VGLUTs and glutamate synthesis-focus on DRG neurons and pain

Autores
Malet, Mariana; Brumovsky, Pablo Rodolfo
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The amino acid glutamate is the principal excitatory transmitter in the nervous system, including in sensory neurons that convey pain sensation from the periphery to the brain. It is now well established that a family of membrane proteins, termed vesicular glutamate transporters (VGLUTs), serve a critical function in these neurons: they incorporate glutamate into synaptic vesicles. VGLUTs have a central role both under normal neurotransmission and pathological conditions, such as neuropathic or inflammatory pain. In the present short review, we will address VGLUTs in the context of primary afferent neurons. We will focus on the role of VGLUTs in pain triggered by noxious stimuli, peripheral nerve injury, and tissue inflammation, as mostly explored in transgenic mice. The possible interplay between glutamate biosynthesis and VGLUT-dependent packaging in synaptic vesicles, and its potential impact in various pain states will be presented.
Fil: Malet, Mariana. Universidad Austral. Facultad de Ciencias Biomédicas. Laboratorio de Investigaciones Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Brumovsky, Pablo Rodolfo. Universidad Austral. Facultad de Ciencias Biomédicas. Laboratorio de Investigaciones Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
AXOTOMY
DRG
GLUTAMATE
NEUROPATHY
NEUROPEPTIDES
PAIN
PERIPHERAL NERVES
SENSORY NEURONS
VESICULAR GLUTAMATE TRANSPORTER
VISCERAL ORGANS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/70860
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/70860
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling VGLUTs and glutamate synthesis-focus on DRG neurons and painMalet, MarianaBrumovsky, Pablo RodolfoAXOTOMYDRGGLUTAMATENEUROPATHYNEUROPEPTIDESPAINPERIPHERAL NERVESSENSORY NEURONSVESICULAR GLUTAMATE TRANSPORTERVISCERAL ORGANShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The amino acid glutamate is the principal excitatory transmitter in the nervous system, including in sensory neurons that convey pain sensation from the periphery to the brain. It is now well established that a family of membrane proteins, termed vesicular glutamate transporters (VGLUTs), serve a critical function in these neurons: they incorporate glutamate into synaptic vesicles. VGLUTs have a central role both under normal neurotransmission and pathological conditions, such as neuropathic or inflammatory pain. In the present short review, we will address VGLUTs in the context of primary afferent neurons. We will focus on the role of VGLUTs in pain triggered by noxious stimuli, peripheral nerve injury, and tissue inflammation, as mostly explored in transgenic mice. The possible interplay between glutamate biosynthesis and VGLUT-dependent packaging in synaptic vesicles, and its potential impact in various pain states will be presented.Fil: Malet, Mariana. Universidad Austral. Facultad de Ciencias Biomédicas. Laboratorio de Investigaciones Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Brumovsky, Pablo Rodolfo. Universidad Austral. Facultad de Ciencias Biomédicas. Laboratorio de Investigaciones Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaMDPI2015-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/70860Malet, Mariana; Brumovsky, Pablo Rodolfo; VGLUTs and glutamate synthesis-focus on DRG neurons and pain; MDPI; Biomolecules; 5; 4; 12-2015; 3416-34372218-273XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3390/biom5043416info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2218-273X/5/4/3416info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/26633536/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:04:03Zoai:ri.conicet.gov.ar:11336/70860instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:04:03.376CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv VGLUTs and glutamate synthesis-focus on DRG neurons and pain
title VGLUTs and glutamate synthesis-focus on DRG neurons and pain
spellingShingle VGLUTs and glutamate synthesis-focus on DRG neurons and pain
Malet, Mariana
