from group A com- pared with those in group B (p>0.05). Similarly, IFN-γ levels did not change among experimental groups (p>0.05). DNA was de- tected in calves from groups A and B at 7 Days Post Administra- tion (dpa) and from group A at 14 dpa. Even when DXM adminis- tration induced hemotological parameter changes, no reactivation of Neospora-infection was observed according to specific IgG titers and presence of the parasite on leukocytes in naturally seropositive beef male calves.
Fil: Idarraga Bedoya, S.. Universidad Nacional de Mar del Plata; Argentina
Fil: Armendano, Joaquín Ignacio. Universidad Nacional de Mar del Plata; Argentina
Fil: Gual, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Mar del Plata; Argentina
Fil: Hecker, Yanina Paola. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Leunda, M. R.. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce; Argentina
Fil: Pereyra, S.. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce; Argentina
Fil: Verna, Andrea Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce; Argentina
Fil: Campero, C. M.. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce; Argentina
Fil: Odeón, Anselmo Carlos. Universidad Nacional de Mar del Plata; Argentina
Fil: Moore, Dadin Prando. Universidad Nacional de Mar del Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina - Materia
-
calves
dexamethasone
Neospora caninum
immunology - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/169391
Ver los metadatos del registro completo
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Effect of Dexamethasone in Neospora Caninum Seropositive CalvesIdarraga Bedoya, S.Armendano, Joaquín IgnacioGual, IgnacioHecker, Yanina PaolaLeunda, M. R.Pereyra, S.Verna, Andrea ElizabethCampero, C. M.Odeón, Anselmo CarlosMoore, Dadin PrandocalvesdexamethasoneNeospora caninumimmunologyhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4The aim of this study was to evaluate the effect of Dexamethasone (DXM) on clinical parameters, absolute and differential leukocyte count, specific IgG titers, IFN-γ production and parasitemia in beef calves seropositive to Neospora caninum. Fifteen calves were assigned to four experimental groups as follow: group A: 4 sero- positive calves treated with DXM; group B: 4 seropositive calves without DXM; group C: 3 seronegative calves treated with DXM, and group D: 4 seronegative calves without DXM treatment. The absolute leukocyte count was higher in both groups A and C in the 3rd day after the first dose of DXM mainly due to a significant neutrophilia (p<0.05). No changes in the total specific IgG titers or ratios between their subisotypes or antibodies against NcGRA7 and NcSAG4 antigens were observed in calves from group A com- pared with those in group B (p>0.05). Similarly, IFN-γ levels did not change among experimental groups (p>0.05). DNA was de- tected in calves from groups A and B at 7 Days Post Administra- tion (dpa) and from group A at 14 dpa. Even when DXM adminis- tration induced hemotological parameter changes, no reactivation of Neospora-infection was observed according to specific IgG titers and presence of the parasite on leukocytes in naturally seropositive beef male calves.Fil: Idarraga Bedoya, S.. Universidad Nacional de Mar del Plata; ArgentinaFil: Armendano, Joaquín Ignacio. Universidad Nacional de Mar del Plata; ArgentinaFil: Gual, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Mar del Plata; ArgentinaFil: Hecker, Yanina Paola. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Leunda, M. R.. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce; ArgentinaFil: Pereyra, S.. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce; ArgentinaFil: Verna, Andrea Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce; ArgentinaFil: Campero, C. M.. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce; ArgentinaFil: Odeón, Anselmo Carlos. Universidad Nacional de Mar del Plata; ArgentinaFil: Moore, Dadin Prando. Universidad Nacional de Mar del Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaMDPI2020-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/169391Idarraga Bedoya, S.; Armendano, Joaquín Ignacio; Gual, Ignacio; Hecker, Yanina Paola; Leunda, M. R.; et al.; Effect of Dexamethasone in Neospora Caninum Seropositive Calves; MDPI; Korean Journal of Clinical Medicine; 1; 1; 4-2020; 1-62077-0383CONICET DigitalCONICETenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:45:34Zoai:ri.conicet.gov.ar:11336/169391instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:45:34.757CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Effect of Dexamethasone in Neospora Caninum Seropositive Calves |
| title |
Effect of Dexamethasone in Neospora Caninum Seropositive Calves |
| spellingShingle |
Effect of Dexamethasone in Neospora Caninum Seropositive Calves Idarraga Bedoya, S. calves dexamethasone Neospora caninum immunology |
| title_short |
Effect of Dexamethasone in Neospora Caninum Seropositive Calves |
| title_full |
Effect of Dexamethasone in Neospora Caninum Seropositive Calves |
| title_fullStr |
Effect of Dexamethasone in Neospora Caninum Seropositive Calves |
| title_full_unstemmed |
Effect of Dexamethasone in Neospora Caninum Seropositive Calves |
| title_sort |
Effect of Dexamethasone in Neospora Caninum Seropositive Calves |
| dc.creator.none.fl_str_mv |
Idarraga Bedoya, S. Armendano, Joaquín Ignacio Gual, Ignacio Hecker, Yanina Paola Leunda, M. R. Pereyra, S. Verna, Andrea Elizabeth Campero, C. M. Odeón, Anselmo Carlos Moore, Dadin Prando |
