Computer-aided identification of anticonvulsant effect of natural nonnutritive sweeteners stevioside and rebaudioside A

Autores
Di Ianni, Mauricio Emiliano; del Valle, Maria Eugenia; Enrique, Andrea Verónica; Rosella, Maria Adelaida; Bruno, Fiorella; Bruno Blanch, Luis Enrique; Talevi, Alan
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Steviol glycosides are natural constituents of Stevia rebaudiana (Bert.) Bert. (Asteraceae) that have recently gained worldwide approval as nonnutritive sweeteners by the Joint Food and Agriculture Organization/World Organization Expert Committee on Food Additives. Cheminformatic tools suggested that the aglycone steviol and several of its phase I metabolites were predicted as potential anticonvulsant agents effective in the seizure animal model maximal electroshock seizure (MES) test. Thus, aqueous infusion from S. rebaudiana was tested in the MES test (mice, intraperitoneal administration), confirming dose-dependent anticonvulsant effect. Afterward, isolated stevioside and rebaudioside A were tested in the MES test, with positive results. Though drug repositioning most often focuses on known therapeutics, this article illustrates the possibilities of this strategy to find new functionalities and therapeutic indications for food constituents and natural products.
Fil: Di Ianni, Mauricio Emiliano. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: del Valle, Maria Eugenia. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Enrique, Andrea Verónica. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rosella, Maria Adelaida. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina
Fil: Bruno, Fiorella. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina
Fil: Bruno Blanch, Luis Enrique. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Talevi, Alan. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Stevia Rebaudiana
Steviosides
Steviol
Epilepsy
Anticonvulsant
Knowledge-Based Drug Repurposing
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/39662
Acceder
id CONICETDig_fbdc24782f65fdf3fb8057061ae2151b
oai_identifier_str oai:ri.conicet.gov.ar:11336/39662
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Computer-aided identification of anticonvulsant effect of natural nonnutritive sweeteners stevioside and rebaudioside ADi Ianni, Mauricio Emilianodel Valle, Maria EugeniaEnrique, Andrea VerónicaRosella, Maria AdelaidaBruno, FiorellaBruno Blanch, Luis EnriqueTalevi, AlanStevia RebaudianaSteviosidesSteviolEpilepsyAnticonvulsantKnowledge-Based Drug Repurposinghttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Steviol glycosides are natural constituents of Stevia rebaudiana (Bert.) Bert. (Asteraceae) that have recently gained worldwide approval as nonnutritive sweeteners by the Joint Food and Agriculture Organization/World Organization Expert Committee on Food Additives. Cheminformatic tools suggested that the aglycone steviol and several of its phase I metabolites were predicted as potential anticonvulsant agents effective in the seizure animal model maximal electroshock seizure (MES) test. Thus, aqueous infusion from S. rebaudiana was tested in the MES test (mice, intraperitoneal administration), confirming dose-dependent anticonvulsant effect. Afterward, isolated stevioside and rebaudioside A were tested in the MES test, with positive results. Though drug repositioning most often focuses on known therapeutics, this article illustrates the possibilities of this strategy to find new functionalities and therapeutic indications for food constituents and natural products.Fil: Di Ianni, Mauricio Emiliano. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: del Valle, Maria Eugenia. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Enrique, Andrea Verónica. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Rosella, Maria Adelaida. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; ArgentinaFil: Bruno, Fiorella. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; ArgentinaFil: Bruno Blanch, Luis Enrique. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Talevi, Alan. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaMary Ann Liebert2015-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/39662Di Ianni, Mauricio Emiliano; del Valle, Maria Eugenia; Enrique, Andrea Verónica; Rosella, Maria Adelaida; Bruno, Fiorella; et al.; Computer-aided identification of anticonvulsant effect of natural nonnutritive sweeteners stevioside and rebaudioside A; Mary Ann Liebert; Assay and Drug Development Technologies; 13; 6; 7-2015; 313-3181540-658XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1089/adt.2015.29010.meddrrrinfo:eu-repo/semantics/altIdentifier/url/https://www.liebertpub.com/doi/10.1089/adt.2015.29010.meddrrrinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:19:40Zoai:ri.conicet.gov.ar:11336/39662instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:19:41.013CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Computer-aided identification of anticonvulsant effect of natural nonnutritive sweeteners stevioside and rebaudioside A
title Computer-aided identification of anticonvulsant effect of natural nonnutritive sweeteners stevioside and rebaudioside A
spellingShingle Computer-aided identification of anticonvulsant effect of natural nonnutritive sweeteners stevioside and rebaudioside A
Di Ianni, Mauricio Emiliano
Stevia Rebaudiana
