New proposal involving nanoformulated melatonin targeted to the mitochondria as a potential COVID-19 treatment

Autores
Martín Giménez, Virna Margarita; Prado, Natalia Jorgelina; Diez, Emiliano Raúl; Manucha, Walter Ariel Fernando; Reiter, Russel
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Melatonin may be a powerful auxiliary therapy in the prevention and treatment of viral infections, such as coronavirus disease 2019 (COVID-19). Casually, the so-called ‘super immunity’ of bats and the usually high levels of melatonin in children could contribute to their high resistance to the SARS-CoV-2 virus. Melatonin seems to play a key role in suppressing COVID-19 infections. This endogenous antioxidant inhibits cell apoptosis, blocks the inflammasomes that mediate lung inflammation, reduces blood vessel permeability which limits alveolar edema, improves anxiety and sleeps habits that stimulate general immunity and prevents lung fibrosis. These complications, which are usually the main consequences of COVID-19, may be significantly attenuated by melatonin...
Fil: Martín Giménez, Virna Margarita. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Católica de Cuyo. Facultad de Ciencias Químicas y Tecnológicas; Argentina
Fil: Prado, Natalia Jorgelina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Departamento de Patología; Argentina
Fil: Diez, Emiliano Raúl. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Fisiología; Argentina
Fil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Fisiología; Argentina
Fil: Reiter, Russel. University of Texas at San Antonio; Estados Unidos
Materia
ACUTE RESPIRATORY DISTRESS SYNDROME
CYTOKINE STORM
EDEMA
MITOCHONDRIAL DYSFUNCTION
NANOFORMULATIONS
SARS-COV-2
VIRAL INFECTION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/122667
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/122667
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling New proposal involving nanoformulated melatonin targeted to the mitochondria as a potential COVID-19 treatmentMartín Giménez, Virna MargaritaPrado, Natalia JorgelinaDiez, Emiliano RaúlManucha, Walter Ariel FernandoReiter, RusselACUTE RESPIRATORY DISTRESS SYNDROMECYTOKINE STORMEDEMAMITOCHONDRIAL DYSFUNCTIONNANOFORMULATIONSSARS-COV-2VIRAL INFECTIONhttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2Melatonin may be a powerful auxiliary therapy in the prevention and treatment of viral infections, such as coronavirus disease 2019 (COVID-19). Casually, the so-called ‘super immunity’ of bats and the usually high levels of melatonin in children could contribute to their high resistance to the SARS-CoV-2 virus. Melatonin seems to play a key role in suppressing COVID-19 infections. This endogenous antioxidant inhibits cell apoptosis, blocks the inflammasomes that mediate lung inflammation, reduces blood vessel permeability which limits alveolar edema, improves anxiety and sleeps habits that stimulate general immunity and prevents lung fibrosis. These complications, which are usually the main consequences of COVID-19, may be significantly attenuated by melatonin...Fil: Martín Giménez, Virna Margarita. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Católica de Cuyo. Facultad de Ciencias Químicas y Tecnológicas; ArgentinaFil: Prado, Natalia Jorgelina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Departamento de Patología; ArgentinaFil: Diez, Emiliano Raúl. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Fisiología; ArgentinaFil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Fisiología; ArgentinaFil: Reiter, Russel. University of Texas at San Antonio; Estados UnidosFuture Medicine2020-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/122667Martín Giménez, Virna Margarita; Prado, Natalia Jorgelina; Diez, Emiliano Raúl; Manucha, Walter Ariel Fernando; Reiter, Russel; New proposal involving nanoformulated melatonin targeted to the mitochondria as a potential COVID-19 treatment; Future Medicine; Nanomedicine; 15; 29; 12-2020; 2819-28211743-5889CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.futuremedicine.com/doi/10.2217/nnm-2020-0371info:eu-repo/semantics/altIdentifier/doi/10.2217/nnm-2020-0371info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:52:52Zoai:ri.conicet.gov.ar:11336/122667instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:52:53.181CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv New proposal involving nanoformulated melatonin targeted to the mitochondria as a potential COVID-19 treatment
title New proposal involving nanoformulated melatonin targeted to the mitochondria as a potential COVID-19 treatment
spellingShingle New proposal involving nanoformulated melatonin targeted to the mitochondria as a potential COVID-19 treatment
Martín Giménez, Virna Margarita
ACUTE RESPIRATORY DISTRESS SYNDROME
CYTOKINE STORM
