MAVS Deficiency Is Associated With a Reduced T Cell Response Upon Secondary RSV Infection in Mice

Autores
Paulsen, Michelle; Varese, Augusto; Pinpathomrat, Nawamin; Kirsebom, Freja C. M.; Paulsen, Malte; Johansson, Cecilia
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Infections with respiratory syncytial virus (RSV) occurs repeatedly throughout life because sustained, protective memory responses fail to develop. Why this occurs is not known. During RSV infection the recognition of the virus via the cytosolic RIG-I like receptors and signaling via the adaptor protein MAVS is crucial for mounting an innate immune response. However, if this signaling pathway is important for T cell responses during primary infection and during re-infection is not fully elucidated. We describe a second peak of pro-inflammatory mediators during the primary immune response to RSV that coincides with the arrival of T cells into the lung. This second peak of cytokines/chemokines is regulated differently than the early peak and is largely independent of signaling via MAVS. This was concurrent with Mavs−/− mice mounting a strong T cell response to primary RSV infection, with robust IFN-γ; and Granzyme B production. However, after RSV re-infection, Mavs−/− mice showed fewer CD4+ and CD8+ short term memory T cells and their capacity to produce IFN-γ; and Granzyme B, was decreased. In sum, cytosolic recognition of RSV is important not only for initiating innate anti-viral responses but also for generating or maintaining efficient, short term T cell memory responses.
Fil: Paulsen, Michelle. Imperial College London; Reino Unido
Fil: Varese, Augusto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Pinpathomrat, Nawamin. Imperial College London; Reino Unido
Fil: Kirsebom, Freja C. M.. Imperial College London; Reino Unido
Fil: Paulsen, Malte. Imperial College London; Reino Unido
Fil: Johansson, Cecilia. Imperial College London; Reino Unido
Materia
CYTOKINES
INNATE IMMUNITY
LUNG
MEMORY T CELLS
RESPIRATORY VIRAL INFECTION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/217155
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling MAVS Deficiency Is Associated With a Reduced T Cell Response Upon Secondary RSV Infection in MicePaulsen, MichelleVarese, AugustoPinpathomrat, NawaminKirsebom, Freja C. M.Paulsen, MalteJohansson, CeciliaCYTOKINESINNATE IMMUNITYLUNGMEMORY T CELLSRESPIRATORY VIRAL INFECTIONhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Infections with respiratory syncytial virus (RSV) occurs repeatedly throughout life because sustained, protective memory responses fail to develop. Why this occurs is not known. During RSV infection the recognition of the virus via the cytosolic RIG-I like receptors and signaling via the adaptor protein MAVS is crucial for mounting an innate immune response. However, if this signaling pathway is important for T cell responses during primary infection and during re-infection is not fully elucidated. We describe a second peak of pro-inflammatory mediators during the primary immune response to RSV that coincides with the arrival of T cells into the lung. This second peak of cytokines/chemokines is regulated differently than the early peak and is largely independent of signaling via MAVS. This was concurrent with Mavs−/− mice mounting a strong T cell response to primary RSV infection, with robust IFN-γ; and Granzyme B production. However, after RSV re-infection, Mavs−/− mice showed fewer CD4+ and CD8+ short term memory T cells and their capacity to produce IFN-γ; and Granzyme B, was decreased. In sum, cytosolic recognition of RSV is important not only for initiating innate anti-viral responses but also for generating or maintaining efficient, short term T cell memory responses.Fil: Paulsen, Michelle. Imperial College London; Reino UnidoFil: Varese, Augusto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Pinpathomrat, Nawamin. Imperial College London; Reino UnidoFil: Kirsebom, Freja C. M.. Imperial College London; Reino UnidoFil: Paulsen, Malte. Imperial College London; Reino UnidoFil: Johansson, Cecilia. Imperial College London; Reino UnidoFrontiers Media2020-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/217155Paulsen, Michelle; Varese, Augusto; Pinpathomrat, Nawamin; Kirsebom, Freja C. M.; Paulsen, Malte; et al.; MAVS Deficiency Is Associated With a Reduced T Cell Response Upon Secondary RSV Infection in Mice; Frontiers Media; Frontiers in Immunology; 11; 10-2020; 1-111664-3224CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://doi.org/10.3389/fimmu.2020.572747info:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2020.572747info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:04:11Zoai:ri.conicet.gov.ar:11336/217155instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:04:11.841CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv MAVS Deficiency Is Associated With a Reduced T Cell Response Upon Secondary RSV Infection in Mice
title MAVS Deficiency Is Associated With a Reduced T Cell Response Upon Secondary RSV Infection in Mice
spellingShingle MAVS Deficiency Is Associated With a Reduced T Cell Response Upon Secondary RSV Infection in Mice
Paulsen, Michelle
CYTOKINES
INNATE IMMUNITY
LUNG
MEMORY T CELLS
RESPIRATORY VIRAL INFECTION
title_short MAVS Deficiency Is Associated With a Reduced T Cell Response Upon Secondary RSV Infection in Mice
title_full MAVS Deficiency Is Associated With a Reduced T Cell Response Upon Secondary RSV Infection in Mice
title_fullStr MAVS Deficiency Is Associated With a Reduced T Cell Response Upon Secondary RSV Infection in Mice
title_full_unstemmed MAVS Deficiency Is Associated With a Reduced T Cell Response Upon Secondary RSV Infection in Mice
title_sort MAVS Deficiency Is Associated With a Reduced T Cell Response Upon Secondary RSV Infection in Mice
dc.creator.none.fl_str_mv Paulsen, Michelle
Varese, Augusto
Pinpathomrat, Nawamin
Kirsebom, Freja C. M.
