Mucosal targeting of therapeutic molecules using genetically modified lactic acid bacteria: an update

Autores
Leblanc, Jean Guy Joseph; Aubry, Camille; Cortes-Perez, Naima G.; de Moreno, Maria Alejandra; Vergnolle, Nathalie; Langella, Philippe; Azevedo, Vasco; Chatel, Jean-Marc; Miyoshi, Anderson; Berúdez-Humarán, Luis G.
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Lactic acid bacteria (LAB) represent a heterogeneous group of microorganisms naturally present in many foods and those have proved to be effective mucosal delivery vectors. Moreover, some specific strains of LAB exert beneficial properties (known as probiotic effect) on both human and animal health. Although probiotic effects are strain-specific traits, it is theoretically possible, using genetic engineering techniques, to design strains that can exert a variety of beneficial properties. During the two past decades, a large variety of therapeutic molecules has been successfully expressed in LAB, and although this field has been largely reviewed in recent years, approximately 20 new publications appear each year. Thus, the aim of this minireview is not to extensively assess the entire literature but to update progress made within the last 2 years regarding the use of the model LAB Lactococcus lactis and certain species of lactobacilli as live recombinant vectors for the development of new safe mucosal vaccine.
Fil: Leblanc, Jean Guy Joseph. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia Para Lactobacilos (i); Argentina. Universidad Nacional de Tucuman. Facultad de Medicina. Departamento de Investigacion. Catedra de Metodologia de la Invest.cientifica; Argentina
Fil: Aubry, Camille. Institut National de la Recherche Agronomique; Francia;
Fil: Cortes-Perez, Naima G.. Institut National de la Recherche Agronomique; Francia;
Fil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia Para Lactobacilos (i); Argentina
Fil: Vergnolle, Nathalie. Centre National de la Recherche Scientifique; Francia; . Universite Paul Sabatier; Francia;
Fil: Langella, Philippe. Institut National de la Recherche Agronomique; Francia;
Fil: Azevedo, Vasco. Universidade Federal Do Minas Gerais; Brasil;
Fil: Chatel, Jean-Marc. Institut National de la Recherche Agronomique; Francia;
Fil: Miyoshi, Anderson. Universidade Federal Do Minas Gerais; Brasil;
Fil: Berúdez-Humarán, Luis G.. Institut National de la Recherche Agronomique; Francia;
Materia
Lactic Acid Bactera
Mucosal Vaccines
Cytokines
Therapeutic Molecules
Lactococcus
Lactobacillus
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/2317
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/2317
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Mucosal targeting of therapeutic molecules using genetically modified lactic acid bacteria: an updateLeblanc, Jean Guy JosephAubry, CamilleCortes-Perez, Naima G.de Moreno, Maria AlejandraVergnolle, NathalieLangella, PhilippeAzevedo, VascoChatel, Jean-MarcMiyoshi, AndersonBerúdez-Humarán, Luis G.Lactic Acid BacteraMucosal VaccinesCytokinesTherapeutic MoleculesLactococcusLactobacillushttps://purl.org/becyt/ford/2.11https://purl.org/becyt/ford/2Lactic acid bacteria (LAB) represent a heterogeneous group of microorganisms naturally present in many foods and those have proved to be effective mucosal delivery vectors. Moreover, some specific strains of LAB exert beneficial properties (known as probiotic effect) on both human and animal health. Although probiotic effects are strain-specific traits, it is theoretically possible, using genetic engineering techniques, to design strains that can exert a variety of beneficial properties. During the two past decades, a large variety of therapeutic molecules has been successfully expressed in LAB, and although this field has been largely reviewed in recent years, approximately 20 new publications appear each year. Thus, the aim of this minireview is not to extensively assess the entire literature but to update progress made within the last 2 years regarding the use of the model LAB Lactococcus lactis and certain species of lactobacilli as live recombinant vectors for the development of new safe mucosal vaccine.Fil: Leblanc, Jean Guy Joseph. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia Para Lactobacilos (i); Argentina. Universidad Nacional de Tucuman. Facultad de Medicina. Departamento de Investigacion. Catedra de Metodologia de la Invest.cientifica; ArgentinaFil: Aubry, Camille. Institut National de la Recherche Agronomique; Francia;Fil: Cortes-Perez, Naima G.. Institut National de la Recherche Agronomique; Francia;Fil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia Para Lactobacilos (i); ArgentinaFil: Vergnolle, Nathalie. Centre National de la Recherche Scientifique; Francia; . Universite Paul Sabatier; Francia;Fil: Langella, Philippe. Institut National de la Recherche Agronomique; Francia;Fil: Azevedo, Vasco. Universidade Federal Do Minas Gerais; Brasil;Fil: Chatel, Jean-Marc. Institut National de la Recherche Agronomique; Francia;Fil: Miyoshi, Anderson. Universidade Federal Do Minas Gerais; Brasil;Fil: Berúdez-Humarán, Luis G.. Institut National de la Recherche Agronomique; Francia;Oxford University Press2013-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/2317Leblanc, Jean Guy Joseph; Aubry, Camille; Cortes-Perez, Naima G.; de Moreno, Maria Alejandra; Vergnolle, Nathalie; et al.; Mucosal targeting of therapeutic molecules using genetically modified lactic acid bacteria: an update; Oxford University Press; Fems Microbiology Letters; 344; 1; 7-2013; 1-90378-10971574-6968enginfo:eu-repo/semantics/altIdentifier/url/http://femsle.oxfordjournals.org/content/344/1info:eu-repo/semantics/altIdentifier/doi/10.1111/1574-6968.12159info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:10:35Zoai:ri.conicet.gov.ar:11336/2317instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:10:35.541CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Mucosal targeting of therapeutic molecules using genetically modified lactic acid bacteria: an update
title Mucosal targeting of therapeutic molecules using genetically modified lactic acid bacteria: an update
spellingShingle Mucosal targeting of therapeutic molecules using genetically modified lactic acid bacteria: an update
Leblanc, Jean Guy Joseph
Lactic Acid Bactera
Mucosal Vaccines
Cytokines
Therapeutic Molecules
Lactococcus
Lactobacillus
title_short Mucosal targeting of therapeutic molecules using genetically modified lactic acid bacteria: an update
title_full Mucosal targeting of therapeutic molecules using genetically modified lactic acid bacteria: an update
title_fullStr Mucosal targeting of therapeutic molecules using genetically modified lactic acid bacteria: an update
title_full_unstemmed Mucosal targeting of therapeutic molecules using genetically modified lactic acid bacteria: an update
title_sort Mucosal targeting of therapeutic molecules using genetically modified lactic acid bacteria: an update
dc.creator.none.fl_str_mv Leblanc, Jean Guy Joseph
Aubry, Camille
Cortes-Perez, Naima G.
de Moreno, Maria Alejandra
Vergnolle, Nathalie
Langella, Philippe
Azevedo, Vasco
Chatel, Jean-Marc
Miyoshi, Anderson
Berúdez-Humarán, Luis G.
author Leblanc, Jean Guy Joseph
author_facet Leblanc, Jean Guy Joseph
Aubry, Camille
Cortes-Perez, Naima G.
de Moreno, Maria Alejandra
Vergnolle, Nathalie
Langella, Philippe
Azevedo, Vasco
Chatel, Jean-Marc
Miyoshi, Anderson
Berúdez-Humarán, Luis G.
author_role author
author2 Aubry, Camille
Cortes-Perez, Naima G.
