First national survey of antibiotic susceptibility of the Bacteroides fragilis group: emerging resistance to carbapenems in Argentina

Autores
Fernández Canigia, Liliana; Litterio, Mirta; Legaria, María C.; Castello, Liliana; Predari, Silvia C.; Di Martino, Ana; Rossetti, Adelaida; Rollet, Raquel; Carloni, Graciela; Bianchini, Hebe; Cejas, Daniela; Radice, Marcela Alejandra; Gutkind, Gabriel Osvaldo; Anaerobe Surveillance Team
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The antibiotic susceptibility rates of 363 clinical Bacteroides fragilis group isolates collected from 17 centers in Argentina during the period from 2006 to 2009 were as follows: piperacillin-tazobactam, 99%; ampicillin-sulbactam, 92%; cefoxitin, 72%; tigecycline, 100%; moxifloxacin, 91%; and clindamycin, 52%. No metronidazole resistance was detected in these isolates during this time period. Resistance to imipenem, doripenem, and ertapenem was observed in 1.1%, 1.6%, and 2.3% of B. fragilis group strains, respectively. B. fragilis species showed a resistance profile of 1.5% to imipenem, 1.9% to doripenem, and 2.4% to ertapenem. This is the first report of carbapenem resistance in Argentina. The cfiA gene was present in 8 out of 23 isolates, all of them belonging to the B. fragilis species and displaying reduced susceptibility or resistance to carbapenems (MICs ≥ 4 μg/ml). Three out of eight cfiA-positive isolates were fully resistant to carbapenems, while 5 out of 8 isolates showed low-level resistance (MICs, 4 to 8 μg/ml). The inhibition by EDTA was a good predictor of the presence of metallo-β-lactamases in the fully resistant B. fragilis strains, but discrepant results were observed for low-level resistant isolates. B. fragilis was more susceptible to antimicrobial agents than other Bacteroides species. Bacteroides vulgatus species was the most resistant to ampicillin-sulbactam and piperacillin-tazobactam, and B. thetaiotaomicron/ovatus strains showed the highest level of resistance to carbapenems, with an unknown resistance mechanism. B. vulgatus and the uncommon non-Bacteroides fragilis species were the most resistant to moxifloxacin, showing an overall resistance rate of 15.1%.
Fil: Fernández Canigia, Liliana. Asociación Argentina de Microbiología; Argentina
Fil: Litterio, Mirta. Asociación Argentina de Microbiología; Argentina
Fil: Legaria, María C.. Asociación Argentina de Microbiología; Argentina
Fil: Castello, Liliana. Asociación Argentina de Microbiología; Argentina
Fil: Predari, Silvia C.. Asociación Argentina de Microbiología; Argentina
Fil: Di Martino, Ana. Asociación Argentina de Microbiología; Argentina
Fil: Rossetti, Adelaida. Asociación Argentina de Microbiología; Argentina
Fil: Rollet, Raquel. Asociación Argentina de Microbiología; Argentina
Fil: Carloni, Graciela. Asociación Argentina de Microbiología; Argentina
Fil: Bianchini, Hebe. Asociación Argentina de Microbiología; Argentina
Fil: Cejas, Daniela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Radice, Marcela Alejandra. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gutkind, Gabriel Osvaldo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Anaerobe Surveillance Team.
