Effects of the GnRH antagonist acyline on the testis of the domestic cat (Felis catus)

Autores
Garcia Romero, Guadalupe; Fernández, Patricia Elena; Gimeno, Eduardo Juan; Barbeito, Claudio Gustavo; Gobello, María Cristina
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of this study was to describe the effects of a single dose of the gonadotrophin releasing hormone 20(GnRH) antagonist acyline on testicular characteristics of the domestic cat. Twelve mature cats were 21orchidectomized unilaterally (right testis) on Day 7 (n = 7) or Day 15 (n = 5). On Day 0, 330 lg/kg acyline 22was administered SC to all the animals. Left orchidectomy was carried out on Day 15 (n = 2), Day 30 23(n = 4) and Day 60 (n = 6). Sperm were recovered from the epididymis and the testes were evaluated 24grossly, histologically and immunohistochemically. 25Significant differences (P < 0.05) were found between days for epididymal sperm motility, vigor, abnor- 26mal morphology, germinal epithelium height, spermatocytes, spermatids, spermatozoa, lumen and cellu- 27lar debris. Conversely, no significant differences were found for gross testicular and tubular 28characteristics, spermatogonia, Sertoli and Leydig cells and intertubular compartments. It was concluded 29that a single dose of acyline reversibly impaired spermiogenesis, spermatocytogenesis and sperm motil- 30ity for 2 weeks.
Fil: Garcia Romero, Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina
Fil: Fernández, Patricia Elena. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina
Fil: Gimeno, Eduardo Juan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Barbeito, Claudio Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Gobello, María Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Materia
Feline
GnRH analogs
Testicular histology
Acyline
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/270726
Acceder
id CONICETDig_79a9b9b8a48c9c6d7dd18b0c9177c57d
oai_identifier_str oai:ri.conicet.gov.ar:11336/270726
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Effects of the GnRH antagonist acyline on the testis of the domestic cat (Felis catus)Garcia Romero, GuadalupeFernández, Patricia ElenaGimeno, Eduardo JuanBarbeito, Claudio GustavoGobello, María CristinaFelineGnRH analogsTesticular histologyAcylinehttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4The aim of this study was to describe the effects of a single dose of the gonadotrophin releasing hormone 20(GnRH) antagonist acyline on testicular characteristics of the domestic cat. Twelve mature cats were 21orchidectomized unilaterally (right testis) on Day 7 (n = 7) or Day 15 (n = 5). On Day 0, 330 lg/kg acyline 22was administered SC to all the animals. Left orchidectomy was carried out on Day 15 (n = 2), Day 30 23(n = 4) and Day 60 (n = 6). Sperm were recovered from the epididymis and the testes were evaluated 24grossly, histologically and immunohistochemically. 25Significant differences (P < 0.05) were found between days for epididymal sperm motility, vigor, abnor- 26mal morphology, germinal epithelium height, spermatocytes, spermatids, spermatozoa, lumen and cellu- 27lar debris. Conversely, no significant differences were found for gross testicular and tubular 28characteristics, spermatogonia, Sertoli and Leydig cells and intertubular compartments. It was concluded 29that a single dose of acyline reversibly impaired spermiogenesis, spermatocytogenesis and sperm motil- 30ity for 2 weeks.Fil: Garcia Romero, Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; ArgentinaFil: Fernández, Patricia Elena. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; ArgentinaFil: Gimeno, Eduardo Juan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Barbeito, Claudio Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaFil: Gobello, María Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaElsevier2012-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/270726Garcia Romero, Guadalupe; Fernández, Patricia Elena; Gimeno, Eduardo Juan; Barbeito, Claudio Gustavo; Gobello, María Cristina; Effects of the GnRH antagonist acyline on the testis of the domestic cat (Felis catus); Elsevier; The Veterinary Journal; 193; 1; 7-2012; 279-2821090-0233CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1090023311003820info:eu-repo/semantics/altIdentifier/doi/10.1016/j.tvjl.2011.09.028info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:47:18Zoai:ri.conicet.gov.ar:11336/270726instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:47:18.658CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effects of the GnRH antagonist acyline on the testis of the domestic cat (Felis catus)
title Effects of the GnRH antagonist acyline on the testis of the domestic cat (Felis catus)
spellingShingle Effects of the GnRH antagonist acyline on the testis of the domestic cat (Felis catus)
