IFN-γ production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM, and CREB

Autores
Pasquinelli, Virginia; Townsend, James C.; Jurado, Javier Oscar; Alvarez, Ivana Belén; Quiroga, María Florencia; Barnes, Peter F.; Samten, Buka; García, Verónica Edith
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Interferon-γ (IFN-γ) is crucial for protection against Mycobacterium tuberculosis, and the transcription factor cAMP response element binding protein (CREB) increases IFN-γ transcription. We determined whether the transmembrane receptor signaling lymphocyte activation molecule (SLAM) and interleukin-17 (IL-17) affect CREB phosphorylation and IFN-γ production in persons with tuberculosis. When T cells from patients with tuberculosis were activated with M. tuberculosis, 80% of SLAM+ T cells expressed phosphorylated CREB, and SLAM activation increased CREB phosphorylation and IFN-γ production. In contrast, IL-17 down-regulated SLAM expression, CREB phosphorylation, and IFN-γ production. Therefore, IL-17 and SLAM have opposing effects on IFN-γ production through CREB activation in persons with tuberculosis. © 2009 by the Infectious Diseases Society of America. All rights reserved.
Fil: Pasquinelli, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Townsend, James C.. University of Texas; Estados Unidos
Fil: Jurado, Javier Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Alvarez, Ivana Belén. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Quiroga, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Barnes, Peter F.. University of Texas; Estados Unidos
Fil: Samten, Buka. University of Texas; Estados Unidos
Fil: García, Verónica Edith. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Materia
TUBERCULOSIS
IFN-GAMMA
SIGNALING PROTEINS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/67285
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/67285
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling IFN-γ production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM, and CREBPasquinelli, VirginiaTownsend, James C.Jurado, Javier OscarAlvarez, Ivana BelénQuiroga, María FlorenciaBarnes, Peter F.Samten, BukaGarcía, Verónica EdithTUBERCULOSISIFN-GAMMASIGNALING PROTEINShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Interferon-γ (IFN-γ) is crucial for protection against Mycobacterium tuberculosis, and the transcription factor cAMP response element binding protein (CREB) increases IFN-γ transcription. We determined whether the transmembrane receptor signaling lymphocyte activation molecule (SLAM) and interleukin-17 (IL-17) affect CREB phosphorylation and IFN-γ production in persons with tuberculosis. When T cells from patients with tuberculosis were activated with M. tuberculosis, 80% of SLAM+ T cells expressed phosphorylated CREB, and SLAM activation increased CREB phosphorylation and IFN-γ production. In contrast, IL-17 down-regulated SLAM expression, CREB phosphorylation, and IFN-γ production. Therefore, IL-17 and SLAM have opposing effects on IFN-γ production through CREB activation in persons with tuberculosis. © 2009 by the Infectious Diseases Society of America. All rights reserved.Fil: Pasquinelli, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaFil: Townsend, James C.. University of Texas; Estados UnidosFil: Jurado, Javier Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaFil: Alvarez, Ivana Belén. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaFil: Quiroga, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaFil: Barnes, Peter F.. University of Texas; Estados UnidosFil: Samten, Buka. University of Texas; Estados UnidosFil: García, Verónica Edith. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaUniversity of Chicago Press2009-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/67285Pasquinelli, Virginia; Townsend, James C.; Jurado, Javier Oscar; Alvarez, Ivana Belén; Quiroga, María Florencia; et al.; IFN-γ production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM, and CREB; University of Chicago Press; Journal Of Infectious Diseases; 199; 5; 3-2009; 661-6650022-1899CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1086/596742info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jid/article/199/5/661/901283info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:49:38Zoai:ri.conicet.gov.ar:11336/67285instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:49:38.974CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv IFN-γ production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM, and CREB
title IFN-γ production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM, and CREB
spellingShingle IFN-γ production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM, and CREB
Pasquinelli, Virginia
TUBERCULOSIS
IFN-GAMMA
SIGNALING PROTEINS
title_short IFN-γ production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM, and CREB
title_full IFN-γ production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM, and CREB
title_fullStr IFN-γ production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM, and CREB
title_full_unstemmed IFN-γ production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM, and CREB
title_sort IFN-γ production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM, and CREB
dc.creator.none.fl_str_mv Pasquinelli, Virginia
Townsend, James C.
