Elovl3: a model gene to dissect homeostatic links between the circadian clock and nutrition status

Autores
Anzulovich Miranda, Ana Cecilia; Mir, Alain; Brewer, Michelle; Ferreyra, Gabriela; Vinson, Charles; Baler, Ruben
Año de publicación
2006
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The ELOVL3 protein is a very long-chain fatty acid elongase found in liver, skin, and brown adipose tissues. Circadian expression of the Elovl3 gene in the liver is perturbed in mutant CLOCK mice but persists in mice with severe hepatic dysfunction. A reliance on an intact clock, combined with the refractoriness to liver decompensation and the finding of a robust sexually dimorphic pattern of expression, evince a particularly complex mode of transcriptional control. The Elovl3 gene upstream region was repressed by RevErbα and activated by sterol-regulatory element binding protein-1 (SREBP1) transcription factors. We propose that the temporal coordination of RevErbα and SREBP1 activities integrates clock and nutrition signals to drive a subset of oscillatory transcripts in the liver. Proteolytic activation of SREBP1 is circadian in the liver, and because the cycle of SREBP1 activation was reversed after restricting meals to the inactive phase of the day, this factor could serve as an acute sensor of nutritional state. SREBP1 regulates many known lipogenic and cholesterogenic circadian genes; hence, our results could explain how feeding can override brain-derived entraining signals in the liver. This mechanism would permit a rapid adjustment in the sequence of key aspects of the absorptive and postabsorptive phases in the liver.
Fil: Anzulovich Miranda, Ana Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina. National Institutes of Health; Estados Unidos
Fil: Mir, Alain. National Institutes of Health; Estados Unidos
Fil: Brewer, Michelle. National Institutes of Health; Estados Unidos
Fil: Ferreyra, Gabriela. National Institutes of Health; Estados Unidos
Fil: Vinson, Charles. National Institutes of Health; Estados Unidos
Fil: Baler, Ruben. National Institutes of Health; Estados Unidos
Materia
ELOVL3
CIRCADIAN RHYTHM
LIPID METABOLISM
LIVER
FATTY ACID
ELONGASE
STEROL-REGULATORY ELEMENT BINDING PROTEIN TARGET GENES
RESTRICTED FEEDING
DAILY RHYTHM
PHASE SHIFT
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/158895
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/158895
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Elovl3: a model gene to dissect homeostatic links between the circadian clock and nutrition statusAnzulovich Miranda, Ana CeciliaMir, AlainBrewer, MichelleFerreyra, GabrielaVinson, CharlesBaler, RubenELOVL3CIRCADIAN RHYTHMLIPID METABOLISMLIVERFATTY ACIDELONGASESTEROL-REGULATORY ELEMENT BINDING PROTEIN TARGET GENESRESTRICTED FEEDINGDAILY RHYTHMPHASE SHIFThttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The ELOVL3 protein is a very long-chain fatty acid elongase found in liver, skin, and brown adipose tissues. Circadian expression of the Elovl3 gene in the liver is perturbed in mutant CLOCK mice but persists in mice with severe hepatic dysfunction. A reliance on an intact clock, combined with the refractoriness to liver decompensation and the finding of a robust sexually dimorphic pattern of expression, evince a particularly complex mode of transcriptional control. The Elovl3 gene upstream region was repressed by RevErbα and activated by sterol-regulatory element binding protein-1 (SREBP1) transcription factors. We propose that the temporal coordination of RevErbα and SREBP1 activities integrates clock and nutrition signals to drive a subset of oscillatory transcripts in the liver. Proteolytic activation of SREBP1 is circadian in the liver, and because the cycle of SREBP1 activation was reversed after restricting meals to the inactive phase of the day, this factor could serve as an acute sensor of nutritional state. SREBP1 regulates many known lipogenic and cholesterogenic circadian genes; hence, our results could explain how feeding can override brain-derived entraining signals in the liver. This mechanism would permit a rapid adjustment in the sequence of key aspects of the absorptive and postabsorptive phases in the liver.Fil: Anzulovich Miranda, Ana Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina. National Institutes of Health; Estados UnidosFil: Mir, Alain. National Institutes of Health; Estados UnidosFil: Brewer, Michelle. National Institutes of Health; Estados UnidosFil: Ferreyra, Gabriela. National Institutes of Health; Estados UnidosFil: Vinson, Charles. National Institutes of Health; Estados UnidosFil: Baler, Ruben. National Institutes of Health; Estados UnidosAmerican Society for Biochemistry and Molecular Biology2006-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/mswordapplication/pdfhttp://hdl.handle.net/11336/158895Anzulovich Miranda, Ana Cecilia; Mir, Alain; Brewer, Michelle; Ferreyra, Gabriela; Vinson, Charles; et al.; Elovl3: a model gene to dissect homeostatic links between the circadian clock and nutrition status; American Society for Biochemistry and Molecular Biology; Journal of Lipid Research Papers In Press; 47; 12; 12-2006; 2690-27000022-22751539-7262CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1194/jlr.M600230-JLR200info:eu-repo/semantics/altIdentifier/url/https://www.jlr.org/article/S0022-2275(20)43261-4/fulltextinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0022227520432614info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:44:06Zoai:ri.conicet.gov.ar:11336/158895instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:44:06.925CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Elovl3: a model gene to dissect homeostatic links between the circadian clock and nutrition status
title Elovl3: a model gene to dissect homeostatic links between the circadian clock and nutrition status
spellingShingle Elovl3: a model gene to dissect homeostatic links between the circadian clock and nutrition status
Anzulovich Miranda, Ana Cecilia
ELOVL3
CIRCADIAN RHYTHM
LIPID METABOLISM
LIVER
FATTY ACID
ELONGASE
STEROL-REGULATORY ELEMENT BINDING PROTEIN TARGET GENES
RESTRICTED FEEDING
DAILY RHYTHM
PHASE SHIFT
title_short Elovl3: a model gene to dissect homeostatic links between the circadian clock and nutrition status
title_full Elovl3: a model gene to dissect homeostatic links between the circadian clock and nutrition status
title_fullStr Elovl3: a model gene to dissect homeostatic links between the circadian clock and nutrition status
title_full_unstemmed Elovl3: a model gene to dissect homeostatic links between the circadian clock and nutrition status
title_sort Elovl3: a model gene to dissect homeostatic links between the circadian clock and nutrition status
dc.creator.none.fl_str_mv Anzulovich Miranda, Ana Cecilia
Mir, Alain
Brewer, Michelle
Ferreyra, Gabriela
Vinson, Charles
Baler, Ruben
author Anzulovich Miranda, Ana Cecilia
author_facet Anzulovich Miranda, Ana Cecilia
Mir, Alain
Brewer, Michelle
Ferreyra, Gabriela
Vinson, Charles
Baler, Ruben
author_role author
author2 Mir, Alain
Brewer, Michelle
Ferreyra, Gabriela
Vinson, Charles
Baler, Ruben
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv ELOVL3
CIRCADIAN RHYTHM
LIPID METABOLISM
LIVER
FATTY ACID
ELONGASE
STEROL-REGULATORY ELEMENT BINDING PROTEIN TARGET GENES
RESTRICTED FEEDING
DAILY RHYTHM
PHASE SHIFT
topic ELOVL3
CIRCADIAN RHYTHM
LIPID METABOLISM
LIVER
FATTY ACID
ELONGASE
STEROL-REGULATORY ELEMENT BINDING PROTEIN TARGET GENES
RESTRICTED FEEDING
DAILY RHYTHM
PHASE SHIFT
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The ELOVL3 protein is a very long-chain fatty acid elongase found in liver, skin, and brown adipose tissues. Circadian expression of the Elovl3 gene in the liver is perturbed in mutant CLOCK mice but persists in mice with severe hepatic dysfunction. A reliance on an intact clock, combined with the refractoriness to liver decompensation and the finding of a robust sexually dimorphic pattern of expression, evince a particularly complex mode of transcriptional control. The Elovl3 gene upstream region was repressed by RevErbα and activated by sterol-regulatory element binding protein-1 (SREBP1) transcription factors. We propose that the temporal coordination of RevErbα and SREBP1 activities integrates clock and nutrition signals to drive a subset of oscillatory transcripts in the liver. Proteolytic activation of SREBP1 is circadian in the liver, and because the cycle of SREBP1 activation was reversed after restricting meals to the inactive phase of the day, this factor could serve as an acute sensor of nutritional state. SREBP1 regulates many known lipogenic and cholesterogenic circadian genes; hence, our results could explain how feeding can override brain-derived entraining signals in the liver. This mechanism would permit a rapid adjustment in the sequence of key aspects of the absorptive and postabsorptive phases in the liver.