Materia
Bacteroides fragilis group
Emerging resistance to carbapenems
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/14250

id CONICETDig_fbc5fead47a1636a2688738eb8530c44
oai_identifier_str oai:ri.conicet.gov.ar:11336/14250
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling First national survey of antibiotic susceptibility of the Bacteroides fragilis group: emerging resistance to carbapenems in ArgentinaFernández Canigia, LilianaLitterio, MirtaLegaria, María C.Castello, LilianaPredari, Silvia C.Di Martino, AnaRossetti, AdelaidaRollet, RaquelCarloni, GracielaBianchini, HebeCejas, DanielaRadice, Marcela AlejandraGutkind, Gabriel OsvaldoAnaerobe Surveillance TeamBacteroides fragilis groupEmerging resistance to carbapenemshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The antibiotic susceptibility rates of 363 clinical Bacteroides fragilis group isolates collected from 17 centers in Argentina during the period from 2006 to 2009 were as follows: piperacillin-tazobactam, 99%; ampicillin-sulbactam, 92%; cefoxitin, 72%; tigecycline, 100%; moxifloxacin, 91%; and clindamycin, 52%. No metronidazole resistance was detected in these isolates during this time period. Resistance to imipenem, doripenem, and ertapenem was observed in 1.1%, 1.6%, and 2.3% of B. fragilis group strains, respectively. B. fragilis species showed a resistance profile of 1.5% to imipenem, 1.9% to doripenem, and 2.4% to ertapenem. This is the first report of carbapenem resistance in Argentina. The cfiA gene was present in 8 out of 23 isolates, all of them belonging to the B. fragilis species and displaying reduced susceptibility or resistance to carbapenems (MICs ≥ 4 μg/ml). Three out of eight cfiA-positive isolates were fully resistant to carbapenems, while 5 out of 8 isolates showed low-level resistance (MICs, 4 to 8 μg/ml). The inhibition by EDTA was a good predictor of the presence of metallo-β-lactamases in the fully resistant B. fragilis strains, but discrepant results were observed for low-level resistant isolates. B. fragilis was more susceptible to antimicrobial agents than other Bacteroides species. Bacteroides vulgatus species was the most resistant to ampicillin-sulbactam and piperacillin-tazobactam, and B. thetaiotaomicron/ovatus strains showed the highest level of resistance to carbapenems, with an unknown resistance mechanism. B. vulgatus and the uncommon non-Bacteroides fragilis species were the most resistant to moxifloxacin, showing an overall resistance rate of 15.1%.Fil: Fernández Canigia, Liliana. Asociación Argentina de Microbiología; ArgentinaFil: Litterio, Mirta. Asociación Argentina de Microbiología; ArgentinaFil: Legaria, María C.. Asociación Argentina de Microbiología; ArgentinaFil: Castello, Liliana. Asociación Argentina de Microbiología; ArgentinaFil: Predari, Silvia C.. Asociación Argentina de Microbiología; ArgentinaFil: Di Martino, Ana. Asociación Argentina de Microbiología; ArgentinaFil: Rossetti, Adelaida. Asociación Argentina de Microbiología; ArgentinaFil: Rollet, Raquel. Asociación Argentina de Microbiología; ArgentinaFil: Carloni, Graciela. Asociación Argentina de Microbiología; ArgentinaFil: Bianchini, Hebe. Asociación Argentina de Microbiología; ArgentinaFil: Cejas, Daniela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Radice, Marcela Alejandra. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gutkind, Gabriel Osvaldo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Anaerobe Surveillance Team.American Society for Microbiology2012-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/14250Fernández Canigia, Liliana; Litterio, Mirta; Legaria, María C.; Castello, Liliana; Predari, Silvia C.; et al.; First national survey of antibiotic susceptibility of the Bacteroides fragilis group: emerging resistance to carbapenems in Argentina; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 56; 3; 1-2012; 1309-13140066-48041098-6596enginfo:eu-repo/semantics/altIdentifier/url/http://aac.asm.org/content/56/3/1309.fullinfo:eu-repo/semantics/altIdentifier/doi/10.1128/AAC.05622-11info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:00:25Zoai:ri.conicet.gov.ar:11336/14250instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:00:25.6CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv First national survey of antibiotic susceptibility of the Bacteroides fragilis group: emerging resistance to carbapenems in Argentina
title First national survey of antibiotic susceptibility of the Bacteroides fragilis group: emerging resistance to carbapenems in Argentina
spellingShingle First national survey of antibiotic susceptibility of the Bacteroides fragilis group: emerging resistance to carbapenems in Argentina
Fernández Canigia, Liliana
Bacteroides fragilis group
Emerging resistance to carbapenems
title_short First national survey of antibiotic susceptibility of the Bacteroides fragilis group: emerging resistance to carbapenems in Argentina
title_full First national survey of antibiotic susceptibility of the Bacteroides fragilis group: emerging resistance to carbapenems in Argentina
title_fullStr First national survey of antibiotic susceptibility of the Bacteroides fragilis group: emerging resistance to carbapenems in Argentina
title_full_unstemmed First national survey of antibiotic susceptibility of the Bacteroides fragilis group: emerging resistance to carbapenems in Argentina
title_sort First national survey of antibiotic susceptibility of the Bacteroides fragilis group: emerging resistance to carbapenems in Argentina
dc.creator.none.fl_str_mv Fernández Canigia, Liliana
Litterio, Mirta
Legaria, María C.
