Indomethacin for intracranial hypertension secondary to severe traumatic brain injury in adults

• Autores: Martín Saborido, Carlos; López Alcalde, Jesús; Ciapponi, Agustín; Sánchez Martín, Carlos Enrique; Garcia Garcia, Elena; Escobar Aguilar, Gema; Palermo, Maria Carolina; Baccaro, Fernando G
• Año de publicación: 2019
• Idioma: inglés
• Tipo de recurso: artículo
• Materia: hypertension
• Institución: Consejo Nacional de Investigaciones Científicas y Técnicas

Background: Among people who have suffered a traumatic brain injury, increased intracranial pressure continues to be a major cause of early death; it is estimated that about 11 people per 100 with traumatic brain injury die. Indomethacin (also known as indometacin) is a powerful cerebral vasoconstrictor that can reduce intracranial pressure and, ultimately, restore cerebral perfusion and oxygenation. Thus, indomethacin may improve the recovery of a person with traumatic brain injury. Objectives: To assess the effects of indomethacin for adults with severe traumatic brain injury. Search methods: We ran the searches from inception to 23 August 2019. We searched the Cochrane Central Register of Controlled Trials (CENTRAL; 2019, Issue 8) in the Cochrane Library, Ovid MEDLINE, Ovid Embase, CINAHL Plus (EBSCO), four other databases, and clinical trials registries. We also screened reference lists and conference abstracts, and contacted experts in the field. Selection criteria: Our search criteria included randomised controlled trials (RCTs) that compared indomethacin with any control in adults presenting with severe traumatic brain injury associated with elevated intracranial pressure, with no previous decompressive surgery. Data collection and analysis: Two review authors independently decided on the selection of the studies. We followed standard Cochrane methods. Main results: We identified no eligible studies for this review, either completed or ongoing. Authors' conclusions: We found no studies, either completed or ongoing, that assessed the effects of indomethacin in controlling intracranial hypertension secondary to severe traumatic brain injury. Thus, we cannot draw any conclusions about the effects of indomethacin on intracranial pressure, mortality rates, quality of life, disability or adverse effects. This absence of evidence should not be interpreted as evidence of no effect for indomethacin in controlling intracranial hypertension secondary to severe traumatic brain injury. It means that we have not identified eligible research for this review.
Fil: Martín Saborido, Carlos. Universidad Nebrija; España
Fil: López Alcalde, Jesús. No especifíca;
Fil: Ciapponi, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Sánchez Martín, Carlos Enrique. No especifíca;
Fil: Garcia Garcia, Elena. Gobierno de la Provincia de Buenos Aires. Hospital Interzonal Especializado de Agudos y Cronicos San Juan de Dios.; Argentina
Fil: Escobar Aguilar, Gema. Universidad Nebrija; España
Fil: Palermo, Maria Carolina. Universidad de Buenos Aires; Argentina
Fil: Baccaro, Fernando G. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina