Effect of GnRH analogs in postnatal domestic cats

Autores
Carranza Martin, Ana Cristina; Faya, Marcela Inés; López Merlo, Mariana Lucía; Batista, Pablo Rodrigo; Gobello, María Cristina
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of this study was to reproductively assess the clinical and hormonal effects of a GnRH agonist (AG) and an antagonist (AN) administered during the postnatal period in domestic cats. Forty-eight male and female postnatal kittens were randomly assigned to deslorelin acetate 1.6 mg subcutaneous (AG; n¼16), acyline 33mg/100 g subcutaneous weekly for 3 months (AN; n¼16), or control (CO; n¼16) which remained untreated. The cats were followed up (behavioral observation, physical examination, fecal sexual steroid determinations, mating test, and pregnancy diagnosis) up to puberty. Puberty was delayed (weeks) in the AG animals (62.93.5; P<0.01) but not in the AN (15.51.7; P>0.05)when they were compared with CO kittens (13.40.4). Fifteen (15/16) of the AN and CO animals, and only 11 of 16 cats of the AG group were fertile (P>0.1). No differences were found in body weight (P >0.1) and measurements (P>0.1), libido (P>0.1) and in the appearance of side effects (P>0.1; except a pyometra in an AG female) among groups. In both AG- and AN-treated males (testosterone; P<0.01) and females (estradiol-17b;P<0.01) fecal hormone concentrations were lower than in CO group during thefirstfive postnatal weeks but not later. It is concluded that the neonatal administration of these AG and AN decreased fecal sexual steroids during thefirst postnatal weeks causing, the agonists but not the antagonist, a significant, reversible delay in puberty appearance.
Fil: Carranza Martin, Ana Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Faya, Marcela Inés. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Universidad Católica de Córdoba; Argentina
Fil: López Merlo, Mariana Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Batista, Pablo Rodrigo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Gobello, María Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Materia
Feline
Gnrh Agonist
Gnrh Antagonist
Neonate
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/32576
Acceder
id CONICETDig_fe2068dc998d4e7ca5c150198339245a
oai_identifier_str oai:ri.conicet.gov.ar:11336/32576
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Effect of GnRH analogs in postnatal domestic catsCarranza Martin, Ana CristinaFaya, Marcela InésLópez Merlo, Mariana LucíaBatista, Pablo RodrigoGobello, María CristinaFelineGnrh AgonistGnrh AntagonistNeonateThe aim of this study was to reproductively assess the clinical and hormonal effects of a GnRH agonist (AG) and an antagonist (AN) administered during the postnatal period in domestic cats. Forty-eight male and female postnatal kittens were randomly assigned to deslorelin acetate 1.6 mg subcutaneous (AG; n¼16), acyline 33mg/100 g subcutaneous weekly for 3 months (AN; n¼16), or control (CO; n¼16) which remained untreated. The cats were followed up (behavioral observation, physical examination, fecal sexual steroid determinations, mating test, and pregnancy diagnosis) up to puberty. Puberty was delayed (weeks) in the AG animals (62.93.5; P<0.01) but not in the AN (15.51.7; P>0.05)when they were compared with CO kittens (13.40.4). Fifteen (15/16) of the AN and CO animals, and only 11 of 16 cats of the AG group were fertile (P>0.1). No differences were found in body weight (P >0.1) and measurements (P>0.1), libido (P>0.1) and in the appearance of side effects (P>0.1; except a pyometra in an AG female) among groups. In both AG- and AN-treated males (testosterone; P<0.01) and females (estradiol-17b;P<0.01) fecal hormone concentrations were lower than in CO group during thefirstfive postnatal weeks but not later. It is concluded that the neonatal administration of these AG and AN decreased fecal sexual steroids during thefirst postnatal weeks causing, the agonists but not the antagonist, a significant, reversible delay in puberty appearance.Fil: Carranza Martin, Ana Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaFil: Faya, Marcela Inés. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Universidad Católica de Córdoba; ArgentinaFil: López Merlo, Mariana Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaFil: Batista, Pablo Rodrigo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaFil: Gobello, María Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaElsevier Science Inc2014-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/32576Batista, Pablo Rodrigo; López Merlo, Mariana Lucía; Faya, Marcela Inés; Carranza Martin, Ana Cristina; Gobello, María Cristina; Effect of GnRH analogs in postnatal domestic cats; Elsevier Science Inc; Theriogenology; 82; 1; 7-2014; 138-1430093-691XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.theriogenology.2014.03.012info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0093691X14001538info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:27:49Zoai:ri.conicet.gov.ar:11336/32576instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:27:49.962CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effect of GnRH analogs in postnatal domestic cats
title Effect of GnRH analogs in postnatal domestic cats
spellingShingle Effect of GnRH analogs in postnatal domestic cats
Carranza Martin, Ana Cristina
