Dysfunctional mitochondria in age-related neurodegeneration: Utility of melatonin as an antioxidant treatment

Autores
Reiter, Russel J.; Sharma, Ramaswamy N.; Manucha, Walter Ariel Fernando; Rosales Corral, Sergio; de Almieda Chuffa, Luiz Gustavo; Loh, Doris; Luchetti, Francesca; Balduini, Walter; Govitrapong, Piyarat
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
As humans live longer, our bodies struggle to keep up. Organs like hips and hearts wear out, and our nervous system suffers as irreplaceable neurons die. This decline is linked to high energy use, which creates damaging molecules that accumulate over time. This free radical damage weakens neurons, contributing to age-related diseases and death. While these harmful molecules come from various sources, the energy-producing mitochondria are a major culprit. The more energy a cell uses, the faster it seems to age.To highlight, the pineal gland produces melatonin, a hormone that regulates sleep-wake cycles. Melatonin production declines with age, disrupting circadian rhythms and potentially contributing to age-related diseases. However, melatonin is also produced by other cells throughout the body, including brain cells. These cells use mitochondria, the energy centers of cells, to make melatonin. This local production may help protect brain cells from damage caused by free radicals, harmful molecules linked to aging. Studies suggest that melatonin production in the brain and other tissues can be stimulated in response to inflammation or other stressors. This may be a natural defense mechanism to combat free radical damage. Further research is needed to understand how melatonin production in different parts of the body works together to influence health and aging.
Fil: Reiter, Russel J.. No especifíca;
Fil: Sharma, Ramaswamy N.. University of the Incarnate Word; Estados Unidos
Fil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Rosales Corral, Sergio. Instituto Mexicano del Seguro Social; México
Fil: de Almieda Chuffa, Luiz Gustavo. No especifíca;
Fil: Loh, Doris. No especifíca;
Fil: Luchetti, Francesca. Università Degli Studi Di Urbino Carlo Bo.; Italia
Fil: Balduini, Walter. Università Degli Studi Di Urbino Carlo Bo.; Italia
Fil: Govitrapong, Piyarat. Chulabhorn Royal Academy; Tailandia
Materia
MELATONIN
MITOCHONDRIA
NEURAL PHATOLOGY
MITOCHONDRIAL DYSFUNCTION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/266877
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Dysfunctional mitochondria in age-related neurodegeneration: Utility of melatonin as an antioxidant treatmentReiter, Russel J.Sharma, Ramaswamy N.Manucha, Walter Ariel FernandoRosales Corral, Sergiode Almieda Chuffa, Luiz GustavoLoh, DorisLuchetti, FrancescaBalduini, WalterGovitrapong, PiyaratMELATONINMITOCHONDRIANEURAL PHATOLOGYMITOCHONDRIAL DYSFUNCTIONhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3As humans live longer, our bodies struggle to keep up. Organs like hips and hearts wear out, and our nervous system suffers as irreplaceable neurons die. This decline is linked to high energy use, which creates damaging molecules that accumulate over time. This free radical damage weakens neurons, contributing to age-related diseases and death. While these harmful molecules come from various sources, the energy-producing mitochondria are a major culprit. The more energy a cell uses, the faster it seems to age.To highlight, the pineal gland produces melatonin, a hormone that regulates sleep-wake cycles. Melatonin production declines with age, disrupting circadian rhythms and potentially contributing to age-related diseases. However, melatonin is also produced by other cells throughout the body, including brain cells. These cells use mitochondria, the energy centers of cells, to make melatonin. This local production may help protect brain cells from damage caused by free radicals, harmful molecules linked to aging. Studies suggest that melatonin production in the brain and other tissues can be stimulated in response to inflammation or other stressors. This may be a natural defense mechanism to combat free radical damage. Further research is needed to understand how melatonin production in different parts of the body works together to influence health and aging.Fil: Reiter, Russel J.. No especifíca;Fil: Sharma, Ramaswamy N.. University of the Incarnate Word; Estados UnidosFil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Rosales Corral, Sergio. Instituto Mexicano del Seguro Social; MéxicoFil: de Almieda Chuffa, Luiz Gustavo. No especifíca;Fil: Loh, Doris. No especifíca;Fil: Luchetti, Francesca. Università Degli Studi Di Urbino Carlo Bo.; ItaliaFil: Balduini, Walter. Università Degli Studi Di Urbino Carlo Bo.; ItaliaFil: Govitrapong, Piyarat. Chulabhorn Royal Academy; TailandiaElsevier Ireland2024-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/266877Reiter, Russel J.; Sharma, Ramaswamy N.; Manucha, Walter Ariel Fernando; Rosales Corral, Sergio; de Almieda Chuffa, Luiz Gustavo; et al.; Dysfunctional mitochondria in age-related neurodegeneration: Utility of melatonin as an antioxidant treatment; Elsevier Ireland; Ageing Research Reviews; 101; 11-2024; 1-181568-1637CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.arr.2024.102480info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:01:52Zoai:ri.conicet.gov.ar:11336/266877instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:01:53.053CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Dysfunctional mitochondria in age-related neurodegeneration: Utility of melatonin as an antioxidant treatment
title Dysfunctional mitochondria in age-related neurodegeneration: Utility of melatonin as an antioxidant treatment
spellingShingle Dysfunctional mitochondria in age-related neurodegeneration: Utility of melatonin as an antioxidant treatment
Reiter, Russel J.