Jurado, Javier Oscar
Alvarez, Ivana Belén
Quiroga, María Florencia
Barnes, Peter F.
Samten, Buka
García, Verónica Edith
author Pasquinelli, Virginia
author_facet Pasquinelli, Virginia
Townsend, James C.
Jurado, Javier Oscar
Alvarez, Ivana Belén
Quiroga, María Florencia
Barnes, Peter F.
Samten, Buka
García, Verónica Edith
author_role author
author2 Townsend, James C.
Jurado, Javier Oscar
Alvarez, Ivana Belén
Quiroga, María Florencia
Barnes, Peter F.
Samten, Buka
García, Verónica Edith
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv TUBERCULOSIS
IFN-GAMMA
SIGNALING PROTEINS
topic TUBERCULOSIS
IFN-GAMMA
SIGNALING PROTEINS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Interferon-γ (IFN-γ) is crucial for protection against Mycobacterium tuberculosis, and the transcription factor cAMP response element binding protein (CREB) increases IFN-γ transcription. We determined whether the transmembrane receptor signaling lymphocyte activation molecule (SLAM) and interleukin-17 (IL-17) affect CREB phosphorylation and IFN-γ production in persons with tuberculosis. When T cells from patients with tuberculosis were activated with M. tuberculosis, 80% of SLAM+ T cells expressed phosphorylated CREB, and SLAM activation increased CREB phosphorylation and IFN-γ production. In contrast, IL-17 down-regulated SLAM expression, CREB phosphorylation, and IFN-γ production. Therefore, IL-17 and SLAM have opposing effects on IFN-γ production through CREB activation in persons with tuberculosis. © 2009 by the Infectious Diseases Society of America. All rights reserved.
Fil: Pasquinelli, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Townsend, James C.. University of Texas; Estados Unidos
Fil: Jurado, Javier Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Alvarez, Ivana Belén. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Quiroga, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Barnes, Peter F.. University of Texas; Estados Unidos
Fil: Samten, Buka. University of Texas; Estados Unidos
Fil: García, Verónica Edith. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
description Interferon-γ (IFN-γ) is crucial for protection against Mycobacterium tuberculosis, and the transcription factor cAMP response element binding protein (CREB) increases IFN-γ transcription. We determined whether the transmembrane receptor signaling lymphocyte activation molecule (SLAM) and interleukin-17 (IL-17) affect CREB phosphorylation and IFN-γ production in persons with tuberculosis. When T cells from patients with tuberculosis were activated with M. tuberculosis, 80% of SLAM+ T cells expressed phosphorylated CREB, and SLAM activation increased CREB phosphorylation and IFN-γ production. In contrast, IL-17 down-regulated SLAM expression, CREB phosphorylation, and IFN-γ production. Therefore, IL-17 and SLAM have opposing effects on IFN-γ production through CREB activation in persons with tuberculosis. © 2009 by the Infectious Diseases Society of America. All rights reserved.
publishDate 2009
dc.date.none.fl_str_mv 2009-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/67285
Pasquinelli, Virginia; Townsend, James C.; Jurado, Javier Oscar; Alvarez, Ivana Belén; Quiroga, María Florencia; et al.; IFN-γ production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM, and CREB; University of Chicago Press; Journal Of Infectious Diseases; 199; 5; 3-2009; 661-665
0022-1899
CONICET Digital
CONICET
url http://hdl.handle.net/11336/67285
identifier_str_mv Pasquinelli, Virginia; Townsend, James C.; Jurado, Javier Oscar; Alvarez, Ivana Belén; Quiroga, María Florencia; et al.; IFN-γ production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM, and CREB; University of Chicago Press; Journal Of Infectious Diseases; 199; 5; 3-2009; 661-665
0022-1899
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1086/596742
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jid/article/199/5/661/901283
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv University of Chicago Press
publisher.none.fl_str_mv University of Chicago Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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