First national survey of antibiotic susceptibility of the Bacteroides fragilis group: emerging resistance to carbapenems in Argentina
- Autores
- Fernández Canigia, Liliana; Litterio, Mirta; Legaria, María C.; Castello, Liliana; Predari, Silvia C.; Di Martino, Ana; Rossetti, Adelaida; Rollet, Raquel; Carloni, Graciela; Bianchini, Hebe; Cejas, Daniela; Radice, Marcela Alejandra; Gutkind, Gabriel Osvaldo; Anaerobe Surveillance Team
- Año de publicación
- 2012
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The antibiotic susceptibility rates of 363 clinical Bacteroides fragilis group isolates collected from 17 centers in Argentina during the period from 2006 to 2009 were as follows: piperacillin-tazobactam, 99%; ampicillin-sulbactam, 92%; cefoxitin, 72%; tigecycline, 100%; moxifloxacin, 91%; and clindamycin, 52%. No metronidazole resistance was detected in these isolates during this time period. Resistance to imipenem, doripenem, and ertapenem was observed in 1.1%, 1.6%, and 2.3% of B. fragilis group strains, respectively. B. fragilis species showed a resistance profile of 1.5% to imipenem, 1.9% to doripenem, and 2.4% to ertapenem. This is the first report of carbapenem resistance in Argentina. The cfiA gene was present in 8 out of 23 isolates, all of them belonging to the B. fragilis species and displaying reduced susceptibility or resistance to carbapenems (MICs ≥ 4 μg/ml). Three out of eight cfiA-positive isolates were fully resistant to carbapenems, while 5 out of 8 isolates showed low-level resistance (MICs, 4 to 8 μg/ml). The inhibition by EDTA was a good predictor of the presence of metallo-β-lactamases in the fully resistant B. fragilis strains, but discrepant results were observed for low-level resistant isolates. B. fragilis was more susceptible to antimicrobial agents than other Bacteroides species. Bacteroides vulgatus species was the most resistant to ampicillin-sulbactam and piperacillin-tazobactam, and B. thetaiotaomicron/ovatus strains showed the highest level of resistance to carbapenems, with an unknown resistance mechanism. B. vulgatus and the uncommon non-Bacteroides fragilis species were the most resistant to moxifloxacin, showing an overall resistance rate of 15.1%.
Fil: Fernández Canigia, Liliana. Asociación Argentina de Microbiología; Argentina
Fil: Litterio, Mirta. Asociación Argentina de Microbiología; Argentina
Fil: Legaria, María C.. Asociación Argentina de Microbiología; Argentina
Fil: Castello, Liliana. Asociación Argentina de Microbiología; Argentina
Fil: Predari, Silvia C.. Asociación Argentina de Microbiología; Argentina
Fil: Di Martino, Ana. Asociación Argentina de Microbiología; Argentina
Fil: Rossetti, Adelaida. Asociación Argentina de Microbiología; Argentina
Fil: Rollet, Raquel. Asociación Argentina de Microbiología; Argentina
Fil: Carloni, Graciela. Asociación Argentina de Microbiología; Argentina
Fil: Bianchini, Hebe. Asociación Argentina de Microbiología; Argentina
Fil: Cejas, Daniela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Radice, Marcela Alejandra. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gutkind, Gabriel Osvaldo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Anaerobe Surveillance Team. - Materia
-
Bacteroides fragilis group
Emerging resistance to carbapenems - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/14250
