Complexation of a 1-indanone thiosemicarbazone with hydroxypropyl-beta-cyclodextrin enhances its activity against a Hepatitis C Virus surrogate model

Autores
Glisoni, Romina Julieta; Castro, Eliana Florencia; Cavallaro, Lucia Vicenta; Moglioni, Albertina Gladys; Sosnik, Alejandro Dario
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The current standard of care of the infection by hepatitis C virus (HCV) is effective in a limited number of patients and the high cost hinders therapy affordability and compliance. In this context, the research of new direct-acting antiviral agents (DAAs) for a more effective and long-lasting therapy is an urgent need and an area of active investigation. In an effort to develop novel DAAs, a series of 1-indanone thiosemicarbazones (TSCs) was synthesized and fully characterized. However, the high self-aggregation tendency and extremely poor aqueous solubility of these antiviral candidates often preclude their reliable biological evaluation in vitro. To maintain constant TSC concentrations over the biological assays, different TSC/cyclodextrin complexes were produced. In the present work, we report for the first time the cytotoxicity and antiviral activity of 5,6-dimethoxy TSC inclusion complexes with hydroxypropyl-β-cyclodextrin on bovine viral diarrhea virus (BVDV) as HCV surrogate model. Results showed a potent suppression of the virus replication, with greater activity for the inclusion complexes than the free compound.
Fil: Glisoni, Romina Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Castro, Eliana Florencia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cavallaro, Lucia Vicenta. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Moglioni, Albertina Gladys. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina
Fil: Sosnik, Alejandro Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina. Technion - Israel Institute of Technology; Israel
Materia
Bovine Viral Diarrhea Virus (Bvdv)
Hydroxypropyl-B-Cyclodextrin Inclusion Complexes
1-Indanone Thiosemicarbazones
Hcv Surrogate Model
Hydroxypropyl-Β-Cyclodextrin Inclusion Complexes
Direct-Acting Antiviral Agents
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/18429
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/18429
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Complexation of a 1-indanone thiosemicarbazone with hydroxypropyl-beta-cyclodextrin enhances its activity against a Hepatitis C Virus surrogate modelGlisoni, Romina JulietaCastro, Eliana FlorenciaCavallaro, Lucia VicentaMoglioni, Albertina GladysSosnik, Alejandro DarioBovine Viral Diarrhea Virus (Bvdv)Hydroxypropyl-B-Cyclodextrin Inclusion Complexes1-Indanone ThiosemicarbazonesHcv Surrogate ModelHydroxypropyl-Β-Cyclodextrin Inclusion ComplexesDirect-Acting Antiviral Agentshttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The current standard of care of the infection by hepatitis C virus (HCV) is effective in a limited number of patients and the high cost hinders therapy affordability and compliance. In this context, the research of new direct-acting antiviral agents (DAAs) for a more effective and long-lasting therapy is an urgent need and an area of active investigation. In an effort to develop novel DAAs, a series of 1-indanone thiosemicarbazones (TSCs) was synthesized and fully characterized. However, the high self-aggregation tendency and extremely poor aqueous solubility of these antiviral candidates often preclude their reliable biological evaluation in vitro. To maintain constant TSC concentrations over the biological assays, different TSC/cyclodextrin complexes were produced. In the present work, we report for the first time the cytotoxicity and antiviral activity of 5,6-dimethoxy TSC inclusion complexes with hydroxypropyl-β-cyclodextrin on bovine viral diarrhea virus (BVDV) as HCV surrogate model. Results showed a potent suppression of the virus replication, with greater activity for the inclusion complexes than the free compound.Fil: Glisoni, Romina Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Castro, Eliana Florencia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cavallaro, Lucia Vicenta. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Moglioni, Albertina Gladys. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; ArgentinaFil: Sosnik, Alejandro Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina. Technion - Israel Institute of Technology; IsraelAmerican Scientific Publishers2015-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/18429Glisoni, Romina Julieta; Castro, Eliana Florencia; Cavallaro, Lucia Vicenta; Moglioni, Albertina Gladys; Sosnik, Alejandro Dario; Complexation of a 1-indanone thiosemicarbazone with hydroxypropyl-beta-cyclodextrin enhances its activity against a Hepatitis C Virus surrogate model; American Scientific Publishers; Journal of Nanoscience and Nanotechnology; 15; 6; 2-2015; 4224-42281533-4880CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.ingentaconnect.com/content/asp/jnn/2015/00000015/00000006/art00027info:eu-repo/semantics/altIdentifier/doi/10.1166/jnn.2014.9613info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:14:57Zoai:ri.conicet.gov.ar:11336/18429instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:14:57.669CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Complexation of a 1-indanone thiosemicarbazone with hydroxypropyl-beta-cyclodextrin enhances its activity against a Hepatitis C Virus surrogate model
title Complexation of a 1-indanone thiosemicarbazone with hydroxypropyl-beta-cyclodextrin enhances its activity against a Hepatitis C Virus surrogate model
spellingShingle Complexation of a 1-indanone thiosemicarbazone with hydroxypropyl-beta-cyclodextrin enhances its activity against a Hepatitis C Virus surrogate model
Glisoni, Romina Julieta
Bovine Viral Diarrhea Virus (Bvdv)
Hydroxypropyl-B-Cyclodextrin Inclusion Complexes
1-Indanone Thiosemicarbazones
Hcv Surrogate Model
Hydroxypropyl-Β-Cyclodextrin Inclusion Complexes