AXOTOMY
DRG
GLUTAMATE
NEUROPATHY
NEUROPEPTIDES
PAIN
PERIPHERAL NERVES
SENSORY NEURONS
VESICULAR GLUTAMATE TRANSPORTER
VISCERAL ORGANS
title_short VGLUTs and glutamate synthesis-focus on DRG neurons and pain
title_full VGLUTs and glutamate synthesis-focus on DRG neurons and pain
title_fullStr VGLUTs and glutamate synthesis-focus on DRG neurons and pain
title_full_unstemmed VGLUTs and glutamate synthesis-focus on DRG neurons and pain
title_sort VGLUTs and glutamate synthesis-focus on DRG neurons and pain
dc.creator.none.fl_str_mv Malet, Mariana
Brumovsky, Pablo Rodolfo
author Malet, Mariana
author_facet Malet, Mariana
Brumovsky, Pablo Rodolfo
author_role author
author2 Brumovsky, Pablo Rodolfo
author2_role author
dc.subject.none.fl_str_mv AXOTOMY
DRG
GLUTAMATE
NEUROPATHY
NEUROPEPTIDES
PAIN
PERIPHERAL NERVES
SENSORY NEURONS
VESICULAR GLUTAMATE TRANSPORTER
VISCERAL ORGANS
topic AXOTOMY
DRG
GLUTAMATE
NEUROPATHY
NEUROPEPTIDES
PAIN
PERIPHERAL NERVES
SENSORY NEURONS
VESICULAR GLUTAMATE TRANSPORTER
VISCERAL ORGANS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The amino acid glutamate is the principal excitatory transmitter in the nervous system, including in sensory neurons that convey pain sensation from the periphery to the brain. It is now well established that a family of membrane proteins, termed vesicular glutamate transporters (VGLUTs), serve a critical function in these neurons: they incorporate glutamate into synaptic vesicles. VGLUTs have a central role both under normal neurotransmission and pathological conditions, such as neuropathic or inflammatory pain. In the present short review, we will address VGLUTs in the context of primary afferent neurons. We will focus on the role of VGLUTs in pain triggered by noxious stimuli, peripheral nerve injury, and tissue inflammation, as mostly explored in transgenic mice. The possible interplay between glutamate biosynthesis and VGLUT-dependent packaging in synaptic vesicles, and its potential impact in various pain states will be presented.
Fil: Malet, Mariana. Universidad Austral. Facultad de Ciencias Biomédicas. Laboratorio de Investigaciones Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Brumovsky, Pablo Rodolfo. Universidad Austral. Facultad de Ciencias Biomédicas. Laboratorio de Investigaciones Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description The amino acid glutamate is the principal excitatory transmitter in the nervous system, including in sensory neurons that convey pain sensation from the periphery to the brain. It is now well established that a family of membrane proteins, termed vesicular glutamate transporters (VGLUTs), serve a critical function in these neurons: they incorporate glutamate into synaptic vesicles. VGLUTs have a central role both under normal neurotransmission and pathological conditions, such as neuropathic or inflammatory pain. In the present short review, we will address VGLUTs in the context of primary afferent neurons. We will focus on the role of VGLUTs in pain triggered by noxious stimuli, peripheral nerve injury, and tissue inflammation, as mostly explored in transgenic mice. The possible interplay between glutamate biosynthesis and VGLUT-dependent packaging in synaptic vesicles, and its potential impact in various pain states will be presented.
publishDate 2015
dc.date.none.fl_str_mv 2015-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/70860
Malet, Mariana; Brumovsky, Pablo Rodolfo; VGLUTs and glutamate synthesis-focus on DRG neurons and pain; MDPI; Biomolecules; 5; 4; 12-2015; 3416-3437
2218-273X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/70860
identifier_str_mv Malet, Mariana; Brumovsky, Pablo Rodolfo; VGLUTs and glutamate synthesis-focus on DRG neurons and pain; MDPI; Biomolecules; 5; 4; 12-2015; 3416-3437
2218-273X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3390/biom5043416
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2218-273X/5/4/3416
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/26633536/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842980124770697216
score 12.993085

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