| author |
Idarraga Bedoya, S. |
| author_facet |
Idarraga Bedoya, S. Armendano, Joaquín Ignacio Gual, Ignacio Hecker, Yanina Paola Leunda, M. R. Pereyra, S. Verna, Andrea Elizabeth Campero, C. M. Odeón, Anselmo Carlos Moore, Dadin Prando |
| author_role |
author |
| author2 |
Armendano, Joaquín Ignacio Gual, Ignacio Hecker, Yanina Paola Leunda, M. R. Pereyra, S. Verna, Andrea Elizabeth Campero, C. M. Odeón, Anselmo Carlos Moore, Dadin Prando |
| author2_role |
author author author author author author author author author |
| dc.subject.none.fl_str_mv |
calves dexamethasone Neospora caninum immunology |
| topic |
calves dexamethasone Neospora caninum immunology |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/4.3 https://purl.org/becyt/ford/4 |
| dc.description.none.fl_txt_mv |
The aim of this study was to evaluate the effect of Dexamethasone (DXM) on clinical parameters, absolute and differential leukocyte count, specific IgG titers, IFN-γ production and parasitemia in beef calves seropositive to Neospora caninum. Fifteen calves were assigned to four experimental groups as follow: group A: 4 sero- positive calves treated with DXM; group B: 4 seropositive calves without DXM; group C: 3 seronegative calves treated with DXM, and group D: 4 seronegative calves without DXM treatment. The absolute leukocyte count was higher in both groups A and C in the 3rd day after the first dose of DXM mainly due to a significant neutrophilia (p<0.05). No changes in the total specific IgG titers or ratios between their subisotypes or antibodies against NcGRA7 and NcSAG4 antigens were observed in calves from group A com- pared with those in group B (p>0.05). Similarly, IFN-γ levels did not change among experimental groups (p>0.05). DNA was de- tected in calves from groups A and B at 7 Days Post Administra- tion (dpa) and from group A at 14 dpa. Even when DXM adminis- tration induced hemotological parameter changes, no reactivation of Neospora-infection was observed according to specific IgG titers and presence of the parasite on leukocytes in naturally seropositive beef male calves. Fil: Idarraga Bedoya, S.. Universidad Nacional de Mar del Plata; Argentina Fil: Armendano, Joaquín Ignacio. Universidad Nacional de Mar del Plata; Argentina Fil: Gual, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Mar del Plata; Argentina Fil: Hecker, Yanina Paola. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Leunda, M. R.. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce; Argentina Fil: Pereyra, S.. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce; Argentina Fil: Verna, Andrea Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce; Argentina Fil: Campero, C. M.. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce; Argentina Fil: Odeón, Anselmo Carlos. Universidad Nacional de Mar del Plata; Argentina Fil: Moore, Dadin Prando. Universidad Nacional de Mar del Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
| description |
The aim of this study was to evaluate the effect of Dexamethasone (DXM) on clinical parameters, absolute and differential leukocyte count, specific IgG titers, IFN-γ production and parasitemia in beef calves seropositive to Neospora caninum. Fifteen calves were assigned to four experimental groups as follow: group A: 4 sero- positive calves treated with DXM; group B: 4 seropositive calves without DXM; group C: 3 seronegative calves treated with DXM, and group D: 4 seronegative calves without DXM treatment. The absolute leukocyte count was higher in both groups A and C in the 3rd day after the first dose of DXM mainly due to a significant neutrophilia (p<0.05). No changes in the total specific IgG titers or ratios between their subisotypes or antibodies against NcGRA7 and NcSAG4 antigens were observed in calves from group A com- pared with those in group B (p>0.05). Similarly, IFN-γ levels did not change among experimental groups (p>0.05). DNA was de- tected in calves from groups A and B at 7 Days Post Administra- tion (dpa) and from group A at 14 dpa. Even when DXM adminis- tration induced hemotological parameter changes, no reactivation of Neospora-infection was observed according to specific IgG titers and presence of the parasite on leukocytes in naturally seropositive beef male calves. |
| publishDate |
2020 |
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2020-04 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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article |
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publishedVersion |
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http://hdl.handle.net/11336/169391 Idarraga Bedoya, S.; Armendano, Joaquín Ignacio; Gual, Ignacio; Hecker, Yanina Paola; Leunda, M. R.; et al.; Effect of Dexamethasone in Neospora Caninum Seropositive Calves; MDPI; Korean Journal of Clinical Medicine; 1; 1; 4-2020; 1-6 2077-0383 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/169391 |
| identifier_str_mv |
Idarraga Bedoya, S.; Armendano, Joaquín Ignacio; Gual, Ignacio; Hecker, Yanina Paola; Leunda, M. R.; et al.; Effect of Dexamethasone in Neospora Caninum Seropositive Calves; MDPI; Korean Journal of Clinical Medicine; 1; 1; 4-2020; 1-6 2077-0383 CONICET Digital CONICET |
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eng |
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