Direct-Acting Antiviral Agents
title_short Complexation of a 1-indanone thiosemicarbazone with hydroxypropyl-beta-cyclodextrin enhances its activity against a Hepatitis C Virus surrogate model
title_full Complexation of a 1-indanone thiosemicarbazone with hydroxypropyl-beta-cyclodextrin enhances its activity against a Hepatitis C Virus surrogate model
title_fullStr Complexation of a 1-indanone thiosemicarbazone with hydroxypropyl-beta-cyclodextrin enhances its activity against a Hepatitis C Virus surrogate model
title_full_unstemmed Complexation of a 1-indanone thiosemicarbazone with hydroxypropyl-beta-cyclodextrin enhances its activity against a Hepatitis C Virus surrogate model
title_sort Complexation of a 1-indanone thiosemicarbazone with hydroxypropyl-beta-cyclodextrin enhances its activity against a Hepatitis C Virus surrogate model
dc.creator.none.fl_str_mv Glisoni, Romina Julieta
Castro, Eliana Florencia
Cavallaro, Lucia Vicenta
Moglioni, Albertina Gladys
Sosnik, Alejandro Dario
author Glisoni, Romina Julieta
author_facet Glisoni, Romina Julieta
Castro, Eliana Florencia
Cavallaro, Lucia Vicenta
Moglioni, Albertina Gladys
Sosnik, Alejandro Dario
author_role author
author2 Castro, Eliana Florencia
Cavallaro, Lucia Vicenta
Moglioni, Albertina Gladys
Sosnik, Alejandro Dario
author2_role author
author
author
author
dc.subject.none.fl_str_mv Bovine Viral Diarrhea Virus (Bvdv)
Hydroxypropyl-B-Cyclodextrin Inclusion Complexes
1-Indanone Thiosemicarbazones
Hcv Surrogate Model
Hydroxypropyl-Β-Cyclodextrin Inclusion Complexes
Direct-Acting Antiviral Agents
topic Bovine Viral Diarrhea Virus (Bvdv)
Hydroxypropyl-B-Cyclodextrin Inclusion Complexes
1-Indanone Thiosemicarbazones
Hcv Surrogate Model
Hydroxypropyl-Β-Cyclodextrin Inclusion Complexes
Direct-Acting Antiviral Agents
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The current standard of care of the infection by hepatitis C virus (HCV) is effective in a limited number of patients and the high cost hinders therapy affordability and compliance. In this context, the research of new direct-acting antiviral agents (DAAs) for a more effective and long-lasting therapy is an urgent need and an area of active investigation. In an effort to develop novel DAAs, a series of 1-indanone thiosemicarbazones (TSCs) was synthesized and fully characterized. However, the high self-aggregation tendency and extremely poor aqueous solubility of these antiviral candidates often preclude their reliable biological evaluation in vitro. To maintain constant TSC concentrations over the biological assays, different TSC/cyclodextrin complexes were produced. In the present work, we report for the first time the cytotoxicity and antiviral activity of 5,6-dimethoxy TSC inclusion complexes with hydroxypropyl-β-cyclodextrin on bovine viral diarrhea virus (BVDV) as HCV surrogate model. Results showed a potent suppression of the virus replication, with greater activity for the inclusion complexes than the free compound.
Fil: Glisoni, Romina Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Castro, Eliana Florencia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cavallaro, Lucia Vicenta. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Moglioni, Albertina Gladys. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina
Fil: Sosnik, Alejandro Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina. Technion - Israel Institute of Technology; Israel
description The current standard of care of the infection by hepatitis C virus (HCV) is effective in a limited number of patients and the high cost hinders therapy affordability and compliance. In this context, the research of new direct-acting antiviral agents (DAAs) for a more effective and long-lasting therapy is an urgent need and an area of active investigation. In an effort to develop novel DAAs, a series of 1-indanone thiosemicarbazones (TSCs) was synthesized and fully characterized. However, the high self-aggregation tendency and extremely poor aqueous solubility of these antiviral candidates often preclude their reliable biological evaluation in vitro. To maintain constant TSC concentrations over the biological assays, different TSC/cyclodextrin complexes were produced. In the present work, we report for the first time the cytotoxicity and antiviral activity of 5,6-dimethoxy TSC inclusion complexes with hydroxypropyl-β-cyclodextrin on bovine viral diarrhea virus (BVDV) as HCV surrogate model. Results showed a potent suppression of the virus replication, with greater activity for the inclusion complexes than the free compound.
publishDate 2015
dc.date.none.fl_str_mv 2015-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/18429
Glisoni, Romina Julieta; Castro, Eliana Florencia; Cavallaro, Lucia Vicenta; Moglioni, Albertina Gladys; Sosnik, Alejandro Dario; Complexation of a 1-indanone thiosemicarbazone with hydroxypropyl-beta-cyclodextrin enhances its activity against a Hepatitis C Virus surrogate model; American Scientific Publishers; Journal of Nanoscience and Nanotechnology; 15; 6; 2-2015; 4224-4228
1533-4880
CONICET Digital
CONICET
url http://hdl.handle.net/11336/18429
identifier_str_mv Glisoni, Romina Julieta; Castro, Eliana Florencia; Cavallaro, Lucia Vicenta; Moglioni, Albertina Gladys; Sosnik, Alejandro Dario; Complexation of a 1-indanone thiosemicarbazone with hydroxypropyl-beta-cyclodextrin enhances its activity against a Hepatitis C Virus surrogate model; American Scientific Publishers; Journal of Nanoscience and Nanotechnology; 15; 6; 2-2015; 4224-4228
1533-4880
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.ingentaconnect.com/content/asp/jnn/2015/00000015/00000006/art00027
info:eu-repo/semantics/altIdentifier/doi/10.1166/jnn.2014.9613
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Scientific Publishers
publisher.none.fl_str_mv American Scientific Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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