Sulfamethoxazole: Hydroxypropyl-β-cyclodextrin complex: Preparation and characterization

Autores
Garnero, Claudia; Aiassa, Virginia; Longhi, Marcela Raquel
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A complex of sulfamethoxazole (SMX) and hydroxypropyl-β-cyclodextrin (HP-β-CD) was developed and characterized in order to investigate their interactions in aqueous solution and the solid state. The SMX solubility was significantly increased upon complexation with HP-β-CD, with the solubility isotherm being an AN type due to the presence of aggregates and the stability constant calculated for a 1:1 complex being 302±3M-1. Fourier-transform infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM) experiments were used to compare the freeze-dried system with a physical mixture, and demonstrated the complex formation in the solid state. The differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) showed that the thermal stability of SMX was enhanced in the presence of HP-β-CD.
Fil: Garnero, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina
Fil: Aiassa, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina
Fil: Longhi, Marcela Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina
Materia
AGGREGATION
CONDUCTIVITY
HYDROXYPROPYL-Β-CYCLODEXTRIN
SOLID-STATE ANALYSIS
SULFAMETHOXAZOLE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/199087
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Sulfamethoxazole: Hydroxypropyl-β-cyclodextrin complex: Preparation and characterizationGarnero, ClaudiaAiassa, VirginiaLonghi, Marcela RaquelAGGREGATIONCONDUCTIVITYHYDROXYPROPYL-Β-CYCLODEXTRINSOLID-STATE ANALYSISSULFAMETHOXAZOLEhttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2A complex of sulfamethoxazole (SMX) and hydroxypropyl-β-cyclodextrin (HP-β-CD) was developed and characterized in order to investigate their interactions in aqueous solution and the solid state. The SMX solubility was significantly increased upon complexation with HP-β-CD, with the solubility isotherm being an AN type due to the presence of aggregates and the stability constant calculated for a 1:1 complex being 302±3M-1. Fourier-transform infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM) experiments were used to compare the freeze-dried system with a physical mixture, and demonstrated the complex formation in the solid state. The differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) showed that the thermal stability of SMX was enhanced in the presence of HP-β-CD.Fil: Garnero, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; ArgentinaFil: Aiassa, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; ArgentinaFil: Longhi, Marcela Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; ArgentinaElsevier Science2012-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/199087Garnero, Claudia; Aiassa, Virginia; Longhi, Marcela Raquel; Sulfamethoxazole: Hydroxypropyl-β-cyclodextrin complex: Preparation and characterization; Elsevier Science; Journal of Pharmaceutical and Biomedical Analysis; 63; 4-2012; 74-790731-7085CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0731708512000155info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jpba.2012.01.011info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:58:17Zoai:ri.conicet.gov.ar:11336/199087instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:58:18.028CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Sulfamethoxazole: Hydroxypropyl-β-cyclodextrin complex: Preparation and characterization
title Sulfamethoxazole: Hydroxypropyl-β-cyclodextrin complex: Preparation and characterization
spellingShingle Sulfamethoxazole: Hydroxypropyl-β-cyclodextrin complex: Preparation and characterization
Garnero, Claudia
AGGREGATION
CONDUCTIVITY
HYDROXYPROPYL-Β-CYCLODEXTRIN
SOLID-STATE ANALYSIS
SULFAMETHOXAZOLE
title_short Sulfamethoxazole: Hydroxypropyl-β-cyclodextrin complex: Preparation and characterization
title_full Sulfamethoxazole: Hydroxypropyl-β-cyclodextrin complex: Preparation and characterization
title_fullStr Sulfamethoxazole: Hydroxypropyl-β-cyclodextrin complex: Preparation and characterization
title_full_unstemmed Sulfamethoxazole: Hydroxypropyl-β-cyclodextrin complex: Preparation and characterization
title_sort Sulfamethoxazole: Hydroxypropyl-β-cyclodextrin complex: Preparation and characterization
dc.creator.none.fl_str_mv Garnero, Claudia
Aiassa, Virginia
Longhi, Marcela Raquel
author Garnero, Claudia
author_facet Garnero, Claudia
Aiassa, Virginia
Longhi, Marcela Raquel
author_role author
author2 Aiassa, Virginia
Longhi, Marcela Raquel
author2_role author
author
dc.subject.none.fl_str_mv AGGREGATION
CONDUCTIVITY
HYDROXYPROPYL-Β-CYCLODEXTRIN
SOLID-STATE ANALYSIS
SULFAMETHOXAZOLE
topic AGGREGATION
CONDUCTIVITY
HYDROXYPROPYL-Β-CYCLODEXTRIN
SOLID-STATE ANALYSIS
SULFAMETHOXAZOLE
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv A complex of sulfamethoxazole (SMX) and hydroxypropyl-β-cyclodextrin (HP-β-CD) was developed and characterized in order to investigate their interactions in aqueous solution and the solid state. The SMX solubility was significantly increased upon complexation with HP-β-CD, with the solubility isotherm being an AN type due to the presence of aggregates and the stability constant calculated for a 1:1 complex being 302±3M-1. Fourier-transform infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM) experiments were used to compare the freeze-dried system with a physical mixture, and demonstrated the complex formation in the solid state. The differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) showed that the thermal stability of SMX was enhanced in the presence of HP-β-CD.
Fil: Garnero, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina
Fil: Aiassa, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina
Fil: Longhi, Marcela Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina
description A complex of sulfamethoxazole (SMX) and hydroxypropyl-β-cyclodextrin (HP-β-CD) was developed and characterized in order to investigate their interactions in aqueous solution and the solid state. The SMX solubility was significantly increased upon complexation with HP-β-CD, with the solubility isotherm being an AN type due to the presence of aggregates and the stability constant calculated for a 1:1 complex being 302±3M-1. Fourier-transform infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM) experiments were used to compare the freeze-dried system with a physical mixture, and demonstrated the complex formation in the solid state. The differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) showed that the thermal stability of SMX was enhanced in the presence of HP-β-CD.
publishDate 2012
dc.date.none.fl_str_mv 2012-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/199087
Garnero, Claudia; Aiassa, Virginia; Longhi, Marcela Raquel; Sulfamethoxazole: Hydroxypropyl-β-cyclodextrin complex: Preparation and characterization; Elsevier Science; Journal of Pharmaceutical and Biomedical Analysis; 63; 4-2012; 74-79
0731-7085
CONICET Digital
CONICET
url http://hdl.handle.net/11336/199087
identifier_str_mv Garnero, Claudia; Aiassa, Virginia; Longhi, Marcela Raquel; Sulfamethoxazole: Hydroxypropyl-β-cyclodextrin complex: Preparation and characterization; Elsevier Science; Journal of Pharmaceutical and Biomedical Analysis; 63; 4-2012; 74-79
0731-7085
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0731708512000155
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jpba.2012.01.011
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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