Garcia Romero, Guadalupe
Feline
GnRH analogs
Testicular histology
Acyline
title_short Effects of the GnRH antagonist acyline on the testis of the domestic cat (Felis catus)
title_full Effects of the GnRH antagonist acyline on the testis of the domestic cat (Felis catus)
title_fullStr Effects of the GnRH antagonist acyline on the testis of the domestic cat (Felis catus)
title_full_unstemmed Effects of the GnRH antagonist acyline on the testis of the domestic cat (Felis catus)
title_sort Effects of the GnRH antagonist acyline on the testis of the domestic cat (Felis catus)
dc.creator.none.fl_str_mv Garcia Romero, Guadalupe
Fernández, Patricia Elena
Gimeno, Eduardo Juan
Barbeito, Claudio Gustavo
Gobello, María Cristina
author Garcia Romero, Guadalupe
author_facet Garcia Romero, Guadalupe
Fernández, Patricia Elena
Gimeno, Eduardo Juan
Barbeito, Claudio Gustavo
Gobello, María Cristina
author_role author
author2 Fernández, Patricia Elena
Gimeno, Eduardo Juan
Barbeito, Claudio Gustavo
Gobello, María Cristina
author2_role author
author
author
author
dc.subject.none.fl_str_mv Feline
GnRH analogs
Testicular histology
Acyline
topic Feline
GnRH analogs
Testicular histology
Acyline
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv The aim of this study was to describe the effects of a single dose of the gonadotrophin releasing hormone 20(GnRH) antagonist acyline on testicular characteristics of the domestic cat. Twelve mature cats were 21orchidectomized unilaterally (right testis) on Day 7 (n = 7) or Day 15 (n = 5). On Day 0, 330 lg/kg acyline 22was administered SC to all the animals. Left orchidectomy was carried out on Day 15 (n = 2), Day 30 23(n = 4) and Day 60 (n = 6). Sperm were recovered from the epididymis and the testes were evaluated 24grossly, histologically and immunohistochemically. 25Significant differences (P < 0.05) were found between days for epididymal sperm motility, vigor, abnor- 26mal morphology, germinal epithelium height, spermatocytes, spermatids, spermatozoa, lumen and cellu- 27lar debris. Conversely, no significant differences were found for gross testicular and tubular 28characteristics, spermatogonia, Sertoli and Leydig cells and intertubular compartments. It was concluded 29that a single dose of acyline reversibly impaired spermiogenesis, spermatocytogenesis and sperm motil- 30ity for 2 weeks.
Fil: Garcia Romero, Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina
Fil: Fernández, Patricia Elena. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina
Fil: Gimeno, Eduardo Juan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Barbeito, Claudio Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Gobello, María Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
description The aim of this study was to describe the effects of a single dose of the gonadotrophin releasing hormone 20(GnRH) antagonist acyline on testicular characteristics of the domestic cat. Twelve mature cats were 21orchidectomized unilaterally (right testis) on Day 7 (n = 7) or Day 15 (n = 5). On Day 0, 330 lg/kg acyline 22was administered SC to all the animals. Left orchidectomy was carried out on Day 15 (n = 2), Day 30 23(n = 4) and Day 60 (n = 6). Sperm were recovered from the epididymis and the testes were evaluated 24grossly, histologically and immunohistochemically. 25Significant differences (P < 0.05) were found between days for epididymal sperm motility, vigor, abnor- 26mal morphology, germinal epithelium height, spermatocytes, spermatids, spermatozoa, lumen and cellu- 27lar debris. Conversely, no significant differences were found for gross testicular and tubular 28characteristics, spermatogonia, Sertoli and Leydig cells and intertubular compartments. It was concluded 29that a single dose of acyline reversibly impaired spermiogenesis, spermatocytogenesis and sperm motil- 30ity for 2 weeks.
publishDate 2012
dc.date.none.fl_str_mv 2012-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/270726
Garcia Romero, Guadalupe; Fernández, Patricia Elena; Gimeno, Eduardo Juan; Barbeito, Claudio Gustavo; Gobello, María Cristina; Effects of the GnRH antagonist acyline on the testis of the domestic cat (Felis catus); Elsevier; The Veterinary Journal; 193; 1; 7-2012; 279-282
1090-0233
CONICET Digital
CONICET
url http://hdl.handle.net/11336/270726
identifier_str_mv Garcia Romero, Guadalupe; Fernández, Patricia Elena; Gimeno, Eduardo Juan; Barbeito, Claudio Gustavo; Gobello, María Cristina; Effects of the GnRH antagonist acyline on the testis of the domestic cat (Felis catus); Elsevier; The Veterinary Journal; 193; 1; 7-2012; 279-282
1090-0233
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1090023311003820
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.tvjl.2011.09.028
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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