Computer-aided identification of anticonvulsant effect of natural nonnutritive sweeteners stevioside and rebaudioside A
- Autores
- Di Ianni, Mauricio Emiliano; del Valle, Maria Eugenia; Enrique, Andrea Verónica; Rosella, Maria Adelaida; Bruno, Fiorella; Bruno Blanch, Luis Enrique; Talevi, Alan
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Steviol glycosides are natural constituents of Stevia rebaudiana (Bert.) Bert. (Asteraceae) that have recently gained worldwide approval as nonnutritive sweeteners by the Joint Food and Agriculture Organization/World Organization Expert Committee on Food Additives. Cheminformatic tools suggested that the aglycone steviol and several of its phase I metabolites were predicted as potential anticonvulsant agents effective in the seizure animal model maximal electroshock seizure (MES) test. Thus, aqueous infusion from S. rebaudiana was tested in the MES test (mice, intraperitoneal administration), confirming dose-dependent anticonvulsant effect. Afterward, isolated stevioside and rebaudioside A were tested in the MES test, with positive results. Though drug repositioning most often focuses on known therapeutics, this article illustrates the possibilities of this strategy to find new functionalities and therapeutic indications for food constituents and natural products.
Fil: Di Ianni, Mauricio Emiliano. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: del Valle, Maria Eugenia. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Enrique, Andrea Verónica. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rosella, Maria Adelaida. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina
Fil: Bruno, Fiorella. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina
Fil: Bruno Blanch, Luis Enrique. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Talevi, Alan. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina - Materia
-
Stevia Rebaudiana
Steviosides
Steviol
Epilepsy
Anticonvulsant
Knowledge-Based Drug Repurposing - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/39662
Ver los metadatos del registro completo
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CONICET Digital (CONICET) |
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Computer-aided identification of anticonvulsant effect of natural nonnutritive sweeteners stevioside and rebaudioside ADi Ianni, Mauricio Emilianodel Valle, Maria EugeniaEnrique, Andrea VerónicaRosella, Maria AdelaidaBruno, FiorellaBruno Blanch, Luis EnriqueTalevi, AlanStevia RebaudianaSteviosidesSteviolEpilepsyAnticonvulsantKnowledge-Based Drug Repurposinghttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Steviol glycosides are natural constituents of Stevia rebaudiana (Bert.) Bert. (Asteraceae) that have recently gained worldwide approval as nonnutritive sweeteners by the Joint Food and Agriculture Organization/World Organization Expert Committee on Food Additives. Cheminformatic tools suggested that the aglycone steviol and several of its phase I metabolites were predicted as potential anticonvulsant agents effective in the seizure animal model maximal electroshock seizure (MES) test. Thus, aqueous infusion from S. rebaudiana was tested in the MES test (mice, intraperitoneal administration), confirming dose-dependent anticonvulsant effect. Afterward, isolated stevioside and rebaudioside A were tested in the MES test, with positive results. Though drug repositioning most often focuses on known therapeutics, this article illustrates the possibilities of this strategy to find new functionalities and therapeutic indications for food constituents and natural products.Fil: Di Ianni, Mauricio Emiliano. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: del Valle, Maria Eugenia. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Enrique, Andrea Verónica. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Rosella, Maria Adelaida. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; ArgentinaFil: Bruno, Fiorella. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; ArgentinaFil: Bruno Blanch, Luis Enrique. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Talevi, Alan. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaMary Ann Liebert2015-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/39662Di Ianni, Mauricio Emiliano; del Valle, Maria Eugenia; Enrique, Andrea Verónica; Rosella, Maria Adelaida; Bruno, Fiorella; et al.; Computer-aided identification of anticonvulsant effect of natural nonnutritive sweeteners stevioside and rebaudioside A; Mary Ann Liebert; Assay and Drug Development Technologies; 13; 6; 7-2015; 313-3181540-658XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1089/adt.2015.29010.meddrrrinfo:eu-repo/semantics/altIdentifier/url/https://www.liebertpub.com/doi/10.1089/adt.2015.29010.meddrrrinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:03:06Zoai:ri.conicet.gov.ar:11336/39662instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:03:07.306CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Computer-aided identification of anticonvulsant effect of natural nonnutritive sweeteners stevioside and rebaudioside A |
title |
Computer-aided identification of anticonvulsant effect of natural nonnutritive sweeteners stevioside and rebaudioside A |
spellingShingle |
Computer-aided identification of anticonvulsant effect of natural nonnutritive sweeteners stevioside and rebaudioside A Di Ianni, Mauricio Emiliano Stevia Rebaudiana Steviosides Steviol Epilepsy Anticonvulsant Knowledge-Based Drug Repurposing |
