Dietary patterns and breast cancer risk through multilevel modeling coupled to a sensitivity analysis: an ongoing case-control study in Córdoba, Argentina.
- Autores
- Tumas, Natalia; Niclis, Camila; Aballay, Laura Rosana; Osella, Alberto Ruben; Gálvez Díaz, María del Pilar
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Introduction: Several studies have shown the effect of dietary patterns on breast cancer risk but none has been conducted in Argentina. The aim of this study was to extract dietary patterns from FFQ and to estimate their effect on breast cancer occurrence while taking into account aggregation factors (family history of breast cancer),and to explore the sensitivity of the estimates to changes in the assumptions. Methods: A Principal Component Exploratory Factor Analysis was applied to identify dietary patterns, which were then included as covariates in a multilevel logistic regression. Family history of BC was considered as a clustering variable. A multiple probabilistic sensitivity analysis was also performed.Results: The study included 100 cases and 294 controls. Four dietary patterns were identified. Traditional (fat meats, bakery products and vegetable oil and mayonnaise) (OR III tertilevs I 3.13, 95%CI 2.58-3.78), Rural (processed meat) (OR III tertilevs I 2.02, 95%CI 1.21-3.37) and Starchy (refined grains) (OR III tertilevs I 1.82, 95%CI 1.18-2.79) dietary patterns were positively associated with BC risk, whereas the Prudent pattern (fruit and non-starchy vegetables) (OR III tertilevs I 0.56, 95%CI 0.41-0.77) showed a protective effect. For Traditional pattern, the median bias-adjusted ORs (3.52) were higher than the conventional (2.76). Conclusions: While the Prudent pattern was associated with a reduced risk of BC, Traditional, Rural and Starchy patterns showed a promoting effect. Despite the threats to validity, the nature of associations was not strongly affected.
Fil: Tumas, Natalia. Universidad Nacional de Córdoba. Facultad de Medicina. Escuela de Nutrición; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones y Estudios sobre Cultura y Sociedad. Universidad Nacional de Córdoba. Centro de Investigaciones y Estudios sobre Cultura y Sociedad; Argentina
Fil: Niclis, Camila. Universidad Nacional de Córdoba. Facultad de Medicina. Escuela de Nutrición; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Aballay, Laura Rosana. Universidad Nacional de Córdoba. Facultad de Medicina. Escuela de Nutrición; Argentina
Fil: Osella, Alberto Ruben. IRCCS Saverio de Bellis. Laboratorio di Epidemiologia E Biostatistica; Italia
Fil: Gálvez Díaz, María del Pilar. Universidad Nacional de Córdoba. Facultad de Medicina. Escuela de Nutrición; Argentina - Materia
-
ARGENTINA
BREAST CANCER
DIETARY PATTERNS
MULTILEVEL
SENSITIVITY ANALYSIS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/186014
Ver los metadatos del registro completo
id |
CONICETDig_fb3ddb53db8149b75c85be896713d3d2 |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/186014 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Dietary patterns and breast cancer risk through multilevel modeling coupled to a sensitivity analysis: an ongoing case-control study in Córdoba, Argentina.Tumas, NataliaNiclis, CamilaAballay, Laura RosanaOsella, Alberto RubenGálvez Díaz, María del PilarARGENTINABREAST CANCERDIETARY PATTERNSMULTILEVELSENSITIVITY ANALYSIShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Introduction: Several studies have shown the effect of dietary patterns on breast cancer risk but none has been conducted in Argentina. The aim of this study was to extract dietary patterns from FFQ and to estimate their effect on breast cancer occurrence while taking into account aggregation factors (family history of breast cancer),and to explore the sensitivity of the estimates to changes in the assumptions. Methods: A Principal Component Exploratory Factor Analysis was applied to identify dietary patterns, which were then included as covariates in a multilevel logistic regression. Family history of BC was considered as a clustering variable. A multiple probabilistic sensitivity analysis was also performed.Results: The study included 100 cases and 294 controls. Four dietary patterns were identified. Traditional (fat meats, bakery products and vegetable oil and mayonnaise) (OR III tertilevs I 3.13, 95%CI 2.58-3.78), Rural (processed meat) (OR III tertilevs I 2.02, 95%CI 1.21-3.37) and Starchy (refined grains) (OR III tertilevs I 1.82, 95%CI 1.18-2.79) dietary patterns were positively associated with BC risk, whereas the Prudent pattern (fruit and non-starchy vegetables) (OR III tertilevs I 0.56, 95%CI 0.41-0.77) showed a protective effect. For Traditional pattern, the median bias-adjusted ORs (3.52) were higher than the conventional (2.76). Conclusions: While the Prudent pattern was associated with a reduced risk of BC, Traditional, Rural and Starchy patterns showed a promoting effect. Despite the threats to validity, the nature of associations was not strongly affected.Fil: Tumas, Natalia. Universidad Nacional de Córdoba. Facultad de Medicina. Escuela de Nutrición; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones y Estudios sobre Cultura y Sociedad. Universidad Nacional de Córdoba. Centro de Investigaciones y Estudios sobre Cultura y Sociedad; ArgentinaFil: Niclis, Camila. Universidad Nacional de Córdoba. Facultad de Medicina. Escuela de Nutrición; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Aballay, Laura Rosana. Universidad Nacional de Córdoba. Facultad de Medicina. Escuela de Nutrición; ArgentinaFil: Osella, Alberto Ruben. IRCCS Saverio de Bellis. Laboratorio di Epidemiologia E Biostatistica; ItaliaFil: Gálvez Díaz, María del Pilar. Universidad Nacional de Córdoba. Facultad de Medicina. Escuela de Nutrición; ArgentinaSpringer2014-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/186014Tumas, Natalia; Niclis, Camila; Aballay, Laura Rosana; Osella, Alberto Ruben; Gálvez Díaz, María del Pilar; Dietary patterns and breast cancer risk through multilevel modeling coupled to a sensitivity analysis: an ongoing case-control study in Córdoba, Argentina.; Springer; European Journal of Nutrition; 53; 2; 3-2014; 557-5661436-62071436-6215CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007%2Fs00394-013-0564-0#info:eu-repo/semantics/altIdentifier/doi/10.1007/s00394-013-0564-0info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:17:24Zoai:ri.conicet.gov.ar:11336/186014instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:17:24.825CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Dietary patterns and breast cancer risk through multilevel modeling coupled to a sensitivity analysis: an ongoing case-control study in Córdoba, Argentina. |
title |
Dietary patterns and breast cancer risk through multilevel modeling coupled to a sensitivity analysis: an ongoing case-control study in Córdoba, Argentina. |
spellingShingle |
Dietary patterns and breast cancer risk through multilevel modeling coupled to a sensitivity analysis: an ongoing case-control study in Córdoba, Argentina. Tumas, Natalia ARGENTINA BREAST CANCER DIETARY PATTERNS MULTILEVEL SENSITIVITY ANALYSIS |
title_short |
Dietary patterns and breast cancer risk through multilevel modeling coupled to a sensitivity analysis: an ongoing case-control study in Córdoba, Argentina. |
title_full |
Dietary patterns and breast cancer risk through multilevel modeling coupled to a sensitivity analysis: an ongoing case-control study in Córdoba, Argentina. |
title_fullStr |
Dietary patterns and breast cancer risk through multilevel modeling coupled to a sensitivity analysis: an ongoing case-control study in Córdoba, Argentina. |
title_full_unstemmed |
Dietary patterns and breast cancer risk through multilevel modeling coupled to a sensitivity analysis: an ongoing case-control study in Córdoba, Argentina. |
title_sort |
Dietary patterns and breast cancer risk through multilevel modeling coupled to a sensitivity analysis: an ongoing case-control study in Córdoba, Argentina. |
dc.creator.none.fl_str_mv |
Tumas, Natalia Niclis, Camila Aballay, Laura Rosana Osella, Alberto Ruben Gálvez Díaz, María del Pilar |
author |
Tumas, Natalia |
author_facet |
Tumas, Natalia Niclis, Camila Aballay, Laura Rosana Osella, Alberto Ruben Gálvez Díaz, María del Pilar |
author_role |
author |
author2 |
Niclis, Camila Aballay, Laura Rosana Osella, Alberto Ruben Gálvez Díaz, María del Pilar |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
ARGENTINA BREAST CANCER DIETARY PATTERNS MULTILEVEL SENSITIVITY ANALYSIS |
topic |
ARGENTINA BREAST CANCER DIETARY PATTERNS MULTILEVEL SENSITIVITY ANALYSIS |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Introduction: Several studies have shown the effect of dietary patterns on breast cancer risk but none has been conducted in Argentina. The aim of this study was to extract dietary patterns from FFQ and to estimate their effect on breast cancer occurrence while taking into account aggregation factors (family history of breast cancer),and to explore the sensitivity of the estimates to changes in the assumptions. Methods: A Principal Component Exploratory Factor Analysis was applied to identify dietary patterns, which were then included as covariates in a multilevel logistic regression. Family