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First national survey of antibiotic susceptibility of the Bacteroides fragilis group: emerging resistance to carbapenems in ArgentinaFernández Canigia, LilianaLitterio, MirtaLegaria, María C.Castello, LilianaPredari, Silvia C.Di Martino, AnaRossetti, AdelaidaRollet, RaquelCarloni, GracielaBianchini, HebeCejas, DanielaRadice, Marcela AlejandraGutkind, Gabriel OsvaldoAnaerobe Surveillance TeamBacteroides fragilis groupEmerging resistance to carbapenemshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The antibiotic susceptibility rates of 363 clinical Bacteroides fragilis group isolates collected from 17 centers in Argentina during the period from 2006 to 2009 were as follows: piperacillin-tazobactam, 99%; ampicillin-sulbactam, 92%; cefoxitin, 72%; tigecycline, 100%; moxifloxacin, 91%; and clindamycin, 52%. No metronidazole resistance was detected in these isolates during this time period. Resistance to imipenem, doripenem, and ertapenem was observed in 1.1%, 1.6%, and 2.3% of B. fragilis group strains, respectively. B. fragilis species showed a resistance profile of 1.5% to imipenem, 1.9% to doripenem, and 2.4% to ertapenem. This is the first report of carbapenem resistance in Argentina. The cfiA gene was present in 8 out of 23 isolates, all of them belonging to the B. fragilis species and displaying reduced susceptibility or resistance to carbapenems (MICs ≥ 4 μg/ml). Three out of eight cfiA-positive isolates were fully resistant to carbapenems, while 5 out of 8 isolates showed low-level resistance (MICs, 4 to 8 μg/ml). The inhibition by EDTA was a good predictor of the presence of metallo-β-lactamases in the fully resistant B. fragilis strains, but discrepant results were observed for low-level resistant isolates. B. fragilis was more susceptible to antimicrobial agents than other Bacteroides species. Bacteroides vulgatus species was the most resistant to ampicillin-sulbactam and piperacillin-tazobactam, and B. thetaiotaomicron/ovatus strains showed the highest level of resistance to carbapenems, with an unknown resistance mechanism. B. vulgatus and the uncommon non-Bacteroides fragilis species were the most resistant to moxifloxacin, showing an overall resistance rate of 15.1%.Fil: Fernández Canigia, Liliana. Asociación Argentina de Microbiología; ArgentinaFil: Litterio, Mirta. Asociación Argentina de Microbiología; ArgentinaFil: Legaria, María C.. Asociación Argentina de Microbiología; ArgentinaFil: Castello, Liliana. Asociación Argentina de Microbiología; ArgentinaFil: Predari, Silvia C.. Asociación Argentina de Microbiología; ArgentinaFil: Di Martino, Ana. Asociación Argentina de Microbiología; ArgentinaFil: Rossetti, Adelaida. Asociación Argentina de Microbiología; ArgentinaFil: Rollet, Raquel. Asociación Argentina de Microbiología; ArgentinaFil: Carloni, Graciela. Asociación Argentina de Microbiología; ArgentinaFil: Bianchini, Hebe. Asociación Argentina de Microbiología; ArgentinaFil: Cejas, Daniela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Radice, Marcela Alejandra. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gutkind, Gabriel Osvaldo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Anaerobe Surveillance Team.American Society for Microbiology2012-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/14250Fernández Canigia, Liliana; Litterio, Mirta; Legaria, María C.; Castello, Liliana; Predari, Silvia C.; et al.; First national survey of antibiotic susceptibility of the Bacteroides fragilis group: emerging resistance to carbapenems in Argentina; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 56; 3; 1-2012; 1309-13140066-48041098-6596enginfo:eu-repo/semantics/altIdentifier/url/http://aac.asm.org/content/56/3/1309.fullinfo:eu-repo/semantics/altIdentifier/doi/10.1128/AAC.05622-11info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:00:25Zoai:ri.conicet.gov.ar:11336/14250instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:00:25.6CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
First national survey of antibiotic susceptibility of the Bacteroides fragilis group: emerging resistance to carbapenems in Argentina |
title |
First national survey of antibiotic susceptibility of the Bacteroides fragilis group: emerging resistance to carbapenems in Argentina |
spellingShingle |
