Human parvovirus B19 vertical infection and hydrops fetalis: A case report

Autores
Boggio, Gabriel Amilcar; Moreno, Laura; Dicuatro, Nestor Eduardo; Colazo Salbetti, Maria Belen; Pedranti, Mauro; González, Alicia; Grandon, Claudia; Resino, Carlos; Adamo, Maria P.
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Non-immune hydrops fetalis represents a diagnostic challenge in high-risk pregnant women. Vertical infection with human parvovirus B19 (B19V) is a possible cause. National guidelines propose maternal serologic screening (IgG/IgM), which may be insufficient in some situations. We report a case of vertical B19V infection with difficulties in prenatal diagnosis. Preterm newborn, normal weight (2950 g), born to a 30-year-old mother with anemia and hydrops fetalis (week 17). Cardiac, chromosomal, isoimmunization-Rh, and usual infectious causes (TORCH) were ruled out. Maternal serology for B19V showed IgG+ and IgM-, and the diagnosis was dismissed. The newborn presented abdominal distension (ascites), anemia, and jaundice. Postnatal results confirmed the diagnosis with DNA+ for B19V. Discharge at 17 days with good evolution. The protocol for B19V screening in vertical infection needs to be revised by incorporating early molecular studies (PCR) from the early stages of gestation to optimize the diagnosis and treatment of patients with this congenital infection.
Fil: Boggio, Gabriel Amilcar. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina
Fil: Moreno, Laura. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina
Fil: Dicuatro, Nestor Eduardo. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Hospital Universitario de Maternidad y Neonatologia;
Fil: Colazo Salbetti, Maria Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina
Fil: Pedranti, Mauro. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina
Fil: González, Alicia. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Hospital Universitario de Maternidad y Neonatologia;
Fil: Grandon, Claudia. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Hospital Universitario de Maternidad y Neonatologia;
Fil: Resino, Carlos. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Hospital Universitario de Maternidad y Neonatologia;
Fil: Adamo, Maria P.. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina
Materia
CASE REPORTS
CLINICAL LABORATORY TECHNIQUES
HUMAN PARVOVIRUS B19
HYDROPS FETALIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/266419
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Human parvovirus B19 vertical infection and hydrops fetalis: A case reportBoggio, Gabriel AmilcarMoreno, LauraDicuatro, Nestor EduardoColazo Salbetti, Maria BelenPedranti, MauroGonzález, AliciaGrandon, ClaudiaResino, CarlosAdamo, Maria P.CASE REPORTSCLINICAL LABORATORY TECHNIQUESHUMAN PARVOVIRUS B19HYDROPS FETALIShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Non-immune hydrops fetalis represents a diagnostic challenge in high-risk pregnant women. Vertical infection with human parvovirus B19 (B19V) is a possible cause. National guidelines propose maternal serologic screening (IgG/IgM), which may be insufficient in some situations. We report a case of vertical B19V infection with difficulties in prenatal diagnosis. Preterm newborn, normal weight (2950 g), born to a 30-year-old mother with anemia and hydrops fetalis (week 17). Cardiac, chromosomal, isoimmunization-Rh, and usual infectious causes (TORCH) were ruled out. Maternal serology for B19V showed IgG+ and IgM-, and the diagnosis was dismissed. The newborn presented abdominal distension (ascites), anemia, and jaundice. Postnatal results confirmed the diagnosis with DNA+ for B19V. Discharge at 17 days with good evolution. The protocol for B19V screening in vertical infection needs to be revised by incorporating early molecular studies (PCR) from the early stages of gestation to optimize the diagnosis and treatment of patients with this congenital infection.Fil: Boggio, Gabriel Amilcar. Universidad Nacional de Córdoba. Facultad de Medicina; ArgentinaFil: Moreno, Laura. Universidad Nacional de Córdoba. Facultad de Medicina; ArgentinaFil: Dicuatro, Nestor Eduardo. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Hospital Universitario de Maternidad y Neonatologia;Fil: Colazo Salbetti, Maria Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; ArgentinaFil: Pedranti, Mauro. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; ArgentinaFil: González, Alicia. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Hospital Universitario de Maternidad y Neonatologia;Fil: Grandon, Claudia. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Hospital Universitario de Maternidad y Neonatologia;Fil: Resino, Carlos. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Hospital Universitario de Maternidad y Neonatologia;Fil: Adamo, Maria P.. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; ArgentinaSociedad Argentina de Pediatría2024-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/266419Boggio, Gabriel Amilcar; Moreno, Laura; Dicuatro, Nestor Eduardo; Colazo Salbetti, Maria Belen; Pedranti, Mauro; et al.; Human parvovirus B19 vertical infection and hydrops fetalis: A case report; Sociedad Argentina de Pediatría; Archivos Argentinos de Pediatría; 123; 3; 8-2024; 1-60325-00751668-3501CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sap.org.ar/docs/publicaciones/archivosarg/2025/v123n3a05e.pdfinfo:eu-repo/semantics/altIdentifier/doi/10.5546/aap.2024-10420.enginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:31:31Zoai:ri.conicet.gov.ar:11336/266419instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:31:31.739CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Human parvovirus B19 vertical infection and hydrops fetalis: A case report
title Human parvovirus B19 vertical infection and hydrops fetalis: A case report
spellingShingle Human parvovirus B19 vertical infection and hydrops fetalis: A case report
Boggio, Gabriel Amilcar
CASE REPORTS
CLINICAL LABORATORY TECHNIQUES
HUMAN PARVOVIRUS B19
HYDROPS FETALIS
title_short Human parvovirus B19 vertical infection and hydrops fetalis: A case report
title_full Human parvovirus B19 vertical infection and hydrops fetalis: A case report
title_fullStr Human parvovirus B19 vertical infection and hydrops fetalis: A case report
title_full_unstemmed Human parvovirus B19 vertical infection and hydrops fetalis: A case report
title_sort Human parvovirus B19 vertical infection and hydrops fetalis: A case report
dc.creator.none.fl_str_mv Boggio, Gabriel Amilcar
Moreno, Laura
Dicuatro, Nestor Eduardo
Colazo Salbetti, Maria Belen
Pedranti, Mauro
González, Alicia
Grandon, Claudia
Resino, Carlos
Adamo, Maria P.