de Moreno, Maria Alejandra
Vergnolle, Nathalie
Langella, Philippe
Azevedo, Vasco
Chatel, Jean-Marc
Miyoshi, Anderson
Berúdez-Humarán, Luis G.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Lactic Acid Bactera
Mucosal Vaccines
Cytokines
Therapeutic Molecules
Lactococcus
Lactobacillus
topic Lactic Acid Bactera
Mucosal Vaccines
Cytokines
Therapeutic Molecules
Lactococcus
Lactobacillus
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.11
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Lactic acid bacteria (LAB) represent a heterogeneous group of microorganisms naturally present in many foods and those have proved to be effective mucosal delivery vectors. Moreover, some specific strains of LAB exert beneficial properties (known as probiotic effect) on both human and animal health. Although probiotic effects are strain-specific traits, it is theoretically possible, using genetic engineering techniques, to design strains that can exert a variety of beneficial properties. During the two past decades, a large variety of therapeutic molecules has been successfully expressed in LAB, and although this field has been largely reviewed in recent years, approximately 20 new publications appear each year. Thus, the aim of this minireview is not to extensively assess the entire literature but to update progress made within the last 2 years regarding the use of the model LAB Lactococcus lactis and certain species of lactobacilli as live recombinant vectors for the development of new safe mucosal vaccine.
Fil: Leblanc, Jean Guy Joseph. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia Para Lactobacilos (i); Argentina. Universidad Nacional de Tucuman. Facultad de Medicina. Departamento de Investigacion. Catedra de Metodologia de la Invest.cientifica; Argentina
Fil: Aubry, Camille. Institut National de la Recherche Agronomique; Francia;
Fil: Cortes-Perez, Naima G.. Institut National de la Recherche Agronomique; Francia;
Fil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia Para Lactobacilos (i); Argentina
Fil: Vergnolle, Nathalie. Centre National de la Recherche Scientifique; Francia; . Universite Paul Sabatier; Francia;
Fil: Langella, Philippe. Institut National de la Recherche Agronomique; Francia;
Fil: Azevedo, Vasco. Universidade Federal Do Minas Gerais; Brasil;
Fil: Chatel, Jean-Marc. Institut National de la Recherche Agronomique; Francia;
Fil: Miyoshi, Anderson. Universidade Federal Do Minas Gerais; Brasil;
Fil: Berúdez-Humarán, Luis G.. Institut National de la Recherche Agronomique; Francia;
description Lactic acid bacteria (LAB) represent a heterogeneous group of microorganisms naturally present in many foods and those have proved to be effective mucosal delivery vectors. Moreover, some specific strains of LAB exert beneficial properties (known as probiotic effect) on both human and animal health. Although probiotic effects are strain-specific traits, it is theoretically possible, using genetic engineering techniques, to design strains that can exert a variety of beneficial properties. During the two past decades, a large variety of therapeutic molecules has been successfully expressed in LAB, and although this field has been largely reviewed in recent years, approximately 20 new publications appear each year. Thus, the aim of this minireview is not to extensively assess the entire literature but to update progress made within the last 2 years regarding the use of the model LAB Lactococcus lactis and certain species of lactobacilli as live recombinant vectors for the development of new safe mucosal vaccine.
publishDate 2013
dc.date.none.fl_str_mv 2013-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/2317
Leblanc, Jean Guy Joseph; Aubry, Camille; Cortes-Perez, Naima G.; de Moreno, Maria Alejandra; Vergnolle, Nathalie; et al.; Mucosal targeting of therapeutic molecules using genetically modified lactic acid bacteria: an update; Oxford University Press; Fems Microbiology Letters; 344; 1; 7-2013; 1-9
0378-1097
1574-6968
url http://hdl.handle.net/11336/2317
identifier_str_mv Leblanc, Jean Guy Joseph; Aubry, Camille; Cortes-Perez, Naima G.; de Moreno, Maria Alejandra; Vergnolle, Nathalie; et al.; Mucosal targeting of therapeutic molecules using genetically modified lactic acid bacteria: an update; Oxford University Press; Fems Microbiology Letters; 344; 1; 7-2013; 1-9
0378-1097
1574-6968
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://femsle.oxfordjournals.org/content/344/1
info:eu-repo/semantics/altIdentifier/doi/10.1111/1574-6968.12159
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846781468692447232
score 12.982451

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