First national survey of antibiotic susceptibility of the Bacteroides fragilis group: emerging resistance to carbapenems in Argentina Fernández Canigia, Liliana Bacteroides fragilis group Emerging resistance to carbapenems |
title_short |
First national survey of antibiotic susceptibility of the Bacteroides fragilis group: emerging resistance to carbapenems in Argentina |
title_full |
First national survey of antibiotic susceptibility of the Bacteroides fragilis group: emerging resistance to carbapenems in Argentina |
title_fullStr |
First national survey of antibiotic susceptibility of the Bacteroides fragilis group: emerging resistance to carbapenems in Argentina |
title_full_unstemmed |
First national survey of antibiotic susceptibility of the Bacteroides fragilis group: emerging resistance to carbapenems in Argentina |
title_sort |
First national survey of antibiotic susceptibility of the Bacteroides fragilis group: emerging resistance to carbapenems in Argentina |
dc.creator.none.fl_str_mv |
Fernández Canigia, Liliana Litterio, Mirta Legaria, María C. Castello, Liliana Predari, Silvia C. Di Martino, Ana Rossetti, Adelaida Rollet, Raquel Carloni, Graciela Bianchini, Hebe Cejas, Daniela Radice, Marcela Alejandra Gutkind, Gabriel Osvaldo Anaerobe Surveillance Team |
author |
Fernández Canigia, Liliana |
author_facet |
Fernández Canigia, Liliana Litterio, Mirta Legaria, María C. Castello, Liliana Predari, Silvia C. Di Martino, Ana Rossetti, Adelaida Rollet, Raquel Carloni, Graciela Bianchini, Hebe Cejas, Daniela Radice, Marcela Alejandra Gutkind, Gabriel Osvaldo Anaerobe Surveillance Team |
author_role |
author |
author2 |
Litterio, Mirta Legaria, María C. Castello, Liliana Predari, Silvia C. Di Martino, Ana Rossetti, Adelaida Rollet, Raquel Carloni, Graciela Bianchini, Hebe Cejas, Daniela Radice, Marcela Alejandra Gutkind, Gabriel Osvaldo Anaerobe Surveillance Team |
author2_role |
author author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
Bacteroides fragilis group Emerging resistance to carbapenems |
topic |
Bacteroides fragilis group Emerging resistance to carbapenems |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
The antibiotic susceptibility rates of 363 clinical Bacteroides fragilis group isolates collected from 17 centers in Argentina during the period from 2006 to 2009 were as follows: piperacillin-tazobactam, 99%; ampicillin-sulbactam, 92%; cefoxitin, 72%; tigecycline, 100%; moxifloxacin, 91%; and clindamycin, 52%. No metronidazole resistance was detected in these isolates during this time period. Resistance to imipenem, doripenem, and ertapenem was observed in 1.1%, 1.6%, and 2.3% of B. fragilis group strains, respectively. B. fragilis species showed a resistance profile of 1.5% to imipenem, 1.9% to doripenem, and 2.4% to ertapenem. This is the first report of carbapenem resistance in Argentina. The cfiA gene was present in 8 out of 23 isolates, all of them belonging to the B. fragilis species and displaying reduced susceptibility or resistance to carbapenems (MICs ≥ 4 μg/ml). Three out of eight cfiA-positive isolates were fully resistant to carbapenems, while 5 out of 8 isolates showed low-level resistance (MICs, 4 to 8 μg/ml). The inhibition by EDTA was a good predictor of the presence of metallo-β-lactamases in the fully resistant B. fragilis strains, but discrepant results were observed for low-level resistant isolates. B. fragilis was more susceptible to antimicrobial agents than other Bacteroides species. Bacteroides vulgatus species was the most resistant to ampicillin-sulbactam and piperacillin-tazobactam, and B. thetaiotaomicron/ovatus strains showed the highest level of resistance to carbapenems, with an unknown resistance mechanism. B. vulgatus and the uncommon non-Bacteroides fragilis species were the most resistant to moxifloxacin, showing an overall resistance rate of 15.1%. Fil: Fernández Canigia, Liliana. Asociación Argentina de Microbiología; Argentina Fil: Litterio, Mirta. Asociación Argentina