author Boggio, Gabriel Amilcar
author_facet Boggio, Gabriel Amilcar
Moreno, Laura
Dicuatro, Nestor Eduardo
Colazo Salbetti, Maria Belen
Pedranti, Mauro
González, Alicia
Grandon, Claudia
Resino, Carlos
Adamo, Maria P.
author_role author
author2 Moreno, Laura
Dicuatro, Nestor Eduardo
Colazo Salbetti, Maria Belen
Pedranti, Mauro
González, Alicia
Grandon, Claudia
Resino, Carlos
Adamo, Maria P.
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CASE REPORTS
CLINICAL LABORATORY TECHNIQUES
HUMAN PARVOVIRUS B19
HYDROPS FETALIS
topic CASE REPORTS
CLINICAL LABORATORY TECHNIQUES
HUMAN PARVOVIRUS B19
HYDROPS FETALIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Non-immune hydrops fetalis represents a diagnostic challenge in high-risk pregnant women. Vertical infection with human parvovirus B19 (B19V) is a possible cause. National guidelines propose maternal serologic screening (IgG/IgM), which may be insufficient in some situations. We report a case of vertical B19V infection with difficulties in prenatal diagnosis. Preterm newborn, normal weight (2950 g), born to a 30-year-old mother with anemia and hydrops fetalis (week 17). Cardiac, chromosomal, isoimmunization-Rh, and usual infectious causes (TORCH) were ruled out. Maternal serology for B19V showed IgG+ and IgM-, and the diagnosis was dismissed. The newborn presented abdominal distension (ascites), anemia, and jaundice. Postnatal results confirmed the diagnosis with DNA+ for B19V. Discharge at 17 days with good evolution. The protocol for B19V screening in vertical infection needs to be revised by incorporating early molecular studies (PCR) from the early stages of gestation to optimize the diagnosis and treatment of patients with this congenital infection.
Fil: Boggio, Gabriel Amilcar. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina
Fil: Moreno, Laura. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina
Fil: Dicuatro, Nestor Eduardo. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Hospital Universitario de Maternidad y Neonatologia;
Fil: Colazo Salbetti, Maria Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina
Fil: Pedranti, Mauro. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina
Fil: González, Alicia. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Hospital Universitario de Maternidad y Neonatologia;
Fil: Grandon, Claudia. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Hospital Universitario de Maternidad y Neonatologia;
Fil: Resino, Carlos. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Hospital Universitario de Maternidad y Neonatologia;
Fil: Adamo, Maria P.. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina
description Non-immune hydrops fetalis represents a diagnostic challenge in high-risk pregnant women. Vertical infection with human parvovirus B19 (B19V) is a possible cause. National guidelines propose maternal serologic screening (IgG/IgM), which may be insufficient in some situations. We report a case of vertical B19V infection with difficulties in prenatal diagnosis. Preterm newborn, normal weight (2950 g), born to a 30-year-old mother with anemia and hydrops fetalis (week 17). Cardiac, chromosomal, isoimmunization-Rh, and usual infectious causes (TORCH) were ruled out. Maternal serology for B19V showed IgG+ and IgM-, and the diagnosis was dismissed. The newborn presented abdominal distension (ascites), anemia, and jaundice. Postnatal results confirmed the diagnosis with DNA+ for B19V. Discharge at 17 days with good evolution. The protocol for B19V screening in vertical infection needs to be revised by incorporating early molecular studies (PCR) from the early stages of gestation to optimize the diagnosis and treatment of patients with this congenital infection.
publishDate 2024
dc.date.none.fl_str_mv 2024-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/266419
Boggio, Gabriel Amilcar; Moreno, Laura; Dicuatro, Nestor Eduardo; Colazo Salbetti, Maria Belen; Pedranti, Mauro; et al.; Human parvovirus B19 vertical infection and hydrops fetalis: A case report; Sociedad Argentina de Pediatría; Archivos Argentinos de Pediatría; 123; 3; 8-2024; 1-6
0325-0075
1668-3501
CONICET Digital
CONICET
url http://hdl.handle.net/11336/266419
identifier_str_mv Boggio, Gabriel Amilcar; Moreno, Laura; Dicuatro, Nestor Eduardo; Colazo Salbetti, Maria Belen; Pedranti, Mauro; et al.; Human parvovirus B19 vertical infection and hydrops fetalis: A case report; Sociedad Argentina de Pediatría; Archivos Argentinos de Pediatría; 123; 3; 8-2024; 1-6
0325-0075
1668-3501
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sap.org.ar/docs/publicaciones/archivosarg/2025/v123n3a05e.pdf
info:eu-repo/semantics/altIdentifier/doi/10.5546/aap.2024-10420.eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Sociedad Argentina de Pediatría
publisher.none.fl_str_mv Sociedad Argentina de Pediatría
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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