Steviosides
Steviol
Epilepsy
Anticonvulsant
Knowledge-Based Drug Repurposing
title_short Computer-aided identification of anticonvulsant effect of natural nonnutritive sweeteners stevioside and rebaudioside A
title_full Computer-aided identification of anticonvulsant effect of natural nonnutritive sweeteners stevioside and rebaudioside A
title_fullStr Computer-aided identification of anticonvulsant effect of natural nonnutritive sweeteners stevioside and rebaudioside A
title_full_unstemmed Computer-aided identification of anticonvulsant effect of natural nonnutritive sweeteners stevioside and rebaudioside A
title_sort Computer-aided identification of anticonvulsant effect of natural nonnutritive sweeteners stevioside and rebaudioside A
dc.creator.none.fl_str_mv Di Ianni, Mauricio Emiliano
del Valle, Maria Eugenia
Enrique, Andrea Verónica
Rosella, Maria Adelaida
Bruno, Fiorella
Bruno Blanch, Luis Enrique
Talevi, Alan
author Di Ianni, Mauricio Emiliano
author_facet Di Ianni, Mauricio Emiliano
del Valle, Maria Eugenia
Enrique, Andrea Verónica
Rosella, Maria Adelaida
Bruno, Fiorella
Bruno Blanch, Luis Enrique
Talevi, Alan
author_role author
author2 del Valle, Maria Eugenia
Enrique, Andrea Verónica
Rosella, Maria Adelaida
Bruno, Fiorella
Bruno Blanch, Luis Enrique
Talevi, Alan
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Stevia Rebaudiana
Steviosides
Steviol
Epilepsy
Anticonvulsant
Knowledge-Based Drug Repurposing
topic Stevia Rebaudiana
Steviosides
Steviol
Epilepsy
Anticonvulsant
Knowledge-Based Drug Repurposing
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Steviol glycosides are natural constituents of Stevia rebaudiana (Bert.) Bert. (Asteraceae) that have recently gained worldwide approval as nonnutritive sweeteners by the Joint Food and Agriculture Organization/World Organization Expert Committee on Food Additives. Cheminformatic tools suggested that the aglycone steviol and several of its phase I metabolites were predicted as potential anticonvulsant agents effective in the seizure animal model maximal electroshock seizure (MES) test. Thus, aqueous infusion from S. rebaudiana was tested in the MES test (mice, intraperitoneal administration), confirming dose-dependent anticonvulsant effect. Afterward, isolated stevioside and rebaudioside A were tested in the MES test, with positive results. Though drug repositioning most often focuses on known therapeutics, this article illustrates the possibilities of this strategy to find new functionalities and therapeutic indications for food constituents and natural products.
Fil: Di Ianni, Mauricio Emiliano. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: del Valle, Maria Eugenia. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Enrique, Andrea Verónica. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rosella, Maria Adelaida. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina
Fil: Bruno, Fiorella. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina
Fil: Bruno Blanch, Luis Enrique. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Talevi, Alan. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Steviol glycosides are natural constituents of Stevia rebaudiana (Bert.) Bert. (Asteraceae) that have recently gained worldwide approval as nonnutritive sweeteners by the Joint Food and Agriculture Organization/World Organization Expert Committee on Food Additives. Cheminformatic tools suggested that the aglycone steviol and several of its phase I metabolites were predicted as potential anticonvulsant agents effective in the seizure animal model maximal electroshock seizure (MES) test. Thus, aqueous infusion from S. rebaudiana was tested in the MES test (mice, intraperitoneal administration), confirming dose-dependent anticonvulsant effect. Afterward, isolated stevioside and rebaudioside A were tested in the MES test, with positive results. Though drug repositioning most often focuses on known therapeutics, this article illustrates the possibilities of this strategy to find new functionalities and therapeutic indications for food constituents and natural products.
publishDate 2015
dc.date.none.fl_str_mv 2015-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/39662
Di Ianni, Mauricio Emiliano; del Valle, Maria Eugenia; Enrique, Andrea Verónica; Rosella, Maria Adelaida; Bruno, Fiorella; et al.; Computer-aided identification of anticonvulsant effect of natural nonnutritive sweeteners stevioside and rebaudioside A; Mary Ann Liebert; Assay and Drug Development Technologies; 13; 6; 7-2015; 313-318
1540-658X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/39662
identifier_str_mv Di Ianni, Mauricio Emiliano; del Valle, Maria Eugenia; Enrique, Andrea Verónica; Rosella, Maria Adelaida; Bruno, Fiorella; et al.; Computer-aided identification of anticonvulsant effect of natural nonnutritive sweeteners stevioside and rebaudioside A; Mary Ann Liebert; Assay and Drug Development Technologies; 13; 6; 7-2015; 313-318
1540-658X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1089/adt.2015.29010.meddrrr
info:eu-repo/semantics/altIdentifier/url/https://www.liebertpub.com/doi/10.1089/adt.2015.29010.meddrrr
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Mary Ann Liebert
publisher.none.fl_str_mv Mary Ann Liebert
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614170201292800
score 13.069144

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