Feline
Gnrh Agonist
Gnrh Antagonist
Neonate
title_short Effect of GnRH analogs in postnatal domestic cats
title_full Effect of GnRH analogs in postnatal domestic cats
title_fullStr Effect of GnRH analogs in postnatal domestic cats
title_full_unstemmed Effect of GnRH analogs in postnatal domestic cats
title_sort Effect of GnRH analogs in postnatal domestic cats
dc.creator.none.fl_str_mv Carranza Martin, Ana Cristina
Faya, Marcela Inés
López Merlo, Mariana Lucía
Batista, Pablo Rodrigo
Gobello, María Cristina
author Carranza Martin, Ana Cristina
author_facet Carranza Martin, Ana Cristina
Faya, Marcela Inés
López Merlo, Mariana Lucía
Batista, Pablo Rodrigo
Gobello, María Cristina
author_role author
author2 Faya, Marcela Inés
López Merlo, Mariana Lucía
Batista, Pablo Rodrigo
Gobello, María Cristina
author2_role author
author
author
author
dc.subject.none.fl_str_mv Feline
Gnrh Agonist
Gnrh Antagonist
Neonate
topic Feline
Gnrh Agonist
Gnrh Antagonist
Neonate
dc.description.none.fl_txt_mv The aim of this study was to reproductively assess the clinical and hormonal effects of a GnRH agonist (AG) and an antagonist (AN) administered during the postnatal period in domestic cats. Forty-eight male and female postnatal kittens were randomly assigned to deslorelin acetate 1.6 mg subcutaneous (AG; n¼16), acyline 33mg/100 g subcutaneous weekly for 3 months (AN; n¼16), or control (CO; n¼16) which remained untreated. The cats were followed up (behavioral observation, physical examination, fecal sexual steroid determinations, mating test, and pregnancy diagnosis) up to puberty. Puberty was delayed (weeks) in the AG animals (62.93.5; P<0.01) but not in the AN (15.51.7; P>0.05)when they were compared with CO kittens (13.40.4). Fifteen (15/16) of the AN and CO animals, and only 11 of 16 cats of the AG group were fertile (P>0.1). No differences were found in body weight (P >0.1) and measurements (P>0.1), libido (P>0.1) and in the appearance of side effects (P>0.1; except a pyometra in an AG female) among groups. In both AG- and AN-treated males (testosterone; P<0.01) and females (estradiol-17b;P<0.01) fecal hormone concentrations were lower than in CO group during thefirstfive postnatal weeks but not later. It is concluded that the neonatal administration of these AG and AN decreased fecal sexual steroids during thefirst postnatal weeks causing, the agonists but not the antagonist, a significant, reversible delay in puberty appearance.
Fil: Carranza Martin, Ana Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Faya, Marcela Inés. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Universidad Católica de Córdoba; Argentina
Fil: López Merlo, Mariana Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Batista, Pablo Rodrigo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Gobello, María Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
description The aim of this study was to reproductively assess the clinical and hormonal effects of a GnRH agonist (AG) and an antagonist (AN) administered during the postnatal period in domestic cats. Forty-eight male and female postnatal kittens were randomly assigned to deslorelin acetate 1.6 mg subcutaneous (AG; n¼16), acyline 33mg/100 g subcutaneous weekly for 3 months (AN; n¼16), or control (CO; n¼16) which remained untreated. The cats were followed up (behavioral observation, physical examination, fecal sexual steroid determinations, mating test, and pregnancy diagnosis) up to puberty. Puberty was delayed (weeks) in the AG animals (62.93.5; P<0.01) but not in the AN (15.51.7; P>0.05)when they were compared with CO kittens (13.40.4). Fifteen (15/16) of the AN and CO animals, and only 11 of 16 cats of the AG group were fertile (P>0.1). No differences were found in body weight (P >0.1) and measurements (P>0.1), libido (P>0.1) and in the appearance of side effects (P>0.1; except a pyometra in an AG female) among groups. In both AG- and AN-treated males (testosterone; P<0.01) and females (estradiol-17b;P<0.01) fecal hormone concentrations were lower than in CO group during thefirstfive postnatal weeks but not later. It is concluded that the neonatal administration of these AG and AN decreased fecal sexual steroids during thefirst postnatal weeks causing, the agonists but not the antagonist, a significant, reversible delay in puberty appearance.
publishDate 2014
dc.date.none.fl_str_mv 2014-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/32576
Batista, Pablo Rodrigo; López Merlo, Mariana Lucía; Faya, Marcela Inés; Carranza Martin, Ana Cristina; Gobello, María Cristina; Effect of GnRH analogs in postnatal domestic cats; Elsevier Science Inc; Theriogenology; 82; 1; 7-2014; 138-143
0093-691X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/32576
identifier_str_mv Batista, Pablo Rodrigo; López Merlo, Mariana Lucía; Faya, Marcela Inés; Carranza Martin, Ana Cristina; Gobello, María Cristina; Effect of GnRH analogs in postnatal domestic cats; Elsevier Science Inc; Theriogenology; 82; 1; 7-2014; 138-143
0093-691X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.theriogenology.2014.03.012
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0093691X14001538
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Inc
publisher.none.fl_str_mv Elsevier Science Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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