Castello, Liliana
Predari, Silvia C.
Di Martino, Ana
Rossetti, Adelaida
Rollet, Raquel
Carloni, Graciela
Bianchini, Hebe
Cejas, Daniela
Radice, Marcela Alejandra
Gutkind, Gabriel Osvaldo
Anaerobe Surveillance Team
author Fernández Canigia, Liliana
author_facet Fernández Canigia, Liliana
Litterio, Mirta
Legaria, María C.
Castello, Liliana
Predari, Silvia C.
Di Martino, Ana
Rossetti, Adelaida
Rollet, Raquel
Carloni, Graciela
Bianchini, Hebe
Cejas, Daniela
Radice, Marcela Alejandra
Gutkind, Gabriel Osvaldo
Anaerobe Surveillance Team
author_role author
author2 Litterio, Mirta
Legaria, María C.
Castello, Liliana
Predari, Silvia C.
Di Martino, Ana
Rossetti, Adelaida
Rollet, Raquel
Carloni, Graciela
Bianchini, Hebe
Cejas, Daniela
Radice, Marcela Alejandra
Gutkind, Gabriel Osvaldo
Anaerobe Surveillance Team
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Bacteroides fragilis group
Emerging resistance to carbapenems
topic Bacteroides fragilis group
Emerging resistance to carbapenems
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The antibiotic susceptibility rates of 363 clinical Bacteroides fragilis group isolates collected from 17 centers in Argentina during the period from 2006 to 2009 were as follows: piperacillin-tazobactam, 99%; ampicillin-sulbactam, 92%; cefoxitin, 72%; tigecycline, 100%; moxifloxacin, 91%; and clindamycin, 52%. No metronidazole resistance was detected in these isolates during this time period. Resistance to imipenem, doripenem, and ertapenem was observed in 1.1%, 1.6%, and 2.3% of B. fragilis group strains, respectively. B. fragilis species showed a resistance profile of 1.5% to imipenem, 1.9% to doripenem, and 2.4% to ertapenem. This is the first report of carbapenem resistance in Argentina. The cfiA gene was present in 8 out of 23 isolates, all of them belonging to the B. fragilis species and displaying reduced susceptibility or resistance to carbapenems (MICs ≥ 4 μg/ml). Three out of eight cfiA-positive isolates were fully resistant to carbapenems, while 5 out of 8 isolates showed low-level resistance (MICs, 4 to 8 μg/ml). The inhibition by EDTA was a good predictor of the presence of metallo-β-lactamases in the fully resistant B. fragilis strains, but discrepant results were observed for low-level resistant isolates. B. fragilis was more susceptible to antimicrobial agents than other Bacteroides species. Bacteroides vulgatus species was the most resistant to ampicillin-sulbactam and piperacillin-tazobactam, and B. thetaiotaomicron/ovatus strains showed the highest level of resistance to carbapenems, with an unknown resistance mechanism. B. vulgatus and the uncommon non-Bacteroides fragilis species were the most resistant to moxifloxacin, showing an overall resistance rate of 15.1%.
