Complex formation of chlorhexidine gluconate with hydroxypropyl-β- cyclodextrin (HPβCD) by proton nuclear magnetic resonance spectroscopy (1H NMR)

Autores
Onnainty, Renée; Longhi, Marcela Raquel; Granero, Gladys Ester
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The complex formation of chlorhexidine digluconate (CHX-G2) with hydroxypropyl-β-cyclodextrin (HPβCD) was studied using NMR spectroscopy. The results revealed that this surfactant agent shows an monomer/aggregate equilibrium, which is dependent on the concentration of this drug. This equilibrium can be modified by the presence of HPβCD, which reduces the aggregation of the CHX-G2 molecules. An inclusion process of the CHX-G2 aromatic residue within the cyclodextrin cavity was confirmed by 2D ROESY spectroscopy. 1H NMR titration studies of CHX-G2 with HPβCD in D2O confirmed the formation of higher order complexes between CHX-G2 and HPβCD. Moreover, the addition of HPβCD into CHX-G2 solutions forms insoluble aggregates. Such insoluble aggregates may result in the stacking of CHX-G 2 molecules on the surface of the CHX-G2:HPβCD complexes.
Fil: Onnainty, Renée. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Longhi, Marcela Raquel. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Granero, Gladys Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba; Argentina
Materia
AGGREGATION EQUILIBRIUM
CHLORHEXIDINE DIGLUCONATE
HYDROXYPROPYL-Β-CYCLODEXTRIN
NMR SPECTROSCOPY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/190861
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Complex formation of chlorhexidine gluconate with hydroxypropyl-β- cyclodextrin (HPβCD) by proton nuclear magnetic resonance spectroscopy (1H NMR)Onnainty, RenéeLonghi, Marcela RaquelGranero, Gladys EsterAGGREGATION EQUILIBRIUMCHLORHEXIDINE DIGLUCONATEHYDROXYPROPYL-Β-CYCLODEXTRINNMR SPECTROSCOPYhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The complex formation of chlorhexidine digluconate (CHX-G2) with hydroxypropyl-β-cyclodextrin (HPβCD) was studied using NMR spectroscopy. The results revealed that this surfactant agent shows an monomer/aggregate equilibrium, which is dependent on the concentration of this drug. This equilibrium can be modified by the presence of HPβCD, which reduces the aggregation of the CHX-G2 molecules. An inclusion process of the CHX-G2 aromatic residue within the cyclodextrin cavity was confirmed by 2D ROESY spectroscopy. 1H NMR titration studies of CHX-G2 with HPβCD in D2O confirmed the formation of higher order complexes between CHX-G2 and HPβCD. Moreover, the addition of HPβCD into CHX-G2 solutions forms insoluble aggregates. Such insoluble aggregates may result in the stacking of CHX-G 2 molecules on the surface of the CHX-G2:HPβCD complexes.Fil: Onnainty, Renée. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Longhi, Marcela Raquel. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Granero, Gladys Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba; ArgentinaElsevier2011-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/190861Onnainty, Renée; Longhi, Marcela Raquel; Granero, Gladys Ester; Complex formation of chlorhexidine gluconate with hydroxypropyl-β- cyclodextrin (HPβCD) by proton nuclear magnetic resonance spectroscopy (1H NMR); Elsevier; Carbohydrate Research; 346; 8; 6-2011; 1037-10460008-6215CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0008621511001406info:eu-repo/semantics/altIdentifier/doi/10.1016/j.carres.2011.03.028info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-05T10:26:01Zoai:ri.conicet.gov.ar:11336/190861instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-05 10:26:01.945CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Complex formation of chlorhexidine gluconate with hydroxypropyl-β- cyclodextrin (HPβCD) by proton nuclear magnetic resonance spectroscopy (1H NMR)
title Complex formation of chlorhexidine gluconate with hydroxypropyl-β- cyclodextrin (HPβCD) by proton nuclear magnetic resonance spectroscopy (1H NMR)
spellingShingle Complex formation of chlorhexidine gluconate with hydroxypropyl-β- cyclodextrin (HPβCD) by proton nuclear magnetic resonance spectroscopy (1H NMR)
Onnainty, Renée
AGGREGATION EQUILIBRIUM
CHLORHEXIDINE DIGLUCONATE
HYDROXYPROPYL-Β-CYCLODEXTRIN
NMR SPECTROSCOPY
