Association of methylenetetrahydrofolate reductase gene 677C>T polymorphism with hypertension in older women in a population of Buenos Aires City

Autores
Fridman, Osvaldo; Porcile, Rafael; Morales, Analía Verónica; Gariglio Zappellini, Luis Osvaldo; Potenzoni, Miguel A.; Turk Noceto, Paula Cecilia
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We examined the relationship between the 677C >T polymorphism in the MTHFR gene and tHcy in normotensive (NT) and hypertensive (HT) subjects and the influence of sex and age in a cross-sectional study. Smoking habits, history of vascular disease, diabetes, and tHcy were significantly associated with T allele as hypertension risk factors. The T allele was significantly related with higher tHcy in (i) men versus women (P < .01), (ii) men and women older than 47 years versus the younger ones (P < .05 and P < .001, respectively), (iii) HT women versus NT women (P < .01), and (iv) older HT women versus older NT women (P < .01). We found an association between the 677C>T MTHFR polymorphism and tHcy with hypertension that in women is manifested with age.
Fil: Fridman, Osvaldo. Universidad Abierta Interamericana. Facultad de Medicina. Centro de Altos Estudios en Ciencias de la Salud; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Porcile, Rafael. Universidad Abierta Interamericana; Argentina
Fil: Morales, Analía Verónica. Universidad Abierta Interamericana. Facultad de Medicina. Centro de Altos Estudios en Ciencias de la Salud; Argentina
Fil: Gariglio Zappellini, Luis Osvaldo. Universidad Abierta Interamericana; Argentina
Fil: Potenzoni, Miguel A.. Universidad Abierta Interamericana; Argentina
Fil: Turk Noceto, Paula Cecilia. Universidad Abierta Interamericana. Facultad de Medicina. Centro de Altos Estudios en Ciencias de la Salud; Argentina
Materia
Age
Gender
Hyperhomocisteinemia
Hypertension
Mthfr
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/23898
Acceder
id CONICETDig_fdf8132c67ccb82e3f39fa66cf45d04f
oai_identifier_str oai:ri.conicet.gov.ar:11336/23898
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Association of methylenetetrahydrofolate reductase gene 677C>T polymorphism with hypertension in older women in a population of Buenos Aires CityFridman, OsvaldoPorcile, RafaelMorales, Analía VerónicaGariglio Zappellini, Luis OsvaldoPotenzoni, Miguel A.Turk Noceto, Paula CeciliaAgeGenderHyperhomocisteinemiaHypertensionMthfrhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3We examined the relationship between the 677C >T polymorphism in the MTHFR gene and tHcy in normotensive (NT) and hypertensive (HT) subjects and the influence of sex and age in a cross-sectional study. Smoking habits, history of vascular disease, diabetes, and tHcy were significantly associated with T allele as hypertension risk factors. The T allele was significantly related with higher tHcy in (i) men versus women (P < .01), (ii) men and women older than 47 years versus the younger ones (P < .05 and P < .001, respectively), (iii) HT women versus NT women (P < .01), and (iv) older HT women versus older NT women (P < .01). We found an association between the 677C>T MTHFR polymorphism and tHcy with hypertension that in women is manifested with age.Fil: Fridman, Osvaldo. Universidad Abierta Interamericana. Facultad de Medicina. Centro de Altos Estudios en Ciencias de la Salud; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Porcile, Rafael. Universidad Abierta Interamericana; ArgentinaFil: Morales, Analía Verónica. Universidad Abierta Interamericana. Facultad de Medicina. Centro de Altos Estudios en Ciencias de la Salud; ArgentinaFil: Gariglio Zappellini, Luis Osvaldo. Universidad Abierta Interamericana; ArgentinaFil: Potenzoni, Miguel A.. Universidad Abierta Interamericana; ArgentinaFil: Turk Noceto, Paula Cecilia. Universidad Abierta Interamericana. Facultad de Medicina. Centro de Altos Estudios en Ciencias de la Salud; ArgentinaTaylor & Francis2013-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/23898Fridman, Osvaldo; Porcile, Rafael; Morales, Analía Verónica; Gariglio Zappellini, Luis Osvaldo; Potenzoni, Miguel A.; et al.; Association of methylenetetrahydrofolate reductase gene 677C>T polymorphism with hypertension in older women in a population of Buenos Aires City; Taylor & Francis; Clinical and Experimental Hypertension; 35; 3; 4-2013; 159-1661064-19631525-6006CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.acmx.2013.12.006info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.3109/10641963.2012.690471info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:04:17Zoai:ri.conicet.gov.ar:11336/23898instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:04:18.098CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Association of methylenetetrahydrofolate reductase gene 677C>T polymorphism with hypertension in older women in a population of Buenos Aires City
title Association of methylenetetrahydrofolate reductase gene 677C>T polymorphism with hypertension in older women in a population of Buenos Aires City
spellingShingle Association of methylenetetrahydrofolate reductase gene 677C>T polymorphism with hypertension in older women in a population of Buenos Aires City
Fridman, Osvaldo
Age
Gender
Hyperhomocisteinemia
Hypertension
Mthfr
title_short Association of methylenetetrahydrofolate reductase gene 677C>T polymorphism with hypertension in older women in a population of Buenos Aires City
title_full Association of methylenetetrahydrofolate reductase gene 677C>T polymorphism with hypertension in older women in a population of Buenos Aires City
title_fullStr Association of methylenetetrahydrofolate reductase gene 677C>T polymorphism with hypertension in older women in a population of Buenos Aires City
title_full_unstemmed Association of methylenetetrahydrofolate reductase gene 677C>T polymorphism with hypertension in older women in a population of Buenos Aires City
title_sort Association of methylenetetrahydrofolate reductase gene 677C>T polymorphism with hypertension in older women in a population of Buenos Aires City
dc.creator.none.fl_str_mv Fridman, Osvaldo
Porcile, Rafael
Morales, Analía Verónica
Gariglio Zappellini, Luis Osvaldo
Potenzoni, Miguel A.
Turk Noceto, Paula Cecilia
author Fridman, Osvaldo
author_facet Fridman, Osvaldo
Porcile, Rafael
Morales, Analía Verónica
Gariglio Zappellini, Luis Osvaldo
Potenzoni, Miguel A.
Turk Noceto, Paula Cecilia
author_role author
author2 Porcile, Rafael
Morales, Analía Verónica
Gariglio Zappellini, Luis Osvaldo
Potenzoni, Miguel A.
Turk Noceto, Paula Cecilia
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Age
Gender
Hyperhomocisteinemia
Hypertension
Mthfr
topic Age
Gender
Hyperhomocisteinemia
Hypertension
Mthfr
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv We examined the relationship between the 677C >T polymorphism in the MTHFR gene and tHcy in normotensive (NT) and hypertensive (HT) subjects and the influence of sex and age in a cross-sectional study. Smoking habits, history of vascular disease, diabetes, and tHcy were significantly associated with T allele as hypertension risk factors. The T allele was significantly related with higher tHcy in (i) men versus women (P < .01), (ii) men and women older than 47 years versus the younger ones (P < .05 and P < .001, respectively), (iii) HT women versus NT women (P < .01), and (iv) older HT women versus older NT women (P < .01). We found an association between the 677C>T MTHFR polymorphism and tHcy with hypertension that in women is manifested with age.
Fil: Fridman, Osvaldo. Universidad Abierta Interamericana. Facultad de Medicina. Centro de Altos Estudios en Ciencias de la Salud; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Porcile, Rafael. Universidad Abierta Interamericana; Argentina
Fil: Morales, Analía Verónica. Universidad Abierta Interamericana. Facultad de Medicina. Centro de Altos Estudios en Ciencias de la Salud; Argentina
Fil: Gariglio Zappellini, Luis Osvaldo. Universidad Abierta Interamericana; Argentina
Fil: Potenzoni, Miguel A.. Universidad Abierta Interamericana; Argentina
Fil: Turk Noceto, Paula Cecilia. Universidad Abierta Interamericana. Facultad de Medicina. Centro de Altos Estudios en Ciencias de la Salud; Argentina
description We examined the relationship between the 677C >T polymorphism in the MTHFR gene and tHcy in normotensive (NT) and hypertensive (HT) subjects and the influence of sex and age in a cross-sectional study. Smoking habits, history of vascular disease, diabetes, and tHcy were significantly associated with T allele as hypertension risk factors. The T allele was significantly related with higher tHcy in (i) men versus women (P < .01), (ii) men and women older than 47 years versus the younger ones (P < .05 and P < .001, respectively), (iii) HT women versus NT women (P < .01), and (iv) older HT women versus older NT women (P < .01). We found an association between the 677C>T MTHFR polymorphism and tHcy with hypertension that in women is manifested with age.
publishDate 2013
dc.date.none.fl_str_mv 2013-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/23898
Fridman, Osvaldo; Porcile, Rafael; Morales, Analía Verónica; Gariglio Zappellini, Luis Osvaldo; Potenzoni, Miguel A.; et al.; Association of methylenetetrahydrofolate reductase gene 677C>T polymorphism with hypertension in older women in a population of Buenos Aires City; Taylor & Francis; Clinical and Experimental Hypertension; 35; 3; 4-2013; 159-166
1064-1963
1525-6006
CONICET Digital
CONICET
url http://hdl.handle.net/11336/23898
identifier_str_mv Fridman, Osvaldo; Porcile, Rafael; Morales, Analía Verónica; Gariglio Zappellini, Luis Osvaldo; Potenzoni, Miguel A.; et al.; Association of methylenetetrahydrofolate reductase gene 677C>T polymorphism with hypertension in older women in a population of Buenos Aires City; Taylor & Francis; Clinical and Experimental Hypertension; 35; 3; 4-2013; 159-166
1064-1963
1525-6006
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.acmx.2013.12.006
info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.3109/10641963.2012.690471
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269849221332992
score 13.13397

Publicaciones similares