de Microbiología; Argentina Fil: Legaria, María C.. Asociación Argentina de Microbiología; Argentina Fil: Castello, Liliana. Asociación Argentina de Microbiología; Argentina Fil: Predari, Silvia C.. Asociación Argentina de Microbiología; Argentina Fil: Di Martino, Ana. Asociación Argentina de Microbiología; Argentina Fil: Rossetti, Adelaida. Asociación Argentina de Microbiología; Argentina Fil: Rollet, Raquel. Asociación Argentina de Microbiología; Argentina Fil: Carloni, Graciela. Asociación Argentina de Microbiología; Argentina Fil: Bianchini, Hebe. Asociación Argentina de Microbiología; Argentina Fil: Cejas, Daniela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Radice, Marcela Alejandra. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Gutkind, Gabriel Osvaldo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Anaerobe Surveillance Team. |
description |
The antibiotic susceptibility rates of 363 clinical Bacteroides fragilis group isolates collected from 17 centers in Argentina during the period from 2006 to 2009 were as follows: piperacillin-tazobactam, 99%; ampicillin-sulbactam, 92%; cefoxitin, 72%; tigecycline, 100%; moxifloxacin, 91%; and clindamycin, 52%. No metronidazole resistance was detected in these isolates during this time period. Resistance to imipenem, doripenem, and ertapenem was observed in 1.1%, 1.6%, and 2.3% of B. fragilis group strains, respectively. B. fragilis species showed a resistance profile of 1.5% to imipenem, 1.9% to doripenem, and 2.4% to ertapenem. This is the first report of carbapenem resistance in Argentina. The cfiA gene was present in 8 out of 23 isolates, all of them belonging to the B. fragilis species and displaying reduced susceptibility or resistance to carbapenems (MICs ≥ 4 μg/ml). Three out of eight cfiA-positive isolates were fully resistant to carbapenems, while 5 out of 8 isolates showed low-level resistance (MICs, 4 to 8 μg/ml). The inhibition by EDTA was a good predictor of the presence of metallo-β-lactamases in the fully resistant B. fragilis strains, but discrepant results were observed for low-level resistant isolates. B. fragilis was more susceptible to antimicrobial agents than other Bacteroides species. Bacteroides vulgatus species was the most resistant to ampicillin-sulbactam and piperacillin-tazobactam, and B. thetaiotaomicron/ovatus strains showed the highest level of resistance to carbapenems, with an unknown resistance mechanism. B. vulgatus and the uncommon non-Bacteroides fragilis species were the most resistant to moxifloxacin, showing an overall resistance rate of 15.1%. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-01 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/14250 Fernández Canigia, Liliana; Litterio, Mirta; Legaria, María C.; Castello, Liliana; Predari, Silvia C.; et al.; First national survey of antibiotic susceptibility of the Bacteroides fragilis group: emerging resistance to carbapenems in Argentina; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 56; 3; 1-2012; 1309-1314 0066-4804 1098-6596 |
url |
http://hdl.handle.net/11336/14250 |
identifier_str_mv |
Fernández Canigia, Liliana; Litterio, Mirta; Legaria, María C.; Castello, Liliana; Predari, Silvia C.; et al.; First national survey of antibiotic susceptibility of the Bacteroides fragilis group: emerging resistance to carbapenems in Argentina; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 56; 3; 1-2012; 1309-1314 0066-4804 1098-6596 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://aac.asm.org/content/56/3/1309.full info:eu-repo/semantics/altIdentifier/doi/10.1128/AAC.05622-11 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
American Society for Microbiology |
publisher.none.fl_str_mv |
American Society for Microbiology |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613784893652992 |
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13.070432 |