MELATONIN
MITOCHONDRIA
NEURAL PHATOLOGY
MITOCHONDRIAL DYSFUNCTION
title_short Dysfunctional mitochondria in age-related neurodegeneration: Utility of melatonin as an antioxidant treatment
title_full Dysfunctional mitochondria in age-related neurodegeneration: Utility of melatonin as an antioxidant treatment
title_fullStr Dysfunctional mitochondria in age-related neurodegeneration: Utility of melatonin as an antioxidant treatment
title_full_unstemmed Dysfunctional mitochondria in age-related neurodegeneration: Utility of melatonin as an antioxidant treatment
title_sort Dysfunctional mitochondria in age-related neurodegeneration: Utility of melatonin as an antioxidant treatment
dc.creator.none.fl_str_mv Reiter, Russel J.
Sharma, Ramaswamy N.
Manucha, Walter Ariel Fernando
Rosales Corral, Sergio
de Almieda Chuffa, Luiz Gustavo
Loh, Doris
Luchetti, Francesca
Balduini, Walter
Govitrapong, Piyarat
author Reiter, Russel J.
author_facet Reiter, Russel J.
Sharma, Ramaswamy N.
Manucha, Walter Ariel Fernando
Rosales Corral, Sergio
de Almieda Chuffa, Luiz Gustavo
Loh, Doris
Luchetti, Francesca
Balduini, Walter
Govitrapong, Piyarat
author_role author
author2 Sharma, Ramaswamy N.
Manucha, Walter Ariel Fernando
Rosales Corral, Sergio
de Almieda Chuffa, Luiz Gustavo
Loh, Doris
Luchetti, Francesca
Balduini, Walter
Govitrapong, Piyarat
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv MELATONIN
MITOCHONDRIA
NEURAL PHATOLOGY
MITOCHONDRIAL DYSFUNCTION
topic MELATONIN
MITOCHONDRIA
NEURAL PHATOLOGY
MITOCHONDRIAL DYSFUNCTION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv As humans live longer, our bodies struggle to keep up. Organs like hips and hearts wear out, and our nervous system suffers as irreplaceable neurons die. This decline is linked to high energy use, which creates damaging molecules that accumulate over time. This free radical damage weakens neurons, contributing to age-related diseases and death. While these harmful molecules come from various sources, the energy-producing mitochondria are a major culprit. The more energy a cell uses, the faster it seems to age.To highlight, the pineal gland produces melatonin, a hormone that regulates sleep-wake cycles. Melatonin production declines with age, disrupting circadian rhythms and potentially contributing to age-related diseases. However, melatonin is also produced by other cells throughout the body, including brain cells. These cells use mitochondria, the energy centers of cells, to make melatonin. This local production may help protect brain cells from damage caused by free radicals, harmful molecules linked to aging. Studies suggest that melatonin production in the brain and other tissues can be stimulated in response to inflammation or other stressors. This may be a natural defense mechanism to combat free radical damage. Further research is needed to understand how melatonin production in different parts of the body works together to influence health and aging.
Fil: Reiter, Russel J.. No especifíca;
Fil: Sharma, Ramaswamy N.. University of the Incarnate Word; Estados Unidos
Fil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Rosales Corral, Sergio. Instituto Mexicano del Seguro Social; México
Fil: de Almieda Chuffa, Luiz Gustavo. No especifíca;
Fil: Loh, Doris. No especifíca;
Fil: Luchetti, Francesca. Università Degli Studi Di Urbino Carlo Bo.; Italia
Fil: Balduini, Walter. Università Degli Studi Di Urbino Carlo Bo.; Italia
Fil: Govitrapong, Piyarat. Chulabhorn Royal Academy; Tailandia
description As humans live longer, our bodies struggle to keep up. Organs like hips and hearts wear out, and our nervous system suffers as irreplaceable neurons die. This decline is linked to high energy use, which creates damaging molecules that accumulate over time. This free radical damage weakens neurons, contributing to age-related diseases and death. While these harmful molecules come from various sources, the energy-producing mitochondria are a major culprit. The more energy a cell uses, the faster it seems to age.To highlight, the pineal gland produces melatonin, a hormone that regulates sleep-wake cycles. Melatonin production declines with age, disrupting circadian rhythms and potentially contributing to age-related diseases. However, melatonin is also produced by other cells throughout the body, including brain cells. These cells use mitochondria, the energy centers of cells, to make melatonin. This local production may help protect brain cells from damage caused by free radicals, harmful molecules linked to aging. Studies suggest that melatonin production in the brain and other tissues can be stimulated in response to inflammation or other stressors. This may be a natural defense mechanism to combat free radical damage. Further research is needed to understand how melatonin production in different parts of the body works together to influence health and aging.
publishDate 2024
dc.date.none.fl_str_mv 2024-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/266877
Reiter, Russel J.; Sharma, Ramaswamy N.; Manucha, Walter Ariel Fernando; Rosales Corral, Sergio; de Almieda Chuffa, Luiz Gustavo; et al.; Dysfunctional mitochondria in age-related neurodegeneration: Utility of melatonin as an antioxidant treatment; Elsevier Ireland; Ageing Research Reviews; 101; 11-2024; 1-18
1568-1637
CONICET Digital
CONICET
url http://hdl.handle.net/11336/266877
identifier_str_mv Reiter, Russel J.; Sharma, Ramaswamy N.; Manucha, Walter Ariel Fernando; Rosales Corral, Sergio; de Almieda Chuffa, Luiz Gustavo; et al.; Dysfunctional mitochondria in age-related neurodegeneration: Utility of melatonin as an antioxidant treatment; Elsevier Ireland; Ageing Research Reviews; 101; 11-2024; 1-18
1568-1637
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.arr.2024.102480
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Ireland
publisher.none.fl_str_mv Elsevier Ireland
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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