title_short Complex formation of chlorhexidine gluconate with hydroxypropyl-β- cyclodextrin (HPβCD) by proton nuclear magnetic resonance spectroscopy (1H NMR)
title_full Complex formation of chlorhexidine gluconate with hydroxypropyl-β- cyclodextrin (HPβCD) by proton nuclear magnetic resonance spectroscopy (1H NMR)
title_fullStr Complex formation of chlorhexidine gluconate with hydroxypropyl-β- cyclodextrin (HPβCD) by proton nuclear magnetic resonance spectroscopy (1H NMR)
title_full_unstemmed Complex formation of chlorhexidine gluconate with hydroxypropyl-β- cyclodextrin (HPβCD) by proton nuclear magnetic resonance spectroscopy (1H NMR)
title_sort Complex formation of chlorhexidine gluconate with hydroxypropyl-β- cyclodextrin (HPβCD) by proton nuclear magnetic resonance spectroscopy (1H NMR)
dc.creator.none.fl_str_mv Onnainty, Renée
Longhi, Marcela Raquel
Granero, Gladys Ester
author Onnainty, Renée
author_facet Onnainty, Renée
Longhi, Marcela Raquel
Granero, Gladys Ester
author_role author
author2 Longhi, Marcela Raquel
Granero, Gladys Ester
author2_role author
author
dc.subject.none.fl_str_mv AGGREGATION EQUILIBRIUM
CHLORHEXIDINE DIGLUCONATE
HYDROXYPROPYL-Β-CYCLODEXTRIN
NMR SPECTROSCOPY
topic AGGREGATION EQUILIBRIUM
CHLORHEXIDINE DIGLUCONATE
HYDROXYPROPYL-Β-CYCLODEXTRIN
NMR SPECTROSCOPY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The complex formation of chlorhexidine digluconate (CHX-G2) with hydroxypropyl-β-cyclodextrin (HPβCD) was studied using NMR spectroscopy. The results revealed that this surfactant agent shows an monomer/aggregate equilibrium, which is dependent on the concentration of this drug. This equilibrium can be modified by the presence of HPβCD, which reduces the aggregation of the CHX-G2 molecules. An inclusion process of the CHX-G2 aromatic residue within the cyclodextrin cavity was confirmed by 2D ROESY spectroscopy. 1H NMR titration studies of CHX-G2 with HPβCD in D2O confirmed the formation of higher order complexes between CHX-G2 and HPβCD. Moreover, the addition of HPβCD into CHX-G2 solutions forms insoluble aggregates. Such insoluble aggregates may result in the stacking of CHX-G 2 molecules on the surface of the CHX-G2:HPβCD complexes.
Fil: Onnainty, Renée. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Longhi, Marcela Raquel. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Granero, Gladys Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba; Argentina
description The complex formation of chlorhexidine digluconate (CHX-G2) with hydroxypropyl-β-cyclodextrin (HPβCD) was studied using NMR spectroscopy. The results revealed that this surfactant agent shows an monomer/aggregate equilibrium, which is dependent on the concentration of this drug. This equilibrium can be modified by the presence of HPβCD, which reduces the aggregation of the CHX-G2 molecules. An inclusion process of the CHX-G2 aromatic residue within the cyclodextrin cavity was confirmed by 2D ROESY spectroscopy. 1H NMR titration studies of CHX-G2 with HPβCD in D2O confirmed the formation of higher order complexes between CHX-G2 and HPβCD. Moreover, the addition of HPβCD into CHX-G2 solutions forms insoluble aggregates. Such insoluble aggregates may result in the stacking of CHX-G 2 molecules on the surface of the CHX-G2:HPβCD complexes.
publishDate 2011
dc.date.none.fl_str_mv 2011-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/190861
Onnainty, Renée; Longhi, Marcela Raquel; Granero, Gladys Ester; Complex formation of chlorhexidine gluconate with hydroxypropyl-β- cyclodextrin (HPβCD) by proton nuclear magnetic resonance spectroscopy (1H NMR); Elsevier; Carbohydrate Research; 346; 8; 6-2011; 1037-1046
0008-6215
CONICET Digital
CONICET
url http://hdl.handle.net/11336/190861
identifier_str_mv Onnainty, Renée; Longhi, Marcela Raquel; Granero, Gladys Ester; Complex formation of chlorhexidine gluconate with hydroxypropyl-β- cyclodextrin (HPβCD) by proton nuclear magnetic resonance spectroscopy (1H NMR); Elsevier; Carbohydrate Research; 346; 8; 6-2011; 1037-1046
0008-6215
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0008621511001406
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.carres.2011.03.028
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.087074

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