Dorsal root ganglion neurons and tyrosine hydroxylase: An intriguing association with implications for sensation and pain

Autores
Brumovsky, Pablo Rodolfo
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Tyrosine hydroxylase (TH) is a rate-limiting enzyme broadly expressed in noradrenergic and dopaminergic neurons in the central nervous system.57,70 Tyrosine hydroxylase is also expressed by peripheral sympathetic neurons98 and by enteric neurons within the gut.81,84 More than 30 years ago, TH was unexpectedly discovered in developing adult rodent cranial and dorsal root ganglion (DRG) neurons. Today, TH-expressing DRG neurons are being rediscovered as a relevant subpopulation. This review addresses the emerging importance of TH-expressing DRG neurons in sensation and pain mechanisms, focusing specifically on (1) their nature as C-low threshold mechanoreceptors (C-LTMRs); (2) their involvement in nociception/pain; and (3) their catecholaminergic phenotype.
Fil: Brumovsky, Pablo Rodolfo. Universidad Austral. Facultad de Ciencias Biomédicas. Laboratorio de Investigaciones Biomédicas; Argentina. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; Argentina
Materia
Pain
Rodents
Sensory Neurons
Tyrosine Hydroxylase
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/40236
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Dorsal root ganglion neurons and tyrosine hydroxylase: An intriguing association with implications for sensation and painBrumovsky, Pablo RodolfoPainRodentsSensory NeuronsTyrosine Hydroxylasehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Tyrosine hydroxylase (TH) is a rate-limiting enzyme broadly expressed in noradrenergic and dopaminergic neurons in the central nervous system.57,70 Tyrosine hydroxylase is also expressed by peripheral sympathetic neurons98 and by enteric neurons within the gut.81,84 More than 30 years ago, TH was unexpectedly discovered in developing adult rodent cranial and dorsal root ganglion (DRG) neurons. Today, TH-expressing DRG neurons are being rediscovered as a relevant subpopulation. This review addresses the emerging importance of TH-expressing DRG neurons in sensation and pain mechanisms, focusing specifically on (1) their nature as C-low threshold mechanoreceptors (C-LTMRs); (2) their involvement in nociception/pain; and (3) their catecholaminergic phenotype.Fil: Brumovsky, Pablo Rodolfo. Universidad Austral. Facultad de Ciencias Biomédicas. Laboratorio de Investigaciones Biomédicas; Argentina. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; ArgentinaElsevier Science2016-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/40236Brumovsky, Pablo Rodolfo; Dorsal root ganglion neurons and tyrosine hydroxylase: An intriguing association with implications for sensation and pain; Elsevier Science; Pain; 157; 2; 2-2016; 314-3200304-3959CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1097/j.pain.0000000000000381info:eu-repo/semantics/altIdentifier/url/https://insights.ovid.com/crossref?an=00006396-201602000-00006info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:23:58Zoai:ri.conicet.gov.ar:11336/40236instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:23:58.774CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Dorsal root ganglion neurons and tyrosine hydroxylase: An intriguing association with implications for sensation and pain
title Dorsal root ganglion neurons and tyrosine hydroxylase: An intriguing association with implications for sensation and pain
spellingShingle Dorsal root ganglion neurons and tyrosine hydroxylase: An intriguing association with implications for sensation and pain
Brumovsky, Pablo Rodolfo
Pain
Rodents
Sensory Neurons
Tyrosine Hydroxylase
title_short Dorsal root ganglion neurons and tyrosine hydroxylase: An intriguing association with implications for sensation and pain
title_full Dorsal root ganglion neurons and tyrosine hydroxylase: An intriguing association with implications for sensation and pain
title_fullStr Dorsal root ganglion neurons and tyrosine hydroxylase: An intriguing association with implications for sensation and pain
title_full_unstemmed Dorsal root ganglion neurons and tyrosine hydroxylase: An intriguing association with implications for sensation and pain
title_sort Dorsal root ganglion neurons and tyrosine hydroxylase: An intriguing association with implications for sensation and pain
dc.creator.none.fl_str_mv Brumovsky, Pablo Rodolfo
author Brumovsky, Pablo Rodolfo
author_facet Brumovsky, Pablo Rodolfo
author_role author
dc.subject.none.fl_str_mv Pain
Rodents
Sensory Neurons
Tyrosine Hydroxylase
topic Pain
Rodents
Sensory Neurons
Tyrosine Hydroxylase
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Tyrosine hydroxylase (TH) is a rate-limiting enzyme broadly expressed in noradrenergic and dopaminergic neurons in the central nervous system.57,70 Tyrosine hydroxylase is also expressed by peripheral sympathetic neurons98 and by enteric neurons within the gut.81,84 More than 30 years ago, TH was unexpectedly discovered in developing adult rodent cranial and dorsal root ganglion (DRG) neurons. Today, TH-expressing DRG neurons are being rediscovered as a relevant subpopulation. This review addresses the emerging importance of TH-expressing DRG neurons in sensation and pain mechanisms, focusing specifically on (1) their nature as C-low threshold mechanoreceptors (C-LTMRs); (2) their involvement in nociception/pain; and (3) their catecholaminergic phenotype.
Fil: Brumovsky, Pablo Rodolfo. Universidad Austral. Facultad de Ciencias Biomédicas. Laboratorio de Investigaciones Biomédicas; Argentina. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; Argentina
description Tyrosine hydroxylase (TH) is a rate-limiting enzyme broadly expressed in noradrenergic and dopaminergic neurons in the central nervous system.57,70 Tyrosine hydroxylase is also expressed by peripheral sympathetic neurons98 and by enteric neurons within the gut.81,84 More than 30 years ago, TH was unexpectedly discovered in developing adult rodent cranial and dorsal root ganglion (DRG) neurons. Today, TH-expressing DRG neurons are being rediscovered as a relevant subpopulation. This review addresses the emerging importance of TH-expressing DRG neurons in sensation and pain mechanisms, focusing specifically on (1) their nature as C-low threshold mechanoreceptors (C-LTMRs); (2) their involvement in nociception/pain; and (3) their catecholaminergic phenotype.
publishDate 2016
dc.date.none.fl_str_mv 2016-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/40236
Brumovsky, Pablo Rodolfo; Dorsal root ganglion neurons and tyrosine hydroxylase: An intriguing association with implications for sensation and pain; Elsevier Science; Pain; 157; 2; 2-2016; 314-320
0304-3959
CONICET Digital
CONICET
url http://hdl.handle.net/11336/40236
identifier_str_mv Brumovsky, Pablo Rodolfo; Dorsal root ganglion neurons and tyrosine hydroxylase: An intriguing association with implications for sensation and pain; Elsevier Science; Pain; 157; 2; 2-2016; 314-320
0304-3959
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1097/j.pain.0000000000000381
info:eu-repo/semantics/altIdentifier/url/https://insights.ovid.com/crossref?an=00006396-201602000-00006
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842981326963081216
score 12.48226

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