history of BC was considered as a clustering variable. A multiple probabilistic sensitivity analysis was also performed.Results: The study included 100 cases and 294 controls. Four dietary patterns were identified. Traditional (fat meats, bakery products and vegetable oil and mayonnaise) (OR III tertilevs I 3.13, 95%CI 2.58-3.78), Rural (processed meat) (OR III tertilevs I 2.02, 95%CI 1.21-3.37) and Starchy (refined grains) (OR III tertilevs I 1.82, 95%CI 1.18-2.79) dietary patterns were positively associated with BC risk, whereas the Prudent pattern (fruit and non-starchy vegetables) (OR III tertilevs I 0.56, 95%CI 0.41-0.77) showed a protective effect. For Traditional pattern, the median bias-adjusted ORs (3.52) were higher than the conventional (2.76). Conclusions: While the Prudent pattern was associated with a reduced risk of BC, Traditional, Rural and Starchy patterns showed a promoting effect. Despite the threats to validity, the nature of associations was not strongly affected. Fil: Tumas, Natalia. Universidad Nacional de Córdoba. Facultad de Medicina. Escuela de Nutrición; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones y Estudios sobre Cultura y Sociedad. Universidad Nacional de Córdoba. Centro de Investigaciones y Estudios sobre Cultura y Sociedad; Argentina Fil: Niclis, Camila. Universidad Nacional de Córdoba. Facultad de Medicina. Escuela de Nutrición; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina Fil: Aballay, Laura Rosana. Universidad Nacional de Córdoba. Facultad de Medicina. Escuela de Nutrición; Argentina Fil: Osella, Alberto Ruben. IRCCS Saverio de Bellis. Laboratorio di Epidemiologia E Biostatistica; Italia Fil: Gálvez Díaz, María del Pilar. Universidad Nacional de Córdoba. Facultad de Medicina. Escuela de Nutrición; Argentina |
description |
Introduction: Several studies have shown the effect of dietary patterns on breast cancer risk but none has been conducted in Argentina. The aim of this study was to extract dietary patterns from FFQ and to estimate their effect on breast cancer occurrence while taking into account aggregation factors (family history of breast cancer),and to explore the sensitivity of the estimates to changes in the assumptions. Methods: A Principal Component Exploratory Factor Analysis was applied to identify dietary patterns, which were then included as covariates in a multilevel logistic regression. Family history of BC was considered as a clustering variable. A multiple probabilistic sensitivity analysis was also performed.Results: The study included 100 cases and 294 controls. Four dietary patterns were identified. Traditional (fat meats, bakery products and vegetable oil and mayonnaise) (OR III tertilevs I 3.13, 95%CI 2.58-3.78), Rural (processed meat) (OR III tertilevs I 2.02, 95%CI 1.21-3.37) and Starchy (refined grains) (OR III tertilevs I 1.82, 95%CI 1.18-2.79) dietary patterns were positively associated with BC risk, whereas the Prudent pattern (fruit and non-starchy vegetables) (OR III tertilevs I 0.56, 95%CI 0.41-0.77) showed a protective effect. For Traditional pattern, the median bias-adjusted ORs (3.52) were higher than the conventional (2.76). Conclusions: While the Prudent pattern was associated with a reduced risk of BC, Traditional, Rural and Starchy patterns showed a promoting effect. Despite the threats to validity, the nature of associations was not strongly affected. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-03 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/186014 Tumas, Natalia; Niclis, Camila; Aballay, Laura Rosana; Osella, Alberto Ruben; Gálvez Díaz, María del Pilar; Dietary patterns and breast cancer risk through multilevel modeling coupled to a sensitivity analysis: an ongoing case-control study in Córdoba, Argentina.; Springer; European Journal of Nutrition; 53; 2; 3-2014; 557-566 1436-6207 1436-6215 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/186014 |
identifier_str_mv |
Tumas, Natalia; Niclis, Camila; Aballay, Laura Rosana; Osella, Alberto Ruben; Gálvez Díaz, María del Pilar; Dietary patterns and breast cancer risk through multilevel modeling coupled to a sensitivity analysis: an ongoing case-control study in Córdoba, Argentina.; Springer; European Journal of Nutrition; 53; 2; 3-2014; 557-566 1436-6207 1436-6215 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007%2Fs00394-013-0564-0# info:eu-repo/semantics/altIdentifier/doi/10.1007/s00394-013-0564-0 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Springer |
publisher.none.fl_str_mv |
Springer |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1844614126450507776 |
score |
13.070432 |