Fil: Anzulovich Miranda, Ana Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina. National Institutes of Health; Estados Unidos
Fil: Mir, Alain. National Institutes of Health; Estados Unidos
Fil: Brewer, Michelle. National Institutes of Health; Estados Unidos
Fil: Ferreyra, Gabriela. National Institutes of Health; Estados Unidos
Fil: Vinson, Charles. National Institutes of Health; Estados Unidos
Fil: Baler, Ruben. National Institutes of Health; Estados Unidos
description The ELOVL3 protein is a very long-chain fatty acid elongase found in liver, skin, and brown adipose tissues. Circadian expression of the Elovl3 gene in the liver is perturbed in mutant CLOCK mice but persists in mice with severe hepatic dysfunction. A reliance on an intact clock, combined with the refractoriness to liver decompensation and the finding of a robust sexually dimorphic pattern of expression, evince a particularly complex mode of transcriptional control. The Elovl3 gene upstream region was repressed by RevErbα and activated by sterol-regulatory element binding protein-1 (SREBP1) transcription factors. We propose that the temporal coordination of RevErbα and SREBP1 activities integrates clock and nutrition signals to drive a subset of oscillatory transcripts in the liver. Proteolytic activation of SREBP1 is circadian in the liver, and because the cycle of SREBP1 activation was reversed after restricting meals to the inactive phase of the day, this factor could serve as an acute sensor of nutritional state. SREBP1 regulates many known lipogenic and cholesterogenic circadian genes; hence, our results could explain how feeding can override brain-derived entraining signals in the liver. This mechanism would permit a rapid adjustment in the sequence of key aspects of the absorptive and postabsorptive phases in the liver.
publishDate 2006
dc.date.none.fl_str_mv 2006-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/158895
Anzulovich Miranda, Ana Cecilia; Mir, Alain; Brewer, Michelle; Ferreyra, Gabriela; Vinson, Charles; et al.; Elovl3: a model gene to dissect homeostatic links between the circadian clock and nutrition status; American Society for Biochemistry and Molecular Biology; Journal of Lipid Research Papers In Press; 47; 12; 12-2006; 2690-2700
0022-2275
1539-7262
CONICET Digital
CONICET
url http://hdl.handle.net/11336/158895
identifier_str_mv Anzulovich Miranda, Ana Cecilia; Mir, Alain; Brewer, Michelle; Ferreyra, Gabriela; Vinson, Charles; et al.; Elovl3: a model gene to dissect homeostatic links between the circadian clock and nutrition status; American Society for Biochemistry and Molecular Biology; Journal of Lipid Research Papers In Press; 47; 12; 12-2006; 2690-2700
0022-2275
1539-7262
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1194/jlr.M600230-JLR200
info:eu-repo/semantics/altIdentifier/url/https://www.jlr.org/article/S0022-2275(20)43261-4/fulltext
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0022227520432614
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/msword
application/pdf
dc.publisher.none.fl_str_mv American Society for Biochemistry and Molecular Biology
publisher.none.fl_str_mv American Society for Biochemistry and Molecular Biology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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