Fil: Fernández Canigia, Liliana. Asociación Argentina de Microbiología; Argentina
Fil: Litterio, Mirta. Asociación Argentina de Microbiología; Argentina
Fil: Legaria, María C.. Asociación Argentina de Microbiología; Argentina
Fil: Castello, Liliana. Asociación Argentina de Microbiología; Argentina
Fil: Predari, Silvia C.. Asociación Argentina de Microbiología; Argentina
Fil: Di Martino, Ana. Asociación Argentina de Microbiología; Argentina
Fil: Rossetti, Adelaida. Asociación Argentina de Microbiología; Argentina
Fil: Rollet, Raquel. Asociación Argentina de Microbiología; Argentina
Fil: Carloni, Graciela. Asociación Argentina de Microbiología; Argentina
Fil: Bianchini, Hebe. Asociación Argentina de Microbiología; Argentina
Fil: Cejas, Daniela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Radice, Marcela Alejandra. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gutkind, Gabriel Osvaldo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Anaerobe Surveillance Team.
description The antibiotic susceptibility rates of 363 clinical Bacteroides fragilis group isolates collected from 17 centers in Argentina during the period from 2006 to 2009 were as follows: piperacillin-tazobactam, 99%; ampicillin-sulbactam, 92%; cefoxitin, 72%; tigecycline, 100%; moxifloxacin, 91%; and clindamycin, 52%. No metronidazole resistance was detected in these isolates during this time period. Resistance to imipenem, doripenem, and ertapenem was observed in 1.1%, 1.6%, and 2.3% of B. fragilis group strains, respectively. B. fragilis species showed a resistance profile of 1.5% to imipenem, 1.9% to doripenem, and 2.4% to ertapenem. This is the first report of carbapenem resistance in Argentina. The cfiA gene was present in 8 out of 23 isolates, all of them belonging to the B. fragilis species and displaying reduced susceptibility or resistance to carbapenems (MICs ≥ 4 μg/ml). Three out of eight cfiA-positive isolates were fully resistant to carbapenems, while 5 out of 8 isolates showed low-level resistance (MICs, 4 to 8 μg/ml). The inhibition by EDTA was a good predictor of the presence of metallo-β-lactamases in the fully resistant B. fragilis strains, but discrepant results were observed for low-level resistant isolates. B. fragilis was more susceptible to antimicrobial agents than other Bacteroides species. Bacteroides vulgatus species was the most resistant to ampicillin-sulbactam and piperacillin-tazobactam, and B. thetaiotaomicron/ovatus strains showed the highest level of resistance to carbapenems, with an unknown resistance mechanism. B. vulgatus and the uncommon non-Bacteroides fragilis species were the most resistant to moxifloxacin, showing an overall resistance rate of 15.1%.
publishDate 2012
dc.date.none.fl_str_mv 2012-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/14250
Fernández Canigia, Liliana; Litterio, Mirta; Legaria, María C.; Castello, Liliana; Predari, Silvia C.; et al.; First national survey of antibiotic susceptibility of the Bacteroides fragilis group: emerging resistance to carbapenems in Argentina; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 56; 3; 1-2012; 1309-1314
0066-4804
1098-6596
url http://hdl.handle.net/11336/14250
identifier_str_mv Fernández Canigia, Liliana; Litterio, Mirta; Legaria, María C.; Castello, Liliana; Predari, Silvia C.; et al.; First national survey of antibiotic susceptibility of the Bacteroides fragilis group: emerging resistance to carbapenems in Argentina; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 56; 3; 1-2012; 1309-1314
0066-4804
1098-6596
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://aac.asm.org/content/56/3/1309.full
info:eu-repo/semantics/altIdentifier/doi/10.1128/AAC.05622-11
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613784893652992
score 13.070432