Paulsen, Malte
Johansson, Cecilia
author Paulsen, Michelle
author_facet Paulsen, Michelle
Varese, Augusto
Pinpathomrat, Nawamin
Kirsebom, Freja C. M.
Paulsen, Malte
Johansson, Cecilia
author_role author
author2 Varese, Augusto
Pinpathomrat, Nawamin
Kirsebom, Freja C. M.
Paulsen, Malte
Johansson, Cecilia
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv CYTOKINES
INNATE IMMUNITY
LUNG
MEMORY T CELLS
RESPIRATORY VIRAL INFECTION
topic CYTOKINES
INNATE IMMUNITY
LUNG
MEMORY T CELLS
RESPIRATORY VIRAL INFECTION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Infections with respiratory syncytial virus (RSV) occurs repeatedly throughout life because sustained, protective memory responses fail to develop. Why this occurs is not known. During RSV infection the recognition of the virus via the cytosolic RIG-I like receptors and signaling via the adaptor protein MAVS is crucial for mounting an innate immune response. However, if this signaling pathway is important for T cell responses during primary infection and during re-infection is not fully elucidated. We describe a second peak of pro-inflammatory mediators during the primary immune response to RSV that coincides with the arrival of T cells into the lung. This second peak of cytokines/chemokines is regulated differently than the early peak and is largely independent of signaling via MAVS. This was concurrent with Mavs−/− mice mounting a strong T cell response to primary RSV infection, with robust IFN-γ; and Granzyme B production. However, after RSV re-infection, Mavs−/− mice showed fewer CD4+ and CD8+ short term memory T cells and their capacity to produce IFN-γ; and Granzyme B, was decreased. In sum, cytosolic recognition of RSV is important not only for initiating innate anti-viral responses but also for generating or maintaining efficient, short term T cell memory responses.
Fil: Paulsen, Michelle. Imperial College London; Reino Unido
Fil: Varese, Augusto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Pinpathomrat, Nawamin. Imperial College London; Reino Unido
Fil: Kirsebom, Freja C. M.. Imperial College London; Reino Unido
Fil: Paulsen, Malte. Imperial College London; Reino Unido
Fil: Johansson, Cecilia. Imperial College London; Reino Unido
description Infections with respiratory syncytial virus (RSV) occurs repeatedly throughout life because sustained, protective memory responses fail to develop. Why this occurs is not known. During RSV infection the recognition of the virus via the cytosolic RIG-I like receptors and signaling via the adaptor protein MAVS is crucial for mounting an innate immune response. However, if this signaling pathway is important for T cell responses during primary infection and during re-infection is not fully elucidated. We describe a second peak of pro-inflammatory mediators during the primary immune response to RSV that coincides with the arrival of T cells into the lung. This second peak of cytokines/chemokines is regulated differently than the early peak and is largely independent of signaling via MAVS. This was concurrent with Mavs−/− mice mounting a strong T cell response to primary RSV infection, with robust IFN-γ; and Granzyme B production. However, after RSV re-infection, Mavs−/− mice showed fewer CD4+ and CD8+ short term memory T cells and their capacity to produce IFN-γ; and Granzyme B, was decreased. In sum, cytosolic recognition of RSV is important not only for initiating innate anti-viral responses but also for generating or maintaining efficient, short term T cell memory responses.
publishDate 2020
dc.date.none.fl_str_mv 2020-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/217155
Paulsen, Michelle; Varese, Augusto; Pinpathomrat, Nawamin; Kirsebom, Freja C. M.; Paulsen, Malte; et al.; MAVS Deficiency Is Associated With a Reduced T Cell Response Upon Secondary RSV Infection in Mice; Frontiers Media; Frontiers in Immunology; 11; 10-2020; 1-11
1664-3224
CONICET Digital
CONICET
url http://hdl.handle.net/11336/217155
identifier_str_mv Paulsen, Michelle; Varese, Augusto; Pinpathomrat, Nawamin; Kirsebom, Freja C. M.; Paulsen, Malte; et al.; MAVS Deficiency Is Associated With a Reduced T Cell Response Upon Secondary RSV Infection in Mice; Frontiers Media; Frontiers in Immunology; 11; 10-2020; 1-11
1664-3224
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://doi.org/10.3389/fimmu.2020.572747
info:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2020.572747
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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