EDEMA
MITOCHONDRIAL DYSFUNCTION
NANOFORMULATIONS
SARS-COV-2
VIRAL INFECTION
title_short New proposal involving nanoformulated melatonin targeted to the mitochondria as a potential COVID-19 treatment
title_full New proposal involving nanoformulated melatonin targeted to the mitochondria as a potential COVID-19 treatment
title_fullStr New proposal involving nanoformulated melatonin targeted to the mitochondria as a potential COVID-19 treatment
title_full_unstemmed New proposal involving nanoformulated melatonin targeted to the mitochondria as a potential COVID-19 treatment
title_sort New proposal involving nanoformulated melatonin targeted to the mitochondria as a potential COVID-19 treatment
dc.creator.none.fl_str_mv Martín Giménez, Virna Margarita
Prado, Natalia Jorgelina
Diez, Emiliano Raúl
Manucha, Walter Ariel Fernando
Reiter, Russel
author Martín Giménez, Virna Margarita
author_facet Martín Giménez, Virna Margarita
Prado, Natalia Jorgelina
Diez, Emiliano Raúl
Manucha, Walter Ariel Fernando
Reiter, Russel
author_role author
author2 Prado, Natalia Jorgelina
Diez, Emiliano Raúl
Manucha, Walter Ariel Fernando
Reiter, Russel
author2_role author
author
author
author
dc.subject.none.fl_str_mv ACUTE RESPIRATORY DISTRESS SYNDROME
CYTOKINE STORM
EDEMA
MITOCHONDRIAL DYSFUNCTION
NANOFORMULATIONS
SARS-COV-2
VIRAL INFECTION
topic ACUTE RESPIRATORY DISTRESS SYNDROME
CYTOKINE STORM
EDEMA
MITOCHONDRIAL DYSFUNCTION
NANOFORMULATIONS
SARS-COV-2
VIRAL INFECTION
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Melatonin may be a powerful auxiliary therapy in the prevention and treatment of viral infections, such as coronavirus disease 2019 (COVID-19). Casually, the so-called ‘super immunity’ of bats and the usually high levels of melatonin in children could contribute to their high resistance to the SARS-CoV-2 virus. Melatonin seems to play a key role in suppressing COVID-19 infections. This endogenous antioxidant inhibits cell apoptosis, blocks the inflammasomes that mediate lung inflammation, reduces blood vessel permeability which limits alveolar edema, improves anxiety and sleeps habits that stimulate general immunity and prevents lung fibrosis. These complications, which are usually the main consequences of COVID-19, may be significantly attenuated by melatonin...
Fil: Martín Giménez, Virna Margarita. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Católica de Cuyo. Facultad de Ciencias Químicas y Tecnológicas; Argentina
Fil: Prado, Natalia Jorgelina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Departamento de Patología; Argentina
Fil: Diez, Emiliano Raúl. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Fisiología; Argentina
Fil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Fisiología; Argentina
Fil: Reiter, Russel. University of Texas at San Antonio; Estados Unidos
description Melatonin may be a powerful auxiliary therapy in the prevention and treatment of viral infections, such as coronavirus disease 2019 (COVID-19). Casually, the so-called ‘super immunity’ of bats and the usually high levels of melatonin in children could contribute to their high resistance to the SARS-CoV-2 virus. Melatonin seems to play a key role in suppressing COVID-19 infections. This endogenous antioxidant inhibits cell apoptosis, blocks the inflammasomes that mediate lung inflammation, reduces blood vessel permeability which limits alveolar edema, improves anxiety and sleeps habits that stimulate general immunity and prevents lung fibrosis. These complications, which are usually the main consequences of COVID-19, may be significantly attenuated by melatonin...
publishDate 2020
dc.date.none.fl_str_mv 2020-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/122667
Martín Giménez, Virna Margarita; Prado, Natalia Jorgelina; Diez, Emiliano Raúl; Manucha, Walter Ariel Fernando; Reiter, Russel; New proposal involving nanoformulated melatonin targeted to the mitochondria as a potential COVID-19 treatment; Future Medicine; Nanomedicine; 15; 29; 12-2020; 2819-2821
1743-5889
CONICET Digital
CONICET
url http://hdl.handle.net/11336/122667
identifier_str_mv Martín Giménez, Virna Margarita; Prado, Natalia Jorgelina; Diez, Emiliano Raúl; Manucha, Walter Ariel Fernando; Reiter, Russel; New proposal involving nanoformulated melatonin targeted to the mitochondria as a potential COVID-19 treatment; Future Medicine; Nanomedicine; 15; 29; 12-2020; 2819-2821
1743-5889
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.futuremedicine.com/doi/10.2217/nnm-2020-0371
info:eu-repo/semantics/altIdentifier/doi/10.2217/nnm-2020-0371
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Future Medicine
publisher.none.fl_str_mv Future Medicine
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846782222486470656
score 12.982451

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