title_short |
Computer-aided identification of anticonvulsant effect of natural nonnutritive sweeteners stevioside and rebaudioside A |
title_full |
Computer-aided identification of anticonvulsant effect of natural nonnutritive sweeteners stevioside and rebaudioside A |
title_fullStr |
Computer-aided identification of anticonvulsant effect of natural nonnutritive sweeteners stevioside and rebaudioside A |
title_full_unstemmed |
Computer-aided identification of anticonvulsant effect of natural nonnutritive sweeteners stevioside and rebaudioside A |
title_sort |
Computer-aided identification of anticonvulsant effect of natural nonnutritive sweeteners stevioside and rebaudioside A |
dc.creator.none.fl_str_mv |
Di Ianni, Mauricio Emiliano del Valle, Maria Eugenia Enrique, Andrea Verónica Rosella, Maria Adelaida Bruno, Fiorella Bruno Blanch, Luis Enrique Talevi, Alan |
author |
Di Ianni, Mauricio Emiliano |
author_facet |
Di Ianni, Mauricio Emiliano del Valle, Maria Eugenia Enrique, Andrea Verónica Rosella, Maria Adelaida Bruno, Fiorella Bruno Blanch, Luis Enrique Talevi, Alan |
author_role |
author |
author2 |
del Valle, Maria Eugenia Enrique, Andrea Verónica Rosella, Maria Adelaida Bruno, Fiorella Bruno Blanch, Luis Enrique Talevi, Alan |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
Stevia Rebaudiana Steviosides Steviol Epilepsy Anticonvulsant Knowledge-Based Drug Repurposing |
topic |
Stevia Rebaudiana Steviosides Steviol Epilepsy Anticonvulsant Knowledge-Based Drug Repurposing |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Steviol glycosides are natural constituents of Stevia rebaudiana (Bert.) Bert. (Asteraceae) that have recently gained worldwide approval as nonnutritive sweeteners by the Joint Food and Agriculture Organization/World Organization Expert Committee on Food Additives. Cheminformatic tools suggested that the aglycone steviol and several of its phase I metabolites were predicted as potential anticonvulsant agents effective in the seizure animal model maximal electroshock seizure (MES) test. Thus, aqueous infusion from S. rebaudiana was tested in the MES test (mice, intraperitoneal administration), confirming dose-dependent anticonvulsant effect. Afterward, isolated stevioside and rebaudioside A were tested in the MES test, with positive results. Though drug repositioning most often focuses on known therapeutics, this article illustrates the possibilities of this strategy to find new functionalities and therapeutic indications for food constituents and natural products. Fil: Di Ianni, Mauricio Emiliano. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: del Valle, Maria Eugenia. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Enrique, Andrea Verónica. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Rosella, Maria Adelaida. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina Fil: Bruno, Fiorella. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina Fil: Bruno Blanch, Luis Enrique. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Talevi, Alan. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
description |
Steviol glycosides are natural constituents of Stevia rebaudiana (Bert.) Bert. (Asteraceae) that have recently gained worldwide approval as nonnutritive sweeteners by the Joint Food and Agriculture Organization/World Organization Expert Committee on Food Additives. Cheminformatic tools suggested that the aglycone steviol and several of its phase I metabolites were predicted as potential anticonvulsant agents effective in the seizure animal model maximal electroshock seizure (MES) test. Thus, aqueous infusion from S. rebaudiana was tested in the MES test (mice, intraperitoneal administration), confirming dose-dependent anticonvulsant effect. Afterward, isolated stevioside and rebaudioside A were tested in the MES test, with positive results. Though drug repositioning most often focuses on known therapeutics, this article illustrates the possibilities of this strategy to find new functionalities and therapeutic indications for food constituents and natural products. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-07 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/39662 Di Ianni, Mauricio Emiliano; del Valle, Maria Eugenia; Enrique, Andrea Verónica; Rosella, Maria Adelaida; Bruno, Fiorella; et al.; Computer-aided identification of anticonvulsant effect of natural nonnutritive sweeteners stevioside and rebaudioside A; Mary Ann Liebert; Assay and Drug Development Technologies; 13; 6; 7-2015; 313-318 1540-658X CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/39662 |
identifier_str_mv |
Di Ianni, Mauricio Emiliano; del Valle, Maria Eugenia; Enrique, Andrea Verónica; Rosella, Maria Adelaida; Bruno, Fiorella; et al.; Computer-aided identification of anticonvulsant effect of natural nonnutritive sweeteners stevioside and rebaudioside A; Mary Ann Liebert; Assay and Drug Development Technologies; 13; 6; 7-2015; 313-318 1540-658X CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1089/adt.2015.29010.meddrrr info:eu-repo/semantics/altIdentifier/url/https://www.liebertpub.com/doi/10.1089/adt.2015.29010.meddrrr |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Mary Ann Liebert |
publisher.none.fl_str_mv |
Mary Ann Liebert |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842269783067721728 |
score |
13.13397 |